Berkhan Genc, Nazlı Cakici Oksuz, Naci Emre Aksehirli, Bahar Tekin, Bayram Ufuk Sakul, Mehmet Tonge
{"title":"Assessing the Potential of Transorbital and Supraorbital Approaches for Stereotactic Surgery: An Anatomical Feasibility Study.","authors":"Berkhan Genc, Nazlı Cakici Oksuz, Naci Emre Aksehirli, Bahar Tekin, Bayram Ufuk Sakul, Mehmet Tonge","doi":"10.5137/1019-5149.JTN.46170-23.2","DOIUrl":"10.5137/1019-5149.JTN.46170-23.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the supraorbital and transorbital approaches as alternative entry sites and trajectories targeting the nucleus accumbens (NAc), subcallosal cingulate gyrus (SCG), and lateral hypothalamic area (LHA), in cadavers and surgical planning station.</p><p><strong>Material and methods: </strong>The three-dimensional relationship of the identified trajectories within the anterior and middle cranial fossae as well as the stereotactically targeted NAc, SCG, and LHA, were demonstrated through dissection studies conducted in cadavers. To validate the accuracy of the measurements from the cadaver, trajectory planning was replicated using radiological imaging of patients without a space-occupying lesion who underwent gamma knife surgery. These measurements were compared with those from cadavers.</p><p><strong>Results: </strong>The transorbital and supraorbital trajectories did not pass through the lateral ventricles and they can be used for subventricular targets. Additionally, the NAc and LHA can be targeted simultaneously. These trajectories pass along a broader anatomical area within the NAc due to the anatomical orientation of the nucleus.</p><p><strong>Conclusion: </strong>These findings suggest that these entry points may offer new opportunities for stimulating different targets in the prefrontal cortex and may serve as an approach for future clinical use.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"141-156"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the Effects of HDAC Activity in Hydroxychloroquine Applied Human Primary Chondrocyte and Nucleus Pulposus Cultures.","authors":"Yasin Emre Kaya, Numan Karaarslan, Ibrahim Yilmaz, Tamer Tamdogan, Sevim Ondul, Duygu Yasar Sirin, Hanefi Ozbek","doi":"10.5137/1019-5149.JTN.46503-24.2","DOIUrl":"10.5137/1019-5149.JTN.46503-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the in vitro effects of hydroxychloroquine (HCQ) on histone deacetylase (HDAC) enzyme activity and interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) expressions.</p><p><strong>Material and methods: </strong>Primary cell cultures were prepared. Samples that did not receive any medication constituted the control group, while culture samples treated with HCQ served as the study group. The surface morphology of cells and the extracellular matrix (ECM) were evaluated by Giemsa staining and inverted light microscopy. Cell viability, proliferation, and cytotoxicity were determined by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetrazolium-bromide (MTT) analysis. The cultures were simultaneously stained with acridine orange (AO)/propidium iodide (PI) and viewed under fluorescence microscopy. HDAC enzyme activity and IL-6, IL-10, and TNF-α expression were evaluated using commercial enzyme-linked immunosorbent assay kits. The obtained data were analyzed using statistical methods. The alpha significance level was accepted as p < 0.05.</p><p><strong>Results: </strong>HCQ applied to cell cultures at the tested doses and durations showed cytotoxic effects on cell viability, proliferation, and cell or ECM morphology. It increased HDAC activity in chondrocytes and caused a proinflammatory response, indicated by an increase in TNF-α in the cells (p < 0.05).</p><p><strong>Conclusion: </strong>The results of this study emphasized that the cytotoxic effect of HCQ increased HDAC activity; therefore, this proinflammatory response should be taken into consideration in the clinical use of HCQ.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"129-140"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kihun Kim, Jong-Hyun Park, Gi Yong Yun, Jae-Min Ahn, Hyuk-Jin Oh, Jai-Joon Shim, Seok Mann Yoon
{"title":"A Comprehensive Analysis of Stent during Stent Assisted Coil Embolization for Cerebral Aneurysms: A 17-Year Institutional Study.","authors":"Kihun Kim, Jong-Hyun Park, Gi Yong Yun, Jae-Min Ahn, Hyuk-Jin Oh, Jai-Joon Shim, Seok Mann Yoon","doi":"10.5137/1019-5149.JTN.46784-24.0","DOIUrl":"10.5137/1019-5149.JTN.46784-24.0","url":null,"abstract":"<p><strong>Aim: </strong>To compare the outcomes and complications of stent-assisted coil (SAC) embolization for the treatment of cerebral aneurysms according to stent type.</p><p><strong>Material and methods: </strong>Since January 2006, a total of 1293 patients have been added to our institutional aneurysm database. We excluded cases with subarachnoid hemorrhage, those not classified as Raymond Roy Class 1, and those in which flow diverters were used. Cases involving the use of overlapping stents, Y-stenting, or multiple stents were also excluded. We recorded demographic information, aneurysm characteristics, and procedural details for all patients. Patients who did not undergo diffusionweighted magnetic resonance imaging (MRI) within 1 day postoperatively or follow-up angiography within 6 months postoperatively were excluded.</p><p><strong>Results: </strong>In total, 188 patients were included in the analysis (129 females; mean age, 58 years) who were treated for aneurysms of different sizes. Regrowth occurred in 21 patients, with the rate varying according to the stent type. In particular, the lower profile stent group had a lower regrowth rate compared to the nitinol laser stent group. The rate of postoperative infarction on diffusionweighted MRI within 1 day postoperatively varied among stent types.</p><p><strong>Conclusion: </strong>None of the stent types demonstrated clear superiority for SAC embolization, indicating that stent selection should be based on surgeon preference. Despite the low regrowth rate, careful stent selection is essential, particularly for patients at high risk of ischemic stroke or regrowth. These findings provide valuable insights for optimizing the treatment of cerebral aneurysms using SAC embolization.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"337-344"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammed Al-Ahmari, Max Keizer, Bander Al-Dhafery, Daniëlle Eekers, Koos Hovinga, Henricus Kunst, Yasin Temel
{"title":"Tumour Shrinkage and Good Facial Nerve Function After Planned Partial Resection and Gamma Knife Radiosurgery in Koos 4 Vestibular Schwannoma.","authors":"Mohammed Al-Ahmari, Max Keizer, Bander Al-Dhafery, Daniëlle Eekers, Koos Hovinga, Henricus Kunst, Yasin Temel","doi":"10.5137/1019-5149.JTN.46381-24.1","DOIUrl":"10.5137/1019-5149.JTN.46381-24.1","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate clinical and radiological outcome in surgically treated Koos 4 vestibular schwannomas.</p><p><strong>Material and methods: </strong>Volumetric analysis of the tumour volumes before surgery, after surgery (before radiation), and at follow-up time-points after radiation was performed. Clinical data on facial nerve function and complications were collected. Approximately 6 months after surgery, all patients were treated with a single fraction of stereotactic radiosurgery using the gamma knife radiosurgery with a mean marginal dose of 12.9 Gy to the residual tumour volume.</p><p><strong>Results: </strong>Mean tumour volume was 11.64 cm3 which was reduced to a mean volume of 4.17 cm3 after partial resection. After a mean follow-up of 100 months, residual tumour showed a decrease in volume in 20 patients, stable disease in one patient and two patients showed progressive tumour volume requiring a second operation in one patient. Facial nerve function was preserved in all patients. One patient suffered from a trigeminal neuralgia after radiation.</p><p><strong>Conclusion: </strong>Planned partial resection followed by radiation for patients with Koos 4 vestibular schwannoma is an effective strategy to preserve facial nerve function and achieve tumour control. Residual tumours after planned partial resection showed a mean decrease in volume of 50% at the last follow-up time point.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"265-273"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Numan Karaarslan, Hidayet Safak Cine, Ece Uysal, Bilgehan Potoglu, Mehmet Ali Kahraman, Emre Herdan, Mohammed Aladdam, Okkes Celil Gokcek, Abdullah Talha Simsek, Ercan Bosnak, Mahmut Demirkol
{"title":"Impact of Rod Material and Spinopelvic Parameters on Distal Junctional Failure Following Lumbar Fusion: A Comparative Study of Semirigid PEEK and Rigid Titanium Alloy Rods.","authors":"Numan Karaarslan, Hidayet Safak Cine, Ece Uysal, Bilgehan Potoglu, Mehmet Ali Kahraman, Emre Herdan, Mohammed Aladdam, Okkes Celil Gokcek, Abdullah Talha Simsek, Ercan Bosnak, Mahmut Demirkol","doi":"10.5137/1019-5149.JTN.47917-24.4","DOIUrl":"10.5137/1019-5149.JTN.47917-24.4","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the incidence of distal junctional failure (DJF) in patients undergoing posterior lumbar fusion with either semirigid polyether ether ketone (PEEK) or rigid titanium alloy rods, focusing on the impact of preoperative and postoperative spinopelvic parameters on DJF development.</p><p><strong>Material and methods: </strong>A retrospective analysis was conducted on patients who underwent short-segment posterior transpedicular stabilization with semirigid PEEK or rigid titanium ally rods between 2015 and 2021. Preoperative and postoperative pelvic parameters, including pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), lumbar lordosis (LL), PI-LL mismatch, and lower instrumented vertebra (LIV) were evaluated.</p><p><strong>Results: </strong>The total cohort consisted of 61 patients with a mean age of 55.85 ± 11.97 years. DJF occurred in 18.03% of patients in the PEEK group (6.67%) compared to the rigid rod group (29.03%) (p < 0.05). Postoperative PI-LL mismatch was a critical factor in DJF development (p < 0.05). Among patients with a preoperative PI-LL mismatch greater than 10°, non-DJF patients achieved a correction of -55.50°. Postoperative reductions in LL were also associated with an increased risk of DJF (p < 0.05). In the PEEK group, DJF patients experienced -19.35° reduction in LL, whereas -11.02° in the rigid rod group.</p><p><strong>Conclusion: </strong>PEEK rods were associated with a lower incidence of DJF compared to rigid titanium rods. Postoperative PI-LL mismatch and changes in lumbar lordosis and PI-LL mismatch are key predictors to prevent DJF.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"222-232"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mutational and Expressional Similarities Among Paraganglioma, Low-Grade Glioma, and Glioblastoma: A Comprehensive Clustering Approach to Central Nervous System Tumors.","authors":"Saliha Acar, Giyasettin Ozcan, Eyyup Gulbandilar","doi":"10.5137/1019-5149.JTN.46886-24.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.46886-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To compare central nervous system (CNS) tumors, such as paraganglioma, low-grade glioma (LGG), and glioblastoma (GBM), in terms of driver genes and gene expression, and to investigate the roles of common driver genes and genes with altered expression in cellular proliferation mechanisms and their interactions.</p><p><strong>Material and methods: </strong>Mutation datasets for pheochromocytoma/paraganglioma, LGG, and GBM from The Cancer Genome Atlas (TCGA) database were used for driver gene prediction. Six datasets from the Gene Expression Omnibus (GEO) database were used for differential gene expression analysis. A hybrid approach combining clustering and computational biology methods was applied to identify driver genes. Gene expression analyses were repeated for two gene expression datasets for each tumor type, and the intersection of the results was taken. Protein interaction analyses, overall survival analyses, and carcinogenesis-related functional analyses were performed on the common driver genes and the genes with the most significant changes in expression.</p><p><strong>Results: </strong>ATRX, NF1, MUC16, and TTN were identified as driver gene candidates for all three tumor types. FSTL5, GABRG2, VSNL1, and LPL were found to be the genes with the most altered expression across all tumor types. Our findings suggest that, while CNS tumors with similar symptoms share molecular features, they can be more accurately differentiated through detailed investigation of the expression and mutation burden of the identified genes. This may also help accelerate the treatment planning process.</p><p><strong>Conclusion: </strong>This study confirms that paraganglioma, LGG, and GBM may share common mutational and expressional gene patterns. The identified genes may serve as potential therapeutic targets in the treatment of glial and neuroendocrine tumors.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 3","pages":"463-473"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Strategies for Preventing Delayed Leukoencephalopathy: A Case Report on the Efficacy of Separate-Axis Catheter Angiography in Coil Embolization.","authors":"Nagatsuki Tomura, Ryutaro Fukuyama, Shigeo Matsunaga, Takashi Shuto","doi":"10.5137/1019-5149.JTN.47232-24.2","DOIUrl":"https://doi.org/10.5137/1019-5149.JTN.47232-24.2","url":null,"abstract":"<p><p>In recent years, there have been multiple reports of delayed leukoencephalopathy (DL) occurring after endovascular treatment for cerebral vascular lesions, with polyvinylpyrrolidone (PVP) identified as a contributing factor. Herein, we present a case of DL developing after coil embolization for an unruptured aneurysm, and following the implementation of measures, we subsequently performed repeat endovascular treatment. A 65-year-old female with a history of bronchial asthma underwent coil embolization using the double catheter technique for the right internal carotid artery-anterior choroidal artery aneurysm. One month postoperatively, she developed DL accompanied by left hemiparesis, which improved with steroid pulse therapy. Investigation into the cause of DL revealed elevated anti-nuclear antibodies, leading to a diagnosis of Sjögren?s syndrome and Hashimoto?s disease. Additionally, metal patch testing yielded negative results. At the 1-year follow-up, an enlargement of a known basilar top aneurysm prompted the decision to perform stent-assisted coil embolization. To prevent peripheral scattering of PVP during the procedure, the decision was made to perform all imaging along a different axis guided by a catheter. Despite complications such as stent thrombosis, with no reduction in contrast agent usage, imaging frequency, or surgical time compared to the initial treatment, DL did not manifest in the postoperative course. For the prevention of DL after endovascular treatment, from a procedural aspect, it is important to reduce the peripheral dispersal of PVP that occurs during treatment. Performing angiography during treatment from a separate axis catheter may be a useful strategy in preventing the development of DL.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 3","pages":"512-517"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abhijit Goyal-Honavar, Ananth P Abraham, H S Asha, Geeta Chacko, Ari G Chacko
{"title":"Functional Transformation of a Corticotroph Pituitary Neuroendocrine Tumor 128 Months Following Primary Excision ? A Case Report.","authors":"Abhijit Goyal-Honavar, Ananth P Abraham, H S Asha, Geeta Chacko, Ari G Chacko","doi":"10.5137/1019-5149.JTN.44912-23.2","DOIUrl":"10.5137/1019-5149.JTN.44912-23.2","url":null,"abstract":"<p><p>Silent corticotroph pituitary neuroendocrine tumours (PitNETs) are rare, aggressive tumours that exhibit clinical and biochemical silence, despite their expression of adrenocorticotrophic hormone (ACTH) and the transcription factor Tpit. They exist on a spectrum of functionality between true silent adenomas and ACTH-secreting adenomas and rarely transform into functioning corticotroph adenomas. In this report, we describe an aggressive silent corticotroph PitNET, which recurred twice following complete excision and displayed functional transformation 128 months after primary excision, with clinical and biochemical profiles suggestive of Cushing?s disease. The patient underwent re-operation followed by hypofractionated stereotactic radiotherapy. This case report demonstrates the importance of long-term clinical and biochemical follow-up in patients with silent corticotroph PitNETs, and highlights the aggressive nature of these tumours that warrants early adjuvant radiation.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":"35 2","pages":"355-359"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcelo Porto Sousa, Sávio Batista, Guilherme Melo Silva, Márcio Yuri Ferreira, Leonardo Oliveira Brenner, José Victor Dantas dos Santos, Raphael Muszkat Besborodco, Filipi Fim Andreão, Agostinho C Pinheiro, Raphael Bertani, José Alberto Almeida Filho
{"title":"Brachial Artery Access for Carotid Artery Stenting: A Pooled Analysis.","authors":"Marcelo Porto Sousa, Sávio Batista, Guilherme Melo Silva, Márcio Yuri Ferreira, Leonardo Oliveira Brenner, José Victor Dantas dos Santos, Raphael Muszkat Besborodco, Filipi Fim Andreão, Agostinho C Pinheiro, Raphael Bertani, José Alberto Almeida Filho","doi":"10.5137/1019-5149.JTN.46534-24.2","DOIUrl":"10.5137/1019-5149.JTN.46534-24.2","url":null,"abstract":"<p><strong>Aim: </strong>To examine the potential of transbrachial access (TBA) in carotid artery stenting (CAS).</p><p><strong>Material and methods: </strong>This systematic review and meta-analysis aimed to comprehensively evaluate the safety and efficacy of TBA for CAS by conducting a thorough search on Medline, Cochrane Library, Embase, and Web of Science databases. Studies reporting TBA for CAS and evaluating primary outcomes such as good neurological results, procedural success, and complications were included. Studies with fewer than 4 patients were excluded.</p><p><strong>Results: </strong>After a meticulous selection of 1837 literature articles, 11 studies were meticulously chosen for the comprehensive examination, involving a total of 273 patients. The analysis of nine studies revealed a consistent 100% procedural success rate with minimal variability (95% CI: 98% to 100%). In the final assessment of neurological status across eight studies, good neurological outcomes were observed in 99% (95% CI: 98% to 100%). Additionally, nineteen complications were identified, leading to a 1% rate (95% CI: 0% to 9%). Among the 223 patients in eight studies, resulting in a pooled estimate of 0% mortality (95% CI: 0% to 1%), indicating a favorable safety profile.</p><p><strong>Conclusion: </strong>The results of TBA for CAS demonstrate a highly effective and safe procedure. Despite the limitations, TBA can be an option in patients with no other access available, and further comparative studies are required to establish definitive conclusions.</p>","PeriodicalId":94381,"journal":{"name":"Turkish neurosurgery","volume":" ","pages":"3-11"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}