African health sciences最新文献

{"title":"The efficacy of lactobacillus reuteri in conjunction with racecadotril in managing pediatric rotavirus enteritis and its impact on intestinal mucosa and immune function.","authors":"Zhihua He, Lin Lan, Nini Chen, Yanling Cheng, Sitang Gong","doi":"10.4314/ahs.v25i2.6","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.6","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effectiveness of combining Lactobacillus reuteri with racecadotril in treating pediatric rotavirus enteritis, focusing on its impact on intestinal mucosa and immune function.</p><p><strong>Methodology: </strong>Eighty-five children diagnosed with pediatric rotavirus enteritis were randomly divided into two groups: the control group (43 cases) receiving racecadotril alone and the observation group (42 cases) treated with both Lactobacillus reuteri and racecadotril. Evaluation of the RV conversion rate and treatment efficacy was conducted at 3d, 5d, and 7d post-treatment. The study also assessed changes in intestinal mucosal barrier function, immune response, and intestinal microbiota.</p><p><strong>Results: </strong>The observation group exhibited significantly higher RV conversion rates at 3d, 5d, and 7d post-treatment compared to the control group (P<0.05), reaching 61.90%, 76.19%, and 92.86%, respectively. Following treatment, the observation group showed improvements in mucosal barrier function, increased CD4+ levels, decreased AGEs, D-lactic acid, endotoxins, and CD8+ levels. There were notable changes in intestinal microbiota, with elevated Lactobacillus and Bifidobacterium levels and decreased Escherichia coli.</p><p><strong>Conclusions: </strong>Combining Lactobacillus reuteri and racecadotril in treating pediatric rotavirus enteritis demonstrated efficacy in regulating intestinal microbiota, alleviating mucosal barrier dysfunction, improving immune function, and enhancing treatment effectiveness.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"38-45"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of the effect of static computer-assisted dental implantation on the accuracy of dental implantation in esthetic area.","authors":"Zhongping Yin, Huifang Kuang, Li Li, Xi Si","doi":"10.4314/ahs.v25i2.40","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.40","url":null,"abstract":"<p><strong>Background: </strong>This system evaluates the effect of static navigation systems on accuracy (platform, apical and angular deviation) in clinical studies of implant surgery in the anterior aesthetic zone to inform clinical decision-making.</p><p><strong>Methodology: </strong>Retrieve Pubmed, Embase, Cochrane library databases, as well as randomized controlled trials (RCT) and controlled clinical trials (CCT) comparing dynamic navigation and static guidance published by the US Clinical Trial Registry before May 1, 2023. The outcome indicators included in the study include measuring the deviation between the preoperative design of the implant and the actual site at the top, apex, and angle. The calculation of meta-analysis was performed using Review Manager version 5.2 software.</p><p><strong>Results: </strong>1134 articles were screened and retrieved, and finally 4 studies were included for quantitative analysis. Meta analysis results showed that the two groups had lower depth angle deviation (WMD=-0.30, 95%CI: (0.24, 1.78), P=0.01) at the top (WMD=0.14, 95% CI: (-0.26, 0.55), P=0.49) and root tip (WMD=0.25, 95%CI: (-0.34, 0.84), P=0.41) compared to the static guide plate group, and the difference was statistically significant.</p><p><strong>Conclusion: </strong>The static guide plate provides a small implant placement error, which is comparable to the error obtained using dynamic navigation systems, but dynamic navigation exhibits a smaller angle deviation.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"343-353"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Salmonella</i> serovars in a tertiary hospital in Turkey, 2015-2017: molecular epidemiology, antimicrobial resistance and molecular characteristics of resistance mechanisms.","authors":"Tugce Unalan-Altintop, Selay Demirci-Duarte, Ozgen Koseoglu-Eser, Aycan Gundogdu, Aslı Cakar, Revasiye Gulesen, Belkıs Levent, Belgin Altun, Banu Sancak, Deniz Gür","doi":"10.4314/ahs.v25i2.10","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.10","url":null,"abstract":"<p><strong>Background: </strong>Increase in antimicrobial resistance poses a global threat for treatment of Salmonellosis.</p><p><strong>Objectives: </strong>In this study, serovar distribution, antimicrobial susceptibility, resistance genes, and clonal diversity were characterized in clinical <i>Salmonella</i> isolates.</p><p><strong>Methods: </strong>In this study, serovar distribution of clinical <i>Salmonella</i> isolates was characterized by the Kauffman-White scheme. The antimicrobial susceptibility was determined by the broth microdilution method. Resistance genes and clonal diversity were investigated by PCR and PFGE.</p><p><strong>Results: </strong>The serovars were <i>Salmonella enterica</i> serovar Enteritidis (n=92), <i>Salmonella enterica</i> serovar Typhimurium (n=14), and others (n=25). Resistance to ciprofloxacin, ceftriaxone, trimethoprim-sulfamethoxazole, azithromycin, meropenem, and colistin were 13.3%, 2.2%, 5.2%, 3.0%, 0%, 29.6%, respectively. Two ESBL-positive isolates carried TEM-type β-lactamases. Carbapenemases, <i>mcr</i>-1 and <i>mcr</i>-2 could not be detected. Colistin-resistant S. Enteritidis isolates were grouped in 4 pulsotypes [A1 (n=12), A2 (n=2), A3 (n=13) and B (n=1)]. All except one (B) were found closely related.</p><p><strong>Conclusions: </strong>A relative decrease in resistance to trimethoprim-sulfamethoxazole was detected with time. Trimethoprim-sulfamethoxazole and azithromycin can be good alternatives to the widely-used ciprofloxacin and third-generation cephalosporins. High resistance of colistin and ciprofloxacin may be due to the extensive use of antibiotics in poultry, which highlights the significance of one health concept.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"70-78"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Apatinib plus Temozolomide in Treating Recurrent Malignant Brain Glioma.","authors":"Guoquan Li, Tao Hu, Yangwu Hu, Hailiang Shi, Ling Li, Gang Xiong","doi":"10.4314/ahs.v25i2.17","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.17","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the efficacy and safety of apatinib plus tenozolomide in the treatment of recurrent malignant brain glioma.</p><p><strong>Methods: </strong>A retrospective analysis of 108 patients with recurrent malignant brain glioma was conducted at our hospital. Out of these, 54 patients received apatinib plus tenozolomide as combination therapy (Combination group) while the remaining 54 were treated with temozolomide alone (Control group). Clinical data was collected and analyzed to compare the treatment efficacy and incidence of adverse reactions between the two groups. Additionally, patient survival and progression-free survival (PFS) were monitored and recorded.</p><p><strong>Results: </strong>The study evaluated the efficacy of a treatment among patients who completed it. The Combination group had a higher objective response rate (ORR) and disease control rate (DCR) compared to the Control group. Treatment-related adverse reactions were mostly grade I-II and improved with symptomatic treatment. The Combination group had higher incidence rates of hypertension, proteinuria, and hand-foot syndrome. Follow-up results showed that the Combination group had a significantly better overall survival (OS) and progression-free survival (PFS) than the Control group.</p><p><strong>Conclusion: </strong>Compared with temozolomide alone, apatinib plus tenozolomide can significantly improve the clinical efficacy in treating recurrent malignant brain glioma, prolong the survival of patients and produce tolerable adverse reactions.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"124-130"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression levels and polymorphisms of the microRNA maturing components; diagnostic values of Drosha, DGCR8 and Dicer in patients with vitiligo.","authors":"Soner Aşır, Özlem İzci Ay, Mustafa Ertan Ay, Kenan Çevik, Gurbet Doğru Özdemir, Merve Türkegün Şengül, Mehmet Emin Erdal, Ümit Türsen","doi":"10.4314/ahs.v25i2.19","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.19","url":null,"abstract":"<p><strong>Background and objective: </strong>Even though the pathogenesis of vitiligo is still unclear, recent studies have suggested that miRNAs can contribute to the occurrence and progression of the disease. The aim of the present study was to investigate the associations between SNPs of miRNA processing genes and their expression levels with vitiligo susceptibility.</p><p><strong>Methods: </strong>55 patients and 56 controls were investigated for Dicer, Drosha, and DGCR8 gene expressions and genotyped for Drosha rs493760, DGCR8 rs1640299, and Dicer rs1057035 by real-time PCR. The correlation of the expression levels of these three genes was analyzed. The ROC curve was used to analyze their diagnostic efficacy for vitiligo.</p><p><strong>Results: </strong>The current findings showed that the Dicer CT genotype was more frequent in vitiligo (p=0.046) compared to controls, while Drosha and DGCR8 polymorphisms did not show significant associations. The relative expression levels of the three genes in vitiligo patients were significantly lower than those in the control group (p<0.05). The areas under the curves for Drosha, DGCR8, and Dicer were 0.969, 0.66, 0.67.</p><p><strong>Conclusions: </strong>For the first time, we demonstrate that the Dicer rs1057035 polymorphism is associated with vitiligo susceptibility, and the downregulation of Drosha, DGCR8, and Dicer suggests their potential roles as biomarkers in the pathogenesis of vitiligo.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"141-152"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional laparoscopic sleeve gastrectomy versus gastric bypass in treating obesity complicated with type 2 diabetes mellitus.","authors":"Jingfeng Gu, Guiqi Wang, Feng Feng, Jian Zhang, Dongyang Xing","doi":"10.4314/ahs.v25i2.25","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.25","url":null,"abstract":"<p><strong>Background: </strong>To compare and analyze the clinical efficacy and safety of Three-dimensional (3D) laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) in the treatment of obesity complicated with type 2 diabetes mellitus (T2DM).</p><p><strong>Methodology: </strong>A total of 132 T2DM patients were divided into LSG group (n=66) and LRYGB group (n=66). The operation time, time of postoperative gastrointestinal function recovery, postoperative hospital stay, and incidence rate of complications were compared. The glucolipid metabolism indexes [fasting plasma glucose (FPG), fasting insulin (FINS), fasting C-peptide (FCP), glycated hemoglobin A1c (HbA1c)], body weight and nutritional status [body mass index (BMI), hemoglobin (Hb)], insulin function and insulin resistance were recorded. Short-from 36 (SF-36) questionnaire was also conducted.</p><p><strong>Results: </strong>LSG group had shorter operation time, less blood loss, and quicker postoperative recovery than LRYGB group. Both groups showed significant improvements in BMI, FBG, FINS, FCP, HbA1c, and HOMA-IR. After 12 months, LRYGB group had significantly higher scores in physical function, general health, vitality, role emotional, and mental health in SF-36 questionnaire compared to LSG group. Compared with LRYGB group, LSG group had significantly decreased operation time, reduced intraoperative blood loss, and shortened postoperative off-bed time. BMI, FBG, FINS, FCP, HbA1c and HOMA-IR all markedly declined in the two groups after operation. At 12 months after operation, the scores of physical function, general health, vitality, role emotional and mental health in the SF-36 questionnaire were all remarkably higher in LRYGB group than those in LSG group.</p><p><strong>Conclusion: </strong>LSG can be used to treat obesity complicated with T2DM, which is characterized by simple operation, small trauma and quick postoperative recovery.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"195-208"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361938/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of decision tree analysis based on nursing vertical management in the allocation of obstetrics and gynecology nurses.","authors":"Xia Wu, Yu Liu","doi":"10.4314/ahs.v25i2.29","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.29","url":null,"abstract":"<p><strong>Background: </strong>Addressing nursing resource challenges in obstetrics and gynecology, this study employs decision tree analysis within nursing vertical management to enhance allocation efficiency and patient care. This study aimed to assess the efficacy of employing decision tree analysis within nursing vertical management for allocating obstetrics and gynecology nurses.</p><p><strong>Methodology: </strong>Sixty-one obstetrics and gynecology nurses were included in the study from January to December 2022 at our hospital. The control group, from January to June 2022, underwent routine nurse allocation management, while the observation group, from July to December 2022, experienced nurse allocation based on nursing vertical management using decision tree analysis. Nursing quality scores and satisfaction with allocation were statistically compared between the groups. Additionally, obstetrics and gynecology nursing level, illness matching rate, nursing quality scores, and patient satisfaction were evaluated.</p><p><strong>Results: </strong>The observation group showed significantly higher nursing quality scores and greater satisfaction with allocation compared to the control group. Moreover, the observation group exhibited higher obstetrics and gynecology nursing levels, illness matching rates, nursing quality scores, and patient satisfaction compared to the control group, all with statistical significance (P<0.05).</p><p><strong>Conclusions: </strong>Implementing the decision tree analysis method within nursing vertical management notably enhanced both satisfaction levels and the quality of care among obstetrics and gynecology nurses. It outperformed traditional deployment management, ensuring improved nursing work quality and heightened patient satisfaction. This approach is pivotal for fostering harmonious nurse-patient relationships and deserves widespread adoption.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"241-249"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and sociodemographic predictors of multiple non-communicable diseases risk behaviours among in-school adolescents in Delta State, Nigeria: A cross-sectional study.","authors":"Patrick Oyibo, Ejiroghene Martha Umuerri, Nyemike Simeon Awunor, Iyabo Aduke Oyibo, Mamodesan Tudjegbe Okumagba","doi":"10.4314/ahs.v25i2.14","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.14","url":null,"abstract":"<p><strong>Background: </strong>NCDs risk behaviours are modifiable and particularly patterned during adolescence. This study assessed the prevalence and sociodemographic predictors of multiple NCDs risk behaviours among in-school adolescents.</p><p><strong>Methods: </strong>A cross-sectional study design was employed to assess the simultaneous occurrence of NCD risk behaviours among a random multistage sample of 607 participants. Data was collected using an interviewer-administered semi-structured questionnaire. Bivariate and multivariate analysis was carried using the IBM SPSS version 22 software.</p><p><strong>Results: </strong>The mean age of the study participants was 14.7 (SD = 1.52) years. The prevalence of two and at least three co-occurring NCDs risk behaviours among the study participants 46.1 % (n=280) and 16.6 % (n = 101). Increasing age (AOR=1.84; 95% CI: 1.11 - 3.05), male sex (AOR=1.75; 95% CI: 1.28 - 2.82) and being an urban resident (AOR=1.41; 95% CI: 1.06 - 2.86) were predictors of at least three co-occurring NCDs risk behaviours.</p><p><strong>Conclusion: </strong>The prevalence of multiple NCDs risk behaviours was relatively high among the study participants. This calls for urgent implementation of interventions at all ecological levels that will equip in-school adolescents with the skills to adopt healthy lifestyles and choices.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"101-110"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations and African Health Sciences: telling it beyond our environs.","authors":"James K Tumwine","doi":"10.4314/ahs.v25i2.1","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.1","url":null,"abstract":"","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"i-iv"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between Vitamin D levels and thyroid autoantibodies in newly diagnosed hashimoto's thyroiditis patients.","authors":"Ahmed Cihad Genç, Aysel Toçoğlu, Fatma Betül Asan, Attila Önmez","doi":"10.4314/ahs.v25i2.22","DOIUrl":"https://doi.org/10.4314/ahs.v25i2.22","url":null,"abstract":"<p><strong>Background: </strong>Vitamin D plays a role in numerous metabolic functions. In this study we aimed to assess vitamin D levels in Hashimoto's Thyroditis (HT) patients, and demonstrate the relationship between these levels and thyroid function tests or thyroid autoantibodies.</p><p><strong>Methods: </strong>A retrospective analysis of 112 newly diagnosed euthyroid HT (EHT) patients and 178 healthy controls was carried out. 25-OH D level was classified as vitamin D deficiency, vitamin D insufficiency, and vitamin D sufficient.</p><p><strong>Results: </strong>Mean age was 35.33±11.54 years in the patient group, and 35.84±10.9 in the control group (p=0.777). Compared with the healthy controls, patients in the EHT group had significantly lower vitamin D levels (p=0.007), and a significantly higher prevalence of vitamin D deficiency (p=0.001). While there was a negative correlation between vitamin D levels and anti-TPO values (r=-0.133, p=0.023), there was no significant relationship between vitamin D and TSH, fT4, fT3, and anti-TG values (p>0.05).</p><p><strong>Conclusıons: </strong>This study showed that EHT patients had lower vitamin D levels compared to healthy controls, and there was a significant negative correlation between vitamin D levels and anti-TPO levels. Based on our study, patients diagnosed with HT should undergo vitamin D screening, and replacement if necessary.</p>","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"25 2","pages":"168-175"},"PeriodicalIF":0.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}