African health sciences最新文献_第10页

Epidemiology and future risk estimates of cutaneous leishmaniasis in district Dera Ismail Khan, Pakistan: analysis of data from 2019-2022. 巴基斯坦德拉伊斯梅尔汗地区皮肤利什曼病的流行病学和未来风险估计：2019-2022年数据分析

African health sciences Pub Date : 2024-12-01 DOI: 10.4314/ahs.v24i4.8

Aqsa Mansoor, Kiran Afshan, Ghulam Narjis, Sabika Firasat

{"title":"Epidemiology and future risk estimates of cutaneous leishmaniasis in district Dera Ismail Khan, Pakistan: analysis of data from 2019-2022.","authors":"Aqsa Mansoor, Kiran Afshan, Ghulam Narjis, Sabika Firasat","doi":"10.4314/ahs.v24i4.8","DOIUrl":"10.4314/ahs.v24i4.8","url":null,"abstract":"Background: Cutaneous leishmaniasis (CL), despite not being a life-threatening condition, has a devastating impact on the public health. CL is widely distributed, exhibiting a distinct epidemiological pattern all over the world. The aim of this study was to investigate CL in District Dera Ismail Khan, Khyber Pakhtunkhwa, Pakistan, and to estimate the risk of epidemics.Objectives: Materials and methods: From 2019 to 2022, 1135 CL patients' epidemiological data were collected from district health facilities. For epidemiological characterization, descriptive statistics were used. The spatial analysis was done using ArcGIS V.10.3. The relationship between CL occurrence and climatic variables was investigated using liner regression analysis.Results: Between 2019 and 2022, there was a decline in the annual CL incidence trend. Males and people under the age of 20 were particularly susceptible. A total of 1204 lesions were identified, with 76.1% of individuals having a single lesion and 23.9% having multiple lesions. Most of the lesions were nodular and ulcerative in nature and were found on exposed body parts such as the lower extremity (34.2%) and the face (30.7%). A choropleth map revealed an increased incidence of CL in Tehsil D.I.K (63%) and Paharpur (10%). According to a digital elevation model, high altitudes have a lower prevalence of CL. For focal transmission and high-risk zones, Inverse Density Weight (IDW) spatial interplation, focal statistics, cluster, and outlier analysis validated that CL cases were high in D.I.K, Kulachi, and Paharpur tehsils. Increased temperature, relative humidity, and precipitation were not significantly associated with CL infection.Conclusions: The study provided essential details for public health sectors to develop intervention strategies for future CL outbreaks.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 4","pages":"51-64"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of midnight-noon Ebb-flow hour-prescription method combined with acupuncture at Baihui Bazhen acupoints in the rehabilitation of Aphasia after ischemic stroke. 午夜-午间退潮时方法配合针刺百会八震穴治疗缺血性脑卒中后失语的疗效观察。

African health sciences Pub Date : 2024-12-01 DOI: 10.4314/ahs.v24i4.34

Yunbo Li, Chaoqi Lu, Lin Chen

{"title":"Efficacy of midnight-noon Ebb-flow hour-prescription method combined with acupuncture at Baihui Bazhen acupoints in the rehabilitation of Aphasia after ischemic stroke.","authors":"Yunbo Li, Chaoqi Lu, Lin Chen","doi":"10.4314/ahs.v24i4.34","DOIUrl":"10.4314/ahs.v24i4.34","url":null,"abstract":"Background: To investigate the clinical effectiveness of combining the midnight-noon ebb-flow hour-prescription method with acupuncture at the Baihui (GV 20) and Bazhen acupoints for rehabilitating aphasia following ischemic stroke.Methodology: 196 patients with aphasia after ischemic stroke were divided into two groups: a research group (n=98) that received language rehabilitation training along with the midnight-noon ebb-flow hour-prescription method and acupuncture at Baihui (GV 20) Bazhen acupoints, and a control group (n=98) that received only language rehabilitation training. The study recorded traditional Chinese medicine symptom scores and scores from various scales, as well as clinical efficacy.Results: The traditional Chinese medicine symptom score and National Institute of Health Stroke Scale (NIHSS) score were lower, and the scores of Stroke-Specific Quality of Life Scale (SS-QOL), Chinese Functional Communication Profile (CFCP), Montreal Cognitive Assessment (MoCA), Chinese Rehabilitation Research Center Standard Aphasia Examination (CRRCAE) were higher in the research group than in the control group after treatment. The research group also had a higher total effective rate compared to the control group.Conclusion: Midnight-noon ebb-flow hour-prescription method combined with acupuncture at Baihui (GV 20) Bazhen acupoints can effectively ameliorate NIHSS scores in patients with aphasia after ischemic stroke, facilitate language functional recovery, and improve rehabilitation.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 4","pages":"262-268"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practices of lactating mothers regarding exclusive breastfeeding in Outapi district, Omusati region: a qualitative study. 奥穆萨提地区Outapi地区哺乳母亲纯母乳喂养的做法：一项定性研究。

African health sciences Pub Date : 2024-12-01 DOI: 10.4314/ahs.v24i4.53

Veremunde Nikanor, Emma Maano Nghitanwa, Monika Nakweenda

{"title":"Practices of lactating mothers regarding exclusive breastfeeding in Outapi district, Omusati region: a qualitative study.","authors":"Veremunde Nikanor, Emma Maano Nghitanwa, Monika Nakweenda","doi":"10.4314/ahs.v24i4.53","DOIUrl":"10.4314/ahs.v24i4.53","url":null,"abstract":"Introduction: Breastfeeding exclusively for the first six months of a child's life is beneficial to the child's health and development.Objectives: The study objectives were to determine and describe the practices of lactating mothers regarding exclusive breastfeeding and to determine the association between the overall level of practice and demographic characteristics.Methods: The study employed a quantitative approach which utilised a descriptive- analytic design. The study population was all women in Outapi district breastfeeding babies aged 0 to 6 months. Data was collected from three clinic selected though cluster sampling and 200 participants were sampled through simple random sampling participated in the study. Data were collected in April 2022 using a questionnaire. Data was analysed using a Software Package for Social Science (SPSS VERSION 25.0). Frequency distribution tables and descriptive statistics were generated to summarise data and bivariate analysis was performed to determine the association between sociodemographic characteristics and the level of breastfeeding practices.Results: The study found that, most 121 (60.5%) participants have poor practice on exclusive breastfeeding. Furthermore, the study found an association between the level of practice and babies' age.Conclusion: Poor practices regarding exclusive breastfeeding may negatively affect babies' health. Therefore there is a need for reinforcement on the practice as well as health education on the benefits of exclusive breastfeeding. It is recommended that the Ministry of Health and Social Services in Namibia formulate a policy to enforce exclusive breastfeeding among women.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 4","pages":"431-437"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Malnutrition and associated factors among children of adolescent mothers attending a tertiary hospital in Uganda. 在乌干达一家三级医院就诊的少女母亲所生儿童的营养不良及其相关因素。

African health sciences Pub Date : 2024-12-01 DOI: 10.4314/ahs.v24i4.51

Geraldine Basanyukira, Violet Okaba, Elizabeth Kiboneka, Sarah Kiguli

{"title":"Malnutrition and associated factors among children of adolescent mothers attending a tertiary hospital in Uganda.","authors":"Geraldine Basanyukira, Violet Okaba, Elizabeth Kiboneka, Sarah Kiguli","doi":"10.4314/ahs.v24i4.51","DOIUrl":"10.4314/ahs.v24i4.51","url":null,"abstract":"Background: Children bearing children\" emphasizes vulnerability of both parties involved. Children of adolescent mothers are prone to poor health outcomes, undernutrition inclusive.Objective: To assess the nutrition status and factors associated with under nutrition among children aged one to twenty-four months, of adolescent mothers(COAM) attending Mulago Hospital.Methodology: A cross-sectional study conducted at pediatric department of Mulago Hospital. COAM were recruited consecutively following consent. Mother-baby pair underwent history, physical exam, anthropometry and HIV testing. Data was extracted by a standardized questionnaire, entered into Epidata 3.1 and analyzed with SPSS Version19.Results: The prevalence of stunting, wasting and underweight was 32%, 31% and 27% respectively. Age above twelve months[OR 4.2CI 95 % (2.12 -8.32)p<0.001], partner lack of financial support[OR2.093CI 95%(1.1- 3.97)p<0.024], chronic illness[OR 3.901CI 95%(2.21-6.87)p<0.001], low birth weight[OR3.537CI 95%(1.5- 8.1)p<0.003], rural residence[OR 2.65CI95%(1.23-5.07)p 0.013] were associated with stunting. Factors associated with wasting: partner lack of financial support[OR 2.0CI 95%(1.06- 3.78)p 0.032], prematurity[OR 2.115CI 95%(1.02-4.35)p0.042], employed mother[OR 2.174CI 95%(1.18- 3.97),p 0.012] and inadequate antenatal care visits[OR1.83CI 95%(0.97-5.55)p 0.031].Conclusion: The high burden of under nutrition among COAM is of concern to parents, community and policy makers. Therefore, delaying teenage pregnancies, education on proper nutrition practices will reduce on the high burden.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 4","pages":"408-419"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nursing for conical telescopic crown prosthodontics in treating periodontitis accompanied by dentition defects. 锥形套筒冠修复治疗牙周炎伴牙列缺损的护理。

African health sciences Pub Date : 2024-12-01 DOI: 10.4314/ahs.v24i4.47

Lina Hu, Miao Liang, Feng Zhu, Rongrong Nie

{"title":"Nursing for conical telescopic crown prosthodontics in treating periodontitis accompanied by dentition defects.","authors":"Lina Hu, Miao Liang, Feng Zhu, Rongrong Nie","doi":"10.4314/ahs.v24i4.47","DOIUrl":"10.4314/ahs.v24i4.47","url":null,"abstract":"Objective: We aimed to investigate the nursing technique and outcomes of conical telescopic crown prosthodontics for patients with periodontitis accompanied by dental defects.Methods: One hundred patients with chronic periodontitis and dental problems from January 2018 to August 2020 were enrolled. They were randomly assigned to an observation group (n=50) and a control group (n=50). The control group received traditional nursing, whereas the observation group received comprehensive nursing. Comparisons were made between the indices related to chewing function and periodontal condition, inflammatory factors, quality-of-life score, and nursing satisfaction rate.Results: The masticatory efficiency and absorbance were greater in the observation group than in the control group following nursing (P<0.05). The observation group had lower levels of plaque index, debris index, sulcus bleeding index, and periodontal probing depth, as well as levels of C-reactive protein, tumor necrosis factor-alpha, and interleukin-6 (P<0.05). The quality-of-life score of the observation group was significantly higher than that of the control group (P<0.05). The nursing satisfaction rate of the observation group was significantly higher than that of the control group (P<0.05).Conclusion: Comprehensive nursing for conical telescopic crown prosthodontics can improve the chewing function and periodontal conditions of patients with periodontitis accompanied by dentition defects.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 4","pages":"383-388"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caesarean sections among east African refugees and their host population: a 20-year retrospective study in western Tanzania. 东非难民及其收容人口的剖腹产：坦桑尼亚西部20年回顾性研究。

African health sciences Pub Date : 2024-12-01 DOI: 10.4314/ahs.v24i4.27

Sarah Rapaport, Hilary Ngude, Chi Chiung Grace Chen, Mohamed Abbas, Amber Lekey, Peter J Winch, Joseph V Sakran, Kent A Stevens, Zachary Obinna Enumah

{"title":"Caesarean sections among east African refugees and their host population: a 20-year retrospective study in western Tanzania.","authors":"Sarah Rapaport, Hilary Ngude, Chi Chiung Grace Chen, Mohamed Abbas, Amber Lekey, Peter J Winch, Joseph V Sakran, Kent A Stevens, Zachary Obinna Enumah","doi":"10.4314/ahs.v24i4.27","DOIUrl":"10.4314/ahs.v24i4.27","url":null,"abstract":"Background: Half of the 35.3 million refugees worldwide are women and a third are of childbearing age, making reproductive healthcare in humanitarian settings indispensable. Caesarean section (CS) is the most common operation worldwide, accounting for 18.6% of births.Objective: This study provides a descriptive analysis of caesarean sections (CS) in a protracted refugee setting.Methods: This study is a retrospective review of CS recorded in logbooks between November 2000 and September 2020, inclusive. Data was abstracted from paper logbooks and included date, nationality, sex, age, and indication. Analysis was performed in STATA.Results: 8,461 CS were performed over the 20-year period. The average age was 24.6 years. Tanzanian patients made up 25% (n=2,116) of the population. The most common indications for CS for both Tanzanians and refugees were cephalopelvic disproportion (CPD), previous scar, and fetal distress. There was a significant difference in the proportion of adolescent and adult patients for the indications of CPD, previous scar, fetal distress, malposition, placenta previa, prolapse, and antepartum hemorrhage (APH).Conclusion: There is a significant amount of CS performed in this humanitarian setting. Refugees and Tanzanians utilize these services. Outcome data are needed to identify if CS in this setting reduces neonatal and maternal morbidity and mortality.Funding: American Society of Tropical Medicine and Hygiene; Ruth L. Kirschstein National Research Service Award T32 (Award: 2T32AR67708-6); Association for Academic Surgery.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 4","pages":"206-213"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of emergency medical services for stroke. 卒中急诊医疗服务综述

IF 0.9

African health sciences Pub Date : 2024-09-01 DOI: 10.4314/ahs.v24i3.42

Yanxia Wu, Ken Li, Lizhen Tang, Guang Li, Dongxue Huang, Yahui Yang, Shihui Song, Li Peng

{"title":"A Review of emergency medical services for stroke.","authors":"Yanxia Wu, Ken Li, Lizhen Tang, Guang Li, Dongxue Huang, Yahui Yang, Shihui Song, Li Peng","doi":"10.4314/ahs.v24i3.42","DOIUrl":"10.4314/ahs.v24i3.42","url":null,"abstract":"In the past decade, Emergency Medical Services have been associated with innovations in technology; the 911 telephone system and two-way radio have developed the notification, scheduling, and response processes. The recent twenty years have witnessed the unparalleled innovation changes of the computer framework. These new frameworks in mobile, social, cloud computing or big data concentrations essentially affect the entire society. In the last ten years, major innovation and strategic improvements have occurred, which will affect the concepts and communication methods of Emergency Medical Service in the future. Emergency Medical Service can treat various diseases in the correct way. For example, Emergency Medical Service personnel's early recognition of stroke performance is an important ideal consideration for patients with stroke patients. Pre-stroke screening tools that have been preliminarily evaluated for sensitivity and specificity are necessary to improve detection rates for the pre-court stroke by Emergency Medical Service experts. This is an excellent time for Emergency Medical Service to play a key role in achieving and transcending vision. The motivation behind this article is to provide extensive investigations and unique opportunities for Emergency Medical Service personnel groups to solve how to improve.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 3","pages":"382-392"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of foot care practice among adults with diabetes mellitus in Ogbomoso, Nigeria. 尼日利亚Ogbomoso市糖尿病成人足部护理实践评估

IF 0.9

African health sciences Pub Date : 2024-09-01 DOI: 10.4314/ahs.v24i3.39

Adeola Idowu, Isaac Amole, Adewumi Durodola, Olatayo Idowu, Stephen Adesina, Adepeju Adegoke, Akinsola Akinwumi

{"title":"Assessment of foot care practice among adults with diabetes mellitus in Ogbomoso, Nigeria.","authors":"Adeola Idowu, Isaac Amole, Adewumi Durodola, Olatayo Idowu, Stephen Adesina, Adepeju Adegoke, Akinsola Akinwumi","doi":"10.4314/ahs.v24i3.39","DOIUrl":"10.4314/ahs.v24i3.39","url":null,"abstract":"Background: The prevalence of diabetes mellitus (DM) has steadily increased as also the number of people bearing its complications. One of such complications is diabetic foot disease. Foot care is an integral part of diabetes self-care and preventive strategy for reduction of diabetic foot disease and ultimate amputation.Aim: To assess foot care practices among adults with diabetes mellitus accessing care at the Out-patient Clinic of the Bowen University Teaching Hospital, Ogbomoso, Nigeria.Methods: This was a cross-sectional study comprising of 384 adults aged 18 years and above with diabetes mellitus of at least 6 months duration. A systematic sampling technique was used to recruit the participants for this study. Nottingham Assessment of Functional Foot Care (NAFFC) was used to assess the foot care practices of the participants. Data analysis was done using Statistical Package for Social Sciences (SPSS) version 23.Results: Of the 384 participants recruited for the study, 321 (83.6%) had good foot care practice and 63 (16.4%) had poor foot care practice. Gender, level of education and medication use had significant association with foot care practice.Conclusion: Foot care practice was good in majority of the participants in this study. As such, clinicians need to be consistent in providing self-foot care practice education to prevent diabetic foot diseases.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 3","pages":"353-360"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with acute kidney injury and outcomes in patients with malaria in a district hospital in Rwanda. 卢旺达一家地区医院疟疾患者急性肾损伤的相关因素和预后。

IF 0.9

African health sciences Pub Date : 2024-09-01 DOI: 10.4314/ahs.v24i3.12

Larrisa Umuhire, Violette Dushimiyimana, Michel Nkuranyabahizi, Flavien Ngendahayo, Jean Claude Shyaka, Innocent Ngerageze, Lakshmi Rajeswaran, Geldine Chironda

{"title":"Factors associated with acute kidney injury and outcomes in patients with malaria in a district hospital in Rwanda.","authors":"Larrisa Umuhire, Violette Dushimiyimana, Michel Nkuranyabahizi, Flavien Ngendahayo, Jean Claude Shyaka, Innocent Ngerageze, Lakshmi Rajeswaran, Geldine Chironda","doi":"10.4314/ahs.v24i3.12","DOIUrl":"10.4314/ahs.v24i3.12","url":null,"abstract":"Introduction: Acute kidney injury (AKI) remains one of the complications of severe malaria. Evidence on associated factors and outcomes for patients with complicated malaria and AKI is limited in Rwanda.Aim: To assess the factors associated with acute kidney injury and outcomes in patients with malaria in a district hospital in Rwanda.Method: A retrospective study design was applied. A census sampling strategy was used to select 122 files of patients admitted as severe malaria patients in 2016-2017. A developed clinical audit form was used to collect data from patients' files. Both descriptive and inferential statistics were used to analyze data.Results: Among the confirmed severe malaria files, 44% of participants were over 50 years and 52.5% were males. The majority, (91.5%) had community-based health insurance and 16.3% had acute kidney injury. The significant associated clinical factors were dehydration (p=.01), high-grade fever (p=.002), profuse sweating (p=.034), vomiting (p=.043), and diarrhea (p=.025). Of the 20 patients who developed AKI, 55% completely recovered, 15% died and 30% of cases were transferred to the highest facilities for hemodialysis.Conclusion: The existence of AKI among severe malaria patients was evident with some recovering and others dying. There is a need for educating healthcare professionals, mostly at district hospitals about the diagnosis and management of AKI as a result of complicated malaria.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 3","pages":"81-89"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro scientific validation of anti-inflammatory activity of Punica granatum L. on Leukemia monocytic cell line. 石榴对白血病单核细胞抗炎作用的体外科学验证。

IF 0.9

African health sciences Pub Date : 2024-09-01 DOI: 10.4314/ahs.v24i3.17

Sharmistha Dutta, Khushbu Nishad, Talambedu Usha, Nijalingappa Ramesh, Sushil Kumar Middha

{"title":"In-vitro scientific validation of anti-inflammatory activity of Punica granatum L. on Leukemia monocytic cell line.","authors":"Sharmistha Dutta, Khushbu Nishad, Talambedu Usha, Nijalingappa Ramesh, Sushil Kumar Middha","doi":"10.4314/ahs.v24i3.17","DOIUrl":"10.4314/ahs.v24i3.17","url":null,"abstract":"Background: The induction of the inflammatory cascade results in the production of a number of inflammatory mediators, including prostaglandin E2 (PGE2), nitric oxide (NO), and proinflammatory cytokines like TNF-, IL-, and IL-6. This study examined the cytotoxicity and anti-inflammatory properties of a methanolic crude extract of Punica granatum L. peel (PPM) on monocytic leukaemia cell line (THP-1).Materials and methods: The PPM along with Quercetin as reference was used to assess the cytotoxic effect on THP-1 cells and describe its effect on pro-inflammatory cytokines such as COX-2, TNF-α, IL-6 against cancer cell line by flow cytometry.Results: The percentage of viable cells significantly decreased which correlates to non-toxicity whereas quercetin was found to be highly toxic, the IC50 could not be calculated because of drug precipitation. There was a significant decrease in the expressions of inflammatory cytokines upon pre-treatment of the cells with PPM prior to LPS stimulation.Conclusion: Our findings indicate that no cytotoxicity was observed after the treatment of THP-1 cells with PPM (25-400 µg/ml), but at higher concentration (400µg/ml), the cell viability decreased to 84% and attenuated the expression level of inflammatory cytokines. The inhibitory effect of the extract on pro-inflammatory factors production may provide a theoretical source on upcoming treatment of inflammation.","PeriodicalId":94295,"journal":{"name":"African health sciences","volume":"24 3","pages":"128-137"},"PeriodicalIF":0.9,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12327121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144801490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0