PhlebologyPub Date : 2025-07-12DOI: 10.1177/02683555251358925
Raz Arman, Mohseni Razieh, Yang Shengping, Pustay Courtney, Collins Tina
{"title":"Potential relationship between chronic venous insufficiency and orthostatic hypotension.","authors":"Raz Arman, Mohseni Razieh, Yang Shengping, Pustay Courtney, Collins Tina","doi":"10.1177/02683555251358925","DOIUrl":"https://doi.org/10.1177/02683555251358925","url":null,"abstract":"<p><p>BackgroundSymptoms of Orthostatic Hypotension have been well-documented for decades, but identifying the cause is often elusive. While many cases are attributed to autonomic dysfunction, drug side effects, and systemic diseases, there remain a significant number of cases where a clear etiology is not found.MethodsMedical records of 646 patients at our vein clinics with venous insufficiency were retrospectively reviewed from 2013 to 2019. Orthostatic vitals were measures at initial visit and post venous ablations. We measured the degree of decrease in systolic BP, diastolic BP, and increase in heart rate associated with change of position from sit to stand. Positive orthostatic was assigned for systolic drop of 20 mmHg or diastolic drop of 10 mmHg or heart rate increase of 10 bpm. Patients had their initial and final vital sign fluctuations analyzed with statistical regression.ResultsOf the 178 positive patients out of 646 total), 59 showed a Systolic drop of 20 mmHg or greater, 24 showed a Diastolic drop of 10 mmHg or greater, and 123 showed a rise in HR by 10 bpm or greater. Data regression showed that after ablative vein treatments, the magnitude of drop in BP (systolic or diastolic), or increase in HR, were significantly reduced (systolic pressure (<i>p</i> ≤ 0.001), diastolic pressure (<i>p</i> ≤ 0.001), and heart rate spike (<i>p</i> ≤ 0.001).ConclusionOur data suggests that venous ablative leg vein treatments might play a significant role in improving orthostatic vital signs. Venous assessment and treatment may offer a potential therapeutic avenue for patients with resistant orthostatic intolerance. However, venous insufficiency needs more investigation in patients with OH to further understand the underlying physiological mechanism.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251358925"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144621651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-11DOI: 10.1177/02683555251358920
Markus Stücker, Walter Olbricht
{"title":"Medical compression stockings reduce the symptoms of obesity-associated functional venous insufficiency.","authors":"Markus Stücker, Walter Olbricht","doi":"10.1177/02683555251358920","DOIUrl":"https://doi.org/10.1177/02683555251358920","url":null,"abstract":"<p><p>Background and ObjectivesMany overweight individuals develop obesity-associated functional venous insufficiency (OA-FVI), also known as obesity-associated dependency syndrome. This study investigates the impact of medical compression stockings (MCS) on the symptoms.Patients and MethodsA total of 49 patients, 37 female and 12 male, with a body-mass-index (BMI) of 30-40 kg/m<sup>2</sup> and a clinical presentation of OA-FVI corresponding to chronic venous insufficiency (CVI) stages C3-C5 were included. During the intervention phase, patients wore knee-length MCS compression class 2 (CCL2). In the first week, flat-knit MCS was worn on the left leg, round-knit MCS on the right leg. In the following 3 weeks, patients wore the MCS of their choice on both legs.ResultsThe average patient age was 54.0 years, and the mean BMI was 35.6 kg/m<sup>2</sup>. The average daily wearing time of the MCS was 9.6 hours. Among 40 patients with analyzable data, the VVSymQ score was reduced to 57% of the baseline value (<i>p</i> < .00001), particularly for the key symptoms of swelling, heaviness and achiness as well as throbbing. Edema was initially present in 22 patients. During the MCS intervention, the edema healed in 73% of the affected patients. The fit and comfort of the MCS was assessed as good or very good by 98% of the patients, donning and doffing was assessed as good or very good by 89% and 78% of the patients.ConclusionsThe symptoms of OA-FVI can be effectively reduced using MCS. The obese patients showed good compliance.Trial registry nameDeutsches Register Klinischer Studien; URL: https://drks.de/search/de/trial/DRKS00015468; registration number: DRKS00015468.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251358920"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-01Epub Date: 2024-12-21DOI: 10.1177/02683555241310749
Ömer Faruk Bucak
{"title":"Unveiling global interest in lymphedema: A decade of search data through google trends global interest in lymphedema: A google trends analysis.","authors":"Ömer Faruk Bucak","doi":"10.1177/02683555241310749","DOIUrl":"10.1177/02683555241310749","url":null,"abstract":"<p><p>IntroductionThe increasing reliance on Internet search engines for health-related queries requires a thorough evaluation of the public's engagement with medical information. This study aims to analyze global trends in interest in lymphedema over the past decade using Google Trends (GT).MethodsA physiatrist with expertise in lymphedema management identified and analyzed 12 key search terms according to the International Society of Lymphology (ISL) guidelines. These terms included 'lymphedema swelling', 'lymphedema treatment', 'lymphedema stages', 'compression therapy for lymphedema', 'manual lymphatic drainage (MLD)', 'complete decongestive therapy (CDT)', 'pneumatic compression pump', 'lymphovenous anastomosis (LVA)', 'lymphedema surgery', 'liposuction for lymphedema', 'lymphedema prevention' and 'post-cancer lymphedema'. GT data was collected using filters set to 'web search', 'all categories', and 'worldwide' to provide a comprehensive overview. The analysis was conducted for two five-year intervals: 1 September 2014 to 31 August 2019 and 1 September 2019 to 31 August 2024. Relative search volume (RSV) was calculated for each term and compared to quantify changes over time.ResultsSignificant increases in search activity were observed for 'lymphedema swelling', 'lymphedema treatment', 'lymphedema stages', 'manual lymphatic drainage', 'lymphedema surgery', and 'post-cancer lymphedema' in the second period (<i>p</i> = 0.001 for each). The average GT score increased from 19 in 2014-2019 to 29 in 2019-2024 (<i>p</i> = 0.001), reflecting a significant increase in public awareness and interest.ConclusionThe study shows a significant increase in global public interest in lymphedema and its minimally invasive treatments over the past 5 years, suggesting a growing awareness of the condition. These findings highlight the need for improved patient education and research to meet the increasing demand for lymphedema care.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"409-414"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-01Epub Date: 2025-04-10DOI: 10.1177/02683555251332988
Zhihong Tang, Na Li, Yongming Tian
{"title":"A nomogram for predicting risk factors for lower limb deep venous thrombosis in elderly postoperative patients with severe traumatic brain injury in the intensive care unit.","authors":"Zhihong Tang, Na Li, Yongming Tian","doi":"10.1177/02683555251332988","DOIUrl":"10.1177/02683555251332988","url":null,"abstract":"<p><p>AimTo investigate the incidence and risk factors for lower limb deep venous thrombosis in elderly postoperative patients with severe traumatic brain injury in the intensive care unit.DesignA retrospective study.MethodsFour hundred and one elderly patients (defined as aged ≥60 years) with severe traumatic brain injury who had undergone surgery and were admitted to the intensive care unit were enrolled in this study. We collected data on the incidence of lower extremity deep vein thrombosis and analyzed its influencing factors. Binary logistic regression analysis was employed to assess the associations between these factors and the occurrence of DVT. A nomogram was developed, and calibration curves were utilized to evaluate the model's accuracy. Additionally, a receiver operating characteristic curve was employed to assess the model's clinical discriminatory power.ResultsThe incidence of lower limb deep venous thrombosis in elderly postoperative patients with severe traumatic brain injury in the intensive care unit was 25.69%. The final nomogram included age, intraoperative hypothermia, intraoperative bleeding volume, surgery time, D-dimer level, any organ failure, and body mass index as independent risk factors. The standard curve fit well with the calibrated prediction curve. The area under the receiver operating characteristic curve was 0.976 (95% CI: 0.958-0.994), and the model had good discrimination ability and reliability.ConclusionsThe risk factors for lower limb deep venous thrombosis in elderly postoperative patients with severe traumatic brain injury in the intensive care unit can be preliminarily assessed via the nomogram prediction model. This information may help guide medical staff in making reasonable decisions regarding the management of deep vein thrombosis prophylaxis.Patient or Public ContributionElderly postoperative patients with severe traumatic brain injury in the intensive care unit participated in the retrospective investigation of this study.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"446-455"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-01Epub Date: 2024-12-19DOI: 10.1177/02683555241310358
Antonio Marsocci, Sheila Santandrea, Elena Lanfranchi, Danilo Donati, Roberto Tedeschi
{"title":"Beyond water: 3D laser scanning offers a cutting-edge alternative for upper limb volume assessment.","authors":"Antonio Marsocci, Sheila Santandrea, Elena Lanfranchi, Danilo Donati, Roberto Tedeschi","doi":"10.1177/02683555241310358","DOIUrl":"10.1177/02683555241310358","url":null,"abstract":"<p><p>ObjectivesThe primary aim of this study was to evaluate the reliability and efficiency of a 3D laser scanner as a tool for volumetric measurement of the upper limbs, comparing it with the gold standard method of non-reflux water displacement. The study sought to determine whether the 3D scanner could serve as a reliable and time-efficient alternative in clinical settings, particularly for managing conditions like lymphedema.MethodsA total of 30 healthy participants (18 women, 12 men) were recruited, and volumetric measurements were taken using both the 3D scanner and water displacement methods. Inter-rater and intra-rater reliability were calculated using the Intraclass Correlation Coefficient (ICC), and agreement between the methods was assessed using a Bland-Altman plot. The time required for each measurement and data processing were recorded and compared between the two methods.ResultsThe 3D scanner demonstrated excellent inter-rater (ICC = 0.995) and intra-rater (ICC = 0.991) reliability, surpassing the water displacement method (ICC = 0.973 and 0.968, respectively). The Bland-Altman plot showed good agreement between the two methods, with only two measurements outside the 95% confidence limits. However, the 3D scanner required significantly more time for both measurement and data processing (28.55 seconds and 120 seconds, respectively) compared to water displacement (9.64 seconds).ConclusionsThe 3D scanner offers high reliability and precision for upper limb volumetric measurements, potentially improving clinical management of conditions such as lymphedema. Despite longer acquisition times, its accuracy and versatility make it a promising tool for future clinical use, especially in scenarios where precise monitoring is crucial.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"400-408"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective chart review of venous thromboembolism incidence and management in rural patients undergoing varicose vein treatment.","authors":"Shivani Thakur, Kamalpreet Kaur, Sandhini Agarwal, Fatima Zabiba, Hussein Maatouk, Ahmed Zabiba, Jasmin Dominguez Cervantes, Tiffany Huang, Ahmadzaki Arjmand, Ahmadzakaria Arjmand, Keshav Kumar","doi":"10.1177/02683555241313272","DOIUrl":"10.1177/02683555241313272","url":null,"abstract":"<p><p>PurposeDetermine the rate of incidence, risk factors, and management for developing venous thromboembolism (VTE) in patients undergoing radiofrequency ablation (RFA) and ultrasound-guided foam sclerotherapy (UGFS) for varicose veins.MethodsAll charts of patients undergoing venous ablation from 2016 to 2023 were reviewed at a rural vein treatment clinic. The incidence of VTE was noted and a chart review was completed to identify risk factors for VTE, EHIT score, EFIT score, and management.ResultsPatients underwent 14,172 UGFS procedures and 4865 RFAs. VTE was noted in 45 patients (0.24%), with no pulmonary embolisms and no fatal outcomes among the patient population. Patients diagnosed with VTE had a median CEAP score of 3 and a modified Caprini risk score of 7.2. Increased risk of VTE was noted in patients with prior history of DVT, patients undergoing UGFS, patients with higher Caprini scores. 90% of patients diagnosed with VTE had a prior history of DVT (<i>p</i> < 0.05). Patients who received UGFS treatments had a higher modified Caprini Risk Score than patients who received an RFA and UGFS, 8.7 and 6.8 respectively (<i>p</i> < 0.05). Increased risk of VTE was noted in patients with swollen legs prior to treatment (0.92%), visible varicose veins (0.92%), obesity (0.49%), and surgery within the prior 3 months to vein treatment (0.41%).ConclusionThe modified Caprini score is a useful tool for risk stratification for VTE and its incidence is low for patients undergoing RFA and UGFS. Prior history of VTE represents a significant risk for recurrence in patients undergoing RFA and UGFS.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"431-440"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142923670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correlation between popliteal vein functional diameter and the severity of chronic venous disease.","authors":"Hao Liu, Liheng Li, Wenjiang Wei, Yinghong Tang, Lina Liu, Chengjiang Xiao","doi":"10.1177/02683555241310531","DOIUrl":"10.1177/02683555241310531","url":null,"abstract":"<p><p>ObjectiveThis study measured the diameter change of the popliteal vein under a rated pressure gradient and evaluated the relationship between popliteal vein functional diameter and severity of chronic venous disease.MethodsUltrasound examination was performed on 173 lower limbs of 173 patients admitted from June 2023 to January 2024. The diameter of the popliteal vein was measured before and after compression with the thigh inflatable cuff. The correlation between popliteal vein functional diameter and venous clinical severity score ( VCSS ) was statistically analyzed.ResultsVenous clinical severity score values ranged from 1 to 28 (median 7). The Spearman correlation analysis between venous clinical severity score and functional diameter had an rs value of -0.222, <i>p</i> (double-tailed) < .001. The correlation between VCSS and popliteal vein diameter variation index yielded rs = -0.633, <i>p</i> (double-tailed) < .001. ConclusionThis study found that popliteal vein functional diameter negatively correlated with the severity of chronic venous disease. Popliteal vein functional diameter and diameter variation index can be used as disease-specific indicators to quantify the severity of chronic venous disease. <b>(Clinicaltrials.gov Identifier: NCT06175481)</b>.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"415-419"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142873809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-01Epub Date: 2025-01-04DOI: 10.1177/02683555241312780
Apostolos G Pitoulias, Nefeli Andrioti Petropoulou, Vangelis Bontinis, Dimitrios A Chatzelas, Alkis Bontinis, Adriana Thano, Georgios A Pitoulias
{"title":"Ultrasonography in the diagnosis of pelvic vein insufficiency, a systematic review and meta-analysis.","authors":"Apostolos G Pitoulias, Nefeli Andrioti Petropoulou, Vangelis Bontinis, Dimitrios A Chatzelas, Alkis Bontinis, Adriana Thano, Georgios A Pitoulias","doi":"10.1177/02683555241312780","DOIUrl":"10.1177/02683555241312780","url":null,"abstract":"<p><p>ObjectiveTo perform a systematic review and meta-analysis to investigate the efficacy of ultrasonography in the diagnosis of pelvic vein insufficiency (PVI).ResultsSeven studies comprised of 802 patients were included. Of these studies, 5 utilised transvaginal ultrasound (TVU), 1 utilised transabdominal ultrasound (TAU) and 1 utilised both ultrasounds as diagnostic tool .The overall pooled sensitivity and specificity was 0.96 and 0.84 respectively. The sensitivity and specificity for TVU were 0.96 and 0.86. The pooled sensitivities between studies employing a <7 mm cutoff in pelvic veins' diameter (PVD) and those employing a >7 mm threshold were 0.99 and 0.94 while the pooled specificities were 0.75 and 0.96 respectively.ConclusionThe evidence supports the efficacy of ultrasonography in the diagnosis of PVI. A threshold of up to 6 mm in PVD yielded excellent sensitivity outcomes, but it is at the expense of specificity. This meta analysis suggests that a PVD threshold of 7 mm should be employed as a cutoff point in the diagnosis of PVI, displaying both excellent sensitivity and specificity outcomes.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"386-394"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
PhlebologyPub Date : 2025-07-01Epub Date: 2024-12-23DOI: 10.1177/02683555241311445
Sergey G Gavrilov, Yekaterina P Moskalenko, Valery M Kulikov, Sergey V Chubchenko, Anatoly V Karalkin
{"title":"Protocol for duplex ultrasound study of the pelvic veins in women.","authors":"Sergey G Gavrilov, Yekaterina P Moskalenko, Valery M Kulikov, Sergey V Chubchenko, Anatoly V Karalkin","doi":"10.1177/02683555241311445","DOIUrl":"10.1177/02683555241311445","url":null,"abstract":"<p><p>The article presents the technique of duplex ultrasound study (DUS) of the pelvic veins in patients with pelvic venous disorders (PeVDs). It provides basics of anatomy of pelvic veins and describes hemodynamic and anatomical parameters that should be assessed during DUS of pelvic veins.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"420-430"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}