发布求助
文献互助 智能选刊 最新文献

Singapore medical journal最新文献

筛选
英文 中文
HER2-low breast cancers: challenges in the interpretation of immunohistochemistry. 低 HER2 乳腺癌：解读免疫组化的挑战。
Singapore medical journal Pub Date : 2024-03-13 DOI: 10.4103/singaporemedj.SMJ-2023-037
Noel Chia, Mihir Ananta Gudi, Emad Rakha, Puay Hoon Tan
{"title":"HER2-low breast cancers: challenges in the interpretation of immunohistochemistry.","authors":"Noel Chia, Mihir Ananta Gudi, Emad Rakha, Puay Hoon Tan","doi":"10.4103/singaporemedj.SMJ-2023-037","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2023-037","url":null,"abstract":"<p><strong>Abstract: </strong>Overexpression of human epidermal growth factor receptor 2 (HER2) protein in breast cancers carries significant prognostic and therapeutic implications. Anti-HER2 blockade has shown to be a useful adjunct to surgery in treating HER2-positive tumours. Up till today, the HER2 immunohistochemistry (IHC) and in situ hybridisation (ISH) scoring algorithms are geared towards identifying HER2-positive cases. A recently published Phase III clinical trial (DESTINY-Breast04) has demonstrated that an antibody-drug conjugate (trastuzumab-deruxtecan) significantly reduced disease progression and death in patients with metastatic disease with IHC score 1+ or 2+ and without ISH amplification, defining a new category of cases known as HER2 low. At present, IHC scores 0, 1+ and 2+ show significant interobserver variability, and identifying HER2-low breast cancers may pose significant challenges with the current algorithms. More work is needed in this area to better define HER2-low breast cancers, target the appropriate group of patients and assess treatment efficacy.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical outcomes of variceal and non-variceal upper gastrointestinal bleeding in cirrhosis patients in Singapore. 新加坡肝硬化患者静脉曲张性和非静脉曲张性上消化道出血的临床结果。
Singapore medical journal Pub Date : 2024-03-06 DOI: 10.4103/singaporemedj.SMJ-2023-046
Garrett Kang, Le Shaun Ang, Wen Hui Leia Teo, Yu Wei Cheryl Huang, Venkataraman Narayan, Andrew Boon Eu Kwek, Tiing Leong Ang, Yu Jun Wong
{"title":"Clinical outcomes of variceal and non-variceal upper gastrointestinal bleeding in cirrhosis patients in Singapore.","authors":"Garrett Kang, Le Shaun Ang, Wen Hui Leia Teo, Yu Wei Cheryl Huang, Venkataraman Narayan, Andrew Boon Eu Kwek, Tiing Leong Ang, Yu Jun Wong","doi":"10.4103/singaporemedj.SMJ-2023-046","DOIUrl":"https://doi.org/10.4103/singaporemedj.SMJ-2023-046","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prehospital stroke care in Singapore. 新加坡的院前中风护理。
Singapore medical journal Pub Date : 2024-03-06 DOI: 10.4103/singaporemedj.SMJ-2023-066
Timothy Jia Rong Lam, Zhenghong Liu, Benjamin Yong-Qiang Tan, Yih Ying Ng, Colin Kaihui Tan, Xiang Yi Wong, Narayanaswamy Venketasubramanian, Leonard Leong Litt Yeo, Andrew Fu Wah Ho, Marcus Eng Hock Ong
{"title":"Prehospital stroke care in Singapore.","authors":"Timothy Jia Rong Lam, Zhenghong Liu, Benjamin Yong-Qiang Tan, Yih Ying Ng, Colin Kaihui Tan, Xiang Yi Wong, Narayanaswamy Venketasubramanian, Leonard Leong Litt Yeo, Andrew Fu Wah Ho, Marcus Eng Hock Ong","doi":"10.4103/singaporemedj.SMJ-2023-066","DOIUrl":"10.4103/singaporemedj.SMJ-2023-066","url":null,"abstract":"<p><strong>Abstract: </strong>Due to the narrow window of opportunity for stroke therapeutics to be employed, effectiveness of stroke care systems is predicated on the efficiency of prehospital stroke systems. A robust prehospital stroke system of care that provides a rapid and well-coordinated response maximises favourable poststroke outcomes, but achieving this presents a unique set of challenges dependent on demographic and geographical circumstances. Set in the context of a highly urbanised first-world nation with a rising burden of stroke, Singapore's prehospital stroke system has evolved to reflect the environment in which it operates. This review aims to characterise the current state of prehospital stroke care in Singapore, covering prehospital aspects of the stroke survival chain from symptom onset till arrival at the emergency department. We identify areas for improvement and innovation, as well as provide insights into the possible future of prehospital stroke care in Singapore.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fitness to drive after trigger or carpal tunnel release surgery: perceptions of patients versus clinicians. 扳机或腕管松解手术后的驾驶能力：患者与临床医生的看法。
Singapore medical journal Pub Date : 2024-03-06 DOI: 10.4103/singaporemedj.SMJ-2021-424
Camelia Qian Ying Tang, Sean Han Sheng Lai, Ellen Yutan Lee, Anthony Foo, Alphonsus Khin Sze Chong
{"title":"Fitness to drive after trigger or carpal tunnel release surgery: perceptions of patients versus clinicians.","authors":"Camelia Qian Ying Tang, Sean Han Sheng Lai, Ellen Yutan Lee, Anthony Foo, Alphonsus Khin Sze Chong","doi":"10.4103/singaporemedj.SMJ-2021-424","DOIUrl":"10.4103/singaporemedj.SMJ-2021-424","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical use cases in artificial intelligence: current trends and future opportunities. 人工智能的临床应用案例：当前趋势与未来机遇。
Singapore medical journal Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.4103/singaporemedj.SMJ-2023-193
Cher Heng Tan, Wilson Wen Bin Goh, Jimmy Bok Yan So, Joseph J Y Sung
{"title":"Clinical use cases in artificial intelligence: current trends and future opportunities.","authors":"Cher Heng Tan, Wilson Wen Bin Goh, Jimmy Bok Yan So, Joseph J Y Sung","doi":"10.4103/singaporemedj.SMJ-2023-193","DOIUrl":"10.4103/singaporemedj.SMJ-2023-193","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to artificial intelligence in medicine. 医学人工智能入门。
Singapore medical journal Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.4103/singaporemedj.SMJ-2024-060
Joseph J Y Sung
{"title":"Introduction to artificial intelligence in medicine.","authors":"Joseph J Y Sung","doi":"10.4103/singaporemedj.SMJ-2024-060","DOIUrl":"10.4103/singaporemedj.SMJ-2024-060","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060645/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ethics of artificial intelligence in medicine. 人工智能医学伦理。
Singapore medical journal Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.4103/singaporemedj.SMJ-2023-279
Julian Savulescu, Alberto Giubilini, Robert Vandersluis, Abhishek Mishra
{"title":"Ethics of artificial intelligence in medicine.","authors":"Julian Savulescu, Alberto Giubilini, Robert Vandersluis, Abhishek Mishra","doi":"10.4103/singaporemedj.SMJ-2023-279","DOIUrl":"10.4103/singaporemedj.SMJ-2023-279","url":null,"abstract":"<p><strong>Abstract: </strong>This article reviews the main ethical issues that arise from the use of artificial intelligence (AI) technologies in medicine. Issues around trust, responsibility, risks of discrimination, privacy, autonomy, and potential benefits and harms are assessed. For better or worse, AI is a promising technology that can revolutionise healthcare delivery. It is up to us to make AI a tool for the good by ensuring that ethical oversight accompanies the design, development and implementation of AI technology in clinical practice.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erectile dysfunction: assessment and management in primary care. 勃起功能障碍：初级保健中的评估与管理。
Singapore medical journal Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.4103/singaporemedj.SMJ-2022-101
Yingxian Natalie Ong, Yu Guang Tan, Dian Handayani, Choon How How
{"title":"Erectile dysfunction: assessment and management in primary care.","authors":"Yingxian Natalie Ong, Yu Guang Tan, Dian Handayani, Choon How How","doi":"10.4103/singaporemedj.SMJ-2022-101","DOIUrl":"10.4103/singaporemedj.SMJ-2022-101","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
'Slowing down when you should': optimising the translation of artificial intelligence into medical school curricula. 该慢下来时就慢下来"：优化人工智能在医学院课程中的转化。
Singapore medical journal Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.4103/singaporemedj.SMJ-2023-190
Simon Kitto, Yih Yng Ng, Jennifer Cleland
{"title":"'Slowing down when you should': optimising the translation of artificial intelligence into medical school curricula.","authors":"Simon Kitto, Yih Yng Ng, Jennifer Cleland","doi":"10.4103/singaporemedj.SMJ-2023-190","DOIUrl":"10.4103/singaporemedj.SMJ-2023-190","url":null,"abstract":"","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical education and physician training in the era of artificial intelligence. 人工智能时代的医学教育和医生培训。
Singapore medical journal Pub Date : 2024-03-01 Epub Date: 2024-03-26 DOI: 10.4103/singaporemedj.SMJ-2023-203
Yueyuan Xu, Zehua Jiang, Daniel Shu Wei Ting, Alfred Wei Chieh Kow, Fernando Bello, Josip Car, Yih-Chung Tham, Tien Yin Wong
{"title":"Medical education and physician training in the era of artificial intelligence.","authors":"Yueyuan Xu, Zehua Jiang, Daniel Shu Wei Ting, Alfred Wei Chieh Kow, Fernando Bello, Josip Car, Yih-Chung Tham, Tien Yin Wong","doi":"10.4103/singaporemedj.SMJ-2023-203","DOIUrl":"10.4103/singaporemedj.SMJ-2023-203","url":null,"abstract":"<p><strong>Abstract: </strong>With the rise of generative artificial intelligence (AI) and AI-powered chatbots, the landscape of medicine and healthcare is on the brink of significant transformation. This perspective delves into the prospective influence of AI on medical education, residency training and the continuing education of attending physicians or consultants. We begin by highlighting the constraints of the current education model, challenges in limited faculty, uniformity amidst burgeoning medical knowledge and the limitations in 'traditional' linear knowledge acquisition. We introduce 'AI-assisted' and 'AI-integrated' paradigms for medical education and physician training, targeting a more universal, accessible, high-quality and interconnected educational journey. We differentiate between essential knowledge for all physicians, specialised insights for clinician-scientists and mastery-level proficiency for clinician-computer scientists. With the transformative potential of AI in healthcare and service delivery, it is poised to reshape the pedagogy of medical education and residency training.</p>","PeriodicalId":94289,"journal":{"name":"Singapore medical journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060639/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140290120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信