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The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population.
Schizophrenia bulletin open Pub Date : 2025-02-19 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgaf005
Melike Karacam Dogan, Thanavadee Prachason, Bochao Lin, Lotta-Katrin Pries, Angelo Arias-Magnasco, Riccardo Bortoletto, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Natascia Brondino, Marco Colizzi, Jurjen Luykx, Laura Fusar-Poli, Sinan Guloksuz
{"title":"The Moderating Role of Genetic and Environmental Risk Factors for Schizophrenia on the Relationship between Autistic Traits and Psychosis Expression in the General Population.","authors":"Melike Karacam Dogan, Thanavadee Prachason, Bochao Lin, Lotta-Katrin Pries, Angelo Arias-Magnasco, Riccardo Bortoletto, Claudia Menne-Lothmann, Jeroen Decoster, Ruud van Winkel, Dina Collip, Philippe Delespaul, Marc De Hert, Catherine Derom, Evert Thiery, Nele Jacobs, Jim van Os, Bart Rutten, Natascia Brondino, Marco Colizzi, Jurjen Luykx, Laura Fusar-Poli, Sinan Guloksuz","doi":"10.1093/schizbullopen/sgaf005","DOIUrl":"10.1093/schizbullopen/sgaf005","url":null,"abstract":"<p><strong>Background: </strong>Psychosis-related environmental risks in autism, along with genetic overlaps between autism and psychosis, have been well-established. However, their moderating roles in the relationship between autistic traits (ATs) and psychotic experiences (PEs) remain underexplored.</p><p><strong>Methods: </strong>First-wave data from 792 twins and siblings (mean age: 17.47 ± 3.6, 60.23% female) in the TwinssCan Project were analyzed. PEs and ATs were assessed using the Community Assessment of Psychic Experiences and the Autism-Spectrum Quotient, respectively. Polygenic risk scores for schizophrenia and psychosis-associated environmental factors (ie, childhood trauma (CT), bullying, negative life events, obstetric complications, cannabis use, winter birth, and hearing impairment) were tested for their independent effects on PEs and their interaction effects with ATs in moderating the relationship between ATs and PEs using separate multilevel linear regression models with Bonferroni's correction.</p><p><strong>Results: </strong>ATs, all CT subtypes, bullying, and negative life events were positively associated with PEs (all <i>P</i> < .004). Moderation analyses revealed that the association between ATs and PEs was amplified by emotional abuse (B:0.08, 95% CI, 0.05-0.11, <i>P</i> < .001), physical abuse (B:0.11, <i>P</i> = .001), sexual abuse (B:0.09, 95% CI, 0.03-0.15, <i>P</i> = .002), and physical neglect (B:0.06, 95% CI, 0.03-0.10, <i>P</i> = .001), emotional neglect (B:0.04, 95% CI, 0.01-0.07, <i>P</i> = .007), and negative life events (B:0.007, 95% CI, 0.0005-0.014, <i>P</i> = .04), although the latter 2 risks did not survive Bonferroni's correction. No significant main or interacting effects of genetic and other risk factors were found.</p><p><strong>Conclusions: </strong>People with high ATs were more likely to have PEs when exposed to CT. Trauma screening and early interventions might be warranted in this at-risk population.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf005"},"PeriodicalIF":0.0,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Motivational Interviewing in Patients with Acute Psychosis: A Feasibility Study. 急性精神病患者的动机访谈:可行性研究
Schizophrenia bulletin open Pub Date : 2025-02-08 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgaf004
Janani Panchalingam, Rahel Horisberger, Claudio Corda, Nicolas Kleisner, Julia Krasnoff, Achim Burrer, Tobias Spiller, Victoria Edkins, Erich Seifritz, Philipp Homan
{"title":"Motivational Interviewing in Patients with Acute Psychosis: A Feasibility Study.","authors":"Janani Panchalingam, Rahel Horisberger, Claudio Corda, Nicolas Kleisner, Julia Krasnoff, Achim Burrer, Tobias Spiller, Victoria Edkins, Erich Seifritz, Philipp Homan","doi":"10.1093/schizbullopen/sgaf004","DOIUrl":"10.1093/schizbullopen/sgaf004","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Psychotic disorders are among the top causes of disability worldwide. Guidelines emphasize the need for psychotherapeutic approaches in the acute phase of this illness. Motivational interviewing (MI) is highly suitable for establishing a therapeutic alliance wherein the patient's intrinsic motivation can be strengthened to adhere to therapy. This pilot study investigated the feasibility and impact of MI for patients with acute psychosis.</p><p><strong>Study design: </strong>A feasibility study was conducted, comparing MI and supportive counseling. The sample included 20 inpatients, who all received 4 therapy sessions. In line with CONSORT guidelines for pilot and feasibility studies, we measured various feasibility outcomes. Clinical outcomes were assessed using linear regression models, with baseline values used as covariates.</p><p><strong>Study results: </strong>The recruitment target (<i>N</i> = 24) was achieved at 83% in a reasonable timeframe (8 months), with a retention rate of 83% and a completion rate of 71%. The eligibility rate (82 %) was high, the consent rate (48%) was moderate, and both the dropout rate 17% and the missing data rate (0.3%) were low. Regarding the clinical outcomes, a group difference was found for the severity of psychotic symptoms, with an advantage for MI (<i>b </i>= -12.0, 95% CI: [-18.7, -5.2], <i>P</i> < 0.01), although the small sample size must be kept in mind.</p><p><strong>Conclusions: </strong>The study demonstrated the feasibility and acceptability of a clinical trial with MI for patients with psychosis in an inpatient setting. MI could offer benefits, particularly in terms of reducing psychotic symptoms.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf004"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-life Affective Forecasting in Young Adults with High Social Anhedonia: An Experience Sampling Study.
Schizophrenia bulletin open Pub Date : 2025-02-05 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgaf003
Rui-Ting Zhang, Yan Gao, Tian-Xiao Yang, Chao Yan, Ya Wang, Simon S Y Lui, Raymond C K Chan
{"title":"Real-life Affective Forecasting in Young Adults with High Social Anhedonia: An Experience Sampling Study.","authors":"Rui-Ting Zhang, Yan Gao, Tian-Xiao Yang, Chao Yan, Ya Wang, Simon S Y Lui, Raymond C K Chan","doi":"10.1093/schizbullopen/sgaf003","DOIUrl":"10.1093/schizbullopen/sgaf003","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>Affective forecasting (AF), the ability to forecast emotional responses for future events, is critical for optimal decision-making and mental health. Most previous AF studies were conducted using laboratory-based tasks but overlooked the impacts of real-life situations and social interactions. This study used the experience sampling method to examine real-life AF in young healthy adults and individuals with high social anhedonia.</p><p><strong>Study design: </strong>In Study 1, 109 young healthy adults reported anticipated and experienced emotions of personal events for 30 days on mobile phones. In Study 2, we examined real-life AF in 28 individuals with high social anhedonia (HSA) and 32 individuals with low social anhedonia (LSA).</p><p><strong>Study results: </strong>In Study 1 (totaling 8031 real-life events), participants anticipated and experienced social events as more positive and more arousing than non-social events, but also with larger AF discrepancy. In Study 2 (totaling 2066 real-life events), compared with the LSA group, the HSA group anticipated less pleasure and displayed a larger valence discrepancy especially for social but not for non-social events. However, the HSA group reported less experienced pleasure for both social and non-social events.</p><p><strong>Conclusions: </strong>Using an ecological method for assessing real-life AF, we extended the previous laboratory-based findings to real-life situations. These findings demonstrate the effects of sociality on real-life AF and elucidate the deficit in anticipating social pleasure among HSA individuals, which reflects liability to schizophrenia-spectrum disorders. Altered AF may be a potential intervention target in people with schizophrenia spectrum disorder.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf003"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online Hearing Voices Peer Support Groups: Assessing Feasibility and Acceptability Within UK National Health Service Settings.
Schizophrenia bulletin open Pub Date : 2025-02-04 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgaf002
Alison Branitsky, Samantha Bowe, Anthony P Morrison, Eleanor Longden, Sandra Bucci, Lee D Mulligan, Filippo Varese
{"title":"Online Hearing Voices Peer Support Groups: Assessing Feasibility and Acceptability Within UK National Health Service Settings.","authors":"Alison Branitsky, Samantha Bowe, Anthony P Morrison, Eleanor Longden, Sandra Bucci, Lee D Mulligan, Filippo Varese","doi":"10.1093/schizbullopen/sgaf002","DOIUrl":"10.1093/schizbullopen/sgaf002","url":null,"abstract":"<p><strong>Background: </strong>User-led hearing voices groups (HVGs) have existed for the past 40 years, but little research has been conducted into if and how this approach can be implemented in statutory mental health settings, and whether they can be delivered effectively when held online. The aim of this study was to conduct a feasibility and acceptability trial of an online HVG for the UK National Health Service (NHS) users who hear voices, to inform a future larger-scale trial.</p><p><strong>Methods: </strong>A mixed-methods, nonrandomized feasibility study of an online HVG was conducted with 9 participants. Participants attended weekly online meetings for 6 months and completed measures of social connectedness, voice hearing, personal recovery, as well as semi-structured interviews, at baseline and postintervention (26-weeks). Primary outcomes were qualitative and quantitative assessments of feasibility and acceptability.</p><p><strong>Results: </strong>Thirty-eight participants were referred to the trial, 9 of whom were recruited (100% of the target sample). The trial had high retention (100%) and engagement (mean = 13.2 groups attended). Participants reported positive features of attending this digital intervention, with 85% reporting it was helpful to meet other voice hearers, that the group helped them make sense of voice hearing experiences, that they received positive messages about recovery, and that the group represented a form of support they could not get elsewhere.</p><p><strong>Discussion: </strong>The findings indicate it is feasible and acceptable to run an online HVG within an NHS setting. A larger trial is needed to further investigate the utility, efficacy, and cost-effectiveness of running online HVGs in the NHS.</p><p><strong>Trial registration: </strong>ISRCTN11873550.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf002"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Reviews of Patient-Reported Measures in Psychosis: Need to Consider Factors Affecting Equity and the Involvement of Patients.
Schizophrenia bulletin open Pub Date : 2025-01-11 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgae032
Neha Nair, Maria Abou Farhat, Navdeep Kaur, Nev Jones, Greeshma Mohan, Jill Boruff, Srividya N Iyer
{"title":"A Review of Reviews of Patient-Reported Measures in Psychosis: Need to Consider Factors Affecting Equity and the Involvement of Patients.","authors":"Neha Nair, Maria Abou Farhat, Navdeep Kaur, Nev Jones, Greeshma Mohan, Jill Boruff, Srividya N Iyer","doi":"10.1093/schizbullopen/sgae032","DOIUrl":"10.1093/schizbullopen/sgae032","url":null,"abstract":"<p><strong>Background: </strong>Patient-reported measures are increasingly valued in psychosis care and research. For patient-reported measures to reflect patient perspectives, patients must be involved in developing them. Furthermore, their development and evaluation must consider sociodemographic characteristics influencing patient experiences and outcomes and measurement. As reviews reflect the state of the field and guide clinicians/researchers in selecting measures, our aim was to evaluate literature reviews of patient-reported measures on their consideration of factors affecting equity and patient involvement.</p><p><strong>Study design: </strong>For this review of reviews, we searched 3 databases (MEDLINE, Embase, and PsycINFO) for reviews on patient-reported measures in psychosis. Two reviewers independently screened titles, abstracts, and full texts, and descriptively synthesized and appraised the quality of included reviews. Using Cochrane's PROGRESS-Plus and a Canadian equity framework, reviews were evaluated on their consideration of sociodemographic characteristics, accessibility, and patient involvement.</p><p><strong>Study results: </strong>Of 10 reviews (6 systematic, 4 nonsystematic; 1111 studies; 313 measures), 6 limited their search to English. Barring 2 reviews that reported the age, gender, and countries of samples in included studies, the reviews did not extract/comment on population/sociodemographic characteristics. One commented on one measure's readability; none commented on the samples' literacy levels. Four reviews considered the availability of translations; only 1 evaluated cross-cultural validity. Only 2 considered the costs of measures. Only 1 evaluated patient involvement in developing patient-reported measures. One referenced equity frameworks/standards.</p><p><strong>Conclusions: </strong>Reviews of patient-reported measures in psychosis demonstrate minimal attention to equity and patient involvement. We offer recommendations to strengthen patient-reported measures research by attending to equity, social determinants, and patient-centrism.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgae032"},"PeriodicalIF":0.0,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preferences for Selecting and Initiating Long-Acting Injectable Antipsychotic Agents for the Treatment of Patients With Schizophrenia: Results From the US DECIDE Survey.
Schizophrenia bulletin open Pub Date : 2025-01-08 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgaf001
Dawn Velligan, Gregory D Salinas, Emily Belcher, Kelli R Franzenburg, Mark Suett, Stephen Thompson, Rolf T Hansen
{"title":"Preferences for Selecting and Initiating Long-Acting Injectable Antipsychotic Agents for the Treatment of Patients With Schizophrenia: Results From the US DECIDE Survey.","authors":"Dawn Velligan, Gregory D Salinas, Emily Belcher, Kelli R Franzenburg, Mark Suett, Stephen Thompson, Rolf T Hansen","doi":"10.1093/schizbullopen/sgaf001","DOIUrl":"10.1093/schizbullopen/sgaf001","url":null,"abstract":"<p><strong>Background: </strong>Long-acting injectable antipsychotics (LAIs) improve adherence and reduce schizophrenia relapse rates. Data on which LAI attributes drive clinician preference are limited.</p><p><strong>Methods: </strong>In the DECIDE survey, 380 psychiatric clinicians (psychiatrists, psychiatric nurse practitioners, and physician assistants) were surveyed regarding preferences when selecting and initiating LAIs for patients with schizophrenia. Responses were analyzed by clinician use of LAIs (high [≥ 31% of their patients using LAIs] or low [≤ 14% of their patients using LAIs]) and mindset toward LAI use (early, severity reserved, adherence reserved, and LAI hesitant).</p><p><strong>Results: </strong>Overall and across subgroups, side effects were the most important consideration when selecting a particular LAI, with 33% of clinicians ranking this as most important (26%-46% across subgroups). Clinician preference for the molecule was most often ranked least important (47% overall; 39%-59% across subgroups). A significantly higher proportion of clinicians with high vs low LAI use ranked product attributes as the most important consideration (26% vs 13%; <i>P</i> < .01). Across subgroups, multiple injection site options, small/on par needle, and price made at least two-thirds of clinicians somewhat/much more likely to use a particular LAI, and 63%-82% of clinicians reported being somewhat/much more likely to select an LAI dosed once monthly or less often vs 6%-11% being somewhat/much more likely to select an LAI dosed once every 2 weeks.</p><p><strong>Conclusions: </strong>Overall, results from DECIDE provide insight into the decision-making process of psychiatric clinicians when selecting an LAI and highlight opportunities to help clinicians deliver optimal care for patients with schizophrenia.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgaf001"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11920864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Startle Response and Prepulse Inhibition in Psychosis and Violence: A Combined Electromyography and Electroencephalography Study.
Schizophrenia bulletin open Pub Date : 2024-12-28 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgae031
Nina Bang, Johanne H Pettersen, Merete Berg Nesset, Kirsten Rasmussen, Hilde Dahl, Natalia Tesli, Christina Bell, Anja Vaskinn, Thomas Fischer-Vieler, Christine Friestad, Ole A Andreassen, Erik G Jönsson, Torbjørn Elvsåshagen, Unn K Haukvik, Torgeir Moberget
{"title":"The Startle Response and Prepulse Inhibition in Psychosis and Violence: A Combined Electromyography and Electroencephalography Study.","authors":"Nina Bang, Johanne H Pettersen, Merete Berg Nesset, Kirsten Rasmussen, Hilde Dahl, Natalia Tesli, Christina Bell, Anja Vaskinn, Thomas Fischer-Vieler, Christine Friestad, Ole A Andreassen, Erik G Jönsson, Torbjørn Elvsåshagen, Unn K Haukvik, Torgeir Moberget","doi":"10.1093/schizbullopen/sgae031","DOIUrl":"https://doi.org/10.1093/schizbullopen/sgae031","url":null,"abstract":"<p><p>There is a pressing need for biomarkers of violent behavior risk in psychosis. Previous research indicates that electrophysiological measures of automatic defensive reactions may have potential. The purpose of this study was to investigate associations between violent behavior in individuals with and without psychosis and electromyography (EMG) and electroencephalography (EEG) responses to startling auditory stimuli. Electromyography and EEG were recorded during an auditory startle paradigm from healthy controls (HC, <i>n</i> = 211), individuals with psychosis and a history of violent behavior (violent-PSY, <i>n</i> = 18), individuals with psychosis without a history of violence (nonviolent-PSY, <i>n</i> = 32), and individuals with a history of violence without psychosis (violent non-PSY, <i>n</i> = 22). We estimated the auditory startle response (ASR) and prepulse inhibition (PPI) using EMG (ie, EMG<sub>ASR</sub> and EMG<sub>PPI</sub>) and the auditory-evoked potential (ie, AEP<sub>ASR</sub> and AEP<sub>PPI</sub>) of the EEG. There were no significant effects of group on the EMG<sub>ASR</sub> (<i>P</i> = .10) or the 30-, 60-, and 120-ms prepulse + pulse EMG<sub>PPI</sub> amplitudes (<i>P</i> = .11, <i>P</i> = .19, and <i>P</i> = .50, respectively). The N1 amplitude of the AEP<sub>ASR</sub> was reduced in the violent-PSY group (<i>P</i> < .001) and the nonviolent-PSY group (<i>P</i> = .015) compared with HC. The P2 amplitude of the AEP<sub>ASR</sub> was reduced in violent-PSY relative to nonviolent-PSY (<i>P</i> = .003), violent non-PSY (<i>P</i> = .016), and HC (<i>P</i> < .001). Together, these results show that EEG-based neural responses to startling auditory stimuli are promising biomarkers of violence risk in psychosis.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgae031"},"PeriodicalIF":0.0,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations Between Klotho Levels, KL-VS Heterozygosity and Cognition in Schizophrenia. 精神分裂症患者的 Klotho 水平、KL-VS 杂合度与认知之间的关系
Schizophrenia bulletin open Pub Date : 2024-12-25 eCollection Date: 2025-01-01 DOI: 10.1093/schizbullopen/sgae030
Vijaya Majumdar, Prosenjeet Chakroborty, Rashmi Arasappa, K Murugesh, Shanthala Hegde, Amrutha Jose, N K Manjunath, Arpitha Dharmappa
{"title":"Associations Between Klotho Levels, <i>KL-VS</i> Heterozygosity and Cognition in Schizophrenia.","authors":"Vijaya Majumdar, Prosenjeet Chakroborty, Rashmi Arasappa, K Murugesh, Shanthala Hegde, Amrutha Jose, N K Manjunath, Arpitha Dharmappa","doi":"10.1093/schizbullopen/sgae030","DOIUrl":"10.1093/schizbullopen/sgae030","url":null,"abstract":"<p><strong>Background and hypothesis: </strong>The relationship between Klotho and cognitive dysfunction in schizophrenia has been scarcely explored, with a few paradoxical findings. Hence, we aimed to enhance our understanding by testing associations between the functional KL-VS gene variant and circulating protein levels.</p><p><strong>Research design: </strong>This case-control study included 239 healthy controls and 241 patients with schizophrenia, who were comprehensively characterized by neurocognitive tests and further subtyped into cognitive clusters; cognitively deficient (CD) and cognitively spared (CS), using <i>K</i>-means cluster analysis. Linear regression models were run to assess the main and iinteraction effects of the KL-VS heterozygosity (KL-VS<sup>Het+</sup>)/KL levels with confounding variables (disease status and age) on cognitive scores.</p><p><strong>Results: </strong>There was no main effect of KL-VS<sup>Het+</sup> on the cognitive domains, but the CD cluster exhibited strong negative interactions between disease status and Klotho for executive function at the gene level, KL-VS<sup>Het+</sup> × disease status, β = -.61, <i>P</i> = .043, with comparatively higher effect observed for KL levels, KL levels × disease status, β = -.91, <i>P</i> = .028. There was an opposing positive interaction for response inhibition, KL-VS<sup>Het+</sup> × disease status, limited again to the CD cluster, β = .35, <i>P</i> = .046, with a higher effect at protein levels, KL levels × disease status, β = .72, <.004, though without CD cluster effect.</p><p><strong>Conclusions: </strong>Overall, these dissociable patterns of association across cognitive domains indicate the need to exert caution over accepting any generalised direction of effect of Klotho at gene or protein level on cognition in schizophrenia.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"6 1","pages":"sgae030"},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11904889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143625847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utilizing Technology to Enhance the Ecological Validity of Cognitive and Functional Assessments in Schizophrenia: An Overview of the State-of-the-Art. 利用技术提高精神分裂症认知和功能评估的生态有效性:技术现状概述》。
Schizophrenia bulletin open Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.1093/schizbullopen/sgae025
William P Horan, Raeanne C Moore, Heather G Belanger, Philip D Harvey
{"title":"Utilizing Technology to Enhance the Ecological Validity of Cognitive and Functional Assessments in Schizophrenia: An Overview of the State-of-the-Art.","authors":"William P Horan, Raeanne C Moore, Heather G Belanger, Philip D Harvey","doi":"10.1093/schizbullopen/sgae025","DOIUrl":"10.1093/schizbullopen/sgae025","url":null,"abstract":"<p><p>Cognitive impairment is a core feature of schizophrenia and a key determinant of functional outcome. Although conventional paper-and-pencil based cognitive assessments used in schizophrenia remained relatively static during most of the 20th century, this century has witnessed the emergence of innovative digital technologies that aim to enhance the ecological validity of performance-based assessments. This narrative review provides an overview of new technologies that show promise for enhancing the ecological validity of cognitive and functional assessments. We focus on 2 approaches that are particularly relevant for schizophrenia research: (1) digital functional capacity tasks, which use simulations to measure performance of important daily life activities (e.g., virtual shopping tasks), delivered both in-person and remotely, and (2) remote device-based assessments, which include self-administered cognitive tasks (e.g., processing speed test) or functionally-focused surveys regarding momentary activities and experiences (e.g., location, social context), as well as passive sensor-based metrics (e.g., actigraphy measures of activity), during daily life. For each approach, we describe the potential for enhancing ecological validity, provide examples of select measures that have been used in schizophrenia research, summarize available data on their feasibility and validity, and consider remaining challenges. Rapidly growing evidence indicates that digital technologies have the potential to enhance the ecological validity of cognitive and functional outcome assessments, and thereby advance research into the causes of, and treatments for, functional disability in schizophrenia.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae025"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142831634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Functional Outcomes of Community-Recruited Individuals at Clinical High-Risk for Psychosis: Results From the Youth Mental Health Risk and Resilience Study (YouR-Study). 社区招募的精神病临床高危个体的临床和功能结局:来自青少年心理健康风险和恢复力研究(YouR-Study)的结果
Schizophrenia bulletin open Pub Date : 2024-11-12 eCollection Date: 2024-01-01 DOI: 10.1093/schizbullopen/sgae029
Kate Haining, Ruchika Gajwani, Joachim Gross, Andrew I Gumley, Stephen M Lawrie, Frauke Schultze-Lutter, Matthias Schwannauer, Peter J Uhlhaas
{"title":"Clinical and Functional Outcomes of Community-Recruited Individuals at Clinical High-Risk for Psychosis: Results From the Youth Mental Health Risk and Resilience Study (YouR-Study).","authors":"Kate Haining, Ruchika Gajwani, Joachim Gross, Andrew I Gumley, Stephen M Lawrie, Frauke Schultze-Lutter, Matthias Schwannauer, Peter J Uhlhaas","doi":"10.1093/schizbullopen/sgae029","DOIUrl":"10.1093/schizbullopen/sgae029","url":null,"abstract":"<p><p>Clinical high-risk for psychosis (CHR-P) individuals are typically recruited from clinical services but the clinical and functional outcomes of community-recruited CHR-P individuals remain largely unclear. The Youth Mental Health Risk and Resilience Study (YouR-Study) obtained a community sample of CHR-P individuals through an online-screening approach and followed-up these individuals for a period of up to 3 years to determine transition rates, persistence of attenuated psychotic symptoms (APS) and functional outcomes. Baseline data were obtained from <i>n</i> = 144 CHR-P participants, <i>n</i> = 51 participants who met online cutoff criteria but not CHR-P criteria (CHR-Ns), and <i>n</i> = 58 healthy controls. Baseline assessments included clinical measures for assessing CHR-P status, including the Comprehensive Assessment of At-Risk Mental States (CAARMS) and the Schizophrenia Proneness Instrument, Adult version (SPI-A), as well as functioning and cognitive measures. CHR-P and CHR-N groups were followed-up. Results show that 12.1% of CHR-P individuals transitioned to psychosis over 3 years, with no transitions in the CHR-N group. Nearly 60% of CHR-P individuals experienced poor functional outcome (PFO) and over 40% experienced persistent APS. A combination of CAARMS/SPI-A criteria was associated with a higher likelihood of PFO, but not with transition to psychosis nor APS persistence. However, transition risk was generally higher among those meeting both CAARMS/SPI-A criteria (64.3%) vs CAARMS (28.6%) or SPI-A (7.1%) alone. In summary, community-recruited CHR-P individuals are characterized by similar clinical characteristics and longitudinal outcomes to those recruited from clinical services, emphasizing the need to widen the scope of early detection and intervention strategies.</p>","PeriodicalId":94380,"journal":{"name":"Schizophrenia bulletin open","volume":"5 1","pages":"sgae029"},"PeriodicalIF":0.0,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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