Cardiology in the Young最新文献

Investigating the possible connection between cystic hygroma, nuchal translucency, and the genetic link underlying cardiac lymphatic abnormalities and congenital heart disease: is there an association?

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-07 DOI: 10.1017/S1047951125001404

Marios Loukas, Ishank Gupta, Brenna Wilson, Shamfa Joseph, Rachel Levene, Michael Montalbano

{"title":"Investigating the possible connection between cystic hygroma, nuchal translucency, and the genetic link underlying cardiac lymphatic abnormalities and congenital heart disease: is there an association?","authors":"Marios Loukas, Ishank Gupta, Brenna Wilson, Shamfa Joseph, Rachel Levene, Michael Montalbano","doi":"10.1017/S1047951125001404","DOIUrl":"https://doi.org/10.1017/S1047951125001404","url":null,"abstract":"Although a direct link between cardiac lymphatics and congenital heart disease (CHD) has not been established, research indicates that abnormalities in the cardiac lymphatic system are involved in several congenital disorders that present with cardiac defects. However, this contribution remains poorly understood and is still an emerging area of study. One theory proposes that abnormal lymphatic development, which can present as cystic hygroma or increased nuchal translucency, may give rise to heart defects such as coarctation of the aorta, hypoplastic left heart syndrome, or bicuspid aortic valves. The genetic pathways for the development of the cardiac lymphatic system and the heart's major vessels may overlap; therefore, mutations in these genes could result in simultaneous defects in both systems. The close anatomical proximity between cardiac lymphatics and the great vessels of the heart suggests a \"cause and effect\" relationship, where an abnormality in one could affect the other and lead to congenital defects. Given that congenital heart disease is the most common birth defect in the United States, this systematic review, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, seeks to explore the potential link between cardiac lymphatics and CHD. Understanding this connection could have significant clinical implications by paving the way for new diagnostic approaches and therapeutic strategies for CHDs.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1-7"},"PeriodicalIF":0.9,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case report: morphological challenges to surgical repair in complete atrioventricular septal defect with isolated ventricular component.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-02 DOI: 10.1017/S1047951125001441

Martina Larsson, Mats Synnergren, Thushara Rodrigo

引用次数: 0

Mitral annular disjunction versus myocardial Ischemia in coronary artery anomalies. 冠状动脉异常的二尖瓣环脱节与心肌缺血。

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-02 DOI: 10.1017/S1047951125001465

Vincent Bui, Silvana Molossi, Lindsay F Eilers, Shagun Sachdeva, Tam T Doan

引用次数: 0

A case of protein-losing enteropathy secondary to constrictive pericarditis in a 3-year-old boy: a rare case report.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-03-12 DOI: 10.1017/S1047951125000216

Ying Lyu, Hongyan Lyu, Xinxin Lyu

引用次数: 0

Aetiological distribution and clinical features in children with large pericardial effusion who underwent pericardiocentesis.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1017/S104795112500054X

Furkan Donbaloğlu, Vehbi Doğan, Serpil Kaya Çelebi, Meryem Beyazal, İlker U Sayıcı, Zeynep Donbaloğlu

{"title":"Aetiological distribution and clinical features in children with large pericardial effusion who underwent pericardiocentesis.","authors":"Furkan Donbaloğlu, Vehbi Doğan, Serpil Kaya Çelebi, Meryem Beyazal, İlker U Sayıcı, Zeynep Donbaloğlu","doi":"10.1017/S104795112500054X","DOIUrl":"10.1017/S104795112500054X","url":null,"abstract":"Background: We aimed to evaluate the clinical and laboratory characteristics and aetiological factors of patients who underwent pericardiocentesis for moderate to large pericardial effusion.Method: A total of 38 patients who underwent pericardiocentesis due to moderate-severe pericardial effusion and not related to cardiac surgery were included in the study.Results: The male-to-female ratio was 2.16, and found to be 7.5 in patients over 3 years of age. Mean age and body weight of the patients were 69.4 ± 74.9 months and 22.5 ± 22.4 kg. Dyspnoea (51.7%) was the most common complaint, followed by chest pain (37.9%). Tamponade was present in 23.7% of the patients. The largest diameter of effusion was 24.4 ± 10.4 mm. The amount of fluid drained was 279.24 ± 279 ml. Macroscopic appearance was serous in 12 (34.3%), and haemorrhagic in 18 (51.4%). No complication related to procedure was seen. Aetiology for efusion was infectious in 26%, idiopathic in 18%, iatrogenic in 11%, rheumatological in 11%, malignancy in 8%, cardiomyopathy in 8%, and other factors related in 18%. Of the 38 patients, 16 received nonsteroidal anti-inflammatory drugs (NSAID), and colchicine and corticostreoid were added in nine and two patients, respectively. A total of eight (21%) patients died during follow-up.Conclusion: In conclusion, percutaneous pericardiocentesis can be applied safely and the underlying aetiology is decisive in the prognosis of the patient. Although pericardial effusion in children is often due to inflammation of the pericardium, it can develop as a finding of many local or systemic diseases that should be kept in mind.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"784-790"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arterial thromboembolism, antithrombotic therapy, and risk of recurrent thromboembolism in children with CHD undergoing cardiac surgery.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1017/S1047951125001271

Amy L Kiskaddon, Nhue L Do, Ernest K Amankwah, Daniel M Witt, Vera Ignjatovic, Therese M Giglia, Gary M Woods, Hilary B Whitworth, Arabela C Stock, Neil A Goldenberg

{"title":"Arterial thromboembolism, antithrombotic therapy, and risk of recurrent thromboembolism in children with CHD undergoing cardiac surgery.","authors":"Amy L Kiskaddon, Nhue L Do, Ernest K Amankwah, Daniel M Witt, Vera Ignjatovic, Therese M Giglia, Gary M Woods, Hilary B Whitworth, Arabela C Stock, Neil A Goldenberg","doi":"10.1017/S1047951125001271","DOIUrl":"10.1017/S1047951125001271","url":null,"abstract":"Introduction: Data on arterial thromboembolism in children undergoing cardiac surgery are limited. We sought to characterise, and estimate rates of, incident and recurrent arterial thromboembolism, and describe antithrombotic therapies for treatment in a large multinational population of children with CHD undergoing cardiac surgery.Methods: We queried the TriNetX global electronic health record (derived real-world data research platform) from 2017 to 2024 for patients less than 18 years of age and an index arterial thromboembolism within 1 year of congenital cardiac surgery. Data were descriptively analysed.Results: Of 20,102 children who underwent an index cardiac surgery for CHD, 206 (1.1%) developed an index arterial thromboembolism within 1 year of surgery: 111 (53.9%) had only arterial thromboembolism and 95 (46.1%) had concomitant venous thromboembolism. The most common anatomic site for arterial thromboembolism was the lower extremity (n = 141, 68.4%), and the most common surgery was the Glenn procedure (n = 35, 17%). Unfractionated heparin was utilised in 136 (67 %) and aspirin in 91 (44.2%) patients. Recurrent thromboembolism occurred in 36 (17.5%) patients within 1 year of the index thromboembolism.Conclusions: Among children undergoing congenital cardiac surgery, arterial thromboembolism was rare (1% of patients), but the 1-year risk of recurrent thromboembolism was high, at 17.5%. Multicentre prospective cohort studies are warranted to further evaluate risk factors for recurrent thromboembolism, to facilitate future risk-stratified interventional trials designed to reduce the high thromboembolism recurrence risk in these children.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"679-682"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pulmonary artery banding for dilated and depressed left ventricle: dilated cardiomyopathy versus left ventricular non-compaction cardiomyopathy.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI: 10.1017/S1047951125000460

Andrey Semyashkin, Julia Nesteruk, Dimitra Giannikopouloui, Michael Scheid, Gleb Tarusinov, Aktam Tannous, Marcel Te Vrugt, Lotfi Ben Mime

{"title":"Pulmonary artery banding for dilated and depressed left ventricle: dilated cardiomyopathy versus left ventricular non-compaction cardiomyopathy.","authors":"Andrey Semyashkin, Julia Nesteruk, Dimitra Giannikopouloui, Michael Scheid, Gleb Tarusinov, Aktam Tannous, Marcel Te Vrugt, Lotfi Ben Mime","doi":"10.1017/S1047951125000460","DOIUrl":"10.1017/S1047951125000460","url":null,"abstract":"Objectives: To retrospectively assess the suitability of pulmonary artery banding as a treatment strategy for dilated cardiomyopathy and left ventricular non-compaction cardiomyopathy with depressed left ventricular ejection fraction.Methods: The study was retrospective and included consecutive patients who met the inclusion criteria: diagnosed with dilated cardiomyopathy or left ventricular non-compaction cardiomyopathy and left ventricular ejection fraction less than 35%. Cardiac indices were documented, and clinical outcomes were followed for 5 years.Results: This study included 21 patients with depressed left ventricular ejection fraction due to dilated cardiomyopathy (n = 11) or left ventricular non-compaction cardiomyopathy (n = 10), treated either with anti-congestion medication alone or in combination with pulmonary artery banding. The groups treated with pulmonary artery banding showed significant improvement in left ventricular ejection fraction compared to controls (ANOVA, p = 0.0002), with no major adverse events. In the subgroup with left ventricular non-compaction, pulmonary artery banding led to significant improvement of the left ventricular ejection fraction (p = 0.00002) and significant reductions in the Z scores of left ventricular end-diastolic diameter (p = 0.0002) and of end-diastolic volume (p = 0.004).Conclusions: Pulmonary artery banding appears to be a viable strategy for improving heart function in patients with non-compaction and dilated cardiomyopathy and depressed left ventricular ejection fraction. While pulmonary artery banding demonstrated more pronounced benefits in the subgroup with non-compaction cardiomyopathy, significantly enhancing cardiac restoration indices throughout the follow-up period, warranting further investigation in larger studies.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"717-721"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wake-up call: paediatric cardiac intensive care nurse and advanced practice provider well-being and intent to vacate.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1017/S1047951125000599

Casey N Bor, Gyasi Moscou-Jackson, Christopher W Mastropietro, Sandra L Staveski

{"title":"Wake-up call: paediatric cardiac intensive care nurse and advanced practice provider well-being and intent to vacate.","authors":"Casey N Bor, Gyasi Moscou-Jackson, Christopher W Mastropietro, Sandra L Staveski","doi":"10.1017/S1047951125000599","DOIUrl":"10.1017/S1047951125000599","url":null,"abstract":"This study aimed to assess Well-Being Index scores in paediatric cardiac ICU (PCICU) registered nurses and advanced practice providers. Secondary objectives included identifying factors correlating with at-risk Well-Being Index scores and exploring predictors of these scores, with attention to the impact of the coronavirus disease 2019 pandemic. A multicentre electronic survey was conducted between October 2021 and January 2022. Registered nurses and advanced practice providers working in PCICUs at US centres participating in the Collaborative Research from the Pediatric Cardiac Intensive Care Society were included.The survey included the nine-item Well-Being Index and questions about demographics and factors influencing well-being, such as coronavirus disease 2019. The Well-Being Index is a validated tool to predict workforce distress and well-being. Out of 218 participants (180 registered nurses, 38 advanced practice providers), 137 registered nurses (76%) and 15 advanced practice providers (39%) had at-risk Well-Being Index scores. A total of 61% of nurses and 34% of advanced practice providers reported an intent to leave. Intent to leave was significantly linked to lower well-being for registered nurses (p = 0.002). Leadership support reduced registered nurses' distress risk by 68% compared to no support (p = 0.04). Increased stress since coronavirus disease 2019 raised registered nurses' poor well-being risk by four times (p = 0.001). PCICU registered nurses and advanced practice providers are at risk for poor well-being, exacerbated by the pandemic. Those with poor well-being may be more likely to leave. Leadership support is vital for nurses' well-being. Further research is needed to establish baseline well-being.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"661-667"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virtual cardiac models as a teaching tool for cardiac morphology.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-03-20 DOI: 10.1017/S1047951125000071

Shelby Scola, Ryan Moore, Jeffrey Cimprich, Matthew Nelson, Albert Chen, Meryl Cohen, Jill Savla, Lindsay Rogers

{"title":"Virtual cardiac models as a teaching tool for cardiac morphology.","authors":"Shelby Scola, Ryan Moore, Jeffrey Cimprich, Matthew Nelson, Albert Chen, Meryl Cohen, Jill Savla, Lindsay Rogers","doi":"10.1017/S1047951125000071","DOIUrl":"10.1017/S1047951125000071","url":null,"abstract":"Background: Understanding complex three-dimensional cardiac structures is the key to knowing CHD. Many learners have limited access to cadaveric specimens, and most alternative teaching modalities are two-dimensional. Therefore, we have developed virtual cardiac models using photogrammetry of actual heart specimens to address this educational need.Methods: A descriptive study was conducted at a single institution during a week-long cardiac morphology conference in October 2022 and 2023. Conference attendees viewed virtual cardiac models via laptop screen and virtual reality headset. Learners were surveyed on their opinions of the virtual models and their perceived effectiveness compared to existing educational materials.Results: Forty-six learners completed the survey. Participants reported the virtual cardiac models to be more effective than textbook diagrams (60%), and equally or more effective compared to didactic teaching (78%) and specimen videos (78%). Approximately half of participants (54%) found the virtual models to be less effective than hands-on cadaveric specimen inspection. Attitudes towards the virtual specimens were overall positive with most responders finding the tool engaging (87%) and enjoyable (85%). A majority reported that the models deepened their understanding of cardiac morphology (79%) and that they would recommend them to other trainees (87%).Conclusions: This study demonstrates that a novel teaching tool, virtual cardiac specimens, is equivalent to or more effective than many current materials for learning cardiac morphology. While they may not replace direct cadaveric specimen review, virtual models are an engaging alternative with the ability to reach a wider audience.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"818-823"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Usefulness of hepatic CT attenuation values in assessment of Fontan-associated liver disease progression: a comparative study with Model of End-stage Liver Disease Excluding International Normalized Ratio scores.

IF 0.9 4区医学

Cardiology in the Young Pub Date : 2025-04-01 Epub Date: 2025-02-13 DOI: 10.1017/S1047951125000393

Yosuke Kugo, Takashi Kido, Takuji Watanabe, Toshiaki Nagashima, Masaki Taira, Daisuke Yoshioka, Kazuo Shimamura, Shigeru Miyagawa

{"title":"Usefulness of hepatic CT attenuation values in assessment of Fontan-associated liver disease progression: a comparative study with Model of End-stage Liver Disease Excluding International Normalized Ratio scores.","authors":"Yosuke Kugo, Takashi Kido, Takuji Watanabe, Toshiaki Nagashima, Masaki Taira, Daisuke Yoshioka, Kazuo Shimamura, Shigeru Miyagawa","doi":"10.1017/S1047951125000393","DOIUrl":"10.1017/S1047951125000393","url":null,"abstract":"Fontan-associated liver disease leads to liver cirrhosis and hepatocellular carcinoma, worsening patient prognosis. Although the Model of End-Stage Liver Disease Excluding International Normalized Ratio score correlates with disease severity, precise prediction methods remain elusive. The hepatic computed tomography (CT) attenuation is used to assess steatohepatitis, which may offer insight into disease progression. This study aimed to determine the usefulness of hepatic CT attenuation values in assessing Fontan-associated liver disease progression. All post-Fontan patients with >20 years' follow-up data between 1980 and 2021 were reviewed. We set five regions of interest with a 20-mm-diameter circle in the peripheral region of the liver to obtain minimum, maximum, mean, and standard deviation of the CT attenuation values, which were adjusted to those of the aorta. The impact of hepatic CT attenuation values on cirrhosis development was evaluated. Cox regression revealed significant associations between adjusted minimum (hazard ratio: 0.01 [0.00-0.02, p < 0.01), adjusted maximum (hazard ratio: 159 [4.34-5831, p < 0.01]), and standard deviation (hazard ratio: 1.89 [1.29-2.76, p < 0.01]) and Model of End-Stage Liver Disease Excluding International Normalized Ratio score (hazard ratio: 1.2 [1.02-1.43, p = 0.03]) with cirrhosis. In cirrhosis cases, the adjusted minimum value exhibited significant longitudinal alteration prior to cirrhosis (p < 0.01), whereas Model of End-Stage Liver Disease Excluding International Normalized Ratio scores remained stable. The hepatic CT attenuation values were associated with cirrhosis development and the longitudinal changes are more sensitive than the Model of End-Stage Liver Disease Excluding International Normalized Ratio score.","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"831-835"},"PeriodicalIF":0.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0