PhlebologyPub Date : 2025-08-01Epub Date: 2024-12-26DOI: 10.1177/02683555241309808
Todd Cartee, Daniel P Friedmann, John Blebea, Stephen Daugherty, Satish Vayuvegula, Vineet Mishra
{"title":"Ultrasound-guided foam sclerotherapy using physician-compounded foam: Position statement from the American vein and lymphatic society.","authors":"Todd Cartee, Daniel P Friedmann, John Blebea, Stephen Daugherty, Satish Vayuvegula, Vineet Mishra","doi":"10.1177/02683555241309808","DOIUrl":"10.1177/02683555241309808","url":null,"abstract":"<p><p><b>Background:</b> Chronic venous disease has a major impact on the quality of life of millions of patients. Large randomized controlled trials have established ultrasound-guided foam sclerotherapy (UGFS) as a safe and effective treatment option for both saphenous vein insufficiency and tributary disease. Ultrasound guidance is a critical component of sclerotherapy of non-visible veins.<b>Method:</b> An expert panel of the American Vein and Lymphatic Society (AVLS) was convened to review the literature and write a Position Statement with recommendations for the use of UGFS with physician-compounded foam for patients with venous insufficiency.<b>Result:</b> Consensus recommendations from the expert panel highlight the advantages and safety of high-quality physician-compounded foam. These recommendations were reviewed, edited and approved by the Guidelines Committee of the AVLS.<b>Conclusion:</b> UGFS with in-office, physician-compounded foam is a safe primary treatment option for varicose, tributary, and truncal veins of the lower extremities and is an important adjunct therapy for tributary disease following or concomitant to endovenous ablation procedures.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"466-472"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-08-01Epub Date: 2025-01-27DOI: 10.1177/02683555251316413
Marta Ramirez Ortega, Olivia Toledo Tejero, Esteban Malo Benages, Amy Griggs, Edem Segbefia, Enrique Puras Mallagray
{"title":"Real-world outcomes of Zilver Vena® Venous Self Expanding Stent placement for thrombotic and non-thrombotic indications in Spain.","authors":"Marta Ramirez Ortega, Olivia Toledo Tejero, Esteban Malo Benages, Amy Griggs, Edem Segbefia, Enrique Puras Mallagray","doi":"10.1177/02683555251316413","DOIUrl":"10.1177/02683555251316413","url":null,"abstract":"<p><p>PurposeTo evaluate longer term outcomes of the Zilver Vena Venous Stent in patients undergoing venous stenting.Materials and MethodsPatients with iliofemoral obstructive venous disease and treated with venous stents were retrospectively enrolled in a physician-led real-world data collection effort. Results were analyzed by etiologies: post-thrombotic syndrome (PTS), non-thrombotic iliac vein lesion (NIVL), and iliocaval acute deep vein thrombosis (aDVT). Patency outcomes (primary, assisted-primary, secondary), reinterventions (in-stent and all), adverse events, and venous clinical outcome measures (VCSS, CEAP, Villalta Score) were reported using Kaplan-Meier estimates and summary statistics.ResultsA total of 219 patients (89.5% women, mean age 45.3 ± 11.9 years) were identified: 56 PTS, 153 NIVL, and 10 aDVT patients. Devices were placed across the inguinal ligament in 80.4%, 0%, and 70.0% of patients in the PTS, NIVL, and aDVT groups, respectively. Through 1-year, Kaplan-Meier estimated primary patency rate was 96.4% for PTS, 99.3% for NIVL, and 100% for aDVT patients, respectively, and followed the same trend through 3 years. Freedom from (FF) all and within stent reinterventions estimated by Kaplan-Meier was 87.9% and 90.1% for PTS, 98.2% and 98.2% for NIVL through 3 years. No reinterventions were reported for the aDVT group. Improved venous clinical outcome measures were seen in all groups at the last follow-up visit. Stent fractures occurred in 2 PTS patients without related reintervention or clinical sequelae. No stent migrations were reported.ConclusionReal-world use showed high patency rates and improved venous clinical outcome measures (VCSS, Villalta, and CEAP) after venous stent placement.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"496-507"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-08-01Epub Date: 2025-01-18DOI: 10.1177/02683555241313240
Yongquan Zhang, Xiaorong Lin, Tebin Chen, Sisi Gong
{"title":"Association between abnormal systemic coagulation inflammation index and recurrence of deep venous thrombosis as well as quality of life: A retrospective study.","authors":"Yongquan Zhang, Xiaorong Lin, Tebin Chen, Sisi Gong","doi":"10.1177/02683555241313240","DOIUrl":"10.1177/02683555241313240","url":null,"abstract":"<p><p>BackgroundDeep vein thrombosis (DVT) of the lower limb is a significant clinical challenge with the potential for recurrence, which can lead to increased morbidity and reduced quality of life.MethodsA retrospective case-control study was conducted involving 367 patients diagnosed with lower limb DVT from June 2020 to June 2023. Patients were categorized into a recurrence group (<i>n</i> = 121) and a non-recurrence group (<i>n</i> = 246) based on DVT occurrence. Data were systematically collected from medical records, including demographic information, thrombus characteristics, patient compliance, coagulation parameters, inflammatory markers, and quality of life assessments using the CIVIQ-20 and SF-36 scales.ResultsThe recurrence group had significantly higher mean age, history of orthopedic diseases, and pregnancy, reduced compliance with compression therapy and anticoagulation, and elevated inflammatory markers including IL-6, IL-8, and TNF-α. Prolonged coagulation times (PT, APTT, TT) were associated with a lower risk of recurrence. The SCI index was significantly lower in the recurrence group. Multivariate logistic regression identified age, IL-6, IL-8, PT, APTT, TT, and SCI index as significant predictors of recurrence. Quality of life scores were lower in the recurrence group, indicating a higher impact on mental and overall health. ROC analyses demonstrated strong predictive capacity (AUC = 0.905) of SCI index.ConclusionThe study underscores the multifactorial nature of DVT recurrence, highlighting the role of age, systemic inflammation, coagulation times, and compliance with therapeutic interventions. The SCI index emerges as a compelling prognostic marker for assessing the risk of DVT recurrence. These findings emphasize the need for comprehensive management strategies incorporating these parameters to prevent recurrence and improve patients' quality of life.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"479-489"},"PeriodicalIF":1.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143019585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Health coaching in lymphedema care: A review of benefits for cancer survivors.","authors":"Loredana Corrias, Danilo Donati, Federica Giorgi, Roberto Tedeschi","doi":"10.1177/02683555251365058","DOIUrl":"https://doi.org/10.1177/02683555251365058","url":null,"abstract":"<p><p>BackgroundLymphedema, particularly in cancer survivors, is a chronic, debilitating condition that lacks a definitive cure. Current management strategies are complex and focus on symptom control. Health coaching (HC) has emerged as a promising intervention to enhance patient self-management and quality of life in chronic diseases, but its specific role in lymphedema care remains underexplored.MethodsThis review synthesized findings from existing literature reviews and systematic reviews examining HC's effectiveness in improving health outcomes in chronic conditions, including lymphedema. Databases searched included MEDLINE, Cochrane Central, Scopus, PEDro, and Web of Science, with no date limitations. Five relevant studies were identified, each evaluating HC's impact on quality of life, mental health, physical activity, self-management, and decision-making.ResultsThe reviewed studies consistently indicated that HC enhances quality of life, reduces mental distress, and supports self-management in chronic conditions. Improvements were also noted in patient engagement in physical activity and informed decision-making. However, outcomes varied in sustainability and were influenced by HC delivery method and duration.ConclusionsThe findings suggest that HC, delivered within multidisciplinary teams, could be a valuable addition to lymphedema management by empowering patients, improving adherence to care routines, and enhancing psychological resilience. Future research should standardize HC protocols and assess their long-term benefits specifically for lymphedema. This review highlights HC's potential in chronic disease care and the need for tailored interventions in lymphedema.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251365058"},"PeriodicalIF":1.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-30DOI: 10.1177/02683555251365068
Alexander V Alenichev, Sergey V Chubchenko, Sergey G Gavrilov
{"title":"Iliac vein stent placement in the treatment of pelvic venous disorders in women: A systematic review.","authors":"Alexander V Alenichev, Sergey V Chubchenko, Sergey G Gavrilov","doi":"10.1177/02683555251365068","DOIUrl":"https://doi.org/10.1177/02683555251365068","url":null,"abstract":"<p><p>BackgroundCompression stenosis of the left common iliac vein (LCIV) in combination with pelvic venous insufficiency (PVI) represents a form of pelvic venous disorders (PeVDs). Iliac vein stent placement (IVSP), aimed at restoring adequate blood flow through the iliac veins, is considered an optimal treatment for this disorder.AimTo evaluate the efficacy and safety of IVSP in the treatment of PVI based on a systematic analysis of literature data.MethodsAn analysis of publications on use of IVSP in the treatment of a combination of LCIV compression and PVI from the PubMed, Scopus, and Web of Science databases for the period from January 2000 to December 2023 was carried out. Eligible were reports from randomized pro- and retrospective cohort studies and case series for more than 10 patients with the clinical and radiological data used to confirm indication for LCIV stenting and to assess the status of iliac and pelvic veins after the procedure. Isolated clinical cases, comments, letters, duplicate articles, publications on IVSP in patients without PVI symptoms and signs or describing the treatment of chronic venous and post-thrombotic diseases were excluded. The risk of bias was assessed using the ROB-ME tool for systematic reviews.ResultsA total of eight studies representing data of 1605 patients with a combination of LCIV compression and PVI were selected. The efficacy of isolated IVSP in relieving CPP and other symptoms and signs of PVI ranged from 16% to 80%. Gonadal vein embolization (GVE) after IVSP was required in 20 to 84% of cases. Complications related to IVSP had low SIR class and occurred in less than 1% of cases.ConclusionThe primary LCIV stenting is an effective and safe treatment for patients with LCIV compression and PVI, while GVE should be reserved as second line treatment in case of its clinical failure.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251365068"},"PeriodicalIF":1.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-29DOI: 10.1177/02683555251360610
Larisa M Chernukha, Vladislav S Horbovets, Mykhailo V Chekhlov, Sofiia-Solomiia V Horbovets
{"title":"Endovenous welding: Basics and 5-year experience in the use of automatic thermal ablation in the treatment of patients with chronic vein diseases.","authors":"Larisa M Chernukha, Vladislav S Horbovets, Mykhailo V Chekhlov, Sofiia-Solomiia V Horbovets","doi":"10.1177/02683555251360610","DOIUrl":"https://doi.org/10.1177/02683555251360610","url":null,"abstract":"<p><p>ObjectivesWe proposed a method of endovenous welding (EVW) in which automatic ablation mode is implemented. The results of clinical studies in short follow-up periods, which were published earlier, showed a high level of effectiveness and safety of EVW.AimsTo analyze the results of the use of EVW in the treatment of patients with CVD in different terms of follow-up.MethodsThe 5-year results of 236 cases of EVW use in 184 consecutive patients with CVD C2-C6 (48 men, 136 women, aged 21 to 74 years) with ostial diameters from 5.7 to 31 mm were studied. EW was performed using EK 300M generator and welding catheters (Svarmed, Ukraine) in accordance with mini-invasive methodology. The results were evaluated according to the ultrasound data, the level of postoperative pain (РР), complications.ResultsAfter the intervention and in the following 6 months and 12 months, successful ablation was noted in 100% of cases. In the next 4 years, no cases of recanalization were noted. In 38 cases (16.1%) progression of the disease was observed as a result of reflux in the previously unchanged veins. Absence of PP was noted in 85.6% of cases, in 14.4% PP did not exceed a moderate level. Serious complications were not detected.ConclusionsEVW is an effective alternative to other thermal methods with a better control algorithm. The automatic welding mode allows to eliminate the influence of subjective factors on the treatment results and significantly reduce the risk of recanalization and complications. The characteristics of EVW expand the possibilities of using thermal ablation in patients with severe forms of CVD with veins of large diameter, their extrafascial location, as well as in patients with incompetent venous trunks below the knee.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251360610"},"PeriodicalIF":1.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evolving medical treatment for vascular malformation.","authors":"Calver Pang, Rebecca Lee, Rebecca Nisbet, George Hamilton, Jocelyn Brookes, Chung Sim Lim","doi":"10.1177/02683555251361663","DOIUrl":"https://doi.org/10.1177/02683555251361663","url":null,"abstract":"<p><p>Vascular malformations are abnormal growth or development of the vascular structure that result from genetic mutations during early vascular development. Traditional invasive treatment for vascular malformations includes embolo-sclerotherapy, cryotherapy, laser therapy and surgery. However, surgical or minimally invasive treatment is rarely optimal due to the risk of treatment complications, and a complete cure is often difficult to achieve. Targeted therapy can be guided by the current understanding of molecular signalling pathways and disease classifications. Existing and novel medical treatments target the major cellular signalling pathways implicated in the pathogenesis of vascular malformations: mTOR inhibitors, phosphatidylinositol-4,5-biphsophate 3-kinase catalytic subunit alpha (PIK3CA) inhibitors, and AKT inhibitors are being developed to target the Phosphoinositide 3-Kinase (PI3K)/AKT/mTOR pathway, while mitogen-activated protein kinase (MEK) inhibitors and BRAF inhibitor are being researched to target the RAS/RAF/MEK/ERK pathway. Angiogenesis inhibitors are also utilised in the treatment of vascular abnormalities. This review aims to discuss the evolving medical therapy available in the treatment of Vascular Malformations.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251361663"},"PeriodicalIF":0.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-20DOI: 10.1177/02683555251357361
Harikrishna K Ragavan Nair, Ahmad Faidzal Bin Othman, Ahmad Rafizi Hariz Bin Ramli, Muhammad Azim Bin Md Idris, Nabil Mohammad Azmi, Muhammad Abd Jaafar
{"title":"Utilizing the adjustable Velcro system Compreflex® for patients with chronic venous leg ulcers: An observational multicenter clinical follow-up study.","authors":"Harikrishna K Ragavan Nair, Ahmad Faidzal Bin Othman, Ahmad Rafizi Hariz Bin Ramli, Muhammad Azim Bin Md Idris, Nabil Mohammad Azmi, Muhammad Abd Jaafar","doi":"10.1177/02683555251357361","DOIUrl":"https://doi.org/10.1177/02683555251357361","url":null,"abstract":"<p><p>IntroductionVenous leg ulcers (VLUs) pose significant challenges that adversely affect patients' quality of life and result in considerable economic burdens. While existing compression therapies are effective, they are often hindered by complexity, discomfort, and environmental concerns.ObjectivesThis study aimed to evaluate the performance and safety of the adjustable Velcro system Compreflex®, an alternative to traditional four-layer bandaging, for patients with chronic venous leg ulcers. The evaluation was conducted through a clinical follow-up trial.MethodsThis prospective, non-randomized, multicenter, single-arm study included 98 patients with VLUs. The Compreflex® Standard Calf and Foot device was assessed based on wound closure rates, patient satisfaction, and edema reduction. Patients were followed up at specific intervals: after 1, 12, and 26 weeks. ResultsOf the 98 enrolled patients, 19 discontinued participation. The mean ulcer area decreased from 52.9 cm<sup>2</sup> (95% CI, 35.9-69.9 cm<sup>2</sup>) to 37.4 cm<sup>2</sup> (95% CI, 20.0-54.7 cm<sup>2</sup>) at 26 weeks (<i>p</i> < .001). The wound closure rate at 26 weeks was 24.3% (95% CI, 16.6-34.9%). Challenges related to self-application were minimal, highlighting the device's usability. A patient satisfaction rate of 76.8% was reported, based on a satisfaction score of six or higher.ConclusionThis study provides valuable real-world evidence supporting the effectiveness and usability of the Compreflex® device, as demonstrated by the high patient satisfaction rate, and highlights its potential as a promising alternative in compression therapy for venous leg ulcers.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251357361"},"PeriodicalIF":0.0,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-18DOI: 10.1177/02683555251361683
Alex Lapenga, Mark S Whiteley
{"title":"Cleaning the tip with povidone-iodine solution significantly reduces power output from a radial emission endovenous laser catheter using 1470 nm.","authors":"Alex Lapenga, Mark S Whiteley","doi":"10.1177/02683555251361683","DOIUrl":"https://doi.org/10.1177/02683555251361683","url":null,"abstract":"<p><p>BackgroundEndovenous laser ablation (EVLA) is a first line recommended treatment for incompetent truncal veins in the legs. The current \"industry standard\" is a single ring radially firing catheter, using a 1470 nm diode laser. It is common for doctors to treat more than one vein, and they often clean the catheter tip before re-introduction. We have observed some doctors using normal saline for this, but others using povidone-iodine. The aim of this in vitro study was to determine whether povidone-iodine reduces the power being emitted from the catheter tip.MethodsFive radial catheters were tested, each connected in turn to a 1470 nm diode laser set at 10 W. Power emission was measured by a laser power detector connected to a power meter. The power meter recorded an average (mode) of the readings once the laser had reached a steady state. Each catheter was tested firing in air, after dipping in normal saline, then povidone-iodine and finally after wiping the povidone-iodine off the tip with a surgical gauze.ResultsThe emitted power recorded for air (9.05 W) was significantly (<i>p</i> < .05) more than for normal saline (8.90 W), povidone-iodine (8.69 W) and post-wiping off povidone-iodine (8.87 W). The power emitted with povidone-iodine on the tip was significantly less than with normal saline, which mimics the situation of the catheter in a vein surrounded by tumescence anaesthesia.ConclusionIn a laboratory setting, povidone-iodine on the tip of a radially firing catheter transmitting laser energy at 1470 nm, significantly reduces the power being emitted. As this was a laboratory-based study, clinical studies are required to see if this translates into a significant problem during EVLA treatment.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251361683"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-18DOI: 10.1177/02683555251359770
Manisha Siriwardene, David E Connor, Kurosh Parsi
{"title":"Regarding: Endovenous treatment for varicose veins of the lower limbs: Comparative histological evaluation of different techniques.","authors":"Manisha Siriwardene, David E Connor, Kurosh Parsi","doi":"10.1177/02683555251359770","DOIUrl":"https://doi.org/10.1177/02683555251359770","url":null,"abstract":"","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251359770"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}