Evaluation of CD4⁺ CD25^+/high CD127^low/- Regulatory T-Cells in Different Stages of Psoriatic Arthritis Patients.

IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Advanced biomedical research Pub Date : 2024-09-23 eCollection Date: 2024-01-01 DOI:10.4103/abr.abr_359_23

Roya Safari, Abdolhussein Shakurnia, Ata Ghadiri, Elham Rajaei, Karim Mowla, Maryam Haidari

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Abstract

Background: Psoriatic arthritis (PsA) is a systemic auto-immune condition characterized by diverse and distinctive inflammation, affecting both musculoskeletal and extra-articular systems. This study aims to investigate the role of regulatory T-cells (Tregs), specifically the CD4+CD25+/high CD127-/low subset, in PsA pathogenesis, and their potential as biomarkers and therapeutic targets.

Materials and methods: In a case-control study involving 40 PsA patients and 25 healthy individuals, CD4+ CD25+/high CD127-/low Tregs were analyzed in peripheral blood mononuclear cells (PBMCs) using flow cytometry. Disease activity was assessed using the Disease Activity in Psoriatic Arthritis (DAPSA) score.

Results: We observed a significant positive correlation between Treg levels and the DAPSA score (P = 0.02) in non-treated PsA patients. Additionally, patient age showed a significant positive correlation with erythrocyte sedimentation rate in the same group (P = 0.04), emphasizing the potential influence of Tregs on disease activity and age-related effects on inflammatory markers in PsA.

Conclusion: While not revealing significant differences in Treg populations, our research underscores the importance of considering specific Treg subsets in PsA. These subsets may respond differently to disease micro-environments and treatments, affecting disease progression. This study contributes to the broader comprehension of immune dysregulation in auto-immune diseases and suggests that further investigation into Treg subsets' function and count is warranted. Such insights may lead to more tailored therapeutic approaches for PsA patients.

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评估不同阶段银屑病关节炎患者体内的 CD4+ CD25+/high CD127low/- 调节性 T 细胞

背景：银屑病关节炎（PsA）是一种全身性自身免疫性疾病，其特征是多样化和独特的炎症，影响肌肉骨骼和关节外系统。本研究旨在探讨调节性 T 细胞（Tregs），特别是 CD4+CD25+/high CD127-/low 亚群在 PsA 发病机制中的作用，以及它们作为生物标志物和治疗靶点的潜力：在一项涉及 40 名 PsA 患者和 25 名健康人的病例对照研究中，使用流式细胞术分析了外周血单核细胞（PBMCs）中的 CD4+ CD25+/high CD127-/low Tregs。疾病活动性采用银屑病关节炎疾病活动性（DAPSA）评分进行评估：我们观察到，在未经治疗的 PsA 患者中，Treg 水平与 DAPSA 评分之间存在明显的正相关性（P = 0.02）。此外，同组患者的年龄与红细胞沉降率呈显著正相关（P = 0.04），强调了Tregs对疾病活动的潜在影响以及年龄对PsA炎症指标的相关影响：结论：我们的研究虽然没有发现 Treg 群体的明显差异，但强调了考虑 PsA 中特定 Treg 亚群的重要性。这些亚群可能会对疾病微环境和治疗做出不同的反应，从而影响疾病的进展。这项研究有助于更广泛地理解自身免疫性疾病中的免疫失调，并表明有必要进一步研究 Treg 亚群的功能和数量。这些见解可能会为PsA患者带来更有针对性的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced biomedical research

CiteScore

0.90

自引率

0.00%

发文量