Psychopharmacology bulletin最新文献_第2页

Bereavement During a Course of TMS for MDD: A Case Report.

Psychopharmacology bulletin Pub Date : 2025-02-03

Gregory M Peterson, Karen Byrne, Tae Dillon, Ahmed Naguy, Yvonne Turnier-Shea, Marzena Rybak, Saxby Pridmore

{"title":"Bereavement During a Course of TMS for MDD: A Case Report.","authors":"Gregory M Peterson, Karen Byrne, Tae Dillon, Ahmed Naguy, Yvonne Turnier-Shea, Marzena Rybak, Saxby Pridmore","doi":"","DOIUrl":"","url":null,"abstract":"Objective: A patient with major depressive disorder (MDD) was receiving transcranial magnetic stimulation (TMS). A little over halfway through the course the patient was bereaved and experienced normal sadness. Our objective is to describe the tracking and outcome of this common emotionally distressing event.Method: Routine assessments conducted at the centre include the six-item Hamiton depression rating (HAMD6) scale, the Clinical Global Impression-Severity (CGI-S) scale, and the Subjective Depression Scale (SDS6). In addition, the Daily Sadness Scale (DSS) is applied at each treatment day; this is a single question asking how much sadness/depression is being experienced.Results: On the 19th treatment day, the patient was bereaved and experienced appropriate sadness. The pathological state (MDD) resolved, as reflected by changes in the psychometric tools. Following the death, normal sadness emerged and lessened over a few weeks.Conclusion: This case illustrates that while TMS can effectively treat MDD, it does not prevent the emergence of sadness in uncomplicated bereavement.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 2","pages":"100-103"},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychopharmacology of Catatonia: A Tour D'horizon. 卡他性精神障碍的精神药理学：A Tour D'horizon.

Psychopharmacology bulletin Pub Date : 2025-01-01

Ahmed Naguy, Saxby Pridmore, Victoria Ozidu, Bibi Alamiri

引用次数: 0

Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers. 基于药物基因组学标记的酒精性幻觉患者精神药物治疗剂量个性化临床决策支持系统的应用

Psychopharmacology bulletin Pub Date : 2025-01-01

VYu Skryabin, A E Petukhov, S A Pozdniakov, V A Ivanchenko, I A Zaytsev, S S Miroshkin, S I Sokolova, I V Bure, V V Smirnov, D A Sychev

{"title":"Use of a Personalized Clinical Decision Support System for Dosing in Psychopharmacotherapy in Patients with Alcoholic Hallucinosis Based on Pharmacogenomic Markers.","authors":"VYu Skryabin, A E Petukhov, S A Pozdniakov, V A Ivanchenko, I A Zaytsev, S S Miroshkin, S I Sokolova, I V Bure, V V Smirnov, D A Sychev","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Alcoholic hallucinosis (AH) is one of the severe complications of chronic alcoholism, characterized by psychotic symptoms such as auditory hallucinations and delusions. Haloperidol is widely used to treat AH; however, its therapy is often complicated by side effects. A personalized approach using pharmacogenetic testing (particularly the CYP2D6 polymorphism) allows individualization of haloperidol dosage, improving both safety and efficacy of therapy.Materials and methods: The study included 100 men diagnosed with \"psychotic disorder induced by alcohol use.\" Patients were randomized into two groups: the main group (45 patients) received haloperidol based on the results of pharmacogenetic testing, while the control group (55 patients) received standard dosing. Genotyping was conducted for the CYP2D6 1846G > A polymorphism. The effectiveness was assessed using the PANSS, UKU, and SAS scales.Results: Genotyping showed an even distribution of CYP2D6 polymorphisms in both groups. The main group demonstrated a significant reduction in side effects and improvement in psychotic symptoms compared to the control group. Differences on the UKU, SAS, and PANSS scales reached statistical significance on days 3-5 of treatment.Conclusion: Using pharmacogenetic testing to adjust haloperidol dosage improves therapy tolerability and accelerates the resolution of psychotic symptoms in patients with alcoholic hallucinosis, confirming the feasibility of a personalized approach in psychopharmacotherapy.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder. 非洲裔双相情感障碍患者中锂使用不足的现象持续存在。

Psychopharmacology bulletin Pub Date : 2025-01-01

Monica J Taylor-Desir, Jorge A Sanchez-Ruiz, Eric J Vallender, Balwinder Singh, Karen M Meagher, Mark A Frye

{"title":"Persistence of Lithium Underutilization in Patients of African Ancestry with Bipolar Disorder.","authors":"Monica J Taylor-Desir, Jorge A Sanchez-Ruiz, Eric J Vallender, Balwinder Singh, Karen M Meagher, Mark A Frye","doi":"","DOIUrl":"","url":null,"abstract":"Bipolar disorder is a chronic disease that imposes a lifelong burden on those that suffer from it. Lithium is still considered both gold standard treatment and first-line maintenance treatment, and access to treatment with lithium is paramount to improving patient outcomes. However, access to adequate treatment is not only contingent on symptom recognition, accurate diagnosis, and individualization of treatment, but also affected by racial and ethnic disparities at each stage of patient experience. Individuals of African Ancestry with bipolar disorder are more frequently misdiagnosed with non-affective psychoses, less likely to receive minimally adequate treatment or be prescribed lithium, and more likely to be prescribed antipsychotics. To compare prescription patterns in the treatment of bipolar disorder between individuals of African and European Ancestry, we conducted a pooled meta-analysis of four cohorts spanning different clinical settings, recruitment periods, and ascertainment methods, followed by sex-stratified analyses. We found that, overall, individuals of African Ancestry with bipolar disorder were significantly less likely to be prescribed lithium, and more likely to be prescribed first and second-generation antipsychotics during their lifetime, than those of European Ancestry. Furthermore, both men and women of African Ancestry were independently less likely to be prescribed lithium and more likely to be prescribed second generation antipsychotics than men and women of European Ancestry. However, women appeared to be more burdened by the significantly increased likelihood of first-generation antipsychotic prescription than men, for whom the association was marginally non-significant. This continued underutilization of lithium likely stems from the complex interaction of multiple biases.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"47-63"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescribing Patterns of Gabapentinoids in Chronic Pain Management: A Single Institution Retrospective Chart Review. 慢性疼痛治疗中加巴喷丁类药物的处方模式：单一机构回顾性病历审查

Psychopharmacology bulletin Pub Date : 2025-01-01

Richard T Tran, Anand S Patil, Parker P Nguyen, Grace H Nguyen, Amad Qadeer, Grant H Chen, Ranganathan Govindaraj, Jamal Hasoon

{"title":"Prescribing Patterns of Gabapentinoids in Chronic Pain Management: A Single Institution Retrospective Chart Review.","authors":"Richard T Tran, Anand S Patil, Parker P Nguyen, Grace H Nguyen, Amad Qadeer, Grant H Chen, Ranganathan Govindaraj, Jamal Hasoon","doi":"","DOIUrl":"","url":null,"abstract":"Gabapentin and pregabalin are widely used in the management of neuropathic pain though their prescribing patterns, effectiveness, and safety profiles remain topics of ongoing research. This retrospective chart review analyzed the prevalence of gabapentinoid use in a chronic pain clinic over a one-year period from May 1, 2023, to April 30, 2024. The study examined patient records from four pain management physicians, focusing on those prescribed gabapentin or pregabalin. Of the 2,395 patients reviewed, 478 (19.96%) were prescribed gabapentin, while 236 (9.85%) received pregabalin. Combined, 714 patients (29.81%) were managed with either medication, highlighting the significant role gabapentinoids play in chronic pain treatment. The study found that gabapentin was prescribed more frequently than pregabalin. Although both medications are effective for neuropathic pain, their use comes with notable side effects, including dizziness, somnolence, and, in some cases, an increased risk of suicidal ideation. This review underscores the importance of careful patient monitoring and individualized treatment approaches when prescribing gabapentinoids. Future research across multiple sites and further stratification of patient demographics would enhance understanding of gabapentinoid use in clinical practice.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"26-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complete Resolution of Catatonia Following a Single Intravenous Lorazepam Challenge Test: An Early Intervention in Psychosis Case Report. 一次静脉注射劳拉西泮挑战试验后，紧张症完全缓解：精神病早期干预病例报告。

Psychopharmacology bulletin Pub Date : 2025-01-01

Chinenye Okoro, Kaye Homer, Marlene Kelbrick, Jonny Walker, Mary Sam, Justine Burge, Rosie Richards, Gabriela Paduret, Feras Ali Mustafa

引用次数: 0

Salty Despair: An Adolescent's Suicide Attempt through Salt Overdose. 盐的绝望：一个青少年因盐过量而企图自杀。

Psychopharmacology bulletin Pub Date : 2025-01-01

Alana Hull, Abhishek Reddy

{"title":"Salty Despair: An Adolescent's Suicide Attempt through Salt Overdose.","authors":"Alana Hull, Abhishek Reddy","doi":"","DOIUrl":"","url":null,"abstract":"Salt is found in nearly every kitchen across the world; however, it is not typically thought of to be a means for suicide. Depending on the age and size of the person, anywhere from 2 to 4 tablespoons of salt consumed rapidly can be lethal. To put that in perspective, the average person in the United States consumes approximately 0.5 tablespoons of salt over the course of the day, which is still above what is recommended. Most cases discussing salt overdose or salt poisoning happen accidentally, however there are case studies and reviews discussing intentional salt overdoses that mostly occur either as exorcism rituals in adults or parents poisoning their young children in cases of factitious disorder imposed on another (formally Munchausen's by proxy). Adolescents using salt as a suicide method, especially in the United States, is either very rare or not well documented due to the lack of available case reports. Here we present a case of an adolescent female who consumed approximately 4 dessertspoons of kosher salt (equivalent to 2-3 tablespoons) to kill herself after reportedly seeing the idea on social media. Although this patient had a favorable outcome with no signs of neurological damage, our goal is to bring awareness to the dangers of salt overdose and warn about a potential rise in cases due to circulating videos on popular apps social media apps.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"76-79"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Positive Report of Viloxazine for a Child with Hyperkinetic Autism. 维洛沙嗪治疗一名过度运动自闭症儿童的早期阳性报告。

Psychopharmacology bulletin Pub Date : 2025-01-01

Ahmed Naguy, Nadyah Alayadhi, Saxby Pridmore, Bibi Alamiri

引用次数: 0

Macrophage Migration Inhibitory Factor and Interleukin 1-β mRNA Levels as Predictors of Antidepressant Treatment Response in Major Depression. 作为重度抑郁症患者抗抑郁治疗反应预测因子的巨噬细胞迁移抑制因子和白细胞介素 1-β mRNA 水平

Psychopharmacology bulletin Pub Date : 2025-01-01

Henry R Kranzler, Annjanette Stone, Steven A Schichman, L Michelle Griffin, Hannah Roggenkamp, Michael E Thase, Kevin G Lynch, David W Oslin

{"title":"Macrophage Migration Inhibitory Factor and Interleukin 1-β mRNA Levels as Predictors of Antidepressant Treatment Response in Major Depression.","authors":"Henry R Kranzler, Annjanette Stone, Steven A Schichman, L Michelle Griffin, Hannah Roggenkamp, Michael E Thase, Kevin G Lynch, David W Oslin","doi":"","DOIUrl":"","url":null,"abstract":"Background: Immunologic measures have been studied as predictors of who will respond to standard antidepressants. Two previous, small studies of pretreatment leukocyte mRNA expression levels of the cytokines macrophage migration inhibitory factor (MIF) and interleukin 1-beta (IL1-β) identified antidepressant treatment responders.Methods: We tested these findings in 1,299 patients from the PRIME Care study, a multi-center pharmacogenetic depression treatment trial. Patients underwent 5 depression-symptom assessments over 24 weeks. mRNA was extracted from peripheral blood, purified, and assayed with TaqMan gene expression assays and a known copy number calibrator to yield relative quantification and copy numbers for each sample. In generalized estimating equations models, we regressed the repeated depression measures and a binary treatment response measure on the baseline MIF and IL-1β measures and relevant covariates.Results: Participants' depression scores decreased monotonically during treatment, with the treatment response percentage increasing concomitantly. We found no significant associations of the cytokine concentrations with either the change in depression scores or the likelihood of a treatment response. A secondary analysis limited to a subsample of 126 participants selected to remove the potential for confounding also showed no significant associations.Limitations: Despite efforts to control for sample and assay method differences, these could have contributed to the lack of replication of prior research.Conclusions: We did not replicate prior findings that pre-treatment expression levels for two cytokines predicted antidepressant treatment response. This raises questions about the clinical utility of using these biomarkers in treating depression.","PeriodicalId":94351,"journal":{"name":"Psychopharmacology bulletin","volume":"55 1","pages":"8-25"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First Episode Psychosis in a Teen with Narcolepsy and Cataplexy. 青少年发作性睡病和猝倒的首发精神病。

Psychopharmacology bulletin Pub Date : 2025-01-01

Trishna Sharma, Annette C Kestner, Abhishek Reddy

引用次数: 0