Phlebology最新文献

{"title":"Eight year results of patients with varicose vein underwent endovenous occlusion using n-butyl cyanoacrylate.","authors":"Alptekin Yasim, Erdinc Eroglu, Mehmet Acipayam, Murat Ari","doi":"10.1177/02683555241308699","DOIUrl":"10.1177/02683555241308699","url":null,"abstract":"<p><p>ObjectiveTo present the 8-year results of 180 patients on whom we performed endovenous occlusion using N-butyl cyanoacrylate in 2014.MethodsWe have previously published the 30-month results for 168 patients available for follow-up. Thirteen more patients were lost to follow-up in the 8-year research period. The remaining 155 patients underwent clinical examinations and their Venous Clinical Severity Score (VCSS) values were recorded. Doppler ultrasonography was performed, and whether the saphenous vein was occluded, or whether partial or complete recanalization were present was evaluated.ResultsThe mean age of the 155 patients we were able to follow-up was 47.4 ± 11.8 years. Sixty-eight of the patients were men, and 87 were women. Mean VCSS scores were 10.2 before the procedure, 2.7 at 30 months, and 2.6 ± 0.7 at 8 years. Complete recanalization was observed in seven patients over the 8 years, and partial recanalization in six. Occlusion rates were 94.1% at 30 months and 91.7% at 8 years.ConclusionThe long-term results of the use of N-butyl cyanoacrylate in the treatment of patients with varices are highly satisfying in terms of a high ablation rate.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"395-399"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pelvic venous disorders (PeVD) are not well represented in obstetrics and gynaecology journals.","authors":"Mark S Whiteley, Hannah A Imran","doi":"10.1177/02683555251314285","DOIUrl":"10.1177/02683555251314285","url":null,"abstract":"<p><p>BackgroundPelvic venous disorders (PeVD), previously \"Pelvic congestion syndrome (PCS)\" is usually defined as a female health problem. However, it is our impression that gynaecologists rarely recognise this condition, and most of the research interest appears to be by vascular and venous surgeons, and radiologists. The aim of this study was to investigate if there was evidence to support this view.MethodsAn online search of the PubMed^® database was performed using the search terms \"pelvic congestion\", \"PCS\", \"pelvic venous disorders\" and \"PeVD\", filtered for relevance to \"pelvic veins\". Articles were collected from 2013 to 2024 and analysed for which type of journal they appeared in (obstetrics and/or gynaecology, radiology, vascular, venous, angiology, other) and what sort of article each was (original article, review, case report).ResultsWe found 281 articles published for PCS and 38 articles for PeVD, a total of 319 overall. There was a general increase in articles over the time course. However, 33.2% appeared in vascular and venous journals, 20.4% in radiology journals and only 11.3% in obstetric and/or gynaecology journals. There was no indication that the percentage of articles on PCS/PeVD was increasing in the female health journals over the time studied.ConclusionPeVD/PCS is under represented in obstetrics and/or gynaecology journals. Most articles appear in vascular and venous journals. This gives rise to concern that women suffering from pelvic pain due to PeVD/PCS tend to consult gynaecologists, rather than vascular and venous specialists who are more actively involved in researching the condition.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"441-445"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142961071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis assessing the impact of pentoxifylline on the healing and recurrence of venous leg ulcers.","authors":"Marwah Salih, Hussein Elghazaly, Sarah Salih, Sarah Onida, Alun H Davies","doi":"10.1177/02683555241309797","DOIUrl":"10.1177/02683555241309797","url":null,"abstract":"<p><p>IntroductionVenous leg ulcers (VLU) are the most severe manifestation of venous insufficiency and carry a poor prognosis because of delayed healing and recurrent ulceration. Pentoxifylline (PTX) is an example of a vasoactive medication that can be used alongside compression therapy to help improve ulcer healing rates. A previous review highlighted improved healing of VLU with PTX, although no analysis was made for complete ulcer healing and recurrence following treatment.MethodsA systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The EMBASE, MEDLINE and Cochrane databases were searched for all relevant English-language human studies between January 1980 and August 2023. Two independent authors screened and reviewed all articles for inclusion, performed data extraction and assessed methodological quality according to Cochrane's risk of bias tool. Primary outcomes included complete ulcer healing and recurrence rates in the ipsilateral limb.ResultsTen studies were eligible for analysis, of which nine were randomised trials and one was an observational cohort study. There were a total of 1,025 participants, with 515 having received PTX. In those receiving 1200 mg PTX, venous leg ulcers healed in 62% (315 participants). Compared to controls, PTX administration was associated with a significantly higher likelihood of complete ulcer healing (OR 2.56, 95% CI 1.97-3.32, <i>p</i> < .001). The rate and time of ulcer recurrence were not recorded in any of the studies included.ConclusionThe evidence demonstrates that PTX may have a significant beneficial impact on the rate of complete ulcer healing. Little evidence is currently present in the literature evaluating the recurrence rates of ulcers following PTX treatment. Large scale, high quality RCTs with an adequate follow-up period are needed to evaluate this and assess whether treatment with PTX shows a significant benefit in prevention of recurrence in venous ulcers.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"379-385"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188020/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the origin of postsclerotherapy hyperpigmentation: Identification of melanin and hemosiderin as causative pigments in a histopathological study.","authors":"Simon Bossart, Albert-Adrien Ramelet, S Morteza Seyed Jafari, Nikhil Yawalkar, Laurence Feldmeyer, Kristine Heidemeyer","doi":"10.1177/02683555251357095","DOIUrl":"https://doi.org/10.1177/02683555251357095","url":null,"abstract":"<p><p>IntroductionPostsclerotherapy hyperpigmentation (PSH) is a common side effect of sclerotherapy that can persist in a small proportion of patients. Up to now, hemosiderin has been the only histologically proven causative pigment, making laser treatment the primary therapeutic option.ObjectivesThe aim of the study was to identify the origin of pigment in post-sclerotherapy hyperpigmentation based on histopathological findings.MethodsWe analyzed 20 skin biopsies from 19 patients including identification of the type of pigment and pigment location. 10 biopsies were taken from patients with PSH >3 months and 10 from those with PSH <3 months. The analyses included hematoxylin-eosin, Prussian blue, Masson-Fontana and CD68 staining.ResultsHemosiderin was detected in all biopsies, predominantly in the reticular dermis and in the subcutis, with a particular prevalence in newer PSH cases. Epidermal melanin was enhanced in three patients, whereas dermal melanin was increased in seven patients, three of whom also exhibited a decrease in epidermal pigment.ConclusionHemosiderin and postinflammatory hyperpigmentation with increased dermal or epidermal melanin contribute to the development of PSH in some patients.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251357095"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected phlebological abstracts.","authors":"Lowell S Kabnick, Kathleen Ozsvath, Jorge H Ulloa","doi":"10.1177/02683555251356799","DOIUrl":"https://doi.org/10.1177/02683555251356799","url":null,"abstract":"","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251356799"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with lymphedema volume in patients with unilateral lower extremity lymphedema.","authors":"Gülbin Ergin, Ertan Şahinoğlu, Didem Karadibak","doi":"10.1177/02683555251357141","DOIUrl":"https://doi.org/10.1177/02683555251357141","url":null,"abstract":"<p><p>ObjectiveWe aimed to investigate demographic and clinical characteristics associated with lymphedema volume in this patient population.MethodsThis was a single centre, cross-sectional study. Eighty-six patients with unilateral lower extremity lymphedema were included. The dependent variable was lymphedema volume. The independent variables were age, body mass index, gender, employment status, smoking status, duration of lymphedema, history of infection, type of lymphedema, and the interactions between history of infection and smoking status and between history of infection and type of lymphedema.ResultsThe interactions between history of infection and smoking status (<i>B</i> = 25.04, 95% CI [8.87, 41.22], <i>p</i> < .01) and between history of infection and type of lymphedema (<i>B</i> = 13.11, 95% CI [0.62, 25.60], <i>p</i> = .04) were associated with lymphedema volume. Being employed was associated with lower lymphedema volume (<i>B</i> = -10.53, 95% CI [-18.36, -2.70], <i>p</i> < .01). Age, body mass index, gender, and duration of lymphedema were not associated with lymphedema volume (<i>p</i> > .05).ConclusionsIn patients with unilateral lower extremity lymphedema, smokers or patients with primary lymphedema tend to have higher lymphedema volume when they experience an infection. Employed patients exhibit lower lymphedema volume compared to non-employed patients. Age, body mass index, gender, and duration of lymphedema are not associated with lymphedema volume.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251357141"},"PeriodicalIF":0.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144532370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From innovation to standard: Proprietary foam Sclerotherapy's rise as a pillar in venous disease treatment.","authors":"Edward M Boyle, James D Albert, James D Fonger","doi":"10.1177/02683555251353009","DOIUrl":"10.1177/02683555251353009","url":null,"abstract":"","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251353009"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144337408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1% polidocanol endovenous microfoam (Varithena^TM) for the treatment of chronic venous disease: A position statement from the American vein and lymphatic society.","authors":"Mark H Meissner, Michael Di Iorio, Alun Davies","doi":"10.1177/02683555251353150","DOIUrl":"https://doi.org/10.1177/02683555251353150","url":null,"abstract":"<p><p>BackgroundA variety of minimally invasive thermal and non-thermal techniques to treat superficial truncal vein reflux have been introduced over the past 2 decades. Among these has been polidocanol endovenous microfoam (PEM, VarithenaTM). This position statement reviews the clinical results of the use of PEM in chronic venous disease as well as those situations where PEM may have distinct advantages over other endovenous modalities.MethodAn expert panel of the American Vein and Lymphatic Society reviewed the literature, focusing on the clinical outcomes and unique advantages associated with the use of PEM.ResultIn vitro, ex vivo, and clinical studies have shown PEM to have greater stability and efficacy than physician compounded foam, while other studies have demonstrated saphenous closure rates and clinical outcomes similar to those achieved with thermal ablation. Despite the benefits across the spectrum of chronic venous disease, PEM may have advantages in minimizing the risk of nerve injury associated with treatment of the below knee reflux, treating venous ulcers, and managing recurrent varicose veins and difficult saphenous anatomy due to tortuosity or intraluminal synechia.ConclusionAs the only FDA approved foam sclerosant, PEM provides flexibility in treating patients with standard, variant, and recurrent venous anatomy. The American Vein and Lymphatic Society supports PEM as a safe and effective treatment option for the treatment of C2-C6 disease associated with superficial venous reflux.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251353150"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of transvaginal duplex ultrasound compared to catheter venography for the identification of pelvic vein incompetence.","authors":"Daxina Bhatt, Shaneel Patel, David Riding, Katja Norse, Stephen Butterfield, Dare Seriki, Ganapathy Anantha-Krishnan, Jonathan Ghosh","doi":"10.1177/02683555251353550","DOIUrl":"https://doi.org/10.1177/02683555251353550","url":null,"abstract":"<p><p>ObjectiveChronic pelvic pain (CPP) is a debilitating condition affecting a quarter of premenopausal women and has been associated with pelvic vein incompetence (PVI). Catheter venography (CV) is the standard investigation, although transvaginal duplex (TVDU) ultrasound has emerged as a promising alternative. The accuracy of TVDU compared to CV is undefined and the optimal reflux time measured by TVDU to diagnose PVI is unknown. This study aimed to establish the diagnostic accuracy of TVDU in those with suspected PVI.MethodsThis cohort study included women enrolled into a randomised controlled trial comparing pelvic vein embolisation to no treatment, who underwent both TVDU and CV. Three consultant vascular interventional radiologists, blinded to TVDU results, independently reviewed catheter venograms. Reflux in bilateral ovarian and internal iliac veins was reported as a binary outcome. Pelvic reflux times, in both supine and semi-standing positions, were retrieved from TVDU reports. Diagnostic accuracy of TVDU was assessed using CV as the comparator. Sensitivity, specificity and area under the ROC curve (AUC) were calculated.Results124 pelvic veins were analysed in 31 women. For a diagnostic reflux time threshold of 500 ms, TVDU had a sensitivity of 64% and specificity of 78% (AUI 0.71,95%CI 0.66-0.76). For a threshold of 700 ms, TVDU had a sensitivity of 74% and a specificity of 78% (AUI 0.76,95%CI 0.71-0.80). For a threshold of 700 ms, TVDU performed semi-standing had a sensitivity of 78% and specificity of 78% (AUC of 0.78,95%CI 0.72-0.84) as compared to TVDU performed supine which had a sensitivity of 70% and specificity of 78% (AUC 0.74,95%CI 0.67-0.80).ConclusionsTVDU demonstrates good diagnostic accuracy for PVI using a 700 ms reflux time threshold. Performing the test in a semi-standing position optimises accuracy. TVDU has potential as a diagnostic tool and may eliminate unnecessary invasive investigations, thus preserving catheter venography for intention to treat.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251353550"},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144334762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary thigh telangiectasias after endovenous laser ablation of the great saphenous vein.","authors":"D Borsuk, V Kozlova, A Fokin, R Tauraginskii, M Galchenko, K Lobastov","doi":"10.1177/02683555251351368","DOIUrl":"https://doi.org/10.1177/02683555251351368","url":null,"abstract":"<p><p>ObjectivesTo assess the incidence of secondary telangiectasias (TAEs) after endovenous laser ablation (EVLA) of the great saphenous vein (GSV) and discuss the possible risk factors for its development.MethodThis prospective observational study enrolled 123 lower limbs of 103 patients with varicose veins of C2 or C4 clinical classes who underwent EVLA of the GSV trunk from the saphenofemoral junction to the below knee level without simultaneous removal of varicose tributaries and/or perforating veins. The primary outcome was the occurrence and amount of secondary TAEs (matting) that developed at the medial aspect of the thigh along the treated GSV within a 3-month follow-up. The assessment was made by analysis of before and after photos by three experienced surgeons using a four-point scale. Fleiss' Kappa was used to measure the agreement between the assessors.ResultsSecondary TAE development was reported in 26 limbs (21.1%; 95% CI, 15.0-29.0%). Almost perfect agreement was observed between assessors for any matting (κ = 0.92; <i>p</i> < .0001) and different amounts of it (κ = 0.93, κ = 0.90, κ = 0.85, and κ = 1.00 for the score of 0, 1, 2, and 3, respectively). The most prevalent was a low amount of new TAEs (score of 1 in 17.9%). The only significant difference between the patients with and without secondary TAEs was age: 52.5 (IQR, 43-61) versus 40 (IQR, 34-53) years old.ConclusionsIn most cases (96,8%), secondary TAEs are either absent or could be found in a low amount. Older patients are more predisposed to its development.</p>","PeriodicalId":94350,"journal":{"name":"Phlebology","volume":" ","pages":"2683555251351368"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}