Psychopharmacology bulletin最新文献_第4页

Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia. 猴头菌补充剂作为慢性和治疗难治性精神分裂症抗精神病药物补充的理论潜力。

Psychopharmacology bulletin Pub Date : 2025-02-03

Joni F Baker, Sharlene D Newman

{"title":"Theoretical Potential of Hericium Erinaceus Supplementation as an Add-On to Antipsychotics in Chronic and Treatment-Resistant Schizophrenia.","authors":"Joni F Baker, Sharlene D Newman","doi":"","DOIUrl":"","url":null,"abstract":"Schizophrenia is a serious mental illness that is a leading cause of disability worldwide. While antipsychotic agents are the most effective medications, up to one-third of patients experience treatment resistance, and approximately one-sixth of patients experience ultra-resistant illness. There is a growing body of evidence that inflammation, oxidative stress, and neurodegeneration may be contributing to pathophysiology and treatment response. Several agents with potential to improve inflammation and oxidative stress have been investigated, with some showing statistically significant benefits, though robust improvement in symptomatology has not been consistently demonstrated. Hericium erinaceus (HE) is an edible mushroom that has been used as a medicinal food for centuries. In pre-clinical studies, it has demonstrated anti-inflammatory, antioxidant, neuroprotective, and neurogenesis-promoting effects. The specific inflammatory markers that are impacted by HE align well with biomarkers shown to be altered in chronic and treatment resistant schizophrenia. Most clinical studies to date have assessed HE for the treatment of mild cognitive impairment, depression, and anxiety. In clinical studies, HE has been well tolerated, with the most common adverse effect of gastrointestinal disturbance. Given potential for HE to improve inflammation, reduce oxidative stress, and promote adult neurogenesis in the hippocampus, it is theorized that HE may have beneficial effects on symptomatology when used as an add-on to antipsychotic therapy in those with residual symptoms or treatment resistance. The goal of this review is to describe theoretical benefits and potential dosing strategies based on pre-clinical and clinical data.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 2","pages":"41-59"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paliperidone Induced Hypothyroidism: A Case Report. 帕利哌酮所致甲状腺功能减退1例。

Psychopharmacology bulletin Pub Date : 2025-02-03

Mohammed A Mohammed, Abdullah Almarzogi, Anas Ibn Auf

{"title":"Paliperidone Induced Hypothyroidism: A Case Report.","authors":"Mohammed A Mohammed, Abdullah Almarzogi, Anas Ibn Auf","doi":"","DOIUrl":"","url":null,"abstract":"The relationship between antipsychotic medications and thyroid dysfunction has been highlighted in various studies and case reports, particularly concerning subclinical hypothyroidism. This report presents the case of a 31-year-old male patient diagnosed with schizophrenia who received short-term treatment with paliperidone. Routine follow-up assessments revealed significant changes in thyroid function, including marked elevation in thyroid-stimulating hormone (TSH) levels and a slight decrease in free thyroxine (FT4) levels. These alterations were associated with ongoing paliperidone use, suggesting a potential link to hypothyroidism. The findings underscore the importance of continuous thyroid function monitoring in patients prescribed paliperidone to identify potential side effects and ensure comprehensive management of both psychiatric and endocrine health. This case emphasizes the need for increased awareness among healthcare providers regarding the endocrine effects of antipsychotic medications, particularly second-generation agents like paliperidone, to facilitate early detection and timely intervention, ultimately improving patient outcomes.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 2","pages":"104-109"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Raised Creatine Kinase with Numerous Antipsychotics Responded to Clozapine. 肌酸激酶升高与多种抗精神病药物对氯氮平有反应。

Psychopharmacology bulletin Pub Date : 2025-02-03

Michael Dixon, Richard Nixon, James O'Neill, Nick Venters

引用次数: 0

Bereavement During a Course of TMS for MDD: A Case Report. 经颅磁刺激治疗重度抑郁症过程中的丧亲：一例报告。

Psychopharmacology bulletin Pub Date : 2025-02-03

Gregory M Peterson, Karen Byrne, Tae Dillon, Ahmed Naguy, Yvonne Turnier-Shea, Marzena Rybak, Saxby Pridmore

{"title":"Bereavement During a Course of TMS for MDD: A Case Report.","authors":"Gregory M Peterson, Karen Byrne, Tae Dillon, Ahmed Naguy, Yvonne Turnier-Shea, Marzena Rybak, Saxby Pridmore","doi":"","DOIUrl":"","url":null,"abstract":"Objective: A patient with major depressive disorder (MDD) was receiving transcranial magnetic stimulation (TMS). A little over halfway through the course the patient was bereaved and experienced normal sadness. Our objective is to describe the tracking and outcome of this common emotionally distressing event.Method: Routine assessments conducted at the centre include the six-item Hamiton depression rating (HAMD6) scale, the Clinical Global Impression-Severity (CGI-S) scale, and the Subjective Depression Scale (SDS6). In addition, the Daily Sadness Scale (DSS) is applied at each treatment day; this is a single question asking how much sadness/depression is being experienced.Results: On the 19th treatment day, the patient was bereaved and experienced appropriate sadness. The pathological state (MDD) resolved, as reflected by changes in the psychometric tools. Following the death, normal sadness emerged and lessened over a few weeks.Conclusion: This case illustrates that while TMS can effectively treat MDD, it does not prevent the emergence of sadness in uncomplicated bereavement.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 2","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychopharmacology of Catatonia: A Tour D'horizon. 卡他性精神障碍的精神药理学：A Tour D'horizon.

Psychopharmacology bulletin Pub Date : 2025-01-01

Ahmed Naguy, Saxby Pridmore, Victoria Ozidu, Bibi Alamiri

引用次数: 0

Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers. 基于药物基因组学标记的酒精性幻觉患者精神药物治疗剂量个性化临床决策支持系统的应用

Psychopharmacology bulletin Pub Date : 2025-01-01

VYu Skryabin, A E Petukhov, S A Pozdniakov, V A Ivanchenko, I A Zaytsev, S S Miroshkin, S I Sokolova, I V Bure, V V Smirnov, D A Sychev

{"title":"Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers.","authors":"VYu Skryabin, A E Petukhov, S A Pozdniakov, V A Ivanchenko, I A Zaytsev, S S Miroshkin, S I Sokolova, I V Bure, V V Smirnov, D A Sychev","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Alcoholic hallucinosis (AH) is one of the severe complications of chronic alcoholism, characterized by psychotic symptoms such as auditory hallucinations and delusions. Haloperidol is widely used to treat AH; however, its therapy is often complicated by side effects. A personalized approach using pharmacogenetic testing (particularly the CYP2D6 polymorphism) allows individualization of haloperidol dosage, improving both safety and efficacy of therapy.Materials and methods: The study included 100 men diagnosed with \"psychotic disorder induced by alcohol use.\" Patients were randomized into two groups: the main group (45 patients) received haloperidol based on the results of pharmacogenetic testing, while the control group (55 patients) received standard dosing. Genotyping was conducted for the CYP2D6 1846G > A polymorphism. The effectiveness was assessed using the PANSS, UKU, and SAS scales.Results: Genotyping showed an even distribution of CYP2D6 polymorphisms in both groups. The main group demonstrated a significant reduction in side effects and improvement in psychotic symptoms compared to the control group. Differences on the UKU, SAS, and PANSS scales reached statistical significance on days 3-5 of treatment.Conclusion: Using pharmacogenetic testing to adjust haloperidol dosage improves therapy tolerability and accelerates the resolution of psychotic symptoms in patients with alcoholic hallucinosis, confirming the feasibility of a personalized approach in psychopharmacotherapy.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder. 非洲裔双相情感障碍患者中锂使用不足的现象持续存在。

Psychopharmacology bulletin Pub Date : 2025-01-01

Monica J Taylor-Desir, Jorge A Sanchez-Ruiz, Eric J Vallender, Balwinder Singh, Karen M Meagher, Mark A Frye

{"title":"Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder.","authors":"Monica J Taylor-Desir, Jorge A Sanchez-Ruiz, Eric J Vallender, Balwinder Singh, Karen M Meagher, Mark A Frye","doi":"","DOIUrl":"","url":null,"abstract":"Bipolar disorder is a chronic disease that imposes a lifelong burden on those that suffer from it. Lithium is still considered both gold standard treatment and first-line maintenance treatment, and access to treatment with lithium is paramount to improving patient outcomes. However, access to adequate treatment is not only contingent on symptom recognition, accurate diagnosis, and individualization of treatment, but also affected by racial and ethnic disparities at each stage of patient experience. Individuals of African Ancestry with bipolar disorder are more frequently misdiagnosed with non-affective psychoses, less likely to receive minimally adequate treatment or be prescribed lithium, and more likely to be prescribed antipsychotics. To compare prescription patterns in the treatment of bipolar disorder between individuals of African and European Ancestry, we conducted a pooled meta-analysis of four cohorts spanning different clinical settings, recruitment periods, and ascertainment methods, followed by sex-stratified analyses. We found that, overall, individuals of African Ancestry with bipolar disorder were significantly less likely to be prescribed lithium, and more likely to be prescribed first and second-generation antipsychotics during their lifetime, than those of European Ancestry. Furthermore, both men and women of African Ancestry were independently less likely to be prescribed lithium and more likely to be prescribed second generation antipsychotics than men and women of European Ancestry. However, women appeared to be more burdened by the significantly increased likelihood of first-generation antipsychotic prescription than men, for whom the association was marginally non-significant. This continued underutilization of lithium likely stems from the complex interaction of multiple biases.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"47-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing Patterns of Gabapentinoids in Chronic Pain Management: A Single Institution Retrospective Chart Review. 慢性疼痛治疗中加巴喷丁类药物的处方模式：单一机构回顾性病历审查

Psychopharmacology bulletin Pub Date : 2025-01-01

Richard T Tran, Anand S Patil, Parker P Nguyen, Grace H Nguyen, Amad Qadeer, Grant H Chen, Ranganathan Govindaraj, Jamal Hasoon

{"title":"Prescribing Patterns of Gabapentinoids in Chronic Pain Management: A Single Institution Retrospective Chart Review.","authors":"Richard T Tran, Anand S Patil, Parker P Nguyen, Grace H Nguyen, Amad Qadeer, Grant H Chen, Ranganathan Govindaraj, Jamal Hasoon","doi":"","DOIUrl":"","url":null,"abstract":"Gabapentin and pregabalin are widely used in the management of neuropathic pain though their prescribing patterns, effectiveness, and safety profiles remain topics of ongoing research. This retrospective chart review analyzed the prevalence of gabapentinoid use in a chronic pain clinic over a one-year period from May 1, 2023, to April 30, 2024. The study examined patient records from four pain management physicians, focusing on those prescribed gabapentin or pregabalin. Of the 2,395 patients reviewed, 478 (19.96%) were prescribed gabapentin, while 236 (9.85%) received pregabalin. Combined, 714 patients (29.81%) were managed with either medication, highlighting the significant role gabapentinoids play in chronic pain treatment. The study found that gabapentin was prescribed more frequently than pregabalin. Although both medications are effective for neuropathic pain, their use comes with notable side effects, including dizziness, somnolence, and, in some cases, an increased risk of suicidal ideation. This review underscores the importance of careful patient monitoring and individualized treatment approaches when prescribing gabapentinoids. Future research across multiple sites and further stratification of patient demographics would enhance understanding of gabapentinoid use in clinical practice.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"26-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete Resolution of Catatonia Following a Single Intravenous Lorazepam Challenge Test: An Early Intervention in Psychosis Case Report. 一次静脉注射劳拉西泮挑战试验后，紧张症完全缓解：精神病早期干预病例报告。

Psychopharmacology bulletin Pub Date : 2025-01-01

Chinenye Okoro, Kaye Homer, Marlene Kelbrick, Jonny Walker, Mary Sam, Justine Burge, Rosie Richards, Gabriela Paduret, Feras Ali Mustafa

引用次数: 0

Salty Despair: An Adolescent's Suicide Attempt through Salt Overdose. 盐的绝望：一个青少年因盐过量而企图自杀。

Psychopharmacology bulletin Pub Date : 2025-01-01

Alana Hull, Abhishek Reddy

{"title":"Salty Despair: An Adolescent's Suicide Attempt through Salt Overdose.","authors":"Alana Hull, Abhishek Reddy","doi":"","DOIUrl":"","url":null,"abstract":"Salt is found in nearly every kitchen across the world; however, it is not typically thought of to be a means for suicide. Depending on the age and size of the person, anywhere from 2 to 4 tablespoons of salt consumed rapidly can be lethal. To put that in perspective, the average person in the United States consumes approximately 0.5 tablespoons of salt over the course of the day, which is still above what is recommended. Most cases discussing salt overdose or salt poisoning happen accidentally, however there are case studies and reviews discussing intentional salt overdoses that mostly occur either as exorcism rituals in adults or parents poisoning their young children in cases of factitious disorder imposed on another (formally Munchausen's by proxy). Adolescents using salt as a suicide method, especially in the United States, is either very rare or not well documented due to the lack of available case reports. Here we present a case of an adolescent female who consumed approximately 4 dessertspoons of kosher salt (equivalent to 2-3 tablespoons) to kill herself after reportedly seeing the idea on social media. Although this patient had a favorable outcome with no signs of neurological damage, our goal is to bring awareness to the dangers of salt overdose and warn about a potential rise in cases due to circulating videos on popular apps social media apps.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"76-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0