Cardiology in the Young最新文献

{"title":"Mental, behavioural, and developmental disorders among U.S. Children with and without heart conditions, 2016-2021.","authors":"Amanda N Dorsey, Karrie F Downing, Melissa Danielson, Vijaya Kancherla, Matthew E Oster, Sherry L Farr","doi":"10.1017/S1047951125100760","DOIUrl":"10.1017/S1047951125100760","url":null,"abstract":"<p><strong>Background: </strong>Children with heart conditions, particularly CHDs, may experience adverse neurodevelopmental and psychosocial outcomes. Our study aimed to: (1) compare national prevalence of mental, behavioural, and developmental disorders among children by heart condition status and (2) identify associated characteristics among children with heart conditions.</p><p><strong>Methods: </strong>Nationally representative data from the National Survey of Children's Health (2016-2021) on U.S. children aged 6-17 years without Down syndrome were analysed. Caregivers reported whether a healthcare provider told them their child has ever had a heart condition or currently has depression, anxiety, ADHD, behavioural, or conduct problems, Tourette syndrome, autism spectrum disorder, developmental delay, intellectual disability, learning disability, or a speech or other language disorder. Logistic regression analysis compared disorder prevalence by heart condition status and, among children with heart conditions, assessed whether disorders were associated with demographic and contextual characteristics.</p><p><strong>Results: </strong>Among 3,440 children with heart conditions, 42% had an examined disorder, compared to 23% of 133,280 children without heart conditions (adjusted prevalence ratio = 1.8; 95% confidence interval: 1.7, 2.0). Each disorder was more prevalent among children with versus without heart conditions (adjusted prevalence ratio range: 1.9 to 5.1), with anxiety (22.1%), ADHD (20.4%), and learning disabilities (19.6%) most common. Among children with heart conditions, disorders were consistently associated with an increased number of adverse childhood experiences.</p><p><strong>Conclusion: </strong>These findings support clinical guidelines recommending neurodevelopmental and mental health screening and interventions for children with heart conditions and can be used as a national baseline to gauge progress of guideline implementation.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1577-1588"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12462410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reaching consensus as to how knowledge of development underscores our understanding of deficient ventricular septation.","authors":"Robert H Anderson, Lucile Houyel, Leo Lopez, Niraj N Pandey, Diane E Spicer, Andrew C Cook, Colin J McMahon, R Krishna Kumar, Adrian Crucean, Justin T Tretter","doi":"10.1017/S104795112510139X","DOIUrl":"10.1017/S104795112510139X","url":null,"abstract":"<p><p>Some of us recently discussed the problems existing in describing the channels that permit interventricular shunting. We offered suggestions for improvement, particularly when assessing the channel that is found when both arterial trunks arise from the morphologically right ventricle. Our proposals engendered significant debate, with several criticisms appearing in an editorial commentary. The commentator now accepts that not all of the criticisms were justified. In an attempt to seek further consensus, we have now joined with additional colleagues so as to clarify the aspects of our initial work that created potential confusion. Having reviewed the aspects producing the misconceptions, we again provide an overview of the evidence relevant to deficient ventricular septation now provided by knowledge of cardiac development. We show how remodelling of the primary interventricular communication involves the provision of an inlet for the developing right ventricle and an outlet for the developing right ventricle. During this process, the secondary interventricular foramen, which is a subaortic-left ventricular communication when the outflow tract remains supported exclusively by the right ventricle, becomes the outflow tract for the left ventricle, with a subaortic-right ventricular communication then being closed to complete ventricular septation. We show how knowledge of these processes, coupled with an appreciation of the mechanism of formation of the muscular ventricular septum and the separate formation of an embryonic muscular outlet septum, which with normal development becomes the subpulmonary infundibulum, provides the basis for understanding the various phenotypic lesions that permit interventricular shunting in the postnatal heart.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1617-1630"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Ozaki technique in the treatment of aortic valve disease in children: a 15-year retrospective review.","authors":"Zhangwei Wang, Honghao Fu, Shoujun Li","doi":"10.1017/S1047951125101534","DOIUrl":"10.1017/S1047951125101534","url":null,"abstract":"<p><p>With the steady improvement in the efficacy of Ozaki technique in children over the past decade, it is more active and widely used in children with aortic valve disease. Ozaki technique has obvious advantages over traditional prosthetic valve replacement. It preserves the natural motion of the aortic annulus, preserves the coordination of the left ventricle, the sinus of Valsalva and the aorta, naturally dilates the aortic root during systole, restores the physiological laminar flow pattern, and retains the continuous growth potential of the aortic annulus. It has good early and mid-term valve durability, no need for anticoagulation, short learning curve time, easy to promote, suitable for a wide range of people, and significant economic benefits, especially in developing countries with serious shortage of medical resources but a large number of CHD patients. Theoretically, Ozaki techniques can be considered in patients of all ages (adults and children) and in those with acquired and congenital aortic valve disease, including those with previous mechanical, bioprosthetic, or Ross procedures. We currently support the concept of using Ozaki technique as a surgical repair method for children with severe aortic valve disease, but the specific strategy should be made individually according to the patient's condition. This article reviews the past and present, surgical indications, surgical procedures, advantages, prognosis, and prospects of Ozaki technique in treating aortic valve disease in children.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1540-1548"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening congenital cardiac care in Vietnam: opportunities for system-level reform.","authors":"Tam T Doan, Huong Tran, Khanh-Linh Kaitlin Doan, Minh Phuc Vu, Casey B Culbertson","doi":"10.1017/S1047951125109207","DOIUrl":"10.1017/S1047951125109207","url":null,"abstract":"<p><p>Critical CHD refers to life-threatening cardiac anomalies present at birth that require surgical or catheter-based intervention within the first year of life. Without punctual diagnosis and treatment, these conditions can result in significant morbidity or mortality. In high-income countries like the United States (U.S.), early detection and management of Critical CHD have been greatly improved through universal prenatal screening, pulse oximetry screening, regionalised care, and subspecialty training. In contrast, Vietnam, a low- and middle-income country, faces persistent challenges. The absence of newborn screening policies and limited prenatal detection infrastructure leads to delayed diagnoses. Paediatric cardiac expertise and surgical services are largely confined to urban centres, leaving rural areas underserved. Vietnam also lacks national CHD registries, standardised referral pathways, and consistent training programmes, impeding quality improvement and equitable access. This manuscript compares the U.S. and Vietnamese Critical CHD systems, highlighting structural, infrastructural, and workforce-related disparities. We identify barriers, key areas for intervention, and offer targeted strategic considerations to address these discrepancies. We strongly believe that efforts to implement universal newborn screening, develop regional cardiac hubs with mandatory outreach support to rural proximity, expand workforce training, invest in ICU infrastructure, and establish national data systems are of immediate need. These reforms could significantly improve survival and outcomes for children with Critical CHD in Vietnam and inform similar efforts in other low- and middle-income countries.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1558-1566"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracardiac repair of Raghib syndrome along with ventricular septal defect closure: a successful single-surgery outcome.","authors":"Fekede D Agwar, Mikias A Gebresenbet, Azene D Mengistu","doi":"10.1017/S1047951125101479","DOIUrl":"10.1017/S1047951125101479","url":null,"abstract":"<p><p>A five-year-old boy was diagnosed intraoperatively with the Raghib complex, consisting of an absent coronary sinus, persistent left superior vena cava, and an atrial septal defect associated with a ventricular septal defect. The surgical management, which included intracardiac rerouting of the left superior vena cava to the right atrium along with closure of both septal defects, was successfully performed.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1713-1715"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug treatment analysis of infective endocarditis in children-a retrospective, single-centre study.","authors":"Sanni Li, Yan Meng, Nan Zhang, Guying Zhang","doi":"10.1017/S1047951125101637","DOIUrl":"10.1017/S1047951125101637","url":null,"abstract":"<p><strong>Objective: </strong>A retrospective analysis of paediatric infective endocarditis characterised causative pathogens, antimicrobial susceptibility patterns, and treatment outcomes to guide clinical decision-making.</p><p><strong>Methods: </strong>The data of patients who received infective endocarditis between 2016 and 2023 were retrospectively collected from the medical records database. The clinical characteristics, treatment plans, and pharmaceutical monitoring characteristics were analysed and summarised.</p><p><strong>Results: </strong>A total of 12 paediatric infective endocarditis cases were identified. Bacterial isolates included 27 Gram-positive and 1 Gram-negative strains. The most common pathogen was <i>Staphylococcus aureus</i> (<i>n</i> = 13), all methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), followed by <i>Abiotrophia defectiva</i> (<i>n</i> = 6), <i>Streptococcus mitis</i> (<i>n</i> = 5), <i>Streptococcus sanguinis</i> (<i>n</i> = 2), <i>Bacillus cereus</i> (<i>n</i> = 1), and <i>Klebsiella oxytoca</i> (<i>n</i> = 1). Antimicrobial therapy primarily involved linezolid, vancomycin, and cephalosporin/enzyme inhibitor combinations. Cardiac glycosides were used in 10 cases, and all patients received phosphocreatine to support myocardial energy metabolism. Therapeutic drug monitoring for vancomycin was performed in 25% of cases, while no therapeutic drug monitoring was conducted for meropenem or linezolid.</p><p><strong>Conclusion: </strong>All the causative organisms were predominantly Gram-positive cocci, with MRSA accounting for the largest proportion; different streptococci varied considerably in terms of drug resistance. The antimicrobial drugs used were predominantly linezolid and glycopeptides. The rate of blood concentration monitoring was low.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1589-1594"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial impact of inherited arrhythmia syndromes on anxiety in paediatric patients and their families.","authors":"Sevil Babayeva, Sinem Akgül, Tevfik Karagöz, İlker Ertuğrul","doi":"10.1017/S1047951125101236","DOIUrl":"10.1017/S1047951125101236","url":null,"abstract":"<p><strong>Background: </strong>Inherited cardiac arrhythmias are life-threatening conditions associated with a high risk of sudden cardiac death. These diseases impose a substantial psychological burden. Parents experience heightened anxiety due to uncertainty, medical interventions, and risk of adverse events. However, limited research has examined anxiety levels in affected individuals and their families.</p><p><strong>Objective: </strong>This study aimed to assess anxiety levels in children and adolescents diagnosed with inherited cardiac arrhythmias, specifically Long QT Syndrome and Catecholaminergic Polymorphic Ventricular Tachycardia, and to identify factors influencing anxiety in both patients and parents.</p><p><strong>Methods: </strong>A prospective, survey-based cohort study was conducted between June 2023 and June 2024, including 53 patients (0-18 years) diagnosed with inherited arrhythmias. Anxiety was assessed using the State-Trait Anxiety Inventory. Demographic and clinical variables, including disease type, invasive procedures, family history of sudden cardiac death, and parental education, were analysed.</p><p><strong>Results: </strong>Mothers exhibited the highest anxiety (STAI-T: 46.6 ± 10.6) while fathers had the lowest (37.3 ± 7.0). Catecholaminergic polymorphic ventricular tachycardia patients reported significantly higher anxiety (49.2 ± 7.7) than long QT syndrome patients (38.0 ± 7.0, <i>p</i> < 0.01). Children undergoing invasive procedures, particularly sympathetic denervation, had elevated anxiety (45.1 ± 8.2 vs. 36.5 ± 6.4, <i>p</i> < 0.05). Mothers of male children and those with a family history of sudden cardiac death had significantly higher anxiety (<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Inherited arrhythmias significantly impact psychological well-being, with mothers experiencing the highest anxiety levels. Disease severity, invasive procedures, and family history of sudden cardiac death contribute to increased anxiety, emphasising the need for psychological support in managing these conditions.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1683-1689"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for maternal cardiac and obstetric outcomes in patients with and without CHD.","authors":"Ciara Brown, Sarah Voskamp, Alicia Kube, Lauren Cervantes, Sophia Hibner, Noah Babbins, William DeCampli","doi":"10.1017/S1047951125101017","DOIUrl":"10.1017/S1047951125101017","url":null,"abstract":"<p><strong>Background: </strong>Physiologic changes in the peripartum period put women with CHD at increased risk for morbidity. This study examines factors associated with peripartum complications and length of stay compared to patients without CHD.</p><p><strong>Methods: </strong>This single-institution retrospective case-control study included women with CHD (2000-2017) and a control population without CHD. A review of clinical and echocardiographic data was used to assign baseline characteristics, disease severity, and adverse outcomes. Primary outcomes were composite variables of cardiac and obstetric adverse events, along with peripartum length of stay. The relationship between maternal CHD, baseline characteristics, and peripartum adverse events was evaluated by multivariable regression.</p><p><strong>Results: </strong>The cohort and control groups included 162 deliveries among 113 women and 321 deliveries among 321 women, respectively. Cardiac complications, including arrhythmia, heart failure, pulmonary oedema, and thromboembolic events, occurred in 8.6% of the cohort (RR 2.52, 95% CI 1.17-5.42), with the most common event being arrhythmia. Obstetric events, such as caesarean delivery, assisted vaginal delivery, preterm birth, and pre-eclampsia, occurred in 67.9% versus 56.1% in the control group (RR 1.21, 95% CI 1.05-1.40). In multivariable models, increasing age was associated with increased composite cardiac events. Length of stay was longer in the cohort group (<i>p</i> < 0.001) and significantly associated with modified World Health Organization classification (<i>p</i> = 0.016).</p><p><strong>Conclusions: </strong>Women with CHD experience increased cardiac and obstetric morbidity compared to controls during peripartum admission. Those with CHD have longer hospital stays around delivery, which is associated with disease severity.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1663-1668"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144943835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful treat-and-repair strategy in a 5 year old with partial anomalous pulmonary venous connection, atrial septal defect, and severe pulmonary hypertension.","authors":"Ken Hayashi, Kumiyo Matsuo, Hisaaki Aoki","doi":"10.1017/S1047951125101583","DOIUrl":"10.1017/S1047951125101583","url":null,"abstract":"<p><p>We report the case of a 5-year-old boy with severe pulmonary arterial hypertension due to partial anomalous pulmonary venous connection and atrial septal defect. Sequential combination therapy using multiple pulmonary vasodilators enabled safe surgical repair. In this case of severe pulmonary arterial hypertension-associated with partial anomalous pulmonary venous connection and atrial septal defect-the treat-and-repair strategy proved effective.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1727-1729"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of ventricular repolarisation parameters in children with dilated cardiomyopathy.","authors":"Shuo Wang, Miao Wang, Ting Zhao, Ping Liu, Fang Li, Liping Liu, Erlin Hu, Yuwen Wang, Runmei Zou, Yi Xu, Cheng Wang","doi":"10.1017/S1047951125100954","DOIUrl":"10.1017/S1047951125100954","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the prognostic value of electrocardiographic ventricular repolarisation parameters in children with dilated cardiomyopathy.</p><p><strong>Methods: </strong>A retrospective study was conducted involving 89 children with dilated cardiomyopathy [age 5.24 (4.32, 6.15) years] as the research group, and a control group consisting of 80 healthy children matched for age and sex. Within the research group, there were 76 cases in the survival subgroup and 13 cases in the death subgroup. Ventricular repolarisation parameters were measured.</p><p><strong>Results: </strong>(1) Compared to the control group, both QTcmax and QTcmin were significantly prolonged in the research group (<i>P</i> < 0.01). Additionally, Tp-Te /QT ratios for leads III, aVL, V1, V2, and V3 showed an increase (<i>P</i> < 0.05), while T-wave amplitudes for leads I, II, aVL, aVF, V4, V5, and V6 exhibited a decrease (<i>P</i> < 0.05). (2) In comparison to the survival subgroup, the diameters of the LV, RV, LA, and RA in the death subgroup were enlarged, while the left ventricular ejection fraction and eft ventricular fractional shortening were decreased (<i>P</i> < 0.05). The Tp-Te /QT ratios for leads aVR, V5, and V6 also increased notably (<i>P</i> < 0.05 or <i>P</i> < 0.01). The T-wave amplitude readings from leads II, aVF, and V6 demonstrated significant reductions (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Abnormal ventricular repolarisation parameters were found in dilated cardiomyopathy children. Increased Tp-Te /QT ratios in aVR, V5, and V6 leads and decreased T-wave amplitudes in II, aVF, and V6 leads were risk factors for predicting mortality in children with dilated cardiomyopathy.</p>","PeriodicalId":9435,"journal":{"name":"Cardiology in the Young","volume":" ","pages":"1637-1643"},"PeriodicalIF":0.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}