Psychopharmacology bulletin最新文献_第3页

Mirtazapine-Induced Asymptomatic Hepatotoxicity: A Case Report. 米氮平所致无症状肝毒性1例报告。

Psychopharmacology bulletin Pub Date : 2026-06-05 DOI: 10.64719/pb.18543

Rim Sellami, Ines Feki, Jawaher Masmoudi

引用次数: 0

Traumatic Brain Injury and Delusional Disorder: A Narrative Synthesis with Psychopharmacologic Implications. 创伤性脑损伤与妄想障碍：具有精神药理学意义的叙事综合。

Psychopharmacology bulletin Pub Date : 2026-06-05 DOI: 10.64719/pb.18528

Mridul Sarangal, Charmi Sarangal

{"title":"Traumatic Brain Injury and Delusional Disorder: A Narrative Synthesis with Psychopharmacologic Implications.","authors":"Mridul Sarangal, Charmi Sarangal","doi":"10.64719/pb.18528","DOIUrl":"10.64719/pb.18528","url":null,"abstract":"Background: Traumatic brain injury (TBI) is associated with a range of neuropsychiatric sequelae, including secondary psychotic disorders. Delusional syndromes are a prominent and clinically significant manifestation, often classified as Psychotic Disorder Due to Another Medical Condition.1,2.Methods: This narrative synthesis reviews case series, cohort studies, retrospective analyses, and conceptual literature published between 1998 and 2025, focusing on epidemiology, clinical features, pathophysiology, diagnosis, and psychopharmacologic management of post-TBI delusional syndromes.Results: Delusions-commonly persecutory or misidentification types-frequently emerge after a latency of months to years and are more prevalent than schizophrenia-like presentations.1,2,6 Risk factors include moderate-to-severe injury, frontal or temporal lesions (particularly right-sided), post-traumatic epilepsy, and genetic vulnerability.3-6 Compared to primary psychotic disorders, negative symptoms are typically less prominent, though cognitive impairment is nearly universal.6,7,12 Low-dose atypical antipsychotics demonstrate favorable response rates, but tolerability concerns-including sedation, extrapyramidal symptoms, and seizure risk-necessitate cautious use.8,9 Adjunctive anticonvulsants may be beneficial, particularly in patients with comorbid epilepsy.10,15.Conclusions: Post-TBI delusional syndromes highlight the role of structural brain injury in the development of psychosis. Careful diagnostic evaluation and individualized, low-dose psychopharmacologic strategies are essential. Further research is needed to guide evidence-based treatment in this population.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 3","pages":"117-123"},"PeriodicalIF":0.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148214062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Abrupt Discontinuation of Clozapine Cause Seizures? 突然停用氯氮平会引起癫痫发作吗？

Psychopharmacology bulletin Pub Date : 2026-06-05 DOI: 10.64719/pb.18537

Matheus Moraes Alves Pereira, Paulo José Ribeiro Teixeira, Fábio Lopes Rocha, Bárbara Perdigão Stumpf

{"title":"Can Abrupt Discontinuation of Clozapine Cause Seizures?","authors":"Matheus Moraes Alves Pereira, Paulo José Ribeiro Teixeira, Fábio Lopes Rocha, Bárbara Perdigão Stumpf","doi":"10.64719/pb.18537","DOIUrl":"10.64719/pb.18537","url":null,"abstract":"Abrupt discontinuation of clozapine can result in serious and potentially life-threatening psychiatric and physical complications, including psychotic rebound, increased risk of suicide, catatonia, cholinergic rebound, and autonomic instability. Although exceedingly rare, the literature contains case reports describing seizures following abrupt clozapine withdrawal. We report and discuss an additional case of this phenomenon. A 45-year-old man with a diagnosis of paranoid schizophrenia, treated with clozapine 300 mg/day for at least 20 years, abruptly discontinued the medication. Two weeks later, he experienced two generalized tonic-clonic seizures. No alternative medical cause was identified, and the temporal association suggests clozapine withdrawal as the precipitating factor. This case highlights the importance of preventing abrupt clozapine discontinuation. In clinical situations where abrupt discontinuation is unavoidable, it should be performed in a hospital setting. When feasible, gradual tapering is recommended to minimize withdrawal-related complications.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 3","pages":"148-151"},"PeriodicalIF":0.0,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13244332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148213856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cariprazine for Autism-A Case Report. Cariprazine治疗自闭症的案例报告。

Psychopharmacology bulletin Pub Date : 2026-06-05 DOI: 10.64719/pb.18549

Ahmed Naguy, Saxby Pridmore, Bibi Alamiri

引用次数: 0

Body Dysmorphic Disorder Among Young Individuals: Prevalence and Psychological Correlates. 青少年身体畸形障碍：患病率和心理相关因素。

Psychopharmacology bulletin Pub Date : 2026-03-11 DOI: 10.64719/pb.16590

Aastha Shah, Rahul Gandhi, Aesha Variya, Apurva Vaishnav, Archana Navale

{"title":"Body Dysmorphic Disorder Among Young Individuals: Prevalence and Psychological Correlates.","authors":"Aastha Shah, Rahul Gandhi, Aesha Variya, Apurva Vaishnav, Archana Navale","doi":"10.64719/pb.16590","DOIUrl":"10.64719/pb.16590","url":null,"abstract":"Body Dysmorphic Disorder (BDD) is an emerging mental health concern among young adults, particularly in urban settings where social media exposure intensifies appearance-related pressures. This study aimed to assess the prevalence of BDD among individuals aged 18-25 years in Vadodara and to examine its association with cognitive-behavioral patterns, psychiatric comorbidities, and social media influence. A cross-sectional study was conducted among college students using validated self-report questionnaires to assess BDD symptoms, obsessive-compulsive behaviors, depression, anxiety, stress, suicidal ideation, and patterns of digital media use. Data were analyzed using descriptive statistics, independent t-tests, chi-square tests, Pearson correlation, and regression analysis. Approximately 10% of participants screened positive for BDD. Individuals with BDD demonstrated significantly higher levels of obsessive-compulsive symptoms, depression, anxiety, stress, suicidal ideation, and negative social media impact compared to those without BDD (p < 0.05). Strong positive correlations were observed between BDD severity and psychological distress, supporting a cognitive-behavioral framework of the disorder. Social media exposure appeared to reinforce distorted self-image and maladaptive behaviors, contributing to symptom severity. The findings highlight the importance of early identification of BDD in academic and primary care settings. Routine screening, cognitive-behavioral therapy, and media literacy interventions are recommended to address both core symptoms and associated psychological comorbidities. A multidisciplinary approach is essential to reduce unnecessary cosmetic procedures and improve mental health outcomes. Limitations include the cross-sectional design and reliance on self-reported measures. Future longitudinal and culturally sensitive studies using clinical interviews are warranted.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 2","pages":"108-121"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clavulanic Acid Attenuated Cocaine Craving in Individuals with Cocaine Use Disorder. 克拉维酸可减轻可卡因使用障碍患者的可卡因渴求。

Psychopharmacology bulletin Pub Date : 2026-03-11 DOI: 10.64719/pb.16587

Mary F Morrison, Ronan Cunningham, M Ingre Walters, Daohai Yu, Xiaoning Lu, Joya Maser, Kyle M Kampman

{"title":"Clavulanic Acid Attenuated Cocaine Craving in Individuals with Cocaine Use Disorder.","authors":"Mary F Morrison, Ronan Cunningham, M Ingre Walters, Daohai Yu, Xiaoning Lu, Joya Maser, Kyle M Kampman","doi":"10.64719/pb.16587","DOIUrl":"10.64719/pb.16587","url":null,"abstract":"This randomized, controlled trial examined the safety of clavulanic acid (CLAV), a GLT-1 (astrocytic glutamate transporter) modulator, in combination with intravenous cocaine to determine whether CLAV can be safely studied in outpatients with cocaine use disorder who may continue to use cocaine. Participants were adults with moderate to severe cocaine use disorder planning to continue regular cocaine use. In a placebo controlled, crossover, inpatient study, the safety of 3 doses of oral CLAV (250 mg/day, 500 mg/day, and added later 750 mg/day) were studied in combination with 40 mg intravenous cocaine on a medical unit with close cardiac monitoring and pharmacokinetic sampling. Ten participants, 8 men and 2 women with cocaine use disorder, were studied with all participants receiving CLAV (250 mg, 500 mg, and placebo) and 5 participants receiving the additional 750 mg dose, in combination with cocaine. There were no clinically significant drug or dose related changes in vital signs, electrocardiogram intervals, pupillary diameters between CLAV and placebo. CLAV 500 mg decreased cocaine craving, using the 10 item Cocaine Craving Questionnaire-Brief, with a large effect size (Cohen's d = 1.25). Thirty-two mild to moderate adverse events were recorded, with most drug related events being gastrointestinal. CLAV, at the doses of 250 mg, 500 mg, and 750 mg was reasonably well tolerated and safe in combination with intravenous cocaine. Associated adverse events were mild to moderate and resolved. CLAV 500 mg was associated with decreased craving for cocaine in people with cocaine use disorder.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 2","pages":"94-107"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Academic Stress in Dental Students Analysis: Questionnaire Design and Validation Study. 牙科学生学业压力分析：问卷设计与验证研究。

Psychopharmacology bulletin Pub Date : 2026-03-11 DOI: 10.64719/pb.16575

Abdul Gani Soulissa, Indrayadi Gunardi, Tri Erri Astoeti, Mita Juliawati, Komariah, Lia Hapsari Andayani

{"title":"Academic Stress in Dental Students Analysis: Questionnaire Design and Validation Study.","authors":"Abdul Gani Soulissa, Indrayadi Gunardi, Tri Erri Astoeti, Mita Juliawati, Komariah, Lia Hapsari Andayani","doi":"10.64719/pb.16575","DOIUrl":"10.64719/pb.16575","url":null,"abstract":"Objective: To develop and validate a comprehensive questionnaire to assess academic stress, integrating academic anxiety and burnout.Method: This study involved questionnaire development using existing instruments, namely DES, PSS, DASS-21, and MBI, and subsequent validation. Content validity was established with 7 experts, face validity with 50 students, and construct validity and reliability with 100 students. Data analysis employed I-CVI, S-CVI, I-FVI, S-FVI, and the Rasch model.Result: The study included 50% students in the preclinical program and 50% students in the clinical program, and a mean age of 20.04 ± 1.79 years. Regarding context validity, only 3 out of 46 items scored below 1.00 but above 0.78. While the S-CVI scores showed that almost all domains had scores of 1.00, the face validity showed all items scored more than 0.80, and the S-CVI scores also more than 0.83. Person-map analysis demonstrated the questionnaire's ability to capture distinct stress dimensions, with preclinical students showing higher scores on social support (SS) and clinical students on personal aspects (PP), suggesting differences in perceived support and self-doubt, respectively. A Cronbach's Alpha of 0.94 across both preclinical and clinical programs shows that the questionnaire is reliable and that the interaction between respondents and items is of high quality.Conclusion: The questionnaire exhibited strong evidence of content, face, and construct validity, as well as high reliability. This validated questionnaire offers a practical and comprehensive approach for measuring academic stress, with the potential to support proactive interventions and improve dental students' well-being and educational outcomes.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 2","pages":"29-51"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Concepts and Treatment Options in the Management of Fibromyalgia. 纤维肌痛管理的当前概念和治疗方案。

Psychopharmacology bulletin Pub Date : 2026-03-11 DOI: 10.64719/pb.16599

Nathan Li, Joshua Cooper, Tanisha Fleming, Stewart Lockett, William Sherman, Azem A Chami, Jamal Hasoon, Christopher L Robinson, Farnad Imani, Alan D Kaye

引用次数: 0

Missing the Forest for the Trees: Delayed Diagnosis and Management of Treatment Resistant Schizophrenia. 只见树木不见森林：难治性精神分裂症的延迟诊断和管理。

Psychopharmacology bulletin Pub Date : 2026-03-11 DOI: 10.64719/pb.16614

Irene Kuriakose, Greg Noe, William Montgomery, Sahil Munjal

{"title":"Missing the Forest for the Trees: Delayed Diagnosis and Management of Treatment Resistant Schizophrenia.","authors":"Irene Kuriakose, Greg Noe, William Montgomery, Sahil Munjal","doi":"10.64719/pb.16614","DOIUrl":"10.64719/pb.16614","url":null,"abstract":"We present a case of a 36-year-old female with schizophrenia, coronary artery disease, and type 2 diabetes who was hospitalized for altered mental status and persistent psychosis. Initial evaluation revealed myocardial infarction, pulmonary embolism, and urinary tract infection. While delirium resolved with treatment, psychotic symptoms persisted. Brain MRI showed diffuse cortical microhemorrhages, prompting extensive workup for vasculitis, infection, and prothrombotic syndromes, all of which were negative. Despite multiple antipsychotic trials (quetiapine, risperidone, ziprasidone), the patient remained symptomatic, with a PANSS score of 156, consistent with treatment-resistant schizophrenia (TRS). The patient was started on clozapine that was later augmented with electroconvulsive therapy (ECT). After 10 ECT sessions and clozapine titrated to 300 mg daily, her PANSS score improved significantly to 60. This case highlights the diagnostic complexity in medically ill psychiatric patients and the risk of delayed TRS diagnosis. Early use of standardized tools like PANSS in the general medical setting may be useful in differentiating psychiatric from medical causes and can expedite treatment. Though clozapine remains first-line for TRS, 45-70% may not respond to monotherapy.5,6,7 ECT augmentation was effective in our case, but evidence remains mixed,9 highlighting the need for further research into optimal TRS augmentation strategies.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 2","pages":"187-190"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976942/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suzetrigine for Pain Management: An Observational Study of Early Adoption Patterns. 舒三嗪用于疼痛管理：早期采用模式的观察性研究。

Psychopharmacology bulletin Pub Date : 2026-03-11 DOI: 10.64719/pb.16578

Jamal Hasoon, Ivan Urits, Omar Viswanath, Farnad Imani, Alaa Abd-Elsayed

{"title":"Suzetrigine for Pain Management: An Observational Study of Early Adoption Patterns.","authors":"Jamal Hasoon, Ivan Urits, Omar Viswanath, Farnad Imani, Alaa Abd-Elsayed","doi":"10.64719/pb.16578","DOIUrl":"10.64719/pb.16578","url":null,"abstract":"Background: Suzetrigine is a novel non-opioid analgesic initially approved for acute pain management. There has been growing interest in its potential applications for chronic pain conditions. As clinical awareness and accessibility expand, evaluating early outpatient prescribing patterns is essential to better understand its adoption and possible role in broader pain management strategies.Objective: To evaluate outpatient prescribing trends of suzetrigine at a single academic institution over 5 months to evaluate early adoption and prescription trends.Methods: This retrospective observational study examined outpatient prescriptions of suzetrigine from March 1, 2025, to July 31, 2025. Prescription counts were extracted from the institutional electronic medical record system and analyzed by month.Results: A total of 367 Suzetrigine prescriptions were written over the 5-month period. Monthly distribution was as follows:March: 3 prescriptionsApril: 44 prescriptionsMay: 97 prescriptionsJune: 93 prescriptionsJuly: 130 prescriptionsThere was a clear upward trend in prescribing from March to July. This increase may reflect growing provider familiarity and favorable patient response to the medication.Conclusion: Suzetrigine outpatient prescribing has increased significantly over a short time frame at our institution. Continued monitoring of prescription trends, indications, and patient outcomes will be essential as this medication becomes more widely utilized in pain management.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"56 2","pages":"52-57"},"PeriodicalIF":0.0,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12976945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147446691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0