Lymphology最新文献_第6页

Modified Lymphoscintigraphy in Primary Lymphatic Insufficiency of the Lower Limb. 原发性下肢淋巴功能不全的改良淋巴管造影术

Lymphology Pub Date : 2023-01-01

M Wald, J Svobodova, H Krizova

{"title":"Modified Lymphoscintigraphy in Primary Lymphatic Insufficiency of the Lower Limb.","authors":"M Wald, J Svobodova, H Krizova","doi":"","DOIUrl":"","url":null,"abstract":"Primary lymphedema of the foot and toes could be sometimes misdiagnosed by lymphoscintigraphy as a whole lower limb lymphatic insufficiency (LLLI). This is caused by using standard lymphoscintigraphic protocol based on one interstitial injection of radiotracer applied into the first interdigital space followed by image analysis of lower limb lymphatic vessels and lymph nodes. Here, we show that a modification of the lymphoscintigraphic protocol and introduction of a second dose of radiotracer right above the inner ankle to the clinically healthy tissue can more accurately describe morphological abnormalities of the superficial lymphatic system at the lower limb and thereby refine the diagnosis of the LLLI. Fourteen patients with swelling of the foot and toes (16 lower limbs) were examined using standard lymphoscintigraphic protocol. Subsequently, modified lymphoscintigraphy was performed. While standard lymphoscintigraphy showed severe lymphatic insufficiency of the superficial lymphatic system in all 14 patients (in 16 lower limbs), including significantly reduced number of inguinal nodes, modified lymphoscintigraphy revealed almost normal morphology of superficial lymphatic vessels in 11 patients (in 13 lower limbs) throughout the entire lower limb proximal to the application site. In conclusion, using the modified lymphoscintigraphy protocol in patients with foot and toes primary lymphedema can refine diagnosis and follow-up medical management.","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"56 2","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of Inguinal Lymph Node Number and Volume with Lower Extremity Lymphedema Severity. 腹股沟淋巴结数量和体积与下肢淋巴水肿严重程度的相关性

Lymphology Pub Date : 2023-01-01

M Adondakis, H Ali, B P Salehi, R Friedman, W Sun, K Donohoe, G Kim, D Singhal, L L Tsai, J Weinstein

{"title":"Correlation of Inguinal Lymph Node Number and Volume with Lower Extremity Lymphedema Severity.","authors":"M Adondakis, H Ali, B P Salehi, R Friedman, W Sun, K Donohoe, G Kim, D Singhal, L L Tsai, J Weinstein","doi":"","DOIUrl":"","url":null,"abstract":"There are very limited studies on the relationship of inguinal lymph node number and volume correlated with lower extremity lymphedema severity. In this IRB-approved retrospective study, patients who obtained an MRI for lower extremity lymphedema and who did not have lymph node resection or biopsy were identified. The MRI images were used to determine the number and volume of inguinal lymph nodes for each limb in addition to fat and fluid-based scoring using a validated grading system. Wilcoxon signed-rank tests were used to compare the greater-affected limbs with the lesser-affected limbs. The spear-man-rank correlation was performed on a 'per limb' basis for MRI-based scoring and clinical parameters with ipsilateral lymph node number and volume and for differences between the limbs. A total of 32 patients were included. The greater-affected limb had higher MRI fluid scores (median (interquartile range) = 3 (3 - 3) vs. 0 (0 - 1), (p < 0.01) relative to the contra-lateral limb and had a median fat asymmetry score of 2 (1 - 3). On the per-limb analysis, lymph node number and volume inversely correlated with total MRI scores (ρ = -0.47, p < 0.01 for node number and volume). The difference of lymph node number and volume correlated with MRI score difference (node number: ρ = -0.66, p < 0.01; node volume: ρ = -0.64, p < 0.01) and perometer difference (node number: ρ = -0.58, p < 0.01; node volume: ρ = -0.59, p < 0.01). Inguinal lymph node number and volume inversely correlate with lower extremity edema presence and severity.","PeriodicalId":94343,"journal":{"name":"Lymphology","volume":"56 4","pages":"160-167"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142116791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oncolymphology: Immune Interactions and Cancer. 肿瘤淋巴:免疫相互作用与癌症。

Lymphology Pub Date : 2023-01-01

S P Leong

引用次数: 0

Lack of embryonic homozygous or adult heterozygous lymphatic phenotypes for a Sos1 mutation and lack of lymphatic embryonic phenotypes for a homozygous Cx47 mutation in mice. 小鼠缺乏Sos1突变的胚胎纯合子或成年杂合子淋巴表型，以及纯合子Cx47突变的淋巴胚胎表型。

Lymphology Pub Date : 2022-01-01

X Geng, L Chen, R S Srinivasan, R J Kylat, M H Witte, R J Erickson

引用次数: 0