{"title":"Diagnosis of Kikuchi-Fujimoto Disease Based on Ultrasound and Clinical Findings.","authors":"X Q Tan, L X Qian, J F Zhao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kikuchi-Fujimoto disease (KFD) shares similar clinical manifestations and ultrasonic features with non-specific reactive lymphadenopathy (NSRL). This study aims to elucidate the independent predictors distinguishing these two diseases. A total of 136 lymph nodes (136 patients) with pathologically proven KFD from January 2015 to December 2019 were included. The control group comprised 117 NSRL lymph nodes (117 patients). Clinical information and imaging features were collected and analyzed. The main complaints of KFD were fever (84.6%). The patients with KFD and immune system diseases were older and had longer duration of symptoms. No significant differences (p< 0.05) were observed in sex, white blood cell count, short and long axis, shape, and margin. A binary logistic regression analysis revealed that the independent diagnostic factors were patient age (odds ratio [OR]=3.120, p=0.008), fever or pain (OR=0.100, p=0.038), failure of empirical antibiotic or antiviral therapy (OR= 305.88, p<0.001), vascular pattern (OR=0.049, p=0.042), CRP (OR=2.679, p=0.035), laterality (OR=0.352, p=0.020), and loose conglomeration (OR=3.605, p=0.019). The combined diagnosis effectiveness was 88.9%. Fever/pain, age range of 20-32 years, increased CRP, ineffective empirical treatment, loose conglomeration, unilateral, and non-abnormal vascular pattern were independent predictors.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 2","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Format Correction: The Re-Discovery of Dural (Meningeal) Lymphatics: Amnesia or Ambition?","authors":"R P Erickson","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>There were multiple formatting issues identified with the article: \"The Re-Discovery of Dural (Meningeal) Lymphatics: Amnesia or Ambition?\" By R.P. Erickson (Lymphology 56 (2023) 125-130; https://doi.org/10.2458/lymph.6179). These have been corrected and the article has been updated. The journal regrets the original errors in formatting.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary Lymphatics History, Anatomy, and Pathophysiology: Emerging Knowledge and a Look to the Future.","authors":"B Kelly, S Daley","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Central lymphatic disorders of the lung have not received intense investigation. Lymphatic system physiology is presented in the context of historical developments and basic lung lymphatic anatomy is reviewed followed by emerging characteristics of primary and secondary pathophysiological disturbances of lymphatic involvement in a number of pulmonary diseases including Gorham-Stout disease, pulmonary edema and infections and inflammatory conditions including lymphangioleiomyomatosis (LAM). The future includes potential molecular targeting of lymphangiogenesis or lymphatic vessels for interventional occlusion. This article is an amalgamation of presentations at the 2023 ISL International Congress of Lymphology, Genoa, Italy in a special symposium on central and regional lymphatic system in health and disease and as part of a Special Symposium on the Lymphatic system of the Heart and Lung in Health and Disease at the 26th International Congress of Lymphology meeting held in Barcelona, Spain, September 2017, which has been updated to 2024.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 1","pages":"19-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Liver Lymphatic Anatomy and Its Role in Systemic Health and Disease.","authors":"C Smith","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphatic anatomy of the abdomen is reviewed with focus on hepatic and mesenteric vessels in normal and pathologic conditions. Anatomy and pathophysiology is highlight using both specialized fluoroscopy and T2 Dynamic Contrast MR lymphangiography (DCMRL). Plastic bronchitis, chylothorax, protein losing enteropathy, and both cirrhosis and ascites due to hepatic lymphatics are highlighted. Presented at the 2023 ISL International Congress of Lymphology, Genoa, Italy in a special symposium on central and regional lymphatic system in health and disease.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 1","pages":"12-15"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging and Interventional Management of Lymphatic Disorders.","authors":"E Pinto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphatic flow disorders are reviewed, and a classification based on magnetic resonance lymphography findings outlined. Examples of successful interventional management based on this classification are provided. Presented at the 2023 ISL International Congress of Lymphology, Genoa, Italy in a special symposium on central and regional lymphatic system in health and disease.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 1","pages":"8-11"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lymphatic Imaging and Intervention in Central Lymphatic Disorders.","authors":"Y Dori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Advances in lymphatic imaging for both diagnosis and intervention are reviewed, and specific examples given for protein-losing enteropathy, multi compartment lymphatic failure, congestive heart failure. Presented at the 2023 ISL International Congress of Lymphology, Genoa, Italy in a special symposium on central and regional lymphatic system in health and disease.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 1","pages":"4-7"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J E Trihan, S Mestre, I Quere, D Laneelle, A Perez-Martin
{"title":"Toe-Brachial Index Rise in Lymphedema Patients with Multilayer Bandage.","authors":"J E Trihan, S Mestre, I Quere, D Laneelle, A Perez-Martin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Multilayer compression bandaging (MLB) remains the primary treatment in lymphedema in association with manual lymphatic drainage. However, MLB can be contraindicated in patients with advanced lower extremity artery disease (LEAD). Presently, the prevalence of LEAD in lymphedema patients remains unknown. The goals of this study included i) to estimate the prevalence of LEAD, defined by toe-brachial index (TBI) less than 0.7, and ii) to measure the evolution of TBI after 30 min of MLB. A cross-sectional study was performed during a 3-month period on patients presenting with lower extremity lymphedema. Demographic data, basal TBI (T=0min) and TBI after 30 min of MLB at rest (T=30min) were recorded. Twenty-four patients with a total of 29 lymphedema limbs were included with a mean age of 62 years-old [Inter-quartile range (IQR) = 48 - 68] and 65.5% presenting with primary lymph-edema. Non-symptomatic LEAD, defined as TBI < 0.7, was found in 8 lymphedema limbs (27.6%). Advanced age, severe stages, and longer duration of lymphedema were associated with LEAD in univariate analysis. Median TBI increased significantly between T=0min and T=30min of MLB: 0.81 [IQR: 0.68 - 0.93] and 0.96 [IQR: 0.82 - 1.12] respectively (p= 0.004). Distal localization of lymphedema was associated with a decrease in TBI at T=30min in univariate analysis. Subclinical LEAD was found in over a quarter of lymphedema limbs and was more frequent in patients with advanced age, severe stages, and longer duration of lymphedema. Based on these findings, sub-clinical peripheral artery disease may be widely underestimated in lymphatic pathologies.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 2","pages":"76-83"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P Brouillard, M H Witte, R P Erickson, L Luy, M Vikkula
{"title":"Updated Human Chromosome Map of Lymphedema-lymphangiogenesis Genes: Template for Current and Future Discovery.","authors":"P Brouillard, M H Witte, R P Erickson, L Luy, M Vikkula","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>We have updated the human chromosomal map of the location of known and candidate genes involved in primary lymphedema (PL) originally published in 2021. This should facilitate further discovery and provide a basis for understanding microdeletions which cause lymphedema.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 4","pages":"186-190"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S Eyigor, Z Deveci Kocbilek, M Ozgur Inbat, S Caliskan Kabayel, B D Akgu
{"title":"Investigation of the Effect of Lymphedema Self-Care Patient School on Functionality, Quality of Life, Lymphedema Volume, and Body Value in Patients with Lower Extremity Lymphedema: A Quasi-Experimental Study.","authors":"S Eyigor, Z Deveci Kocbilek, M Ozgur Inbat, S Caliskan Kabayel, B D Akgu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study examined the effect of lymphedema self-care patient school education on patient functionality, quality of life, body value, and lymphedema volume in patients with lower extremity lymphedema. The study utilized a single-group quasi-experimental design. The study sample included 21 patients with primary and secondary lower extremity lymphedema. A multidisciplinary team created a face-to-face lymphedema self-care patient education program that lasted three weeks with four hours each week to enhance lymphedema self-care management. Data collected from participants prior to the program and then at third and sixth months via Lower Extremity Functional Scale (LEFS), Lymphedema Functionality, Disability and Quality of Life Scale in Lower Extremity Lymphedema (LYMPH-ICF-LL), Body Value Scale, and extremity volumes. The average age of the patients was 54.85±11.99 years and two-thirds had secondary lymphedema. A statistically significant difference was found in the mean scores of LEFS (p<0.001), LYMPH-ICF-LL total (p= 0.006) in the 3rd and 6th months after the completion of the program, and in the lymphedema volume change (p= 0.031) in the 6th month. It was found that the lymphedema self-care patient school improved functionality and quality of life in patients with lower extremity lymphedema and decreased lymphedema volume. This lymphedema self-care patient education pro-gram is a safe and effective educational method for self-care management in individuals with lower extremity lymphedema.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 3","pages":"157-168"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Saferite, B J Blair, A M Price, K A Fox, M D Seckeler
{"title":"Retrograde Thoracic Duct Access for Embolization of Lymphatic Malformations in a Child with Congenital Heart Disease and a Plexiform Thoracic Duct Variant.","authors":"A Saferite, B J Blair, A M Price, K A Fox, M D Seckeler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The physiologic sequelae of the atypical vasculature in patients with congenital heart disease can result in potentially fatal lymphatic complications, especially after corrective cardiac surgery. Transcatheter embolization of the thoracic duct or lymphatic collaterals can reduce morbidity and mortality in these patients. While typically performed transabdominally via an antegrade approach, retrograde embolization may be preferable in cases where this is not feasible, including in rare variants of thoracic duct anatomy. We present a case of a child with severe chylothorax after congenital cardiac surgery who was found to have thoracic lymphatic malformations and a plexiform thoracic duct variant who underwent successful embolization of the malformations.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"57 2","pages":"71-75"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}