Cardiology in the Young最新文献

{"title":"Gabapentin's safety and impact on benzodiazepine exposure post-superior cavopulmonary anastomosis.","authors":"Joshua W Branstetter, Hania Zaki, Samuel Van Horn, Andrew Peter, Maria Cabrera, Susan Hupp, Heather Viamonte","doi":"10.1017/S1047951125001647","DOIUrl":"10.1017/S1047951125001647","url":null,"abstract":"<p><strong>Introduction: </strong>In paediatric cardiac patients requiring staged palliation, superior cavopulmonary anastomosis is common. Pain control is a crucial aspect of postoperative care as agitation, untreated pain, and hypoventilation can cause increased pulmonary vascular resistance reduction and pulmonary blood flow.</p><p><strong>Methods: </strong>This was a large volume single-centre, retrospective cohort study evaluating the impact of gabapentin on opioid and benzodiazepine exposure in infants undergoing superior cavopulmonary anastomosis between January 2018 and December 2022. The primary endpoint was opioid exposure in morphine milligram equivalents per kilogram in infants receiving gabapentin compared to no gabapentin.</p><p><strong>Results: </strong>The study analysed 85 infants, 40 of which received perioperative gabapentin. Other than there being more males in the gabapentin group (70% versus 47%; <i>p</i> = 0.03), there was no difference in baseline characteristics. Opioid use, measured in morphine milligram equivalents per kilogram, was similar in the no gabapentin group compared to the gabapentin group during the first 5 POD's (2.66 (interquartile range1.76, 3.30) versus 2.27 (interquartile range R 1.75, 3.40); <i>p</i> = 0.93. However, there was a lower benzodiazepine exposure, measured in midazolam equivalents per kilogram, in the gabapentin group both on POD 2 (0.05 (interquartile range 0.00, 0.11) versus 0 (interquartile range 0.00, 0.08); <i>p</i> = 0.031) and cumulative (0.15 (interquartile range 0.00, 0.35) versus 0.05 (interquartile range 0.00, 0.15); <i>p</i> = 0.031).</p><p><strong>Conclusions: </strong>Gabapentin did not significantly reduce opioid exposure; however, its use was associated with modest reduction in benzodiazepine exposure. There were no differences in adverse events. Our findings suggest gabapentin is safe in infants undergoing superior cavopulmonary anastomosis; however, additional studies should be conducted to evaluate optimal gabapentin dosing.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"996-1001"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter reduction of a large, stented fenestration in a paediatric patient post-Fontan palliation.","authors":"Judyta Szeliga, Maksym Lazu, Sebastian Góreczny","doi":"10.1017/S1047951125001751","DOIUrl":"10.1017/S1047951125001751","url":null,"abstract":"<p><p>Staged Fontan pathway treatment is a recognised surgical approach for managing congenital heart lesions with single ventricle physiology. Some patients necessitate communication between the tunnel and the atrium to maintain circulatory balance. During follow-up, adjustments to fenestration size may be required. While methods for enlarging or completely closing fenestrations are common, partially reducing flow through a fenestration remains challenging. We present an effective technique for partially reducing the size of a large, stented fenestration using a coronary stent and a vascular occluder.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":"35 5","pages":"1082-1084"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Heart Disease transition practices in the United States: a survey of adult Congenital Heart Disease programs.","authors":"Debora Burger, Reem Hasan, Patrick D Evers, Andrew W McHill, Corina Thomet, Philip Moons, Quin E Denfeld","doi":"10.1017/S1047951125001489","DOIUrl":"10.1017/S1047951125001489","url":null,"abstract":"<p><strong>Background: </strong>International organisations recommend that patients with CHD undergo a structured transition process to prepare for lifelong cardiac care. However, there is a limited understanding of current transition practices in the United States (U.S.) from the perspective of adult CHD programs. The purpose of this study was to characterise adult CHD transition practices across the U.S.</p><p><strong>Method: </strong>We conducted a descriptive, cross-sectional survey of adult CHD programs in the U.S., inquiring about transition practices (preparation, transfer, and integration), resources, specialists, and barriers. We used descriptive statistics to analyse the data.</p><p><strong>Results: </strong>We analysed responses from 38 adult CHD programs (37% response rate). Among these, 25 (66%) of adult CHD programs reported formal transition programs and 26 (68%) reported having a transfer process to receive patients from paediatric cardiology. Reported transition program specialists were interdisciplinary. Few programs reported having psychologists or psychiatrists on their teams or offered support for patients with intellectual disability. The main barriers affecting transition were insurance and health care costs.</p><p><strong>Conclusion: </strong>Around two-thirds of respondent adult CHD programs reported the presence of formal transition programs. More resources may be needed within these programmes to support patient psychological well-being and those with intellectual disability and to address barriers related to insurance and health care costs.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"908-914"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patent ductus arteriosus rupture during percutaneous device closure: a case report.","authors":"Hyun Ho Kim, Jihye You","doi":"10.1017/S1047951125001313","DOIUrl":"10.1017/S1047951125001313","url":null,"abstract":"<p><p>Patent ductus arteriosus is a common condition in preterm neonates, often necessitating medical or surgical intervention. This report presents a case of a preterm neonate born at 27 gestational weeks and who experienced patent ductus arteriosus rupture during a device closure procedure. Patent ductus arteriosus rupturing during device closure is rare and life threatening but can be successfully managed with prompt recognition and intervention.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1040-1042"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the relationship between serum magnesium levels, patent ductus arteriosus, and other neonatal morbidities: a retrospective observational study.","authors":"Selma Aktas, Eda Albayrak, Osman Guvenc, Ebru Kazanci, Aysegul Inamlik, Ayse Pelin Ozcan, Ayse Korkmaz, Serdar Beken","doi":"10.1017/S1047951125001568","DOIUrl":"10.1017/S1047951125001568","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the association between serum magnesium levels and the risk of symptomatic patent ductus arteriosus in premature infants.</p><p><strong>Material and method: </strong>This retrospective single-centre cohort study analysed the medical records of patients. Neonates were categorised into two groups based on the presence or absence of symptomatic patent ductus arteriosus. Demographic factors including gender, gestational age, type of birth, birth weight, multiple pregnancies, medical treatment for duct closure or surgical ligation, length of hospital stay, and mortality and neonatal outcomes were compared between the groups. The relationship between serum magnesium levels at 24 hours of age and the risk of symptomatic patent ductus arteriosus and other neonatal morbidities was assessed.</p><p><strong>Results: </strong>This study found no significant relationship between symptomatic patent ductus arteriosus and serum magnesium levels. Additionally, no significant differences were observed between serum magnesium levels and ductal diameter, nor in the need for medical or surgical intervention for symptomatic patent ductus arteriosus. However, neonates with serum magnesium levels greater than 3 mg/dL exhibited a significantly higher incidence of respiratory distress syndrome. Conversely, the prevalence of bronchopulmonary dysplasia was significantly lower in this group, with both findings reaching statistical significance (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>These results suggest that while serum magnesium levels may not be a reliable marker for symptomatic patent ductus arteriosus, they could have clinical implications in the modulation of neonatal respiratory outcomes. Further research is warranted to explore the underlying mechanisms and assess the potential therapeutic role of magnesium in the management of neonatal morbidities.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"903-907"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of standard intravenous immunoglobulin therapy on Kawasaki disease predicted by long non-coding ribonucleic acid small nucleolar RNA host gene 5 and microRNA-27a.","authors":"Shangming Chen, Haiying Huang","doi":"10.1017/S1047951125001611","DOIUrl":"10.1017/S1047951125001611","url":null,"abstract":"<p><strong>Background: </strong>Kawasaki disease, an acute systemic small- and medium-vessel vasculitis, is mostly detected in children under 5 years old.</p><p><strong>Objective: </strong>We aimed to explore the predictive value of long non-coding ribonucleic acid small nucleolar RNA host gene 5 (SNHG5) and microRNA (miRNA)-27a for the effect of standard intravenous immunoglobulintherapy on children with Kawasaki disease.</p><p><strong>Methods: </strong>The study included 182 children undergoing standard intravenous immunoglobulin therapy for Kawasaki disease and another 182 healthy children receiving physical examinations as a control group. LncRNA SNHG5 and miRNA-27a expression levels were determined at admission.</p><p><strong>Results: </strong>The ineffective group had higher levels of interleukin-6, C-reactive protein, procalcitonin, lncRNA SNHG5, and miRNA-27a and Kobayashi score than those of the effective group (<i>P</i> < 0.05). Multivariate regression analysis showed that Kobayashi score, interleukin-6, C-reactive protein, procalcitonin, lncRNA SNHG5, and miRNA-27a were associated with the treatment outcomes (<i>P</i> < 0.05). LncRNA SNHG5 and miRNA-27a levels were positively correlated with Kobayashi score, interleukin-6, receiver operating characteristic and procalcitonin levels (<i>r</i> > 0, <i>P</i> < 0.05). High Kobayashi score and levels of interleukin-6, c-reactive roe, procalcitonin, lncRNA SNHG5, and miRNA-27a were influencing factors for treatment failure (odds ratio > 1, <i>P</i> < 0.05). The areas under the curves of lncRNA SNHG5, miRNA-27a, and their combination were 0.757, 0.766, and 0.831, respectively.</p><p><strong>Conclusion: </strong>LncRNA SNHG5 and miRNA-27a are highly expressed in children with Kawasaki disease, and their levels are closely correlated with the efficacy of standard immunoglobulin therapy.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"971-977"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular rings - what has changed, and what do I need to know as a practitioner?","authors":"Sarah Madira, William B Orr, Joshua M Rosenblum, Ryan Pitman, Quang-Tuyen Nguyen, David Molter, Ashley Lloyd, Julie Glickstein, Markus Renno, Pirooz Eghtesady, Jacob R Miller","doi":"10.1017/S1047951125001544","DOIUrl":"10.1017/S1047951125001544","url":null,"abstract":"<p><p>Vascular rings represent a heterogeneous set of aberrant great vessel anatomic configurations which can cause respiratory symptoms or dysphagia due to tracheal or oesophageal compression. These symptoms can be subtle and may present at varied ages. More recently, many have been identified in patients without symptoms, including fetal echocardiogram, resulting in a conundrum for practitioners when attempting to determine who will benefit from surgical correction. Here, we provide a review of vascular rings and a guide to the practitioner on when to consider additional imaging or referral. Additionally, we discuss the changing landscape regarding asymptomatic patients and fetal echocardiogram.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"881-887"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of epicardial fat thickness in macrosomic and non-macrosomic infants of mothers with diabetes.","authors":"Celal Varan, Ali Orgun","doi":"10.1017/S1047951125001556","DOIUrl":"10.1017/S1047951125001556","url":null,"abstract":"<p><strong>Background: </strong>Epicardial fat thickness also increases in insulin resistance and diabetes mellitus patients. In our study, we aimed to compare the epicardial fat thickness and interventricular septum diameter in infants of mothers with diabetes with infants of mothers without diabetes. Also, to determine the effect of birth weight on the epicardial fat thickness and the interventricular septum diameter in infants of mothers with diabetes.</p><p><strong>Materials and methods: </strong>Between November 2022 and June 2023, infants of mothers with diabetes and healthy infants were compared. According to birth weight, infants of mothers with diabetes were divided into two groups, macrosomic infants (≥ 4000 g) and non-macrosomic infants (2500-4000 g).</p><p><strong>Results: </strong>A total of 78 infants of mothers with diabetes and 56 infants of mothers without diabetes were evaluated. Epicardial fat thickness and interventricular septum diameter were found to be statistically significantly higher in infants of mothers with diabetes than in healthy infants. Epicardial fat thickness and interventricular septum diameter measurements were found to be statistically significantly higher in the macrosomic of infants than in the non-macrosomic of infants of mothers with diabetes. Asymmetric septal hypertrophy was found to be more common in macrosomic infants of diabetic mothers than in non-macrosomic infants, although not statistically significant. We also found a positive correlation between epicardial fat thickness and asymmetric septal hypertrophy.</p><p><strong>Conclusions: </strong>Epicardial fat thickness is observed to increase along with neonatal macrosomia and heart mass in gestational diabetes mellitus. The lack of a significant increase in epicardial fat thickness and interventricular septum diameter in non-macrosomic infants of mothers with diabetes may be indicative of good glycaemic control in non-macrosomic infants of mothers with diabetes. Therefore, good glycaemic control during pregnancy and long-term follow-up of infants of mothers with diabetes after birth is important.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"953-957"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sudden cardiac death in an adolescent with unusual coronary artery anomaly.","authors":"M Holtrup, L Hernandez, M Diamond","doi":"10.1017/S1047951125001519","DOIUrl":"10.1017/S1047951125001519","url":null,"abstract":"<p><p>A case of an adolescent male with hypoplastic coronary arteries and myocardial bridging who had a sudden cardiac death event playing soccer. This rare anomaly is not easily identified and may be missed during routine work-up. Treatment options are limited and there is a need for discussion of additional treatment considerations that may prevent sudden cardiac death in this population.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1051-1053"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous treatment of aortic isthmus atresia with begraft covered stent in a 25 kg children: a case report.","authors":"G Giusti, A Busti, M Papa","doi":"10.1017/S1047951125001428","DOIUrl":"10.1017/S1047951125001428","url":null,"abstract":"<p><p>We report the case of a 25 kg male with aortic isthmus atresia and small femoral arterial access. A BeGraft covered stent was percutaneously implanted after perforating the atretic segment. This case demonstrates the feasibility and safety of transcatheter treatment using the Bentley stent, which enables smaller femoral access compared to other balloon-expandable stent platforms.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1070-1072"},"PeriodicalIF":0.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}