Schizophrenia bulletin open最新文献

{"title":"Biomarkers for Psychosis: Are We There Yet? Umbrella Review of 1478 Biomarkers.","authors":"Paola Fuentes-Claramonte, Andrés Estradé, Aleix Solanes, Valentina Ramella-Cravaro, Maria Angeles Garcia-Leon, Javier de Diego-Adeliño, Conrad Molins, Eric Fung, Marc Valentí, Gerard Anmella, Edith Pomarol-Clotet, Dominic Oliver, Eduard Vieta, Joaquim Radua, Paolo Fusar-Poli","doi":"10.1093/schizbullopen/sgae018","DOIUrl":"10.1093/schizbullopen/sgae018","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>This umbrella review aims to comprehensively synthesize the evidence of association between peripheral, electrophysiological, neuroimaging, neuropathological, and other biomarkers and diagnosis of psychotic disorders.</p><p><strong>Study design: </strong>We selected systematic reviews and meta-analyses of observational studies on diagnostic biomarkers for psychotic disorders, published until February 1, 2018. Data extraction was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Evidence of association between biomarkers and psychotic disorders was classified as convincing, highly suggestive, suggestive, weak, or non-significant, using a standardized classification. Quality analyses used the Assessment of Multiple Systematic Reviews (AMSTAR) tool.</p><p><strong>Study results: </strong>The umbrella review included 110 meta-analyses or systematic reviews corresponding to 3892 individual studies, 1478 biomarkers, and 392 210 participants. No factor showed a convincing level of evidence. Highly suggestive evidence was observed for transglutaminase autoantibodies levels (odds ratio [OR] = 7.32; 95% CI: 3.36, 15.94), mismatch negativity in auditory event-related potentials (standardized mean difference [SMD] = 0.73; 95% CI: 0.5, 0.96), P300 component latency (SMD = -0.6; 95% CI: -0.83, -0.38), ventricle-brain ratio (SMD = 0.61; 95% CI: 0.5, 0.71), and minor physical anomalies (SMD = 0.99; 95% CI: 0.64, 1.34). Suggestive evidence was observed for folate, malondialdehyde, brain-derived neurotrophic factor, homocysteine, P50 sensory gating (P50 S2/S1 ratio), frontal <i>N</i>-acetyl-aspartate, and high-frequency heart rate variability. Among the remaining biomarkers, weak evidence was found for 626 and a non-significant association for 833 factors.</p><p><strong>Conclusions: </strong>While several biomarkers present highly suggestive or suggestive evidence of association with psychotic disorders, methodological biases, and underpowered studies call for future higher-quality research.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae018"},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial and Ethnic Disparities in the Diagnosis and Early Treatment of First-Episode Psychosis.","authors":"Aubrey M Moe, Elyse Llamocca, Heather M Wastler, Danielle L Steelesmith, Guy Brock, Oladunni Oluwoye, Cynthia A Fontanella","doi":"10.1093/schizbullopen/sgae019","DOIUrl":"10.1093/schizbullopen/sgae019","url":null,"abstract":"<p><strong>Background: </strong>Despite recognition that early intervention for first-episode psychosis (FEP) improves outcomes, Black youth with FEP continue to experience critical disparities in care. A historical lack of scientific focus on racial and ethnic factors in the study of psychosis and scant investigations among publicly insured (ie, Medicaid-enrolled) youth hinder our ability to understand and address factors that contribute to disparities in early FEP care. Strategies for improving FEP services for Black youth are reliant on more precise identification of <i>who</i> faces disparities and <i>when</i> during the early course of illness disparities are experienced.</p><p><strong>Study design: </strong>A retrospective longitudinal analysis of Ohio Medicaid claims data was performed for 987 982 youth aged 15-24 years between 2010 and 2020 to examine: (1) the likelihood of FEP diagnosis, (2) the type of psychotic disorder diagnosis received, and (3) receipt of treatment following psychosis onset.</p><p><strong>Study results: </strong>Non-Hispanic Black (NHB) youth, relative to non-Hispanic White (NHW) peers, were more likely to be diagnosed with a psychotic disorder and were further more likely to receive a diagnosis of schizophrenia relative to an affective psychotic disorder. In the first year following FEP diagnosis, NHB youth were also less likely to receive psychotherapy than NHW youth; this disparity was no longer present when examined at 2 years following FEP.</p><p><strong>Conclusions: </strong>In this study, Black youth experienced disparities in both the diagnosis and early treatment of FEP. Additional efforts are needed to understand and address these observed disparities and to promote equitable access to FEP care during the critical early illness phases.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae019"},"PeriodicalIF":0.0,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11350282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interview Versus Performance Assessment of Cognition as Predictors of Real-World Outcomes in a Large-Scale Cross-Sectional Study in Schizophrenia.","authors":"Pasquale Pezzella, Edoardo Caporusso, Armida Mucci, Paola Bucci, Giulia M Giordano, Mario Amore, Paola Rocca, Alessandro Rossi, Alessandro Bertolino, Joseph Ventura, Silvana Galderisi, Mario Maj","doi":"10.1093/schizbullopen/sgae020","DOIUrl":"10.1093/schizbullopen/sgae020","url":null,"abstract":"<p><p>The Cognitive Assessment Interview (CAI) is an interview-based scale measuring cognitive impairment and its impact on functioning in subjects with schizophrenia (SCZ). It is approved as a coprimary measure of performance-based instruments, such as the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery (MCCB). Recent research highlights negative symptoms, social cognition, and functional capacity as mediators of cognitive impairment's impact on functioning. This study compared mediation analysis outcomes using CAI or MCCB scores, providing insights into the utility of interview-based tools in research and clinical practice. The study included 618 individuals diagnosed with schizophrenia, recruited from 24 Italian psychiatric clinics. Neurocognitive assessments utilized both CAI and MCCB. Mediation analyses explored negative symptoms, social cognition, and functional capacity as mediators of the impact of neurocognition on real-life functioning domains. The study's results extend the validation of the CAI as a coprimary measure that provides valid information on the impact of cognitive impairment on real-life functioning and its possible mediators, complementing the information obtained using the MCCB. Interview-based cognitive assessment might be essential for understanding schizophrenia complexity and its impact on various cognitive and functional domains for clinicians, patients, and caregivers.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae020"},"PeriodicalIF":0.0,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Tale of three spectra: Basic symptoms in clinical high risk of psychosis vary across autism spectrum disorder, schizotypal personality disorder, and borderline personality disorder","authors":"James C Martin, Scott R. Clark, Simon Hartmann, K. O. Schubert","doi":"10.1093/schizbullopen/sgae017","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae017","url":null,"abstract":"\u0000 \u0000 \u0000 The clinical-high-risk (CHR) approach was developed to prevent psychosis through the detection of psychosis-risk. CHR services are transdiagnostic in nature, therefore the appropriate management of comorbidity is a central part of care. Differential diagnosis is particularly challenging across three common comorbidities, schizotypal personality disorder (SPD), autism spectrum disorder (ASD), and borderline personality disorder (BPD). Phenomenological research indicates a disturbance of ‘basic self’ may differentiate between these commonly comorbid disorders and can be captured by Huber’s basic symptoms (BS) concept. We investigated whether BS vary across these disorders and may inform differential diagnosis in young person’s meeting CHR criteria.\u0000 \u0000 \u0000 \u0000 685 participants meeting CHR criteria from the NAPLS-3 cohort completed the COGDIS items of the schizophrenia proneness instrument, a measure of BS, as well as the structured interview for DSM-5 (SCID-5). A Logistic regression model was used to investigate the variation of COGDIS across SPD, ASD, and BPD, whilst controlling for age and SIPs positive severity.\u0000 \u0000 \u0000 \u0000 Meeting COGDIS criteria was positively associated with SPD (OR = 1.72, CI=[1.31-2.28], p=0.001) but not ASD nor BPD.\u0000 \u0000 \u0000 \u0000 Our results indicate that ‘basic self-disturbance’ as indicated by COGDIS differs across SPD, ASD, and BPD. COGDIS may be useful to inform the management of comorbidities in CHR services, by providing insight into subtle subjective experiences that may benefit from disorder-specific interventions.\u0000","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"86 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141797945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Task-fMRI to Explore the Relationship Between Lifetime Cannabis Use and Cognitive Control in Individuals with First Episode Schizophrenia","authors":"T. Lesh, Joshua P Rhilinger, Rylee Brower, Alex M. Mawla, J. Ragland, T. Niendam, C. S. Carter","doi":"10.1093/schizbullopen/sgae016","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae016","url":null,"abstract":"\u0000 While continued cannabis use and misuse in individuals with schizophrenia is associated with a variety of negative outcomes, individuals with a history of use tend to show higher cognitive performance compared to non-users. While this is replicated in the literature, few studies have used task-based functional magnetic resonance imaging (fMRI) to evaluate whether the brain networks underpinning these cognitive features are similarly impacted. Forty-eight first episode individuals with schizophrenia (FES) with a history of cannabis use (FES+CAN), 28 FES individuals with no history of cannabis use (FES-CAN), and 59 controls (CON) performed the AX-Continuous Performance Task during fMRI. FES+CAN showed higher cognitive control performance (d’-context) compared to FES-CAN (p<.05, ηp2=.053), and both FES+CAN (p<.05, ηp2=.049) and FES-CAN (p<.001, ηp2=.216) showed lower performance compared to CON. FES+CAN (p<.05, ηp2=.055) and CON (p<.05, ηp2=.058) showed higher dorsolateral prefrontal cortex (DLPFC) activation during the task compared to FES-CAN, while FES+CAN and CON were not significantly different. Within the FES+CAN group, younger age of initiation of cannabis use was associated with lower IQ and lower global functioning. More frequent use was also associated with higher reality distortion symptoms at the time of the scan. These data are consistent with previous literature suggesting that individuals with schizophrenia and a history of cannabis use have higher cognitive control performance. For the first time, we also reveal that FES+CAN have higher DLPFC brain activity during cognitive control compared to FES-CAN. Several possible explanations for these findings are discussed.","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"69 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"My Impulsivity.","authors":"Jason Jepson","doi":"10.1093/schizbullopen/sgae014","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae014","url":null,"abstract":"","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae014"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological treatment of Cognitive Impairment Associated with Schizophrenia: state of the art and future perspectives","authors":"Antonio Vita, Gabriele Nibbio, Stefano Barlati","doi":"10.1093/schizbullopen/sgae013","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae013","url":null,"abstract":"\u0000 Cognitive Impairment Associated with Schizophrenia (CIAS) represents one of the core dimensions of Schizophrenia Spectrum Disorders (SSD), with an important negative impact on real-world functional outcomes of people living with SSD.\u0000 Treatment of CIAS represents a therapeutic goal of considerable importance, and while cognition-oriented evidence-based psychosocial interventions are available, effective pharmacological treatment could represent a game-changer in the lives of people with SSD.\u0000 The present critical review reports and discusses the evidence regarding the effects of several pharmacological agents that are available in clinical practice or are under study, commenting on both current and future perspectives of CIAS treatment.\u0000 In particular, the effects on CIAS of antipsychotic medications, anticholinergic medications, benzodiazepines, which are currently commonly used in the treatment of SSD, and of iclepertin, D-serine, luvadaxistat, xanomeline-trospium, ulotaront, anti-inflammatory molecules, and oxytocin, which are undergoing regulatory trials or can be considered as experimental agents, will be reported and discussed.\u0000 Currently available pharmacological agents do not appear to provide substantial benefits on CIAS, but an accurate management of antipsychotic medications and avoiding treatments that can further exacerbate CIAS represent important strategies. Some molecules that are currently being investigated in Phase 2 and Phase 3 trials have provided very promising preliminary results, but more information is currently required to assess their effectiveness in real-world contexts and to provide clear recommendations regarding their use in clinical practice. The results of ongoing and future studies will reveal whether any of these molecules represents the awaited pharmacological game-changer in the treatment of CIAS.","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"48 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical Network Disruption Is Minimal in Early Stages of Psychosis.","authors":"Peter C Van Dyken, Michael MacKinley, Ali R Khan, Lena Palaniyappan","doi":"10.1093/schizbullopen/sgae010","DOIUrl":"10.1093/schizbullopen/sgae010","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Schizophrenia is associated with white matter disruption and topological reorganization of cortical connectivity but the trajectory of these changes, from the first psychotic episode to established illness, is poorly understood. Current studies in first-episode psychosis (FEP) patients using diffusion magnetic resonance imaging (dMRI) suggest such disruption may be detectable at the onset of psychosis, but specific results vary widely, and few reports have contextualized their findings with direct comparison to young adults with established illness.</p><p><strong>Study design: </strong>Diffusion and T1-weighted 7T MR scans were obtained from <i>N</i> = 112 individuals (58 with untreated FEP, 17 with established schizophrenia, 37 healthy controls) recruited from London, Ontario. Voxel- and network-based analyses were used to detect changes in diffusion microstructural parameters. Graph theory metrics were used to probe changes in the cortical network hierarchy and to assess the vulnerability of hub regions to disruption. The analysis was replicated with <i>N</i> = 111 (57 patients, 54 controls) from the Human Connectome Project-Early Psychosis (HCP-EP) dataset.</p><p><strong>Study results: </strong>Widespread microstructural changes were found in people with established illness, but changes in FEP patients were minimal. Unlike the established illness group, no appreciable topological changes in the cortical network were observed in FEP patients. These results were replicated in the early psychosis patients of the HCP-EP datasets, which were indistinguishable from controls in most metrics.</p><p><strong>Conclusions: </strong>The white matter structural changes observed in established schizophrenia are not a prominent feature in the early stages of this illness.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae010"},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Auditory Hallucinations Are Not Associated With Specific White Matter Diffusion Alterations in Schizophrenia.","authors":"Stener Nerland, Nora Berz Slapø, Claudia Barth, Lynn Mørch-Johnsen, Kjetil Nordbø Jørgensen, Dani Beck, Laura A Wortinger, Lars T Westlye, Erik G Jönsson, Ole A Andreassen, Ivan I Maximov, Oliver M Geier, Ingrid Agartz","doi":"10.1093/schizbullopen/sgae008","DOIUrl":"10.1093/schizbullopen/sgae008","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Studies have linked auditory hallucinations (AH) in schizophrenia spectrum disorders (SCZ) to altered cerebral white matter microstructure within the language and auditory processing circuitry (LAPC). However, the specificity to the LAPC remains unclear. Here, we investigated the relationship between AH and DTI among patients with SCZ using diffusion tensor imaging (DTI).</p><p><strong>Study design: </strong>We included patients with SCZ with (AH+; <i>n</i> = 59) and without (AH-; <i>n</i> = 81) current AH, and 140 age- and sex-matched controls. Fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD) were extracted from 39 fiber tracts. We used principal component analysis (PCA) to identify general factors of variation across fiber tracts and DTI metrics. Regression models adjusted for sex, age, and age² were used to compare tract-wise DTI metrics and PCA factors between AH+, AH-, and healthy controls and to assess associations with clinical characteristics.</p><p><strong>Study results: </strong>Widespread differences relative to controls were observed for MD and RD in patients without current AH. Only limited differences in 2 fiber tracts were observed between AH+ and controls. Unimodal PCA factors based on MD, RD, and AD, as well as multimodal PCA factors, differed significantly relative to controls for AH-, but not AH+. We did not find any significant associations between PCA factors and clinical characteristics.</p><p><strong>Conclusions: </strong>Contrary to previous studies, DTI metrics differed mainly in patients <i>without</i> current AH compared to controls, indicating a widespread neuroanatomical distribution. This challenges the notion that altered DTI metrics within the LAPC is a specific feature underlying AH.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae008"},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of the link between social cognition and suicidal ideation and behavior in people with serious mental illness","authors":"E. Parrish, Lisa Steenkamp, Samantha Chalker, R. Moore, A. Pinkham, Colin Depp","doi":"10.1093/schizbullopen/sgae007","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae007","url":null,"abstract":"\u0000 \u0000 \u0000 People with serious mental illness (SMI; psychotic and affective disorders with psychosis) are at an increased risk of suicide, yet there is limited research on the correlates of suicide in SMI. Social cognitive impairments are common among people with SMI and several studies have examined social cognition and suicidal ideation (SI) and behavior. This systematic review aims to evaluate the links between various domains of social cognition, SI, and suicidal behavior in SMI.\u0000 \u0000 \u0000 \u0000 Electronic databases (PubMed and PsycInfo) were searched through June 2023. Records obtained through this search (N=618) were screened by two independent reviewers according to inclusion criteria. Relevant data were extracted, and study quality was assessed.\u0000 \u0000 \u0000 \u0000 Studies (N=16) from twelve independent samples were included in the systematic review (N=2,631, sample sizes ranged from N=20 to N=593). Assessments of social cognition and SI and behavior varied widely between studies. Broadly, effects were mixed. Better emotion recognition of negative affect was linked to SI and a history of suicide attempts, though there is little consistent evidence for the relationship of emotion recognition and SI or behavior. On the other hand, better theory of mind ability was linked to SI and a history of suicide attempts. Furthermore, negative attributional bias was linked to current SI, but not a history of SI or attempt.\u0000 \u0000 \u0000 \u0000 This review suggests mixed associations between social cognition, SI, and behavior in SMI. Future research should evaluate additional mediators and moderators of social cognition and suicide, employing prospective designs.\u0000","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"93 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140377808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}