Advanced biomedical research最新文献_第9页

Cost-Utility Analysis of Rosuvastatin (20 mg) to Prevent Cardiovascular Diseases in Iran. 伊朗瑞舒伐他汀（20 毫克）预防心血管疾病的成本效用分析。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_208_22

Aziz Rezapour, Abdosaleh Jafari, Hamid Talebianpour

{"title":"Cost-Utility Analysis of Rosuvastatin (20 mg) to Prevent Cardiovascular Diseases in Iran.","authors":"Aziz Rezapour, Abdosaleh Jafari, Hamid Talebianpour","doi":"10.4103/abr.abr_208_22","DOIUrl":"https://doi.org/10.4103/abr.abr_208_22","url":null,"abstract":"Background: Cardiovascular diseases are a main cause of disease burden in developing and developed countries. This study aimed to evaluate the cost-utility of rosuvastatin 20 mg in contrast with no intervention for the prevention of cardiovascular disease in Iran.Materials and methods: The costs and utility of rosuvastatin 20 mg were compared to nonintervention in patients with cardiovascular disease for the whole lifetime horizon in this study using the Markov model. Cost and utility data were taken from literature. After estimating the incremental cost-effectiveness ratio, a sensitivity analysis was performed using TreeAge Pro 2011 software to cope with uncertainty.Results: Based on finding, the expected cost and quality-adjusted life years (QALYs) of using rosuvastatin 20 mg were $300 and 12, and the values for no intervention were $56 and $10, respectively. Given the threshold of $20800, using rosuvastatin 20 mg was cost-effective compared to no intervention and the incremental cost was $122 per QALY. The results showed that the highest costs were related to admission to the coronary care unit (CCU) ward. Moreover, among the costs of paraclinical services, the highest were those of echocardiography. Furthermore, Troponin accounted for most of the cost of laboratory tests.Conclusion: It is recommended that policymakers consider using rosuvastatin 20 mg by cardiologists while designing clinical guidelines for the diagnosis of patients with cardiovascular diseases. Because of the high cost of cardiovascular diseases in Iran, it is suggested that policymakers should consider cost control strategies to impose lower costs on patients.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"47"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Rated Health and its Impact on Survival of Older Adults. 自评健康状况及其对老年人生存的影响。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_34_23

Ali Bijani, Zahra Shah-Hosseini, Seyed Reza Hosseini, Reza Ghadimi, Simin Mouodi

{"title":"Self-Rated Health and its Impact on Survival of Older Adults.","authors":"Ali Bijani, Zahra Shah-Hosseini, Seyed Reza Hosseini, Reza Ghadimi, Simin Mouodi","doi":"10.4103/abr.abr_34_23","DOIUrl":"https://doi.org/10.4103/abr.abr_34_23","url":null,"abstract":"Background: Self -rated health (SRH) is a subjective assessment of health status that results from asking a question as \"How do you assess your health?\". The aim of this study was to determine the value of SRH for survival of older adults.Materials and methods: This cohort study was conducted among a population aged 60 years and over living in the north region of Iran. The participants' characteristics including demographic information, life-style behaviors, medical history, body mass index, depressive symptoms, cognitive function, and social support were examined. SRH was categorized into two groups (1. poor or fair and 2. good or excellent). All of the study population were followed up again after 5 years to determine the survival condition.Results: Totally, 1475 elderly people were included. Good or excellent SRH showed a significant association with male gender, to be married, higher physical activity, less co-morbid chronic disorders, no depressive symptoms, normal cognitive function, higher social support, smoking (P < 0.001), and normal body mass index (BMI) (P = 0.021); however, no significant association with age (P < 0.083) was observed. Out of 944 elderly people expressing good or excellent SRH, 85 (9%) persons died after 5-year follow-up (P < 0.001). Cox regression analysis revealed that SRH had a significant impact on mortality of older adults (adjusted hazard ratio = 1.447; 95% confidence interval: 1.008-2.076; P = 0.045).Conclusion: Considering health-related characteristics including age, gender, number of drugs the participant was taking, physical activity, BMI, and social support, SRH showed a significant effect on 5-year survival of older adults.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"45"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478776/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomic Response Latency Revisited: Assessment of Repeatability in Healthy Subjects. 重新审视自律神经反应潜伏期：评估健康受试者的可重复性

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_409_23

Annie S Jose, Shival Srivastav, Bharati Mehta

{"title":"Autonomic Response Latency Revisited: Assessment of Repeatability in Healthy Subjects.","authors":"Annie S Jose, Shival Srivastav, Bharati Mehta","doi":"10.4103/abr.abr_409_23","DOIUrl":"https://doi.org/10.4103/abr.abr_409_23","url":null,"abstract":"Background: Autonomic function assessment provides valuable information regarding the status of the autonomic nervous system. The time lag between the onset of orthostasis and the peak/nadir of heart rate response is a surrogate of the integrity of underlying autonomic neural pathways. Autonomic response latency (ARL) is a relatively novel yet underreported parameter in this context. Test-retest repeatability of this parameter has not been evaluated previously.Materials and methods: We recruited 31 healthy adults (17 males and 14 females; 29.00 ± 5.44 years) and subjected them to postural challenge tests on five instances - forenoon and afternoon of day 1, the next day, 1 week later, and 1 month later. Tachycardia and bradycardia latencies (TL and BL) were computed using heart rate derived from digital ECG data. Repeatability was assessed using the intraclass correlation coefficient (ICC) and coefficient of variation (CoV).Results: ICCs for TL and BL were 0.69 (0.56, 0.82) and 0.77 (0.66, 0.87), respectively. The CoVs for TL and BL were 14.8% and 12.4%, respectively. Sex-based subgroup analysis revealed ICCs for TL and BL in males to be 0.71 (0.53, 0.86) and 0.74 (0.57, 0.88) and in females to be 0.68 (0.64, 0.86) and 0.82 (0.66, 0.93), respectively. CoVs for TL and BL were 14.4% and 13.8% in male subjects and 15.4% and 10.7% in female subjects, respectively.Conclusion: ARL to orthostatic challenge demonstrated moderate to good test-retest repeatability. Based on our observations, we propose that ARL has potential as a consistent and repeatable index for the assessment of the integrity of autonomic neural pathways and therefore can help in the diagnosis of autonomic neuropathy.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"60"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systems Biology Approach to the Pathogenesis of Celiac Disease: Identification of Potential Protective and Promoting Mechanisms. 乳糜泻发病机制的系统生物学方法：确定潜在的保护和促进机制。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_229_23

Mahmood Fadaie, Anis Khalafiyan, Elham Ghafouri, Tayebeh Ranjbarnejad, Shiva Moein

{"title":"A Systems Biology Approach to the Pathogenesis of Celiac Disease: Identification of Potential Protective and Promoting Mechanisms.","authors":"Mahmood Fadaie, Anis Khalafiyan, Elham Ghafouri, Tayebeh Ranjbarnejad, Shiva Moein","doi":"10.4103/abr.abr_229_23","DOIUrl":"10.4103/abr.abr_229_23","url":null,"abstract":"Background: Celiac disease (CeD) is an autoimmune enteropathy triggered by dietary gluten. Almost 90% of CeD patients have HLA-DQ2 or -DQ8 haplotypes. As a high proportion of first-degree relatives (FDRs) of CeD patients have the same haplotype, it is assumed that they are at a higher risk of disease development than the general population. Nevertheless, the prevalence of CeD among FDRs is considerably low (7.5%).Materials and methods: In order to figure out this discrepancy, a microarray dataset of intestinal mucosal biopsies of CeD patients, FDRs, and control groups was reanalyzed, and a protein-protein interaction network was constructed.Results: Principal component analysis showed that CeD and FDR groups are far away in terms of gene expression. Comparing differentially expressed genes of both networks demonstrated inverse expression of some genes mainly related to cell cycle mechanisms. Moreover, analysis of the modular structures of up- and downregulated gene networks determined activation of protein degradation mechanisms and inhibition of ribosome-related protein synthesis in celiac patients with an upside-down pattern in FDRs.Conclusions: The top-down systems biology approach determined some regulatory pathways with inverse function in CeD and FDR groups. These genes and molecular mechanisms could be a matter of investigation as potential druggable targets or prognostic markers in CeD.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"42"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lidocaine and Dexamethasone, Ketamine and Dexamethasone, and Dexamethasone Alone in Tonsillectomy Complications. 扁桃体切除术并发症中的利多卡因和地塞米松、氯胺酮和地塞米松以及单用地塞米松。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_234_22

Morteza Heidari, Hamidreza Shetebi, Parastoo Golshiri, Somayeh Hoghughi

{"title":"Lidocaine and Dexamethasone, Ketamine and Dexamethasone, and Dexamethasone Alone in Tonsillectomy Complications.","authors":"Morteza Heidari, Hamidreza Shetebi, Parastoo Golshiri, Somayeh Hoghughi","doi":"10.4103/abr.abr_234_22","DOIUrl":"10.4103/abr.abr_234_22","url":null,"abstract":"Background: Common complications including stridor, laryngospasm, and bronchospasm are important in patients undergoing general anesthesia. Dexamethasone, lidocaine, and ketamine could have significant roles in reducing these complications. Here we aimed to compare the use of these drugs during tonsillectomy.Materials and methods: This study was performed on 100 children that were candidates of tonsillectomy. Patients were divided into 4 groups receiving dexamethasone 0.1 mg/kg and lidocaine 1 mg/kg, ketamine 0.5 mg/kg and dexamethasone 0.1 mg/kg, dexamethasone 0.1 mg/kg, and normal saline after surgical procedures. We evaluated and compared data regarding the duration of anesthesia, oxygenation saturation, blood pressure (systolic and diastolic (SBP and DBP)), re-intubation, laryngospasm, bronchospasm, requiring analgesics after surgeries, recovery stay duration, and nausea and vomiting.Results: Administration of ketamine and dexamethasone was associated with the lowest pain and lowest need for postoperative analgesic administrations in patients (P = 0.02). Patients that received lidocaine and dexamethasone had the lowest frequencies of airway stimulations (P < 0.001). Evaluations of complications in patients revealed that stridor was significantly lower in patients that received ketamine and dexamethasone (P = 0.01).Conclusion: Usage of ketamine and dexamethasone was associated with the lowest pain severities and lowest complications. On the other hand, patients that received lidocaine and dexamethasone had the least airway stimulations.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"40"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking Antibiotic Resistance Trends in Central Iran Amidst the COVID-19 Pandemic From 2021 to 2023: A Comprehensive Epidemiological Study. 追踪 2021 年至 2023 年 COVID-19 大流行期间伊朗中部的抗生素耐药性趋势：流行病学综合研究。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_345_23

Reza Abniki, Amirhossein Tashakor, Melika Masoudi, Arezoo Pourdad, Davood Mansury

{"title":"Tracking Antibiotic Resistance Trends in Central Iran Amidst the COVID-19 Pandemic From 2021 to 2023: A Comprehensive Epidemiological Study.","authors":"Reza Abniki, Amirhossein Tashakor, Melika Masoudi, Arezoo Pourdad, Davood Mansury","doi":"10.4103/abr.abr_345_23","DOIUrl":"10.4103/abr.abr_345_23","url":null,"abstract":"Background: The emergence of coronavirus disease in 2019 (COVID-19) appears to be having an impact on antibiotic resistance patterns. Specific circumstances during the COVID-19 era may have played a role in the spread of antimicrobial resistance (AMR). This study aimed to look at the changes in AMR patterns of Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter baumannii at Al-Zahra Hospital.Materials and methods: From March 2021 to January 2023, 3651 clinical samples were collected from patients hospitalized at Isfahan's Al-Zahra Hospital. The Clinical and Laboratory Standards Institute recommended procedures for detecting gram-negative bacteria and assessing antibiotic susceptibility were used. We divided the information into three years.Results: Highest resistance rates were seen in A. baumannii to Ciprofloxacin (98.0%) and Ampicillin-Sulbactam (97.0%). For P. aeruginosa the resistance rate for Ceftazidime (36.1), Levofloxacin (37.8), and Meropenem (47.1) dropped seriously in 2022.Conclusion: During the second year of the pandemic in central Iran, all three species studied showed rising rates of AMR. This can be attributable to two peaks within Iran on May 6, 2021 and August 27, 2021. The results of this study show that P. aeruginosa, K. pneumoniae, and A. baumannii bacteria in central Iran have a higher level of antibiotic resistance than previously studied strains before the pandemic.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"39"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the Association of Aortic Stiffness and Phase Angle with the Clinical Course of Rheumatoid Arthritis. 调查主动脉僵硬度和相位角与类风湿关节炎临床病程的关系

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_250_23

Shafieh Movassaghi, Taraneh Dormohammadi Toosi, Shila Aghayani, Mahdi Barkhori Mehni, Mohammad Taghi Najafi, Mohammad Sadidi

{"title":"Investigating the Association of Aortic Stiffness and Phase Angle with the Clinical Course of Rheumatoid Arthritis.","authors":"Shafieh Movassaghi, Taraneh Dormohammadi Toosi, Shila Aghayani, Mahdi Barkhori Mehni, Mohammad Taghi Najafi, Mohammad Sadidi","doi":"10.4103/abr.abr_250_23","DOIUrl":"https://doi.org/10.4103/abr.abr_250_23","url":null,"abstract":"Background: Aortic stiffness is an independent predictor of cardiovascular events which is increased in rheumatoid arthritis (RA). It can be measured by carotid-femoral pulse wave velocity (cfPWV). Phase angle (PhA) is lower in patients with cardiovascular disease and may be informative in assessing the clinical course of RA.Materials and methods: In this observational and cross-sectional study, all RA patients referred to the Imam Khomeini Hospital rheumatology clinic between September 2022 and March 2023 were included in the study. RA activity was assessed using the DAS28 criteria. In the patients, PhA and cfPWV were measured using Inbody-s10 and PulsePen tonometer instruments. The relationships between PhA, cfPWV, clinical course of RA, and CRP were evaluated using regression analysis.Results: 53 patients were included in the study (83% female, mean age 46.5 years). Significant inverse relationships existed between PhA, CRP, and age (P value = 0.003, 0.0001, R: 0.69, respectively). People with aortic stiffness had a lower mean PhA (P value = 0.05). In patients with RA duration of less than 10 years, the cfPWV percentile and the prevalence of rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) positive cases were higher than in patients with RA duration >10 years (P values = 0.02, 0.01, respectively).Conclusions: With increasing duration of RA, aortic stiffness and positive serology cases decreased. PhA and cfPWV may be useful in assessing the clinical course of RA to prevent cardiovascular events.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"54"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Survival Prediction Model of Self-Immolation Based on Machine Learning Techniques. 基于机器学习技术的自焚生存预测模型

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_340_23

Malihe Sadeghi, Baran Bayati, Azar Kazemi, Rahime Tajvidi Asr, Mohammadjavad Sayadi

{"title":"A Survival Prediction Model of Self-Immolation Based on Machine Learning Techniques.","authors":"Malihe Sadeghi, Baran Bayati, Azar Kazemi, Rahime Tajvidi Asr, Mohammadjavad Sayadi","doi":"10.4103/abr.abr_340_23","DOIUrl":"https://doi.org/10.4103/abr.abr_340_23","url":null,"abstract":"Background: Self-immolation is one of the violent methods of suicide in developing countries. Predicting the survival of self-immolation patients helps develop therapeutic strategies. Today, machine learning is widely used in diagnosing diseases and predicting the survival of patients. This study aims to provide a model to predict the survival of self-immolation patients using machine learning techniques.Materials and methods: A retrospective cross-sectional study was conducted on 445 hospitalized self-immolated patients admitted to a burn hospital between March 2008 and 2019. Python programming language version 3.7 was used for this goal. All possible machine-learning algorithms were used. Gradient Boosting, support vector machine (SVM), random forest, multilayer perceptron (MLP), and k-nearest neighbors algorithm (KNN) were selected as the high-performance machine learning technique for survival prediction, and then they were compared by evaluation metrics such as F1 score, accuracy, sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve (AUC). Based on this comparison, the best model was reported.Results: SVM was the best algorithm. F1 score, accuracy, and AUC for this machine-learning model were 91.8%, 91.9%, and 0.96, respectively. The machine learning model results revealed that surgical procedures, score, length of stay, anatomical region, and gender obtained the most important and had more impact than other factors on patients' survival prediction.Conclusion: In this paper, machine learning algorithms were used to create a model for survival of self-immolation patients. The results of this study can be used as a model for predicting self-immolation patients' survival, better treatment management, and setting up policies and medical decision-making in burn centers.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"55"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personality Factors Associated with Burnout in the Nursing Profession during the COVID-19 Pandemic. 与 COVID-19 大流行期间护理行业职业倦怠相关的人格因素。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_156_23

Babak Masoumi, Farhad Heydari, Amir Bahador Boroumand, Mehdi Nasr Isfahani, Elham Izadi Dastgerdi, Azadeh Fereidouni Golsefidi

{"title":"Personality Factors Associated with Burnout in the Nursing Profession during the COVID-19 Pandemic.","authors":"Babak Masoumi, Farhad Heydari, Amir Bahador Boroumand, Mehdi Nasr Isfahani, Elham Izadi Dastgerdi, Azadeh Fereidouni Golsefidi","doi":"10.4103/abr.abr_156_23","DOIUrl":"https://doi.org/10.4103/abr.abr_156_23","url":null,"abstract":"Background: Occupational burnout in a pandemic situation occurs faster for some people than others. This study aimed to evaluate the relationship between personality traits and occupational burnout in nursing professionals during the COVID-19 pandemic.Materials and methods: An observational, cross-sectional study was conducted from February to April 2021. This was carried out on 299 nursing professionals who were taking care of COVID-19 cases. Occupational burnout was measured by the Maslach Burnout Inventory, and personality variables were evaluated using the NEO fivefactor inventory.Results: Finally, 299 nurses with a mean age of 35.49 ± 8.80 years participated in the study, of which 74.9% were women and 77.3% were married. The mean scores of emotional exhaustion (EE), depersonalization (DP), and personal accomplishment (PA) subscales were 20.44 ± 11.52, 8.75 ± 4.10, and 27.66 ± 5.92, respectively. High and medium DP and EE levels were reported in 75.2% and 54.9% of the nurses and high PA level was found in 87.6%. There were significant differences in job satisfaction and work experience for all burnout subscales scores. DP and EE subscales had a positive relationship with neuroticism and a negative correlation with extraversion, openness, agreeableness, and conscientiousness. The PA subscale showed a statistically significant positive relationship with extraversion, openness, agreeableness, and conscientiousness.Conclusions: The prevalence of burnout among nurses during the COVID-19 pandemic was moderate to high. The five personality characteristics were significantly associated with burnout in nurses and have a key role in developing burnout syndrome.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"53"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Regulatory Variant -108C/T in the Promoter of Paraoxonase 1 (PON1) Gene has a More Important Role in Regulating PON1 Activity Compared to rs3735590 in 3'-UTR in Patients with Coronary Artery Disease. 与冠状动脉疾病患者 3'-UTR 中的 rs3735590 相比，副氧合酶 1 (PON1) 基因启动子中的调节变异 -108C/T 在调节 PON1 活性方面具有更重要的作用。

IF 0.7

Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_391_22

Mehryar Zargari, Negar Maadi, Maysam Rezapour, Abouzar Bagheri, Samane Fallahpour, Mani Nosrati, Abdolkarim Mahrooz

{"title":"The Regulatory Variant -108C/T in the Promoter of Paraoxonase 1 (PON1) Gene has a More Important Role in Regulating PON1 Activity Compared to rs3735590 in 3'-UTR in Patients with Coronary Artery Disease.","authors":"Mehryar Zargari, Negar Maadi, Maysam Rezapour, Abouzar Bagheri, Samane Fallahpour, Mani Nosrati, Abdolkarim Mahrooz","doi":"10.4103/abr.abr_391_22","DOIUrl":"10.4103/abr.abr_391_22","url":null,"abstract":"Background: This study aimed to assess the serum activity of paraoxonase 1 (PON1) in patients with coronary artery disease (CAD) based on two genetic variants including the -108C/T variant in the promoter region and the rs3735590 variant in the binding site of miR-616 at the 3'-UTR of the PON1 gene.Materials and methods: A total of 140 subjects who exhibited clinical symptoms of CAD underwent diagnostic coronary angiography. The patients with CAD were further categorized into two groups: single-vessel disease (SVD) and multi-vessel disease (MVD). The study variants were genotyped using the restriction fragment length polymorphism (RFLP) technique after polymerase chain reaction amplification.Results: After adjusting for age, gender, body mass index, metformin, and statin usage, a significant association was observed between the -108C/T variant and PON1 activity (P < 0.001). In the sub-groups of both SVD and MVD, individuals with the TC+CC genotypes exhibited significantly higher PON1 activity compared to TT homozygotes (P = 0.001 for SVD and P = 0.01 for MVD). As for the rs3735590 variant, individuals with the A allele (GA+AA genotypes) had higher PON1 activity compared to those with the GG genotype in both the SVD and MVD groups, although the results did not reach statistical significance.Conclusions: Our study findings indicate a significant decrease in PON1 activity among patients with obstructive CAD. Notably, our results suggest that the -108C/T variant exerts a greater influence on PON1 activity compared to the rs3735590 variant. These findings highlight the crucial role of the -108C/T variant in modulating PON1 activity within the context of atherosclerosis.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"38"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0