Schizophrenia bulletin open最新文献

{"title":"Am I Inflamed? Chicken, Egg, and Psychosis.","authors":"Hashwin V S Ganesh, Candice Canonne","doi":"10.1093/schizbullopen/sgae001","DOIUrl":"10.1093/schizbullopen/sgae001","url":null,"abstract":"","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae001"},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Network Structure Of Childhood Trauma, Bodily Disturbances, And Schizotypy In Schizophrenia And Non-Clinical Controls","authors":"Lénie J Torregrossa, Jinyuan Liu, Kristan Armstrong, Stephan Heckers, Julia M Sheffield","doi":"10.1093/schizbullopen/sgae006","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae006","url":null,"abstract":"\u0000 \u0000 \u0000 Exposure to childhood trauma has been linked to the development of psychosis and bodily-self disturbances, two hallmarks of schizophrenia. Prior work demonstrated that bodily disturbances serve as a bridge between childhood trauma and schizophrenia symptomatology, but the diagnostic specificity of these connections remains unknown. This study uses network analysis to bridge this gap by comparing the interplays between childhood trauma, bodily-self disturbances, and schizotypy in clinical and general populations.\u0000 \u0000 \u0000 \u0000 Networks were constructed to examine the relationships between schizotypy (Schizotypal Personality Questionnaire; SPQ), bodily self-disturbances (Perceptual Aberration Scale; PAS), and childhood trauma (Childhood Trauma Questionnaire, CTQ) in 152 people with schizophrenia (SZ) and 162 healthy comparison participants (HC). The Fused Graphical Lasso was used to jointly estimate the networks in the two groups and the structure and strength of the networks were compared. Node centrality and shortest paths between CTQ, PAS, and schizotypy were examined.\u0000 \u0000 \u0000 \u0000 When comparing SZ and HC, the network of bodily self-disturbances, childhood trauma, and schizotypy were similarly structured, but the network was significantly stronger in SZ than HC. In both groups, bodily self-disturbances were on one of the shortest paths between childhood trauma to schizotypal experiences.\u0000 \u0000 \u0000 \u0000 Our findings revealed reliable associations between childhood trauma, bodily-self disturbance, and schizotypy, with bodily disturbances acting as a bridge from childhood trauma to schizotypy. The elevated strength of the SZ network indicates a more highly interconnected, and therefore reactive network in which exposure to childhood trauma can more easily activate bodily disturbances and schizotypy.\u0000","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"26 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140245097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>N</i>-Acetylcysteine and a Specialized Preventive Intervention for Individuals at High Risk for Psychosis: A Randomized Double-Blind Multicenter Trial.","authors":"Sven Wasserthal, Ana Muthesius, René Hurlemann, Stephan Ruhrmann, Stefanie J Schmidt, Martin Hellmich, Frauke Schultze-Lutter, Joachim Klosterkötter, Hendrik Müller, Andreas Meyer-Lindenberg, Timm B Poeppl, Henrik Walter, Dusan Hirjak, Nikolaos Koutsouleris, Andreas J Fallgatter, Andreas Bechdolf, Anke Brockhaus-Dumke, Christoph Mulert, Alexandra Philipsen, Joseph Kambeitz","doi":"10.1093/schizbullopen/sgae005","DOIUrl":"10.1093/schizbullopen/sgae005","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Clinical high risk for psychosis (CHR-P) offers a window of opportunity for early intervention and recent trials have shown promising results for the use of <i>N</i>-acetylcysteine (NAC) in schizophrenia. Moreover, integrated preventive psychological intervention (IPPI), applies social-cognitive remediation to aid in preventing the transition to the psychosis of CHR-P patients.</p><p><strong>Study design: </strong>In this double-blind, randomized, controlled multicenter trial, a 2 × 2 factorial design was applied to investigate the effects of NAC compared to placebo (PLC) and IPPI compared to psychological stress management (PSM). The primary endpoint was the transition to psychosis or deterioration of CHR-P symptoms after 18 months.</p><p><strong>Study results: </strong>While insufficient recruitment led to early trial termination, a total of 48 participants were included in the study. Patients receiving NAC showed numerically higher estimates of event-free survival probability (IPPI + NAC: 72.7 ± 13.4%, PSM + NAC: 72.7 ± 13.4%) as compared to patients receiving PLC (IPPI + PLC: 56.1 ± 15.3%, PSM + PLC: 39.0 ± 17.4%). However, a log-rank chi-square test in Kaplan-Meier analysis revealed no significant difference of survival probability for NAC vs control (point hazard ratio: 0.879, 95% CI 0.281-2.756) or IPPI vs control (point hazard ratio: 0.827, 95% CI 0.295-2.314). The number of adverse events (AE) did not differ significantly between the four groups.</p><p><strong>Conclusions: </strong>The superiority of NAC or IPPI in preventing psychosis in patients with CHR-P compared to controls could not be statistically validated in this trial. However, results indicate a consistent pattern that warrants further testing of NAC as a promising and well-tolerated intervention for CHR patients in future trials with adequate statistical power.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae005"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Using Smartphones to Identify Momentary Characteristics of Persecutory Ideation Associated With Functional Disability.","authors":"","doi":"10.1093/schizbullopen/sgad033","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgad033","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/schizbullopen/sgad021.].</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"4 1","pages":"sgad033"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Pilot Study Examining Feasibility and Initial Efficacy of Remotely Delivered Cognitive Adaptation Training.","authors":"Dawn I Velligan, Feiyu Li, Veronica Sebastian, Cory Kennedy, Jim Mintz","doi":"10.1093/schizbullopen/sgad028","DOIUrl":"10.1093/schizbullopen/sgad028","url":null,"abstract":"<p><p>Cognitive Adaptation Training (CAT) is an evidence-based treatment that uses environmental supports including signs, text messages, checklists, smart pill containers, and the organization of belongings to bypass cognitive and motivational impairments and to cue adaptive behavior in the home or work environment. We developed and tested a remote version of CAT to make the treatment available more broadly. Because CAT is focused on working with the individual in their home environment to establish supports, CAT may not be as easy to translate into an effective virtual treatment as talk-therapies. Fifty-six members of managed care were assigned to or given their treatment preference for CAT or Remote CAT (R-CAT) for 6 months. In-person or virtual pill counts were conducted monthly and assessments of habit-formation, symptoms, functioning, and satisfaction were administered every 2 months by independent raters. Analyses using mixed models with repeated measures focused on pre-planned evaluations of within-group change. Adherence improved significantly in R-CAT, functioning improved significantly in CAT and both groups improved significantly on measures of habit-formation and symptoms across 6 months. Higher functioning individuals appeared to choose R-CAT. Satisfaction with treatment was very high in both groups. R-CAT appears to be a potentially effective treatment, particularly for medication follow-though. However, in contrast to decades of previous research, fewer than 20% of eligible Medicaid recipients agreed to participate in the study. This may have been due to recruitment during and immediately post-pandemic.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"4 1","pages":"sgad028"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576524/pdf/sgad028.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41243007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing a Computerized Digit Symbol Test to a Pen-and-Paper Classic.","authors":"Danielle N Pratt, Lauren Luther, Kyle S Kinney, Kenneth Juston Osborne, Philip R Corlett, Albert R Powers, Scott W Woods, James M Gold, Jason Schiffman, Lauren M Ellman, Gregory P Strauss, Elaine F Walker, Richard Zinbarg, James A Waltz, Steven M Silverstein, Vijay A Mittal","doi":"10.1093/schizbullopen/sgad027","DOIUrl":"10.1093/schizbullopen/sgad027","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Processing speed dysfunction is a core feature of psychosis and predictive of conversion in individuals at clinical high risk (CHR) for psychosis. Although traditionally measured with pen-and-paper tasks, computerized digit symbol tasks are needed to meet the increasing demand for remote assessments. Therefore we: (1) assessed the relationship between traditional and computerized processing speed measurements; (2) compared effect sizes of impairment for progressive and persistent subgroups of CHR individuals on these tasks; and (3) explored causes contributing to task performance differences.</p><p><strong>Study design: </strong>Participants included 92 CHR individuals and 60 healthy controls who completed clinical interviews, the Brief Assessment of Cognition in Schizophrenia Symbol Coding test, the computerized TestMyBrain Digit Symbol Matching Test, a finger-tapping task, and a self-reported motor abilities measure. Correlations, Hedges' g, and linear models were utilized, respectively, to achieve the above aims.</p><p><strong>Study results: </strong>Task performance was strongly correlated (<i>r</i> = 0.505). A similar degree of impairment was seen between progressive (<i>g</i> = -0.541) and persistent (<i>g</i> = -0.417) groups on the paper version. The computerized task uniquely identified impairment for progressive individuals (<i>g</i> = -477), as the persistent group performed similarly to controls (<i>g</i> = -0.184). Motor abilities were related to the computerized version, but the paper version was more related to symptoms and psychosis risk level.</p><p><strong>Conclusions: </strong>The paper symbol coding task measures impairment throughout the CHR state, while the computerized version only identifies impairment in those with worsening symptomatology. These results may be reflective of sensitivity differences, an artifact of existing subgroups, or evidence of mechanistic differences.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"4 1","pages":"sgad027"},"PeriodicalIF":0.0,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/e5/sgad027.PMC10590153.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Belief Updating in Subclinical and Clinical Delusions.","authors":"Sophie Fromm, Teresa Katthagen, Lorenz Deserno, Andreas Heinz, Jakob Kaminski, Florian Schlagenhauf","doi":"10.1093/schizbullopen/sgac074","DOIUrl":"10.1093/schizbullopen/sgac074","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Current frameworks propose that delusions result from aberrant belief updating due to altered prediction error (PE) signaling and misestimation of environmental volatility. We aimed to investigate whether behavioral and neural signatures of belief updating are specifically related to the presence of delusions or generally associated with manifest schizophrenia.</p><p><strong>Methods: </strong>Our cross-sectional design includes human participants (<i>n</i>[female/male] = 66[25/41]), stratified into four groups: healthy participants with minimal (<i>n</i> = 22) or strong delusional-like ideation (<i>n</i> = 18), and participants with diagnosed schizophrenia with minimal (<i>n</i> = 13) or strong delusions (<i>n</i> = 13), resulting in a 2 × 2 design, which allows to test for the effects of delusion and diagnosis. Participants performed a reversal learning task with stable and volatile task contingencies during fMRI scanning. We formalized learning with a hierarchical Gaussian filter model and conducted model-based fMRI analysis regarding beliefs of outcome uncertainty and volatility, precision-weighted PEs of the outcome- and the volatility-belief.</p><p><strong>Results: </strong>Patients with schizophrenia as compared to healthy controls showed lower accuracy and heightened choice switching, while delusional ideation did not affect these measures. Participants with delusions showed increased precision-weighted PE-related neural activation in fronto-striatal regions. People with diagnosed schizophrenia overestimated environmental volatility and showed an attenuated neural representation of volatility in the anterior insula, medial frontal and angular gyrus.</p><p><strong>Conclusions: </strong>Delusional beliefs are associated with altered striatal PE-signals. Juxtaposing, the potentially unsettling belief that the environment is constantly changing and weaker neural encoding of this subjective volatility seems to be associated with manifest schizophrenia, but not with the presence of delusional ideation.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"4 1","pages":"sgac074"},"PeriodicalIF":0.0,"publicationDate":"2022-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventing Suicide in Schizophrenia.","authors":"","doi":"10.1093/schizbullopen/sgac063","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgac063","url":null,"abstract":"","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"4 1","pages":"sgac063"},"PeriodicalIF":0.0,"publicationDate":"2022-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Hyper-methylation Associated With Schizophrenia May Lead to Increased Levels of Autoantibodies.","authors":"Hui Wei, Yanbo Yuan, Caiyun Zhu, Mingjie Ma, Fude Yang, Zheng Lu, Chuanyue Wang, Hong Deng, Jingping Zhao, Runhui Tian, Wanwan Zhu, Yan Shen, Xin Yu, Qi Xu","doi":"10.1093/schizbullopen/sgac047","DOIUrl":"10.1093/schizbullopen/sgac047","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Environmental stressors may influence immune surveillance in B lymphocytes and stimulate autoimmune responses via epigenetic DNA methylation modifications in schizophrenia (SCZ).</p><p><strong>Study design: </strong>A total of 2722, Chinese Han origin subjects were recruited in this study (2005-2011), which included a discovery follow-up cohort with 40 remitters of SCZ (RSCZ), 40 nonremitters of SCZ (NRSCZ), and 40 controls (CTL), and a replication follow-up cohort (64 RSCZ, 16 NRSCZ, and 84 CTL), as well as a case-control validation cohort (1230 SCZ and 1208 CTL). Genomic DNA methylation, target gene mRNA transcripts, and plasma autoantibody levels were measured across cohorts.</p><p><strong>Study results: </strong>We found extensive differences in global DNA methylation profiles between RSCZ and NRSCZ groups, wherein differential methylation sites (DMS) were enriched with immune cell maturation and activation in the RSCZ group. Out of 2722 participants, the foremost DMS cg14341177 was hyper-methylated in the SCZ group and it inhibited the alternative splicing of its target gene <i>BICD2</i> and may have increased its autoantigen exposure, leading to an increase in plasma anti-BICD2 IgG antibody levels. The levels of cg14341177 methylation and anti-BICD2 IgG decreased significantly in RSCZ endpoint samples but not in NRSCZ endpoint samples. There are strong positive correlations between cg14341177 methylation, anti-BICD2 IgG, and positive and negative syndrome scale (PANSS) scores in the RSCZ groups, but not in the NRSCZ groups.</p><p><strong>Conclusions: </strong>These data suggest that abnormal DNA methylation could affect autoreactive responses in SCZ, and that cg14341177 methylation and anti-BICD2 IgG levels may potentially serve as useful biomarkers.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgac047"},"PeriodicalIF":0.0,"publicationDate":"2022-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11207751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COP27 Climate Change Conference: Urgent Action Needed for Africa and the World: Wealthy nations must step up support for Africa and vulnerable countries in addressing past, present and future impacts of climate change.","authors":"Lukoye Atwoli, Gregory E Erhabor, Aiah A Gbakima, Abraham Haileamlak, Jean-Marie Kayembe Ntumba, James Kigera, Laurie Laybourn-Langton, Bob Mash, Joy Muhia, Fhumulani Mavis Mulaudzi, David Ofori-Adjei, Friday Okonofua, Arash Rashidian, Maha El-Adawy, Siaka Sidibé, Abdelmadjid Snouber, James Tumwine, Mohammad Sahar Yassien, Paul Yonga, Lilia Zakhama, Chris Zielinski","doi":"10.1093/schizbullopen/sgac065","DOIUrl":"10.1093/schizbullopen/sgac065","url":null,"abstract":"","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"3 1","pages":"sgac065"},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11205887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}