Annals of dermatology最新文献_第7页

Understanding of Pathomechanisms and Clinical Practice for Vitiligo. 对白癜风发病机制的认识与临床实践。

Annals of dermatology Pub Date : 2023-10-01 DOI: 10.5021/ad.23.065

Atsushi Tanemura

{"title":"Understanding of Pathomechanisms and Clinical Practice for Vitiligo.","authors":"Atsushi Tanemura","doi":"10.5021/ad.23.065","DOIUrl":"10.5021/ad.23.065","url":null,"abstract":"Vitiligo is a disease caused by the acquired depletion of melanocytes and/or melanocyte precursor cells in response to genetic and environmental factors, resulting in depigmentation of the entire body. It is roughly divided into segmental and non-segmental vitiligo, and it has been found that abnormalities of melanocytes themselves and dysregulation of autoimmune responses to melanocytes are greatly involved in the pathology of non-segmental vitiligo. Segmental vitiligo pathology is largely unknown; however, it has been suggested that it may be caused by skin or melanocyte mosaicism. Treatments for vitiligo include topical therapy, ultraviolet therapy, and surgical transplantation, and it is extremely important to correctly understand the pathology to perform optimal treatment. In recent years, the development of vitiligo treatments using Janus kinase (JAK) inhibitors has progressed rapidly. We herein outline the latest pathology of vitiligo, from general vitiligo treatment to the progress of clinical trials using JAK inhibitors, along with what clinicians should consider in archiving precision medicine, including my own ideas thereon.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 5","pages":"333-341"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/62/ee/ad-35-333.PMC10579571.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Clinical Findings, Response to Steroid Treatment, and Recurrence Rate in Alopecia Areata Patients with or without a Nonsynonymous Variant of Coiled-Coil Alpha-Helical Rod Protein 1. 伴有或不伴有螺旋线圈α-螺旋杆蛋白1非同义变体的斑秃患者的临床发现、对类固醇治疗的反应和复发率。

Annals of dermatology Pub Date : 2023-10-01 DOI: 10.5021/ad.22.227

Satoshi Koyama, Nagisa Yoshihara, Atsushi Takagi, Etsuko Komiyama, Akira Oka, Shigaku Ikeda

{"title":"Clinical Findings, Response to Steroid Treatment, and Recurrence Rate in Alopecia Areata Patients with or without a Nonsynonymous Variant of Coiled-Coil Alpha-Helical Rod Protein 1.","authors":"Satoshi Koyama, Nagisa Yoshihara, Atsushi Takagi, Etsuko Komiyama, Akira Oka, Shigaku Ikeda","doi":"10.5021/ad.22.227","DOIUrl":"10.5021/ad.22.227","url":null,"abstract":"Background: Alopecia areata (AA) is considered complex genetic and tissue-specific autoimmune disease. We recently discovered a nonsynonymous variant in the coiled-coil alpha-helical rod protein 1 (CCHCR1) gene within the AA risk haplotype. And a water avoidance stress test on CCHCR1 knockout mice induced AA-like lesions.Objective: To investigate the difference clinical findings of AA in patients with the CCHCR1 variant and without.Methods: We conducted a retrospective analysis of the data from 142 AA patients. Among these patients, 20 (14.1%) had a variant of CCHCR1. We evaluated the sex distribution of the patients, age at onset, distribution of the clinical types, prevalence of a positive family history of AA, prevalence of association of AA with atopic dermatitis, response to steroid therapy, and recurrence rate. We used multivariate logistic regression analysis and Fisher's exact test for statistical analysis. We also investigate electron microscopic observations of hair samples with the CCHCR1 variant and without.Results: The results showed a significant correlation between the CCHCR1 variant and the recurrence rate compared with the variant-negative group (p=0.0072). Electron microscopy revealed abnormalities in the hair shaft structure and hair cuticle in patients with the CCHCR1 variant (p=0.00174).Conclusion: Our results suggest that AA with CCHCR1 variant is clinically characterized by a high recurrence rate and hair morphological abnormality.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 5","pages":"367-373"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/f3/ad-35-367.PMC10579570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hospital Utilization and Medication Prescriptions among Patients with Atopic Dermatitis in South Korea: A Real-World Data Analysis. 韩国特应性皮炎患者的医院利用率和药物处方：真实世界数据分析。

Annals of dermatology Pub Date : 2023-10-01 DOI: 10.5021/ad.22.038

Ji Hyun Lee, Yunha Noh, Ahhyung Choi, In-Sun Oh, Ja-Young Jeon, Hyun-Jeong Yoo, Ju-Young Shin, Sang Wook Son

引用次数: 0

Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss. 家族史和男性雄激素性脱发与女性脱发的关系。

Annals of dermatology Pub Date : 2023-10-01 DOI: 10.5021/ad.22.221

Sang-Hoon Lee, Hyun Kang, Won-Soo Lee

{"title":"Association between Family History and Male Androgenetic Alopecia with Female Pattern Hair Loss.","authors":"Sang-Hoon Lee, Hyun Kang, Won-Soo Lee","doi":"10.5021/ad.22.221","DOIUrl":"10.5021/ad.22.221","url":null,"abstract":"Background: Male androgenetic alopecia (MAGA) is often accompanied by female pattern hair loss (FPHL). However, the risk factors related to MAGA with FPHL are unclear.Objective: To investigate demographic and laboratory factors related to MAGA with FPHL.Methods: This retrospective case-control study was performed in a single tertiary care center for MAGA with FPHL between March 2012 and September 2021. Eligible patients were males >12 years old diagnosed with androgenetic alopecia by a dermatologist. The patients were subdivided into MAGA with FPHL and MAGA without FPHL groups. Comorbidities as well as demographic, laboratory, and disease-specific variables were compared between the two groups. Data analysis was conducted between October 2021 and February 2022. The independent samples t-test, Mann-Whitney U test, and chi-squared test were used to assess the factors that contributed to MAGA with FPHL.Results: Of 469 patients with MAGA, 309 (65.9%) had FPHL, which was a much higher rate than previously reported. Among the variables, only matrilineal (odds ratio, 1.605; 95% confidence interval, 1.014~2.541) and maternal history (odds ratio, 4.705; confidence interval, 1.632~13.559) of androgenetic alopecia were significantly associated with MAGA with FPHL. In the MAGA with FPHL group, a significant positive correlation was noted between body mass index and the type F score (r=0.114, p=0.025).Conclusion: In this case-control study, patients with MAGA and a maternal history of androgenetic alopecia were at risk of FPHL. Therefore, early screening may benefit these patients.","PeriodicalId":94298,"journal":{"name":"Annals of dermatology","volume":"35 5","pages":"348-354"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/50/e6/ad-35-348.PMC10579574.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41224655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of a Temperature-Adjustable Cryotherapy Device on Mice with Lysophosphatidic Acid-Induced Pruritus. 温度可调冷冻治疗装置对溶血磷脂酸诱导的小鼠瘙痒的影响。

Annals of dermatology Pub Date : 2023-10-01 DOI: 10.5021/ad.21.195

Mi Hee Kwack, Chang Hyun Song, Seongjin Lee, Gi Ung Ha, Gun-Ho Kim, Weon Ju Lee

引用次数: 0

Percutaneous Bleomycin Sclerotherapy: A Useful Therapeutic Option for Ganglion Cysts. 经皮博来霉素硬化疗法：治疗神经节囊肿的有效选择。

Annals of dermatology Pub Date : 2023-10-01 DOI: 10.5021/ad.21.245

Kihyuk Shin, Won-Ku Lee, Sang-Hyeon Won, Hyang-Suk You, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim, Hoon-Soo Kim

引用次数: 0

A Case of Primary Cutaneous Perivascular Epithelioid Cell Tumor. 原发性皮肤血管周类上皮细胞瘤1例。

Annals of dermatology Pub Date : 2023-05-01 DOI: 10.5021/ad.20.322

Haneul Oh, Byeong Geun Park, Il-Hwan Kim