Advanced biomedical research最新文献_第8页

Does Gabapentin Have A Role in the Improvement of Feeding Resistance in Infants? 加巴喷丁对改善婴儿喂养抵抗力有作用吗？

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_346_22

Hossein Saneian, Peiman Nasri, Ahmad Heydari, Ali Mohammad Sabzghabaee, Maryam Yazdi, Majid Khademian, Fatemeh Famouri

{"title":"Does Gabapentin Have A Role in the Improvement of Feeding Resistance in Infants?","authors":"Hossein Saneian, Peiman Nasri, Ahmad Heydari, Ali Mohammad Sabzghabaee, Maryam Yazdi, Majid Khademian, Fatemeh Famouri","doi":"10.4103/abr.abr_346_22","DOIUrl":"https://doi.org/10.4103/abr.abr_346_22","url":null,"abstract":"Background: Eating disorders in some infants can be due to the inability to reach a level of relaxation necessary to start the feeding process. Gabapentin (GB) has been proposed as a stabilizer of nerve function in improving this disorder. This study aimed to investigate the effect of GB on improving feeding resistance in infants aged 3-6 months.Materials and methods: This randomized, controlled, double-blind clinical trial was done on 64 infants aged 3-6 months with feeding resistance who were referred to the pediatric clinics and assigned to two groups of 32. The case group was given a dose of 5 mg/kg of GB in the first week, and if not too much sedation, it was increased to 10 mg/kg in the second week every 8 hours, whereas the control group received a placebo. The number of effective breastfeeding and the volume of formula in cc before and after 2 weeks of drug usage were recorded in both groups.Results: The number of breastfeeding sessions significantly had a higher increase in the GB group compared with placebo (median [IQR]: 1 [0,1] vs. 0 [0,1], P = 0.005) as well as an increase in consumed formula volume (mean ± SD: 42.81 ± 24.49 vs. 18.67 ± 14.57, P = 0.003).Conclusion: Considering the significant increase in formula consumption and the number of breastfeeding sessions in the GB group, it is possible to use this drug as a nerve-stabilizer and pain reducer to treat this disorder.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"61"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Growth of A549 Cell Line is Inhibited by Pemetrexed Through Up-regulation of hsa-MiR-320a Expression. 培美曲塞通过上调 hsa-MiR-320a 的表达抑制 A549 细胞株的生长。

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_483_23

Akbar Ghorbani Alvanegh, Hadi Esmaeili Gouvarchin Ghaleh, Shahla Mohammad Ganji

{"title":"The Growth of A549 Cell Line is Inhibited by Pemetrexed Through Up-regulation of hsa-MiR-320a Expression.","authors":"Akbar Ghorbani Alvanegh, Hadi Esmaeili Gouvarchin Ghaleh, Shahla Mohammad Ganji","doi":"10.4103/abr.abr_483_23","DOIUrl":"https://doi.org/10.4103/abr.abr_483_23","url":null,"abstract":"Background: Lung cancer deaths are increasing worldwide and the most common form of lung cancer treatment is chemotherapy. Pemetrexed (PMX) has been shown to be effective as a second-line treatment for advanced patients. Drugs can alter the expression of MicroRNAs, and MicroRNAs also can either enhance or reduce the drug's effectiveness and this is a two-way relationship. Hsa-MiR-320a is known to play a crucial role in the lung cancer. This study aims to investigate the expression of hsa-MiR-320a in lung cancer cells after treatment with PMX.Materials and methods: A549 cells were cultured and treated with varying concentrations of PMX. Various parameters were measured, including cell viability, reactive oxygen species (ROS) production, lactate dehydrogenase (LDH) release, apoptosis assay, caspase 3 and 7 enzyme activity, and scratch assay. Additionally, gene expression profiles of hsa-MiR-320a, VDAC1, STAT3, BAX, and BCL2 were evaluated.Results: PMX reduced the viability and increased apoptosis. After 48 h, ROS production was 3.366-fold higher than in control cells and the LDH release rate was increased by 39%. PMX also up-regulated the expression of hsa-MiR-320a by about 12-fold change.Conclusion: Changes in the expression of MicroRNAs occur after chemotherapy, and these changes play a crucial role in regulating the growth of cancer cells. Identifying these MicroRNAs can be helpful in predicting the efficacy of the chemotherapy or introducing it as combination therapy. Our research has been shown that hsa-MiR-320a can serve as a biomarker of PMX efficacy and also has the potential to be used in combination therapy.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"50"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Support Vector Machine Classification Model to Identification of Vascular Endothelial Growth Factor Receptor Inhibitors. 支持向量机分类模型在血管内皮生长因子受体抑制剂鉴定中的应用。

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_179_23

Nooshin Arabi, Mohammad Reza Torabi, Fahimeh Ghasemi

{"title":"Application of Support Vector Machine Classification Model to Identification of Vascular Endothelial Growth Factor Receptor Inhibitors.","authors":"Nooshin Arabi, Mohammad Reza Torabi, Fahimeh Ghasemi","doi":"10.4103/abr.abr_179_23","DOIUrl":"https://doi.org/10.4103/abr.abr_179_23","url":null,"abstract":"Background: Nowadays, with the increasing prevalence of cancer mortality, finding the best cancer inhibitors is vital. Angiogenesis, which refers to the formation of new blood vessels from existing ones, undergoes abnormal changes in the physiological process of solid tumors. Vascular endothelial growth factor receptor (VEGFR) plays a crucial role in angiogenesis. Hence, one of the suggestions in cancer treatment has been inhibiting VEGFR signaling to prevent angiogenesis. The computational approach as an in vitro alternative method is crucial to reduce time and cost. This study aimed to use classification algorithm to separate potent inhibitors from inactive ones.Materials and methods: In order to apply the machine learning model, biological compounds were extracted from the BindingDB database. Due to the large number of molecular features, the classification model was susceptible to overfitting. To address this issue, a correlation-based feature selection algorithm was proposed as a means of feature reduction. Subsequently, for the classification step, a support vector machine model that utilizes both linear and non-linear kernels was employed.Results: The implementation of the support vector machine model with the radial basis function kernel, along with the correlation-based feature selection method, resulted in a higher accuracy (81.8%, P value = 0.008) compared to other feature selection methods used in this study. Finally, two structures were introduced with the highest binding affinity to inhibit the second VEGFR.Conclusion: According to the results, the correlation-based feature selection method is more accurate than other methods.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"52"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relative Frequency of Gastrointestinal Functional Disorders in Patients with Inflammatory Bowel Disease Based on Rome IV: A Case-Control Study. 基于罗马IV标准的炎症性肠病患者胃肠功能紊乱的相对频率：一项病例对照研究。

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_369_23

Maryam Soheilipour, Tahereh Ghasemi Chermahini, Babak Tamizifar, Nazila Kassaian, Marzieh Rahim Khorasani, Peyman Adibi

{"title":"Relative Frequency of Gastrointestinal Functional Disorders in Patients with Inflammatory Bowel Disease Based on Rome IV: A Case-Control Study.","authors":"Maryam Soheilipour, Tahereh Ghasemi Chermahini, Babak Tamizifar, Nazila Kassaian, Marzieh Rahim Khorasani, Peyman Adibi","doi":"10.4103/abr.abr_369_23","DOIUrl":"10.4103/abr.abr_369_23","url":null,"abstract":"Background: Inflammatory bowel disease (IBD) is a digestive system ailment that causes significant bodily disruption. This problem may coexist with other digestive system illnesses. One of the diseases that reduces the quality of life and other disorders is functional dyspepsia (FD), the diagnosis of which is associated with unique limitations. In this study, we aim to investigate the relative frequency of FD in IBD patients and compare it with a healthy control group.Materials and methods: In a case-control study, we selected a group of IBD patients and healthy controls, and all participants were prepared for a diagnosis of FD symptoms using ROME IV criteria. Data were analyzed and compared using Chi-square and t-test, and P ≤ 0.05 was considered significant.Results: There were 100 IBD patients, including 91 with ulcerative colitis and 9 with Crohn's disease (mean age, 41.37 ± 13; 39 males, 61 females). Furthermore, 100 healthy control subjects (mean age, 44.23 ± 14; 38 males, 62 females) were analyzed. 10% of IBD patients met the criteria of FD, which was comparable with the controls (5, 5%) (P > 0.05). Some of the symptoms of irritable bowel syndrome (IBS) including abdominal pain (P = 0.01) and bowel movement (P = 0.02) were significantly higher in IBD patients than in non-IBD subjects.Conclusions: The symptoms of FD were not significantly greater in IBD patients compared to the control group, while IBS symptoms were significantly higher in IBD individuals, indicating a possible overlap of Rome IV IBS and FD.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"43"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling Potential Biomarkers for Urinary Tract Infection: An Integrated Bioinformatics Approach. 揭示尿路感染的潜在生物标记物：综合生物信息学方法。

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_355_23

Reza Maddah, Fahimeh Ghanbari, Maziyar Veisi, Eman Koosehlar, Marzieh Shadpirouz, Zarrin Basharat, Alireza Hejrati, Bahareh Shateri Amiri, Lina Hejrati

{"title":"Unveiling Potential Biomarkers for Urinary Tract Infection: An Integrated Bioinformatics Approach.","authors":"Reza Maddah, Fahimeh Ghanbari, Maziyar Veisi, Eman Koosehlar, Marzieh Shadpirouz, Zarrin Basharat, Alireza Hejrati, Bahareh Shateri Amiri, Lina Hejrati","doi":"10.4103/abr.abr_355_23","DOIUrl":"10.4103/abr.abr_355_23","url":null,"abstract":"Background: Urinary tract infections (UTIs) are a widespread health concern with high recurrence rates and substantial economic impact, and they can increase the prevalence of antibiotic resistance. This study employed an integrated bioinformatics approach to identify key genes associated with UTI development, offering potential targets for interventions.Materials and methods: For this study, the microarray dataset GSE124917 from the Gene Expression Omnibus (GEO) database was selected and reanalyzed. The differentially expressed genes (DEGs) between UTIs and healthy samples were identified using the LIMMA package in R software. In this section, Enrichr database was utilized to perform functional enrichment analysis of DEGs. Subsequently, the protein-protein interaction (PPI) network of the DEGs was constructed and visualized through Cytoscape, utilizing the STRING online database. The identification of hub genes was performed using Cytoscape's cytoHubba plug-in employing various methods. Receiver operating characteristic (ROC) analysis was performed to assess the diagnostic accuracy of hub genes.Results: Among the outcomes of the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the tumor necrosis factor (TNF) signaling pathway was identified as one of the notable pathways. The PPI network of the DEGs was successfully established and visualized in Cytoscape with the aid of the STRING online database. Using cytoHubba with different methods, we identified seven hub genes (STAT1, IL6, IFIT1, IFIT3, IFIH1, MX1, and IRF7). Based on the ROC analysis, all hub genes showed high diagnostic value.Conclusion: These findings provide a valuable baseline for future research aimed at unraveling the intricate molecular mechanisms behind UTI.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"44"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing the Antioxidant Activity of Alginic Acid Extracted from Sargassum Angustifolium Brown Algae Based on Optimizing the Extraction. 基于优化萃取方法提高从马尾藻中提取的海藻酸的抗氧化活性

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_491_23

Melika Kolahdoozan, Seyed Erfan Mousavi, Mohammad Sadegh Hatamipour, Afsaneh Yegdaneh

{"title":"Enhancing the Antioxidant Activity of Alginic Acid Extracted from Sargassum Angustifolium Brown Algae Based on Optimizing the Extraction.","authors":"Melika Kolahdoozan, Seyed Erfan Mousavi, Mohammad Sadegh Hatamipour, Afsaneh Yegdaneh","doi":"10.4103/abr.abr_491_23","DOIUrl":"https://doi.org/10.4103/abr.abr_491_23","url":null,"abstract":"Background: Researchers are always searching for chemicals with antioxidant properties. The cell wall polysaccharide of Sargassum angustifolium consists of alginic acid. To use this polysaccharide and investigate on its various effects, it must first be isolated from brown algae and the operational parameters of extraction need to be optimized to reach the maximum antioxidant effect.Materials and methods: The effects of changing the parameters (temperature, time, and power of ultrasonic waves) used in the extraction of alginic acid were discussed based on changes in the antioxidant effect. After that, M/G (β-D-mannuronic acid to α-L-guluronic acid ratio) was measured using 1H NMR spectra, and the antioxidant activity of the extracted alginic acid was examined using the DPPH method.Results: The highest antioxidant effect was observed in sample No. 4 with an extraction temperature of 65°C, extraction duration of 25 min, and 640 W of ultrasonication power, whereas the lowest antioxidant effect was observed in sample No. 7 at 45°C, 20 min, and 480 W.Conclusion: Structural changes due to increasing temperature may cause less activity, whereas the optimum temperature was 65°C. There was no direct relationship between M/G and IC50, and it should be examined along with molecular weight. Increasing the intensity of the waves increased the antioxidant activity. The extraction yield can be increased by increasing A/W (Gram of algal sample per mL of solvent). It appears that the extraction under optimum conditions enhances the MM block epimer, which may lead to an increase in the antioxidant activity.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"49"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nystatin Encapsulated Nanoliposomes: Potential Anti-infective against Candida Spp. Isolated from Candidiasis Patients. 奈司他丁包裹纳米脂质体：从念珠菌病患者身上分离出的潜在抗感染药物从念珠菌病患者中分离的念珠菌的潜在抗感染作用。

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_65_23

Mehrdad Asadi, Attabak Toofani-Milani, Katayoun Bahman Soufiani

{"title":"Nystatin Encapsulated Nanoliposomes: Potential Anti-infective against Candida Spp. Isolated from Candidiasis Patients.","authors":"Mehrdad Asadi, Attabak Toofani-Milani, Katayoun Bahman Soufiani","doi":"10.4103/abr.abr_65_23","DOIUrl":"https://doi.org/10.4103/abr.abr_65_23","url":null,"abstract":"Background: Due to the pathogenic role of opportunistic fungi in immunodeficiency patients, many efforts have been made for developing effective treatment strategies to augment current practice standards. Nystatin, as one of the treatment candidates, is characterized by antifungal effects. In this study, we tried to use liposomal formulation as a nystatin carrier to increase its antifungal efficacy.Materials and methods: A total of 87 positive culture samples of yeast agents were applied to the study. Yeast species were identified by culturing on CHROMagar medium (HiMEDIA), culturing on NigerSide agar medium, and Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Characterization of nanoparticles was examined by the size, zeta potential (ZP), scanning electron microscope (SEM), drug loading, and drug release rate. The standard method of broth microdilution according to CLSI M27-A and the quality control standard of Candida parapsilosis ATCC 22019 were used to evaluate the minimum inhibitory concentration (MIC) of nystatin and nystatin nanoliposomes.Results: The particle size for liposomes containing nystatin was 100.8 ± 17.3 nm. Moreover, the ZP for liposomal formulation of nystatin was 21.14 ± 0.92 -mV. The formulation of nystatin in nanoparticles markedly increased the susceptibility of Candida species to nystatin at lower doses, which was statistically significant compared to free nystatin (P ≤ 0.05).Conclusion: Our results showed that liposomal formulation improves the efficiency of nystatin against albicans species. This formulation can be used to develop new antifungal agents to improve the delivery and absorption of hydrophobic drugs.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"56"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Long- and Short-Term Outcomes of Hysteroscopic Polypectomy in Patients with Uterine Polyps. 子宫息肉患者宫腔镜息肉切除术的长期和短期疗效评估

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_66_23

Maryam Hashemi, Elham S Madani, Ataallah Ghahiri, Mohammad J Tarrahi, Safoura Rouholamin

{"title":"Assessment of Long- and Short-Term Outcomes of Hysteroscopic Polypectomy in Patients with Uterine Polyps.","authors":"Maryam Hashemi, Elham S Madani, Ataallah Ghahiri, Mohammad J Tarrahi, Safoura Rouholamin","doi":"10.4103/abr.abr_66_23","DOIUrl":"https://doi.org/10.4103/abr.abr_66_23","url":null,"abstract":"Background: Polyps are a common diagnosis in women of different ages. They can cause a variety of symptoms from bleeding to infertility and can even be the progenitor for malignancies.Materials and methods: This was a retrospective cohort study conducted in Isfahan. A total of 1004 patients were included in this study. After hysteroscopic polypectomy, patients had their information regarding the complications and recurrence recorded.Results: Symptoms improved in 639 (63.8%). Recurrence of polyps was seen in 143 (14.2%) patients. A total of 170 had a successful pregnancy, with 110 of them spontaneous. Using scissors had lower recurrence compared to graspers. Eight cases had complications during the treatment, two of which were major.Conclusion: Hysteroscopic polypectomy is the treatment of choice for uterine polyps. We show hysteroscopic polypectomy to have a high success rate and a low complications rate, with polypectomies done using scissors to have lower risk of complications or recurrence compared to graspers.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"57"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors and Prevalence of Persistent Pain after Total Knee Arthroplasty in One-Year Follow-up. 全膝关节置换术后一年随访中持续疼痛的预测因素和发生率

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_339_23

Mehdi Motifi Fard, Seyyed Mahdi Jazaiery, Milad Ghaderi, Hadi Ravanbod, Amir Mohammad Taravati, Koushan Rostami, Seyedeh Ghazal Shahrokh

{"title":"Predictors and Prevalence of Persistent Pain after Total Knee Arthroplasty in One-Year Follow-up.","authors":"Mehdi Motifi Fard, Seyyed Mahdi Jazaiery, Milad Ghaderi, Hadi Ravanbod, Amir Mohammad Taravati, Koushan Rostami, Seyedeh Ghazal Shahrokh","doi":"10.4103/abr.abr_339_23","DOIUrl":"https://doi.org/10.4103/abr.abr_339_23","url":null,"abstract":"Background: Total knee arthroplasty (TKA) is one of the most common surgeries performed to reduce pain and disability in knee arthritis. Comprehension of the etiology and prevalence of persistent postoperative knee pain can help reduce this pain and identify the predictive factors leading to it. This study aimed to investigate the predictive factors and the prevalence of persistent pain after total knee arthroplasty in one-year follow-up.Materials and methods: This was a prospective cohort study. Demographic data including age, sex, body mass index (BMI), hospital anxiety and depression scale (HADS), and comorbidities were collected. In 242 patients, preoperative and postoperative Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores were measured before and immediately after surgery and in 3-, 6-, and 12-month intervals during follow-up. Loosening of the prosthesis was also investigated by radiographic imaging in every postoperative visit.Result: WOMAC pain decreased from a mean (standard deviation) of 49 before surgery to 18 at 6 months and 13 at 12 months. Despite this, the prevalence of moderate-to-severe persistent postoperative pain (PPP) was 13.22% (n = 32) and 9.09% (n = 22) at 6 and 12 months lower preoperative WOMAC (odd's ratio:2.8), loosening of the prosthesis (odd's ratio:1.9), higher HADS (odd's ratio:2.1) were main predictors for PPP in TKA patients as in rheumatoid arthritis (odd's ratio:1.2).Conclusion: Loosening of the prosthesis and higher preoperative WOMAC scores are key factors in persistent post-TKA pain. Depression and anxiety are more popular among patients with more pain after TKA. RA is more prevalent in patients with PPP after TKA.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"59"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11478738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Relationship between the Severity of Pelvic Organ Prolapse and Female Sexual Function. 评估骨盆器官脱垂的严重程度与女性性功能之间的关系。

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Advanced biomedical research Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI: 10.4103/abr.abr_371_22

Soodabeh Darvish, Farzaneh Rashidi Fakari, Nina Khodadadi Ashka, Azadeh Mazaheri

{"title":"Evaluation of the Relationship between the Severity of Pelvic Organ Prolapse and Female Sexual Function.","authors":"Soodabeh Darvish, Farzaneh Rashidi Fakari, Nina Khodadadi Ashka, Azadeh Mazaheri","doi":"10.4103/abr.abr_371_22","DOIUrl":"10.4103/abr.abr_371_22","url":null,"abstract":"Background: Genital prolapse is one of the main health problems in women that affects various aspects of women's lives. This study aimed to investigate the relationship between pelvic prolapse and female sexual function.Materials and methods: This cross-sectional study was performed on a random sample of married women (96 patients) referred to two university hospitals of Shahid Beheshti University of Medical Sciences. To determine the score of sexual activity, a female sexual function questionnaire was used, which included 19 questions and five linked options. The severity of pelvic organ prolapses (POPs) and the type of prolapse were determined by clinical examination by a female resident based on the POP Quantification (POP-Q) classification system. The results were analyzed with descriptive statistical tests, Pearson's correlation, and one-way analysis of variance with Statistical Package for the Social Sciences (SPSS) version 24 software.Results: About 54.2% (N = 52) of the studied women were over 40 years old, 59.3% (N = 57) had two births, and the type of delivery was normal for more than 83.4% (N = 80) of them. Cystocele and rectocele with a frequency of 66.6% (N = 64) were the most common types of prolapse observed in the studied women. 44.8% (N = 43) of the studied women had stage 2 prolapse. The results of the one-way analysis of variance showed a statistically significant relationship between the average score of sexual activity and the stage of prolapse (P < 0.001).Conclusions: Increased severity of prolapse leads to decreased sexual activity in women.","PeriodicalId":94292,"journal":{"name":"Advanced biomedical research","volume":"13 ","pages":"41"},"PeriodicalIF":0.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0