Singapore medical journal最新文献

{"title":"Management of anaemia in critically ill adults.","authors":"Isaac Kah Siang Ng, Clarice Choong, Shir Lynn Lim, Kay Choong See","doi":"10.4103/singaporemedj.SMJ-2024-005","DOIUrl":"10.4103/singaporemedj.SMJ-2024-005","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 5","pages":"283-290"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A person-centred Healthier SG outcomes framework.","authors":"Simon Jian Chong Ong, Grace Shu Hui Chiang, Chirk Jenn Ng, Wei Mon Wong, Eng Sing Lee, Kheng Hock Lee, Sabrina Kw Wong, José M Valderas, Boon Yeow Tan","doi":"10.4103/singaporemedj.SMJ-2025-074","DOIUrl":"10.4103/singaporemedj.SMJ-2025-074","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 5","pages":"232-234"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and sedentary time distribution among adult residents during COVID-19 circuit breaker movement restrictions in Singapore: a public health perspective.","authors":"Swarup Mukherjee, Kang Jin Tan","doi":"10.4103/singaporemedj.SMJ-2022-113","DOIUrl":"10.4103/singaporemedj.SMJ-2022-113","url":null,"abstract":"<p><strong>Introduction: </strong>Social lockdowns and quarantines have been enforced in various populations to mitigate the spread of coronavirus disease 2019 (COVID-19) in the community. This study investigated the impact of COVID-19 lockdown, known as circuit breaker movement restrictions (CBMR), on physical activity (PA) and sedentary time (ST) distribution patterns among Singapore residents aged 21-65 years.</p><p><strong>Methods: </strong>This was a cross-sectional retrospective study that utilised a 44-item questionnaire that included sections to determine PA and ST distribution patterns before and during CBMR. It also included information on sleep duration, PA preference and routine, awareness of local initiatives and perceptions on barriers towards PA during the CBMR period.</p><p><strong>Results: </strong>There was an overall decrease in PA and a significant increase in physical inactivity and ST during the CBMR period. A greater proportion of participants reported sleeping for longer hours, suggesting positive adaptations in sleep habits during CBMR. Majority were unaware of online exercise initiatives and programmes offered during the CBMR period, and >50% of the respondents never used an online resource for exercise. Singapore residents seemed to prefer outdoor and facility-based venues for exercise and PA, and closure of facilities was the primary barrier for PA during the CBMR period.</p><p><strong>Conclusion: </strong>Reduced PA and increased ST during CBMR reflect negative lifestyle adaptations and may have adverse public health implications. Increased sleep duration suggests successful coping, which may consequently lead to physical and mental health benefits. While Singapore adult residents may be flexible with certain aspects of being physically active, they seemed less adaptive to changes in type of exercise, facility and environment.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":"265-270"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49695736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World Family Doctor's Day reflection: how family medicine is building a sustainable healthcare system in Singapore.","authors":"Yang Luo, Kai Ping Sze, Chirk Jenn Ng, Andrew Fu Wah Ho","doi":"10.4103/singaporemedj.SMJ-2025-093","DOIUrl":"10.4103/singaporemedj.SMJ-2025-093","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 5","pages":"228-229"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The skinny on 'keto': the low-carb, high-fat diet everyone is talking about.","authors":"Wan Xing Michelle Ch'ng, Mark Chung Wai Ng","doi":"10.4103/singaporemedj.SMJ-2022-146","DOIUrl":"10.4103/singaporemedj.SMJ-2022-146","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 5","pages":"278-282"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis on the latest international and local guidelines for the management of hypertension.","authors":"Aloysius Sheng-Ting Leow, Ashish Anil Sule, Jam Chin Tay, Hui Hwang Teong, Wai Lun Moy, Pankaj Kumar Handa, Yik Tian Wu, Veerendra Melagireppa Chadachan, Vernon Min Sen Oh, Ching-Hui Sia, Kian-Keong Poh, Boon Wee Teo, Troy H Puar","doi":"10.4103/singaporemedj.SMJ-2025-094","DOIUrl":"10.4103/singaporemedj.SMJ-2025-094","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":"66 5","pages":"240-243"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12161640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144096722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anaemia in pregnancy: can we improve care?","authors":"Yang Xuan Cassandra Ang, Stella Rizalina Sasha Sugianto, Desiree Yu Ting Yen, Monica Shi Qi Chua, Kai Zhi Ong, Shu Qi Tan","doi":"10.4103/singaporemedj.SMJ-2024-013","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2024-013","url":null,"abstract":"<p><strong>Introduction: </strong>Maternal anaemia is the most common condition in pregnancy. It has profound consequences for both the mother and child, despite being easily treatable with iron supplementation. Our study aimed to investigate its prevalence, risk factors, and the current compliance to screening and treatment.</p><p><strong>Methods: </strong>Women who delivered a baby between 1 October 2019 and 31 December 2019 at KK Women's and Children's Hospital, Singapore, were included. Haemoglobin levels at booking, 24-28 weeks and delivery were analysed. The frequency of treatment with iron supplementation or blood transfusion was also evaluated. Patient demographics were analysed using descriptive statistical methods, while Pearson's chi-square test was used for analyses of proportions.</p><p><strong>Results: </strong>The prevalence of maternal anaemia at the time of delivery was 17.2%. Significant risk factors included receiving subsidised healthcare (associated with lower socioeconomic status), teenage pregnancy, multiparity, Indian ethnicity, thalassaemia and antepartum haemorrhage (P < 0.05). Compliance to screening was 62.8% at 24-28 weeks. Only 38.4% of women with anaemia at booking and 74.9% with anaemia at 24-28 weeks were prescribed oral iron. A total of 11.2% of women with maternal anaemia received intravenous iron. The mean haemoglobin level of women who received blood transfusion was 8.3 g/dL, which may not have been appropriate.</p><p><strong>Conclusion: </strong>Institutions should create guidelines to standardise the screening and treatment of maternal anaemia and conduct regular audits to monitor their implementation. We recommend a multi-pronged strategy targeting prevention, routine screening, and appropriate treatment of maternal anaemia.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convalescent plasma for the treatment of patients with COVID-19: the Singapore experience and lessons learnt.","authors":"Jun Yang Tay, Sharavan Sadasiv Mucheli, Bingwen Eugene Fan, Sing-Zern Fong, Chek Kia Boo, Ying Ding, Wanni Chia, Chee Wah Tan, Barnaby Young, Poh Lian Lim, Yee Sin Leo, Suma Rao, Ai Leen Ang, Allison Tso, Venkata Sreekanth Sampath, Stephrene Seok Wei Chan, Ponnudurai Kuperan, Christopher Dheepa, Wah Wah Say Naw, Ah Eng Ang, Connie Siew Ping Chen, Laurence Sandig, David Lye, Lin-Fa Wang, Kiat Hoe Ong, Shawn Vasoo","doi":"10.4103/singaporemedj.SMJ-2024-089","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2024-089","url":null,"abstract":"<p><strong>Introduction: </strong>We report Singapore's convalescent plasma (CP) programme during the first year of the COVID-19 pandemic. Based on historical data and its potential therapeutic promise, CP was offered as an experimental treatment option for severe or high-risk COVID-19 patients when established therapeutics were lacking.</p><p><strong>Methods: </strong>The CP programme was implemented under monitored expanded access approved by Singapore's Ministry of Health. CP donors were primarily selected based on specific antibody titres, while suitable recipients were chosen based on risk factors and disease severity. Operational protocols and logistical considerations are discussed in-depth.</p><p><strong>Results: </strong>Between April 2020 and September 2020, the CP donor programme successfully collected 33 plasma units from 27 qualified donors. Seven patients received CP treatment under this programme. Six of the seven recipients of CP survived for more than 28 days post-transfusion and were discharged alive. Given the availability of other validated therapeutic options, the CP programme was officially suspended in September 2021.</p><p><strong>Conclusion: </strong>This study provides a comprehensive overview of the intricacies of Singapore's CP programme, from its operational challenges to the observed clinical outcomes, while highlighting the potential benefits and complexities of CP as a therapeutic option. Successful implementation of the CP programme requires robust collaboration across multidisciplinary teams. Access to serological tests was crucial for donor selection. Both the selection of CP with high neutralising antibodies and careful selection of appropriate recipients are key aspects to optimise the therapeutic success of CP. A meticulous approach is warranted if CP were to be used in future pandemics.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oncofertility care and fertility preservation in gynaecological cancer: experience from Singapore's largest tertiary centre.","authors":"Qiu Ju Ng, Tat Xin Ee, Charissa Shu Ying Goh, Shi Hui Lee, Jasmine Earn Huay Low, Jinlin Lin, Jessie Wai Leng Phoon, Jack Junjie Chan, Felicia Hui Xian Chin","doi":"10.4103/singaporemedj.SMJ-2024-094","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2024-094","url":null,"abstract":"<p><strong>Introduction: </strong>Fertility-sparing management is an option for young patients with gynaecological cancers, conferring comparable oncological and favourable reproductive outcomes as standard treatment. With delayed childbearing, the need for fertility-sparing treatment and demand for fertility preservation have increased. We describe the development of an oncofertility model of care at a tertiary hospital, along with our experiences.</p><p><strong>Methods: </strong>This was a retrospective audit of patients who attended the OncoFertility Clinic, KK Women's and Children's Hospital, Singapore, from 9 September 2020 to 9 March 2023, focusing on the epidemiology and short-term outcomes.</p><p><strong>Results: </strong>A total of 144 women (median age 31 years) attended the OncoFertility Clinic, of whom 69 (47.9%) had uterine conditions, 65 (45.1%) had ovarian conditions, six (4.2%) had cervical conditions and four (2.8%) had synchronous uterine and ovarian conditions. Among the 45 women on fertility-sparing management for endometrial cancer, 66.7% had complete regression, 11.1% had persistent carcinoma and 22.2% regressed to endometrial hyperplasia. Fourteen women underwent in vitro fertilisation (IVF), resulting in three live births and one miscarriage. Thirty-two women had ovarian cancer, 23 had borderline ovarian tumours, one had Krukenberg tumour and nine had benign ovarian tumours. Fertility-sparing surgery was performed in 90.6% of the ovarian cancer cases. Fertility preservation was offered to twenty women, four of whom proceeded with fertility-preserving procedures. Three patients underwent assisted reproductive therapy. Four patients had surgery for suspected recurrences, but histologies were benign.</p><p><strong>Conclusion: </strong>A multidisciplinary OncoFertility Clinic provides comprehensive counselling for young women with gynaecological cancers or precancers, addresses their reproductive health concerns, supports their decision-making and ensures timely access to fertility services.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Convalescent plasma: is there still a role in the treatment of COVID-19?","authors":"Sophie Seine Xuan Tan, Thuan Tong Tan","doi":"10.4103/singaporemedj.SMJ-2024-197","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2024-197","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}