Psychopharmacology bulletin最新文献_第9页

Probable Olanzapine-Related Idiopathic Intracranial Hypertension in an Adolescent With First-Episode Psychosis. 首次发作精神病的青少年可能与奥氮平相关的特发性颅内高压。

Psychopharmacology bulletin Pub Date : 2023-08-11

Ahmed Naguy, Camellia Naguy, Sanaa Sabir

引用次数: 0

Association Between Symptom Severity and Medication Adherence in Adolescents with Bipolar Disorder Demonstrating Suboptimal Adherence. 表现出次优依从性的双相情感障碍青少年症状严重程度与药物依从性的关系。

Psychopharmacology bulletin Pub Date : 2023-08-11

Martha Sajatovic, Jennifer B Levin, Avani Modi, Molly McVoy, Larry F Forthun, Raechel Cooley, Jessica Black, Carla Conroy, Kaylee Sarna, Farren B Briggs, Melissa DelBello

{"title":"Association Between Symptom Severity and Medication Adherence in Adolescents with Bipolar Disorder Demonstrating Suboptimal Adherence.","authors":"Martha Sajatovic, Jennifer B Levin, Avani Modi, Molly McVoy, Larry F Forthun, Raechel Cooley, Jessica Black, Carla Conroy, Kaylee Sarna, Farren B Briggs, Melissa DelBello","doi":"","DOIUrl":"","url":null,"abstract":"Objective: While medication non-adherence is common in bipolar disorder (BD), few studies have specifically assessed non-adherent BD adolescents and young adults (AYAs). This analysis, using screening and baseline data from an ongoing randomized controlled trial, examined the relationship between BD symptoms and adherence in poorly adherent AYAs.Methods: AYAs ages 13-21 had sub-optimal adherence defined as missing ⩾ 20% of prescribed BD medication. Mean sample (N = 36) age was 19.1 years (SD = 2.0), 66.7 % (N = 24) female, 25.0 % (n = 9) non-white. Adherence was measured via: 1) self-reported Tablets Routine Questionnaire (TRQ) and 2) electronic monitoring (SimpleMed pillbox). Symptoms were measured with the Hamilton Depression Rating Scale (HAM-D), the Young Mania Rating Scale (YMRS), and the Clinical Global Impression Scale (CGI).Results: Mean percentage of missed BD medications using TRQ was 34.9 (SD = 28.9) at screening and 30.6 (SD = 33.0) at baseline. Mean percentage of missed medication using SimpleMed at baseline was 42.1 (SD = 37.0). The correlation between TRQ and SimpleMed was r = 0.36 (p = 0. 13). Neither CGI nor age were correlated with adherence. Neither TRQ nor SimpleMed were significantly related to HAM-D. YMRS was positively associated with worse adherence for TRQ (r = 0.36, p = 0.03), but not significantly associated with SimpleMed. Adherence did not differ by other demographic attributes.Conclusion: Adherence levels varied widely in AYA with BD. Adherence monitoring increased adherence by approximately 4.5%, and use of electronic pill monitoring identified a greater proportion of missed medication vs. self-report. BD symptoms may not consistently identify AYA with adherence challenges.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"53 3","pages":"8-21"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial Magnetic Stimulation (TMS) for Major Depressive Disorder-Modus Operandi! 经颅磁刺激治疗重度抑郁症Modus Operandi！

Psychopharmacology bulletin Pub Date : 2023-08-11

Saxby Pridmore, Yvonne Turnier-Shea, Marzena Rybak, Ahmed Naguy

{"title":"Transcranial Magnetic Stimulation (TMS) for Major Depressive Disorder-Modus Operandi!","authors":"Saxby Pridmore, Yvonne Turnier-Shea, Marzena Rybak, Ahmed Naguy","doi":"","DOIUrl":"","url":null,"abstract":"Background: Transcranial magnetic stimulation (TMS) is effective in the management of treatment resistant major depressive disorder (MDD) and has recently become widely available. Our aim was to explore the literature for evidence of the mechanism of action.Method: We examined our own accumulating TMS library, the reference lists of all available papers and used a search engine to collect information. We collated and examined this information under relevant heading.Results: TMS produces a large number of physiological changes including site of stimulation neurochemical, brain wave and blood flow effects, and distant structure effects including neurotransmitter effects and volume increase. TMS also corrects generalized and local functional connectivity (FC) abnormalities which are a feature of MDD.Conclusion: TMS produces a range of physiological changes. It is unclear which of these underpin its antidepressant. It is likely more than one work synergistically to this end-almost certainly the capacity to correct MDD induced FC abnormalities makes a strong antidepressant contribution.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"53 3","pages":"55-60"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434311/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Venlafaxine on the Size of Brain and Expression of SHANK3, TUBB5 and DDC Genes in BALB/c Mice. 文拉法辛对BALB/c小鼠脑大小及SHANK3、TUBB5和DDC基因表达的影响。

Psychopharmacology bulletin Pub Date : 2023-08-11

Ramesh Ranjbar, Zahra Zamanzadeh, Ali Mohammad Ahadi

{"title":"Effects of Venlafaxine on the Size of Brain and Expression of SHANK3, TUBB5 and DDC Genes in BALB/c Mice.","authors":"Ramesh Ranjbar, Zahra Zamanzadeh, Ali Mohammad Ahadi","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: A growing body of evidence has recently suggested that taking venlafaxine during pregnancy may be linked to increased risk of certain congenital defects. The study aimed to address the effects of venlafaxine use during pregnancy on the development of the brain in mice.Experimental design: Fourteen female BALB/c mice were randomly divided into two equally-sized groups: venlafaxine-treated and control. After mating, pregnant mice of venlafaxine-treated group were orally received the venlafaxine 35 mg/kg/day throughout pregnancy, while pregnant control mice did not receive any treatment. All pups were killed on postnatal day 21 and brain images were quantified using ImageJ software. The mRNA expression levels of SHANK3, TUBB5 and DDC of genes in pups' brain tissue samples were evaluated using quantitative real-time PCR method.Principal observations: The mean brain size of pups was significantly smaller in the venlafaxine-treated group than in the control group. Results showed that the mRNA expression levels of SHANK3 and TUBB5 was significantly downregulated in venlafaxine-treated mice compared to control group. Expression of DDC gene didn't showed significant differences between two groups.Conclusions: These results provide evidence that use of venlafaxine during pregnancy may affect the brain development in mice and altered the expression of SHANK3 and TUBB5 genes in brain tissue.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"53 3","pages":"22-34"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabis Pen-Induced Psychosisin a First-Time Adolescent User. 首次使用大麻笔的青少年出现心理问题。

Psychopharmacology bulletin Pub Date : 2023-08-11

Patrick J Beck, Abhishek Reddy

{"title":"Cannabis Pen-Induced Psychosisin a First-Time Adolescent User.","authors":"Patrick J Beck, Abhishek Reddy","doi":"","DOIUrl":"","url":null,"abstract":"Cannabis is a widely used illicit substance that is historically consumed via smoking, but alternative methods of cannabis consumption have been growing in popularity over the past several decades. One such modality is vaporization, which can appeal specifically to adolescent consumers given these pen devices' ease of concealment, lack of characteristic odor, and marketability. Cannabis products designed for vaping often have higher concentrations of the psychoactive component of cannabis, tetrahydrocannabinol (THC), when compared with traditional cannabis leaf smoking. This can increase the intensity of cannabis-related effects such as analgesia, relaxation, appetite stimulation, and reduced nausea and emesis, but also potentially increases the risk for adverse effects such as dysphoria, and more severely, cannabis-induced psychosis (CIP). Here, we present the case of an adolescent female who was brought after school to our emergency department presenting with symptoms of acute psychosis. Her subsequent workup was effectively normal apart from a urine drug screen positive for THC, which the patient confirmed was due to use of a cannabis pen prior to leaving school that day. This prompted the diagnosis of CIP, which was self-limited and resolved without significant intervention. We use this case to provide the symptomatology and treatment of CIP secondary to cannabis pen use, as well as more broadly discuss the potential implications of cannabis vaping on adolescent neurodevelopment, substance use, and psychiatric comorbidities.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"53 3","pages":"61-65"},"PeriodicalIF":0.0,"publicationDate":"2023-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0