Schizophrenia bulletin open最新文献

{"title":"Clozapine as a Long-Term Therapeutic Choice: Longitudinal Analysis of Schizophrenia Symptoms in a Naturalistic Setting.","authors":"Rachel K Scheinberg, Zhirui Fu, Laura Scott, Krista K Baker, Arlene Cuerdo, Lilian Zhong, Chloe Bethany, Malaka Harper, Leslie G Nucifora, Allison S Brandt, Russell L Margolis, Gayane Yenokyan, Frederick C Nucifora","doi":"10.1093/schizbullopen/sgaf009","DOIUrl":"10.1093/schizbullopen/sgaf009","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Clozapine remains the gold standard for treatment-resistant schizophrenia (TRS), yet the time course of clinical response in naturalistic settings is not well characterized. We hypothesized that patients initiated on clozapine in an outpatient clinic would demonstrate measurable symptom reduction over time, including delayed response in a subset of patients.</p><p><strong>Study design: </strong>We conducted a retrospective study of TRS patients (<i>N</i> = 26) newly initiated on clozapine at an outpatient clozapine clinic. Symptoms were assessed using the Positive and Negative Syndrome Scale (PANSS) at baseline and follow-up visits. Linear spline regression modeled PANSS trajectories over time. Response was defined as achieving either a ≥ 20% reduction in PANSS total score or a mild level of illness (PANSS score ≤ 58).</p><p><strong>Study results: </strong>Patients demonstrated a mean 18.1-point reduction in PANSS total score during the first year of clozapine treatment, with significant improvements in positive and general psychopathology symptoms. Negative symptoms showed a modest, nonsignificant change. Overall, 20 patients (76.9%) achieved a ≥ 20% PANSS reduction, and 15 (57.7%) reached a mild symptom level. Six patients (23.1%) met response criteria only after 12 months of treatment.</p><p><strong>Conclusions: </strong>In this naturalistic study, clozapine was associated with substantial symptom improvement, particularly within the first year. A subset of patients demonstrated delayed but clinically meaningful response, supporting the continued use of clozapine beyond 12 months. These findings underscore the value of sustained treatment in TRS.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf009"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147019/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in Real-world Functioning Between Adoptees With High or Low Risk for Schizophrenia Spectrum Disorders-The Finnish Adoptive Family Study of Schizophrenia.","authors":"Matilda Raiskila, Helinä Hakko, Karl-Erik Wahlberg, Sami Räsänen","doi":"10.1093/schizbullopen/sgaf011","DOIUrl":"10.1093/schizbullopen/sgaf011","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Schizophrenia spectrum disorders are known to affect the patient's functional performance. The functioning of those who are at familial risk for these disorders is less well understood. In this study, we compared the real-world functioning of adoptees with a genetic high-risk (HR) for schizophrenia spectrum disorders with adoptees without this risk (low-risk, LR). We hypothesized that the HR-group would have more difficulties in real-world functioning compared to the LR-group.</p><p><strong>Study design: </strong>The data were based on the Finnish Adoptive Family Study of Schizophrenia project. The study sample included 127 HR- and 130 LR-adoptees. An interview-based method, Strauss-Carpenter Level of Function (SCLF)-scale, was used to measure functional performance in a setup of adoptees living in comparable adoptive families. The SCLF-scale comprises domains for function, symptoms, social contacts, and work. The Structured Interview of Schizotypy was utilized in assessments of possible schizotypal traits of the HR- and LR-adoptees.</p><p><strong>Study results: </strong>No significant differences in the real-world functioning in total scores or scores of any SCLF domains were observed between HR- and LR-adoptees. Of single SCLF items, the HR-adoptees were characterized as being less likely to have achieved formal education and the LR-adoptees needed more help with their own basic needs.</p><p><strong>Conclusions: </strong>No differences were found in the real-world functioning between HR- and LR-populations. This indicates that the real-world functioning does not express one's genetic risk for schizophrenia spectrum disorders. Our findings highlight the importance of considering environmental factors when comparing genetically different groups.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf011"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12243108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delusional Distress is Associated With Emotion Dysregulation in Schizophrenia-Spectrum Disorders.","authors":"Essence Leslie, Lauren P Weittenhiller, Ali F Sloan, Julia M Sheffield","doi":"10.1093/schizbullopen/sgaf010","DOIUrl":"10.1093/schizbullopen/sgaf010","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>The distressing nature of delusional beliefs is considered key to their persistence. One potential mechanism underlying delusional distress is global emotion dysregulation. Global emotion dysregulation is associated with general psychotic symptom severity, but its specific relationship to delusional distress has yet to be closely examined.</p><p><strong>Study design: </strong>People with (<i>n</i> = 100) and without (<i>n</i> = 52) schizophrenia-spectrum disorders completed measures of delusional ideation (Peters Delusion Inventory; PDI-21) and global emotion dysregulation (Difficulties in Emotion Regulation Scale; DERS-16). Participants with schizophrenia also completed a measure of delusion severity (Psychotic Symptom Rating Scales; PSYRATS). Relationships between delusion severity and global emotion dysregulation were assessed with linear regression, controlling for age, sex, and group. Associations between delusional distress and aspects of emotion dysregulation were determined using stepwise linear regression.</p><p><strong>Study results: </strong>Global emotion dysregulation was significantly elevated in those with schizophrenia compared to non-clinical controls, across all subscales (<i>P</i> < .001). Emotion dysregulation was significantly associated with delusional distress on both the PDI-21 (<i>P</i> < .001) and PSYRATS (<i>P</i> < .001). Stepwise regressions revealed a specific association between limited access to emotion regulation strategies and delusional distress on both scales (<i>P</i>'s < .001). Delusional distress remained associated with emotion dysregulation when controlling for delusional preoccupation, and emotion dysregulation was not significantly associated with delusional conviction on either scale.</p><p><strong>Conclusions: </strong>Emotion dysregulation, particularly the sense that there is little one can do to regulate themselves when upset, relates to delusional distress. Interventions that increase access to more emotion regulation strategies may help decrease distress associated with delusional thinking.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf010"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12216900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning Latent Profiles via Cognitive Growth Charting in Psychosis: Design and Rationale for the PRECOGNITION Project.","authors":"Andre F Marquand, Barbora Rehák Bučková, Giulia Cattaranusi, Camilla Flaaten, Cecilie Busch, Cecilie K Lemvigh, Veenu Gupta, Charlotte Fraza, Lars T Westlye, Ole A Andreassen, Jaroslav Hlinka, Bjørn H Ebdrup, David Shiers, Torill Ueland, Paola Dazzan","doi":"10.1093/schizbullopen/sgaf007","DOIUrl":"10.1093/schizbullopen/sgaf007","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Cognitive impairments are a core feature of psychosis that are often evident before illness onset and have substantial impact on both clinical and real-world functional outcomes. Therefore, these are an excellent target for stratification and early detection in order to facilitate early intervention. While many studies have aimed to characterize the effects of cognition at the group level and others have aimed to detect individual differences by referencing subjects against existing norms, these studies have limited generalizability across clinical populations, demographic backgrounds, and instruments and do not fully account for the interindividual heterogeneity inherent in psychosis.</p><p><strong>Study design: </strong>Here, we outline the rationale, design, and analysis plan for the PRECOGNITION project, which aims to address these challenges.</p><p><strong>Study results: </strong>This project is a collaboration between partners in 5 European countries. The project will not generate any primary data, but by leveraging existing datasets and combining these with novel analytic methods, it will produce multiple contributions including: (i) translating normative modeling approaches pioneered in brain imaging to psychosis data, to yield \"cognitive growth charts\" for longitudinal tracking and individual prediction; (ii) developing machine learning models for harmonizing and stratifying cohorts on the basis of these models; and (iii) providing integrated next-generation norms, having broad sociodemographic coverage including different languages and distinct norms for individuals with psychosis and unaffected individuals.</p><p><strong>Conclusions: </strong>This study will enable precision stratification of psychosis cohorts and furnish predictions for a broad range of functional outcome measures. It will be guided throughout by lived experience experts.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf007"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12084834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personal Explanations for Psychosis: A Systematic Review and Thematic Synthesis.","authors":"Benjamin-Rose Ingall, Merly McPhilbin, Felix Lewandowski, Yasuhiro Kotera, Gerald Jordan, Mike Slade, Fiona Ng","doi":"10.1093/schizbullopen/sgaf006","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgaf006","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Psychosis refers to the state whereby one's experience of reality differs from those around them. The ineffability of psychosis does not render the experience void of meaning, and the ways individuals integrate their experiences of psychosis into their life narratives cannot be dismissed. Meaning is an essential part of recovery. This review aimed to identify categories of personal explanations that people with psychosis use to explain their experiences.</p><p><strong>Study design: </strong>This systematic review is based on a preregistered protocol (CRD42023421125). Four databases, MEDLINE, Embase, Scopus, and PsycINFO, and 5 journals were searched April to November 2023. Qualitative and mixed-methods studies that explored the personal explanations employed by adults who experience psychosis, regardless of diagnostic status, were included.</p><p><strong>Study results: </strong>Twenty-five studies met the inclusion criteria, representing the views of 682 participants from 15 countries. Included studies were appraised using the CASP Qualitative Studies Checklist.</p><p><strong>Results: </strong>were synthesized using thematic analysis. Personal explanations for psychosis experiences were grouped into 5 themes: Physical and psychiatric; Traumatic and adversarial; Emotional; Religious, spiritual, and magical; No explanation. Participants reported multiple explanations for their experiences.</p><p><strong>Conclusions: </strong>Individuals with experience of psychosis seek to explain these experiences, and these personal explanations may be multiple and complex in nature. The identified personal explanations can be used to further explore the ways that people situate their experiences into their personal context. This understanding should be utilized by professionals to support the provision of recovery-oriented care, with implications for assessment, treatment, intervention, and recovery outcomes.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf006"},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population.","authors":"Melike Karacam Dogan, Thanavadee Prachason, Bochao Lin, Lotta-Katrin Pries, Angelo Arias-Magnasco, Riccardo Bortoletto, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Natascia Brondino, Marco Colizzi, Jurjen Luykx, Laura Fusar-Poli, Sinan Guloksuz","doi":"10.1093/schizbullopen/sgaf005","DOIUrl":"10.1093/schizbullopen/sgaf005","url":null,"abstract":"<p><strong>Background: </strong>Psychosis-related environmental risks in autism, along with genetic overlaps between autism and psychosis, have been well-established. However, their moderating roles in the relationship between autistic traits (ATs) and psychotic experiences (PEs) remain underexplored.</p><p><strong>Methods: </strong>First-wave data from 792 twins and siblings (mean age: 17.47 ± 3.6, 60.23% female) in the TwinssCan Project were analyzed. PEs and ATs were assessed using the Community Assessment of Psychic Experiences and the Autism-Spectrum Quotient, respectively. Polygenic risk scores for schizophrenia and psychosis-associated environmental factors (ie, childhood trauma (CT), bullying, negative life events, obstetric complications, cannabis use, winter birth, and hearing impairment) were tested for their independent effects on PEs and their interaction effects with ATs in moderating the relationship between ATs and PEs using separate multilevel linear regression models with Bonferroni's correction.</p><p><strong>Results: </strong>ATs, all CT subtypes, bullying, and negative life events were positively associated with PEs (all <i>P</i> < .004). Moderation analyses revealed that the association between ATs and PEs was amplified by emotional abuse (B:0.08, 95% CI, 0.05-0.11, <i>P</i> < .001), physical abuse (B:0.11, <i>P</i> = .001), sexual abuse (B:0.09, 95% CI, 0.03-0.15, <i>P</i> = .002), and physical neglect (B:0.06, 95% CI, 0.03-0.10, <i>P</i> = .001), emotional neglect (B:0.04, 95% CI, 0.01-0.07, <i>P</i> = .007), and negative life events (B:0.007, 95% CI, 0.0005-0.014, <i>P</i> = .04), although the latter 2 risks did not survive Bonferroni's correction. No significant main or interacting effects of genetic and other risk factors were found.</p><p><strong>Conclusions: </strong>People with high ATs were more likely to have PEs when exposed to CT. Trauma screening and early interventions might be warranted in this at-risk population.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf005"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motivational Interviewing in Patients with Acute Psychosis: A Feasibility Study.","authors":"Janani Panchalingam, Rahel Horisberger, Claudio Corda, Nicolas Kleisner, Julia Krasnoff, Achim Burrer, Tobias Spiller, Victoria Edkins, Erich Seifritz, Philipp Homan","doi":"10.1093/schizbullopen/sgaf004","DOIUrl":"10.1093/schizbullopen/sgaf004","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Psychotic disorders are among the top causes of disability worldwide. Guidelines emphasize the need for psychotherapeutic approaches in the acute phase of this illness. Motivational interviewing (MI) is highly suitable for establishing a therapeutic alliance wherein the patient's intrinsic motivation can be strengthened to adhere to therapy. This pilot study investigated the feasibility and impact of MI for patients with acute psychosis.</p><p><strong>Study design: </strong>A feasibility study was conducted, comparing MI and supportive counseling. The sample included 20 inpatients, who all received 4 therapy sessions. In line with CONSORT guidelines for pilot and feasibility studies, we measured various feasibility outcomes. Clinical outcomes were assessed using linear regression models, with baseline values used as covariates.</p><p><strong>Study results: </strong>The recruitment target (<i>N</i> = 24) was achieved at 83% in a reasonable timeframe (8 months), with a retention rate of 83% and a completion rate of 71%. The eligibility rate (82 %) was high, the consent rate (48%) was moderate, and both the dropout rate 17% and the missing data rate (0.3%) were low. Regarding the clinical outcomes, a group difference was found for the severity of psychotic symptoms, with an advantage for MI (<i>b </i>= -12.0, 95% CI: [-18.7, -5.2], <i>P</i> < 0.01), although the small sample size must be kept in mind.</p><p><strong>Conclusions: </strong>The study demonstrated the feasibility and acceptability of a clinical trial with MI for patients with psychosis in an inpatient setting. MI could offer benefits, particularly in terms of reducing psychotic symptoms.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf004"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life Affective Forecasting in Young Adults with High Social Anhedonia: An Experience Sampling Study.","authors":"Rui-Ting Zhang, Yan Gao, Tian-Xiao Yang, Chao Yan, Ya Wang, Simon S Y Lui, Raymond C K Chan","doi":"10.1093/schizbullopen/sgaf003","DOIUrl":"10.1093/schizbullopen/sgaf003","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Affective forecasting (AF), the ability to forecast emotional responses for future events, is critical for optimal decision-making and mental health. Most previous AF studies were conducted using laboratory-based tasks but overlooked the impacts of real-life situations and social interactions. This study used the experience sampling method to examine real-life AF in young healthy adults and individuals with high social anhedonia.</p><p><strong>Study design: </strong>In Study 1, 109 young healthy adults reported anticipated and experienced emotions of personal events for 30 days on mobile phones. In Study 2, we examined real-life AF in 28 individuals with high social anhedonia (HSA) and 32 individuals with low social anhedonia (LSA).</p><p><strong>Study results: </strong>In Study 1 (totaling 8031 real-life events), participants anticipated and experienced social events as more positive and more arousing than non-social events, but also with larger AF discrepancy. In Study 2 (totaling 2066 real-life events), compared with the LSA group, the HSA group anticipated less pleasure and displayed a larger valence discrepancy especially for social but not for non-social events. However, the HSA group reported less experienced pleasure for both social and non-social events.</p><p><strong>Conclusions: </strong>Using an ecological method for assessing real-life AF, we extended the previous laboratory-based findings to real-life situations. These findings demonstrate the effects of sociality on real-life AF and elucidate the deficit in anticipating social pleasure among HSA individuals, which reflects liability to schizophrenia-spectrum disorders. Altered AF may be a potential intervention target in people with schizophrenia spectrum disorder.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Online Hearing Voices Peer Support Groups: Assessing Feasibility and Acceptability Within UK National Health Service Settings.","authors":"Alison Branitsky, Samantha Bowe, Anthony P Morrison, Eleanor Longden, Sandra Bucci, Lee D Mulligan, Filippo Varese","doi":"10.1093/schizbullopen/sgaf002","DOIUrl":"10.1093/schizbullopen/sgaf002","url":null,"abstract":"<p><strong>Background: </strong>User-led hearing voices groups (HVGs) have existed for the past 40 years, but little research has been conducted into if and how this approach can be implemented in statutory mental health settings, and whether they can be delivered effectively when held online. The aim of this study was to conduct a feasibility and acceptability trial of an online HVG for the UK National Health Service (NHS) users who hear voices, to inform a future larger-scale trial.</p><p><strong>Methods: </strong>A mixed-methods, nonrandomized feasibility study of an online HVG was conducted with 9 participants. Participants attended weekly online meetings for 6 months and completed measures of social connectedness, voice hearing, personal recovery, as well as semi-structured interviews, at baseline and postintervention (26-weeks). Primary outcomes were qualitative and quantitative assessments of feasibility and acceptability.</p><p><strong>Results: </strong>Thirty-eight participants were referred to the trial, 9 of whom were recruited (100% of the target sample). The trial had high retention (100%) and engagement (mean = 13.2 groups attended). Participants reported positive features of attending this digital intervention, with 85% reporting it was helpful to meet other voice hearers, that the group helped them make sense of voice hearing experiences, that they received positive messages about recovery, and that the group represented a form of support they could not get elsewhere.</p><p><strong>Discussion: </strong>The findings indicate it is feasible and acceptable to run an online HVG within an NHS setting. A larger trial is needed to further investigate the utility, efficacy, and cost-effectiveness of running online HVGs in the NHS.</p><p><strong>Trial registration: </strong>ISRCTN11873550.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of Reviews of Patient-Reported Measures in Psychosis: Need to Consider Factors Affecting Equity and the Involvement of Patients.","authors":"Neha Nair, Maria Abou Farhat, Navdeep Kaur, Nev Jones, Greeshma Mohan, Jill Boruff, Srividya N Iyer","doi":"10.1093/schizbullopen/sgae032","DOIUrl":"10.1093/schizbullopen/sgae032","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported measures are increasingly valued in psychosis care and research. For patient-reported measures to reflect patient perspectives, patients must be involved in developing them. Furthermore, their development and evaluation must consider sociodemographic characteristics influencing patient experiences and outcomes and measurement. As reviews reflect the state of the field and guide clinicians/researchers in selecting measures, our aim was to evaluate literature reviews of patient-reported measures on their consideration of factors affecting equity and patient involvement.</p><p><strong>Study design: </strong>For this review of reviews, we searched 3 databases (MEDLINE, Embase, and PsycINFO) for reviews on patient-reported measures in psychosis. Two reviewers independently screened titles, abstracts, and full texts, and descriptively synthesized and appraised the quality of included reviews. Using Cochrane's PROGRESS-Plus and a Canadian equity framework, reviews were evaluated on their consideration of sociodemographic characteristics, accessibility, and patient involvement.</p><p><strong>Study results: </strong>Of 10 reviews (6 systematic, 4 nonsystematic; 1111 studies; 313 measures), 6 limited their search to English. Barring 2 reviews that reported the age, gender, and countries of samples in included studies, the reviews did not extract/comment on population/sociodemographic characteristics. One commented on one measure's readability; none commented on the samples' literacy levels. Four reviews considered the availability of translations; only 1 evaluated cross-cultural validity. Only 2 considered the costs of measures. Only 1 evaluated patient involvement in developing patient-reported measures. One referenced equity frameworks/standards.</p><p><strong>Conclusions: </strong>Reviews of patient-reported measures in psychosis demonstrate minimal attention to equity and patient involvement. We offer recommendations to strengthen patient-reported measures research by attending to equity, social determinants, and patient-centrism.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgae032"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}