Lymphology最新文献

{"title":"Botulism, Botulinus Toxin, Byheart Baby Formula: Life-Saving Thoracic Duct Lymph Drainage?","authors":"M H Witte, K E Carr, N Barnett, M D Seckeler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Editorial- Botulism, Botulinus Toxin, Byheart Baby Formula: Life-Saving Thoracic Duct Lymph Drainage?</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 4","pages":"157-158"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and Quantitative Analysis of Myocardial Lymphatic Architecture in Patients with Different Types of End-Stage Heart Failure.","authors":"Y Wang, J Dou, X Zhang, Z Fu, Z Guo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study explored differences in morphology and distribution of myocardial lymphatic drainage ducts in patients with dilated cardiomyopathy (DCM), ischemic cardiomyopathy (ICM), and hypertrophic cardiomyopathy (HCM) in end-stage heart failure to reveal the relationship between the morphological distribution characteristics of myocardial lymphatic drainage ducts and different etiologies and these disease courses. Hearts of 24 patients (transplant recipients) who underwent heart transplantation and 1 normal heart were collected. Myocardial tissue from the anterior wall of the ventricle was taken and quickly frozen. Immunohistochemical and Western blotting techniques were used to detect the expression of LYVE-1, Podoplanin, and VEGFR-3 in cardiac tissue. Ink injection, immunohistochemical staining, and immunofluorescence double labeling techniques were used to detect the co-localization of three antibodies in hu-man heart tissue. Masson staining was used to observe the distribution and content of collagen fibers in the heart tissue of transplant recipients. Compared with the normal group, expression levels of LYVE-1 (p<0.05) and VEGFR-3 (p<0.001) in the DCM group were significantly increased. Expression level of LYVE-1 (p<0.05) was significantly increased in the ICM and HCM groups, but there was no significant change in the expression level of VEGFR-3. The expression level of Podoplanin in the normal group was higher than that in the heart failure groups, but the protein ex-pression results were the opposite. The expression levels of LYVE-1 and VEGFR-3 in the DCM and ICM groups showed an increasing trend with the progression of the disease, while the expression levels of Podoplanin showed a decreasing trend. The immunofluorescence results showed that on larger lymphatic vessels, LYVE-1 and VEGFR-3 were expressed on the inner side of the lymphatic lumen, while Podoplanin was expressed on the outer side, and there was co-localization between the two layers. Masson's staining results showed that the degree of myocardial fibrosis in the DCM group (p<0.01) and HCM group (p<0.001) increased, while there was no significant change in the ICM group (p<0.05). Positive expression intensity of LYVE-1, Podoplanin, and VEGFR-3 does not have a consistent quantitative relationship with different types of heart failure and the duration of the disease. The expression of three biomarkers confirms that DCM, ICM, and HCM have increased lymphatic vessel architecture compared to normal hearts, and the number of lymphatic vessels increases with prolongation of disease course.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 3","pages":"96-107"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual Lymph Drainage for Alzheimer's Dementia: A Clinical Trial Whose Time Has Come?","authors":"R P Erickson, M J Bernas, M H Witte","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mounting evidence implicates brain lymphatic drainage in the pathogenesis of Alzheimer's disease and other dementias. Several recent basic and clinical science discoveries have suggested the impact of lymphatic therapy to stimulate lymph flow in the head and neck including improvement in cognition. Manual lymphatic drainage has potential as a simple inexpensive way to promote brain lymph drainage and is worthy of a well-designed clinical trial to evaluate its potential as a primary or adjunctive treatment of Alzheimer's disease at this time.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 2","pages":"43-45"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Vitamin D Levels on Breast Cancer-Related Lymphedema.","authors":"G D Karakilic, M A Selcuk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The purpose of this study was to compare plasma vitamin D levels in patients with breast cancer-related lymphedema (BCRL), breast cancer (BC) without lymphedema, and healthy populations, as well as relationship between clinical variables, lymphedema severity grading, and circulating vitamin D concentrations. This Case-control study was conducted between June 2017 and January 2025. The study comprised three cohorts: a case cohort of individuals diagnosed with breast cancer-related lymphedema (BCRL), a disease-matched control cohort of breast cancer (BC) patients without lymphedema (demographically aligned with the BCRL cohort by age and sex), and a reference cohort of healthy participants matched by age and sex. A total of 603 female individuals were included in the study with 201 individuals in each group. Post-hoc Games-Howell test analyses revealed a lower level of Vitamin D in the BCRL group compared to the BC and control groups (p<0.001, p<0.001) and lower levels in the BC group compared to the control group (p<0.001). Vitamin D deficiency was statistically significantly more frequent in BCRL group than in BC and control groups (p:<0.001) and the proportion of those with normal vitamin D were statistically significantly more frequent in control group than in BCRL and BC and control groups (p:<0.001). Analysis revealed a strong, significant negative correlation between circulating vitamin D concentrations and advancing lymphedema stage (r: -0.578, p:<0.001). These observations imply that hypovitaminosis D may contribute to breast cancer pathogenesis and modulate the risk of treatment-associated morbidities, particularly lymphedema progression. Therefore, it is recommended that individuals diagnosed with BC or at risk of lymphedema have their vitamin D levels checked regularly and take supplements if necessary.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 2","pages":"56-65"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Advanced Pneumatic Compression Devices in the Treatment of Lymphedema: A Systematic Review and Meta-Analyses.","authors":"D Panchik, D Klepper, K Knecht, J Pron, M Schuller, V Chinchilli, A Cox, J Hornberger, S Letnaunchyn","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Lymphedema is a chronic, progressive impairment of the lymphatic system that can impact activities and quality of life. Research regarding conservative management of lymphedema primarily consists of complete decongestive therapy (CDT) and compression devices intended to promote lymphatic and venous return. Advanced pneumatic compression devices (APCDs) contain multiple programmable sleeves designed to mimic manual lymph drainage at home. This study aims to determine the effectiveness of APCDs in the treatment of lymphedema through the completion of a systematic review and meta-analysis. A systematic search of five databases was conducted, spanning the years 2010-2021. Only experimental designs of moderate or strong quality were chosen and final review set consists of twelve articles. APCDs are found to be effective for lymphedema treatment based on differences in pre- and post-intervention limb volumes and patient-reported outcomes. Two meta-analyses evaluated the impact of APCDs on both rates of cellulitis and manual therapy. Both analyses demonstrated significant decreases in rates after the APCD interventions. The data showed consistent reduction of limb volume and improved patient-reported outcomes, indicating that APCDs are generally effective as a complementary intervention to CDT in the maintenance phase of lymphedema treatment.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 3","pages":"135-144"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Series on Combining Modified Mediterranean Diet and Ketogenic Diet in a \"Sandwich\" Approach for Patients with Lipedema and Comorbidities.","authors":"B Fedre, S Dessalvi, F Boccardo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Ketogenic Diet (KD) is currently the most widely studied nutritional approach for patients with lipedema, although its use may cause important drawbacks especially in case of comorbidities. A Modified Mediterranean Diet (MMed) is more easily adaptable, better tolerated, and can be temporarily replaced by a ketogenic diet for a short period of time if necessary using a sort of \"sandwich\" approach. We report 10 clinical cases with lipedema and comorbidities subjected to a hypocaloric MMed for 6 months. All patients were properly assessed by anthropometric measurements and body composition before and at the end of nutritional treatment. Only 2 patients needed a short period of KD due to poor response to MMed. At the end of 6-month follow-up, patients showed weight loss with reduction in body circumferences and improvement in body composition. In the two cases where it was necessary to resort to a period of KD, good results were achieved allowing a return to the MMed for the maintenance. In patients suffering from lipedema with associated comorbidities and concomitant pharmacological treatments, the use of MMed as first line treatment allows achievement of better metabolic balance, greater compliance, and improved body composition.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 3","pages":"108-118"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Leo Clodius.","authors":"E Foldi, N B Piller","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In Memoriam: Leo Clodius. April 29, 1930 - September 17, 2025.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 3","pages":"153-155"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressurized Contrast Injection in a Lymphocele Can Reveal an Embolizable Lymphopseudoaneurysm in Postsurgical Chylous Ascites.","authors":"Q Verhalleman, V Hartman, G Roeyen, T Jardinet","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This report describes the technique of lymphopseudoaneurysm (LPA) detection by pressurized contrast injection into a lymphocele, followed by image-guided embolization. A 37-year-old man with pancreatic neuro-endocrine tumor, portal cavernoma, and liver metastasis underwent pancreaticoduodenectomy, right hepatectomy, lymphadenectomy, and left portal vein reconstruction. Postoperative course was complicated by refractory chylous ascites. Computed Tomography (CT) revealed a centrally located lymphocele in the abdominal cavity. Direct puncture of the lymphocele, followed by pressurized contrast injection revealed a tubular connection to a smaller retroperitoneal collection near the surgical site, which was considered to be the culprit LPA. After catheter directed embolization of this LPA with N-butyl-cyanoacrylate glue, chylous ascites ceased and abdominal drainage catheters were removed 12 days later.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 1","pages":"23-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Kikuchi-Fujimoto Disease Based on Ultrasound and Clinical Findings.","authors":"X Q Tan, L X Qian, J F Zhao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Kikuchi-Fujimoto disease (KFD) shares similar clinical manifestations and ultrasonic features with non-specific reactive lymphadenopathy (NSRL). This study aims to elucidate the independent predictors distinguishing these two diseases. A total of 136 lymph nodes (136 patients) with pathologically proven KFD from January 2015 to December 2019 were included. The control group comprised 117 NSRL lymph nodes (117 patients). Clinical information and imaging features were collected and analyzed. The main complaints of KFD were fever (84.6%). The patients with KFD and immune system diseases were older and had longer duration of symptoms. No significant differences (p< 0.05) were observed in sex, white blood cell count, short and long axis, shape, and margin. A binary logistic regression analysis revealed that the independent diagnostic factors were patient age (odds ratio [OR]=3.120, p=0.008), fever or pain (OR=0.100, p=0.038), failure of empirical antibiotic or antiviral therapy (OR= 305.88, p<0.001), vascular pattern (OR=0.049, p=0.042), CRP (OR=2.679, p=0.035), laterality (OR=0.352, p=0.020), and loose conglomeration (OR=3.605, p=0.019). The combined diagnosis effectiveness was 88.9%. Fever/pain, age range of 20-32 years, increased CRP, ineffective empirical treatment, loose conglomeration, unilateral, and non-abnormal vascular pattern were independent predictors.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 2","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144850259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tyrosine-Kinase-Inhibitor-Induced Peno-Scrotal Lymphedema and Functional Issues of the Lymphatic Pathways: A Case Report and Comprehensive Literature Review.","authors":"A Mathivet, M Bertrand, S Bernard de Courvile, M Prudhomme, I Quere, J Frandon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tyrosine kinase inhibitors (TKIs) are widely used in oncology and hematology. While chylous pleural and pericardial effusion have been described, peripheral lymphedema with administration of acalabrutinib has not been documented. Clinical and imaging data were retrospectively collected from the medical record of an 80-year-old patient with a prior history of radical prostatectomy and pelvic lymphadenectomy who was treated with acalabrutinib for chronic lymphocytic leukemia (CLL). A Medline review (from data-base creation to October 2025) and pharmaco-vigilance database searches were conducted to identify TKI-related lymphatic complications. The patient developed progressive peno-scrotal lymphedema after acalabrutinib initiation. Cardiac and venous evaluations were normal. MR-lymphography showed patent central lymphatic pathways and superficial peno-scrotal edema. Dynamic lymphangiography revealed no obstruction or leak, suggesting functional impairment of lymphatic drainage. Literature review identified 28 relevant articles, including 20 cases of chylothorax, mainly under dasatinib, and additional cases of chylous ascites and chylopericardium. To our knowledge, no previous case of TKI-induced lymphedema has been published. Pharmacovigilance databases identified few lymphatic adverse events, including 24 cases of lymphedema in the FAERS database. This first report of TKI-induced lymphedema broadens the spectrum of lymphatic complications associated with these agents and high-lights the potential concept of functional rather than obstructive lymphatic impairment.</p>","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"58 4","pages":"165-174"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147611286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}