Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES最新文献

{"title":"Risk factors for conversion from laparoscopic appendectomy to open appendectomy: A retrospective analysis of single-center experience.","authors":"Cengiz Ceylan, İsa Elbistan, Bora Barut","doi":"10.14744/tjtes.2025.36423","DOIUrl":"https://doi.org/10.14744/tjtes.2025.36423","url":null,"abstract":"<p><strong>Background: </strong>Acute appendicitis (AA) is one of the most common causes of surgical acute abdomen. Currently, laparoscopic appendectomy (LA) is the most frequently preferred surgical approach. As with all laparoscopic procedures, the possibility of conversion to open surgery also exists in LA. This study aims to identify the risk factors associated with conversion to open appendectomy (OA) during the laparoscopic management of AA.</p><p><strong>Methods: </strong>This retrospective case-control study included 445 patients who underwent LA for AA between 2018 and 2023. Patients were divided into two groups based on whether conversion to OA was required during the laparoscopic procedure. Preoperative demographic, clinical, and perioperative data were evaluated. Both univariate and multivariate analyses were performed.</p><p><strong>Results: </strong>The median age of the 445 patients included in the study was 34 years (interquartile range: 25-49). Of these, 58.2% were male. The overall conversion rate to open surgery was 3.8%. In univariate analyses, factors such as age (p=0.002), the American Society of Anesthesiologists (ASA) score (p=0.011), time of arrival at the emergency department (p<0.001), C-reactive protein (CRP) level (p<0.001), amylase level (p=0.012), Malatya Complicated Appendicitis Prediction Score (MCAPS) ≥6 (p<0.001), and presence of complicated appendicitis (p<0.001) were associated with conversion. However, in multivariate analyses, only an MCAPS score of 6 or higher (p=0.034) was identified as an independent risk factor for conversion.</p><p><strong>Conclusion: </strong>Since conversion to OA is sometimes unavoidable in the management of AA, clinicians may benefit from using the easily applicable MCAPS to predict the likelihood of conversion. This scoring system may also assist in considering primary OA when appropriate.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 4","pages":"365-370"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of autopsy cases involving foreign nationals at the Erzurum Forensic Medicine Group, Presidency of the Forensic Medicine Institute between 2016 and 2021.","authors":"Abdulkadir Sancı, Ahmet Nezih Kök, Mustafa Talip Şener","doi":"10.14744/tjtes.2025.23483","DOIUrl":"https://doi.org/10.14744/tjtes.2025.23483","url":null,"abstract":"<p><strong>Background: </strong>Individuals who are not citizens of a country are defined as foreigners, whereas those with citizenship ties are referred to as nationals. In cases where a foreign national dies in our country, a death certificate is issued by the director of the relevant institution if the death occurs in a public health facility, or by the attending physician in a private health institution. In cases of forensic or suspicious deaths, necropsy and autopsy procedures are conducted in accordance with the Code of Criminal Procedure and the circular issued by the High Council of Judges and Prosecutors. Based on the circumstances of the incident, a notification form is forwarded to the relevant consulates and the Ministry of Foreign Affairs. Data on the deaths of foreign nationals are crucial for understanding the demographic characteristics and causes of death within the foreign population. This study aimed to evaluate the deaths of foreign nationals within a geographical and socioeconomic context, to generate scientific data and identify potentially preventable causes of death.</p><p><strong>Methods: </strong>This study retrospectively analyzed autopsy reports of foreign nationals who underwent examination at the Morgue Specialization Department of the Erzurum Group Directorate of the Forensic Medicine Institute between 2016 and 2021.</p><p><strong>Results: </strong>A total of 90 cases were analyzed. Of these, 92% (n=83) were male, and 65.5% (n=59) were in the young to middle-aged group. The mean age was 34.1 years, and 78.8% (n=71) of the individuals were from Central Asia. The causes of death were as follows: diseases in 28.8% (n=26) of cases, traffic accidents in 16.6% (n=15), and hypothermia in 14.4% (n=13). The rate of negative autopsy findings, where no definitive cause of death could be determined due to advanced decomposition, was 5.5% (n=5).</p><p><strong>Conclusion: </strong>The majority of autopsied deaths of foreign nationals were determined to be due to traumatic causes and occurred outside their country of origin, highlighting the fatal consequences of migration-related mobility. In cases involving the deaths of foreign nationals, the provisions of the Vienna Convention on Consular Relations should be observed, death notifications should be properly processed, and biological samples should be preserved for identification purposes.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 4","pages":"350-357"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-center experiences with a novel method for preoperative localization of thoracic spine lesions using computed tomography-guided pedicular spinal needle placement.","authors":"Ali Rıza Güvercin, Mehmet Orbay Bıyık, Mehmet Aktoklu, Uğur Yazar, Ertuğrul Çakır","doi":"10.14744/tjtes.2025.82844","DOIUrl":"https://doi.org/10.14744/tjtes.2025.82844","url":null,"abstract":"<p><strong>Objective: </strong>Thoracic level localization in the treatment of thoracic spine problems is more challenging than other spinal regions. The purpose of this study was to prove the reliability of pedicular spinal needle placement under computed tomography guidance before thoracic spine surgery and to reduce the margin of error, surgery time and operating room radiation exposure during thoracic spine and spinal cord surgery.</p><p><strong>Methods: </strong>Fourteen patients undergoing posterior aproach to the thoracic spine and/or spinal cord related lesions were investigated. Spinocaths were placed under CT guidance, into the pedicle of the relevant vertebra, at the same day or the night before surgery. The surgical field is prepared as usual, and a spinocath is placed to the relevant thoracic pedicle under CT guidance.</p><p><strong>Results: </strong>Intraoperative level localization was more reliable and easier in patients undergoing preoperative CT-guided marking in surgeries on the thoracic region performed for various reasons. Shorter preoperative preparation and intraoperative anesthesia times, a decrease in number of fluoroscopic images taken intraoperatively, and no spinal mislocalizations were observed.</p><p><strong>Conclusion: </strong>The results obtained suggest that localising the level with preoperative CT before all types of thoracic surgery is a safe, reliable, and useful method for thoracic spine surgery.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 4","pages":"371-374"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of rosmarinic acid on red blood cell deformability, morphology, and nitric oxide in rat lower limb skeletal muscle ischemia-reperfusion injury.","authors":"Celalettin Günay, Hakan Kartal, Ertan Demirbaş, Bilgehan Savaş Öz, Şahin Kaymak, Faruk Metin Çomu, Gökhan Erol, Gökhan Arslan, Tayfun Özdem, Tuna Demirkıran, Muharrem Emre Özdaş, Işıl Taşöz Özdaş, Yiğit Tokgöz, Veli Can Özdemir","doi":"10.14744/tjtes.2025.25590","DOIUrl":"https://doi.org/10.14744/tjtes.2025.25590","url":null,"abstract":"<p><strong>Background: </strong>Erythrocyte deformability, the ability of red blood cells to bend and twist as they pass through capillaries, is es-sential for tissue perfusion. This study investigates the effects and underlying mechanisms of rosmarinic acid treatment on erythrocyte deformability in rats subjected to lower limb ischemia-reperfusion injury.</p><p><strong>Methods: </strong>The study was conducted on Wistar albino rats weighing 400-450 g. The rats were randomly divided into five groups: the control group with no treatment (C), the group receiving only the solvent dimethyl sulfoxide (DMSO), the ischemia-reperfusion group (IR) subjected to 90 minutes of ischemia followed by 90 minutes of reperfusion in the femoral artery of the lower limb, the rosmarinic acid control group (RA-C) to assess the effects of rosmarinic acid alone, and the group (IR+RA) in which rosmarinic acid was administered intraperitoneally one hour before the ischemia-reperfusion procedure. At the end of the experiment, intracardiac blood samples were collected. Analyses included May-Grünwald-Giemsa (MGG) staining, measurement of endothelial nitric oxide synthase (eNOS), erythrocyte deformability indexes, malondialdehyde (MDA), and superoxide dismutase (SOD) levels.</p><p><strong>Results: </strong>Significant findings were observed in the study. Erythrocyte deformability was statistically significantly improved in the group that received rosmarinic acid prior to ischemia-reperfusion compared to the group that underwent ischemia-reperfusion alone. Morphological changes of erythrocytes were also significantly better in the IR+RA group than in the IR group. Immunohistochemical analysis of eNOS staining revealed that eNOS activity was higher in the IR group compared to the IR+RA group. Malondialdehyde (MDA) levels were significantly elevated in the IR group compared to all other groups. Analysis of superoxide dismutase levels showed that the SOD levels in the IR+RA group were significantly higher than those in the other groups.</p><p><strong>Conclusion: </strong>Our findings indicate that rosmarinic acid treatment administered prior to ischemia provides protective effects against erythrocyte deformation and morphological deterioration. It is suggested that the improvement in deformability may be mediated by increased SOD activity, which reduces reactive oxygen anions, by-products of nitric oxide (NO) production, thereby exerting an antioxidant effect and enhancing the beneficial actions of NO.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 4","pages":"324-331"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective effects of sesamin on the ileum in superior mesenteric artery ischemia induced in rats.","authors":"Hikmet Özesmer, Mehmet Tolga Kafadar, Eda Yıldızhan, Murat Akkuş","doi":"10.14744/tjtes.2025.97340","DOIUrl":"https://doi.org/10.14744/tjtes.2025.97340","url":null,"abstract":"<p><strong>Background: </strong>Acute mesenteric artery ischemia is recognized as a significant cause of mortality and morbidity, with its incidence increasing with age. This study aims to investigate the efficacy of sesamin in mitigating the histological, immunological, and biochemical damage associated with superior mesenteric artery ischemia and reperfusion (SMA I/R) injury in the ileum.</p><p><strong>Methods: </strong>Twenty-eight Sprague-Dawley rats were randomly assigned into four equal groups. Group I (Control group): Received no treatment. Group II (SMA I/R group): Carboxymethylcellulose was mixed with distilled water and administered orally via gavage at a dose of 1 mL/kg/dose for three weeks. At the end of the third week, SMA ischemia was induced for 60 minutes followed by 120 minutes of reperfusion. Group III (Sesamin group): Received sesamin orally at a dose of 30 mg/kg via gavage for three weeks. Group IV (Sesamin + SMA I/R group): Received sesamin followed by SMA I/R.</p><p><strong>Results: </strong>Serum malondialdehyde (MDA) levels were highest in the SMA I/R group, while lower levels were observed in the Sesamin + SMA I/R group (p<0.05). Similarly, total oxidant status (TOS) was significantly reduced in the Sesamin + SMA I/R group compared to the SMA I/R group (p<0.05). Consistent with these findings, Bax expression, a pro-apoptotic marker, was less intense in the Sesamin + SMA I/R group than in the SMA I/R group.</p><p><strong>Conclusion: </strong>Our findings indicate that the administration of sesamin prior to SMA I/R effectively reduces oxidative damage and prevents histological alterations, as demonstrated by histological, immunohistochemical, and biochemical parameters.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 4","pages":"317-323"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12000974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of intramedullary screw fixation in pediatric proximal phalanx fractures: A prospective case series.","authors":"Ömer Ayık, Serkan Bayram, Uğur Kayık, Murat Taşkın","doi":"10.14744/tjtes.2024.64236","DOIUrl":"10.14744/tjtes.2024.64236","url":null,"abstract":"<p><strong>Background: </strong>This prospective case series aimed to evaluate the short- to medium-term radiological and clinical outcomes of intramedullary screw (IMS) fixation in pediatric patients with extra-articular proximal phalanx fractures.</p><p><strong>Methods: </strong>Eleven patients (eight boys and three girls) aged 5-15 years underwent IMS fixation between January 2020 and June 2022. Antegrade or retrograde techniques were used depending on the fracture location. Postoperatively, patients were immobilized with finger splints for 3-5 days, followed by home exercises and physiotherapy. Bone union and functional status were assessed at one and four weeks after rehabilitation. Patient satisfaction, union status, and finger range of motion were also evaluated. Satisfaction outcomes were categorized as excellent, good, fair, or poor.</p><p><strong>Results: </strong>The mean patient age was 9.4 years (range: 5-15), and the mean follow-up period was 29.1 months (range: 24-36). The right hand was affected in eight cases, the left hand in three cases, and the dominant hand in eight cases. Fracture distribution included four neck, four shaft, and three base fractures. The mechanisms of injury included ball-related trauma (n=5), falls (n=3), crush injuries (n=2), and punching (n=1). The average time from injury to presentation was 2.5 days (range: 0-9). Seven patients underwent surgery using the retrograde fixation technique, while four patients underwent surgery using the antegrade fixation technique. Fracture union was observed within the first month in nine patients and was complete by the end of the second month in two patients. At the last follow-up, the range of motion of the metacarpophalangeal, proximal interphalangeal, and distal interphalangeal joints of the operated finger was assessed. Deficits of 1.8 (range: 0-10), 2.7 (range: 0-10), and 0.9 (range: 0-10) were observed when compared to the contra-lateral side, respectively. Ten patients demonstrated excellent outcomes, while one patient exhibited a good outcome.</p><p><strong>Conclusion: </strong>The intramedullary screw technique offers significant advantages in the surgical management of pediatric proximal phalanx fractures, particularly in rural areas with low socioeconomic status. This approach eliminates the need for pin-bottom fixation with a K-wire, significantly reduces hospitalization and additional treatment requirements, and minimizes the adverse impact of familial factors on the therapeutic process.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 3","pages":"296-302"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of trauma and diabetes mellitus-induced transtibial amputees in terms of gait parameters and functional capacity.","authors":"Neşe Tosun, Fatih Erbahçeci","doi":"10.14744/tjtes.2024.83923","DOIUrl":"10.14744/tjtes.2024.83923","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to compare gait parameters, balance, weight-bearing symmetry, functional capacity, functional mobility, prosthesis satisfaction, and quality of life between individuals with diabetes mellitus-induced and traumatic transtibial amputations (TTAs).</p><p><strong>Methods: </strong>Ten individuals with traumatic transtibial amputation and 10 individuals with diabetes mellitus-induced transtibial amputation were included in the study. All participants in both the trauma and diabetes groups used a vacuum-assisted suction suspension system (VASS) and a carbon composite foot transtibial prosthesis. Gait analysis and weight-bearing symmetry were assessed using a computerized gait analysis system. Balance was evaluated with the Biodex Balance System (BBS), functional capacity with the Six-Minute Walk Test (6MWT), functional mobility with the Timed Up and Go Test (TUG) and the Stair Climbing Test (SCT), prosthesis satisfaction with the Trinity Amputation and Prosthesis Experience Scale (TAPES), and quality of life with the Short Form-36 (SF-36).</p><p><strong>Results: </strong>When comparing the traumatic and diabetic groups, significant differences favoring the trauma group were found in the following parameters: stride length (SL) (p=0.004), amputated limb step length (ASL) (p=0.019), non-affected limb step length (NSL) (p=0.005), balance assessment parameters of general postural stability (p=0.000), anteroposterior (A-P) postural stability (p=0.000), mediolateral (M-L) postural stability (p=0.007), SCT performance (p=0.000), and the activity restriction subsection of TAPES (p=0.029). No significant differences were observed in gait velocity, cadence, step width, weight-bearing percentage of the amputated and non-affected limbs, TUG performance, SF-36 scores, or the psychosocial adjustment, prosthesis satisfaction, and daily use time subsections of the TAPES.</p><p><strong>Conclusion: </strong>In this study, the use of a VASS prosthesis in both traumatic and diabetic amputees had a positive effect on out-comes in the diabetic group, resulting in comparable results to those of the traumatic group. The fact that diabetic amputees used their prostheses as frequently as traumatic amputees, remained active, and benefited from the choice of prosthesis and suspension system provides valuable insights for healthcare professionals as a facilitating factor in rehabilitation.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 3","pages":"259-268"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effects of explosions: A ten-year retrospective study.","authors":"Burak Kaya, Sait Özsoy, Hüseyin Balandız, Mükerrem Safalı, Mesut Akyol","doi":"10.14744/tjtes.2024.40088","DOIUrl":"10.14744/tjtes.2024.40088","url":null,"abstract":"<p><strong>Background: </strong>Explosions are not exclusive to battlefields; they also represent a global security concern that affects all societies worldwide. This study aims to elucidate the effects of injuries caused by explosions with multiple mechanisms, which clinicians may encounter at any time, particularly in the context of military personnel. Furthermore, the clinical characteristics of these injuries were examined.</p><p><strong>Methods: </strong>A total of 7,865 patient files evaluated between 2008 and 2017 by the Forensic Medicine Department of Gülhane Medical Faculty, Health Sciences University, were subjected to retrospective review. The study encompassed a total of 906 cases presenting with blast injuries. Medical records and health reports of these cases were reviewed and analyzed in terms of age- and gender-specific incidence, military ranks, type of explosion, origin of explosion, wound types, affected body areas, and sequelae.</p><p><strong>Results: </strong>The findings of this study indicate that blast injuries predominantly affect young males, particularly those in the military. The most common etiological factor identified was terrorism. Blast injuries were found to occur most frequently in non-vehicular pedestrians and were primarily caused by improvised explosive devices and landmines. Blast injuries most commonly resulted in multiplesite injuries with a shrapnel effect and frequently required surgical intervention. Despite all treatments, 53.4% of explosion-related injuries resulted in long-term sequelae.</p><p><strong>Conclusion: </strong>The results of this study demonstrate that explosion-related injuries present a significant and complex problem. Blasts affect multiple body systems and cause severe injuries. Understanding the impact of explosions on the human body can help develop strategies to minimize or possibly eliminate serious injuries, particularly in explosion incidents encountered by security forces.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 3","pages":"233-241"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of nicardipine on the zone of stasis in burns: An experimental rat model.","authors":"Ramazan Deniz, Murat İğde, Nesrin Tan Başer, Numan Atılgan, Nihat Yumuşak, Nihat Birtane, Ufuk Zan","doi":"10.14744/tjtes.2025.04876","DOIUrl":"10.14744/tjtes.2025.04876","url":null,"abstract":"<p><strong>Background: </strong>The zone of stasis in burns is particularly vulnerable to progressive ischemia, making it a critical target for therapeutic interventions. Preventing damage in this zone is essential, as its viability can be preserved with adequate perfusion. Recognizing this, we aimed to investigate the systemic effects of nicardipine, a calcium channel blocker with vasodilatory properties, on the stasis zone in an experimentally induced burn model in rats. We hypothesized that nicardipine could mitigate ischemic progression in the stasis zone and thereby preserve tissue viability.</p><p><strong>Methods: </strong>A total of 20 Wistar-Albino rats were included in this study and divided into two groups: a control group (n=10) and a treatment group (n=10). The experimental burn model described by Regas and Ehrlich was employed. Under anesthesia, a 1 x 2 cm metal comb, preheated in boiling water, was applied to the dorsal skin of the rats for 30 seconds to create burn wounds. No treatment was administered to the control group. The treatment group, however, received a daily systemic dose of nicardipine (5 mg/kg) via gastric lavage for three days. Wound healing was monitored daily using a digital camera for three consecutive days. One rat in the treatment group was excluded due to mortality. After three days, the burned areas were excised from the dorsal skin of all rats and subjected to histopathological examination. Additionally, photo analysis of the burn areas was conducted using data obtained from the digital images.</p><p><strong>Results: </strong>Nicardipine treatment significantly improved burn healing parameters in the stasis zone. Compared to the control group, the treatment group demonstrated lower scores for edema (0.78 vs. 2.80, p<0.05), congestion (0.22 vs. 2.80, p<0.05), inflammation (0.67 vs. 2.90, p<0.05), vascularization (0.11 vs. 2.70, p<0.05), and fibrosis (0.22 vs. 2.90, p<0.05). Quantitative measurements also revealed a significant reduction in necrosis zone thickness (1079.75 µm vs. 2818.82 µm, p<0.05) and necrosis area (249.33 µm² vs. 400.13 µm², p<0.05). These findings indicate that nicardipine effectively mitigates ischemic progression and promotes tissue recovery in burn injuries.</p><p><strong>Conclusion: </strong>Our experimental study demonstrated that nicardipine has the potential to prevent and treat damage in the burn stasis zone, suggesting its therapeutic role in burn injuries.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 3","pages":"207-213"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT's competence in responding to urological emergencies.","authors":"Mazhar Ortaç, Rıfat Burak Ergül, Hüseyin Burak Yazılı, Muhammet Firat Özervarlı, Şenol Tonyalı, Omer Sarılar, Faruk Özgör","doi":"10.14744/tjtes.2024.03377","DOIUrl":"10.14744/tjtes.2024.03377","url":null,"abstract":"<p><strong>Background: </strong>In recent years, artificial intelligence (AI) applications have been increasingly used as sources of medical information, alongside their applications in many other fields. This study is the first to evaluate ChatGPT's performance in addressing urological emergencies (UE).</p><p><strong>Methods: </strong>The study included frequently asked questions (FAQs) by the public regarding UE, as well as UE-related questions formulated based on the European Association of Urology (EAU) guidelines. The FAQs were selected from questions posed by patients to doctors and hospital accounts on social media platforms (Facebook, Instagram, and X) and on websites. All questions were presented to ChatGPT 4 (premium version) in English, and the responses were recorded. Two urologists assessed the quality of the responses using a Global Quality Score (GQS) on a scale of 1 to 5.</p><p><strong>Results: </strong>Of the 73 total FAQs, 53 (72.6%) received a GQS score of 5, while only two (2.7%) received a GQS score of 1. The questions with a GQS score of 1 pertained to priapism and urosepsis. The topic with the highest proportion of responses receiving a GQS score of 5 was urosepsis (82.3%), whereas the lowest scores were observed in questions related to renal trauma (66.7%) and postrenal acute kidney injury (66.7%). A total of 42 questions were formulated based on the EAU guidelines, of which 23 (54.8%) received a GQS score of 5 from the physicians. The mean GQS score for FAQs was 4.38+-1.14, which was significantly higher (p=0.009) than the mean GQS score for EAU guideline-based questions (3.88+-1.47).</p><p><strong>Conclusion: </strong>This study demonstrated for the first time that nearly three out of four FAQs were answered accurately and satisfactorily by ChatGPT. However, the accuracy and proficiency of ChatGPT's responses significantly decreased when addressing guideline-based questions on UE.</p>","PeriodicalId":94263,"journal":{"name":"Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES","volume":"31 3","pages":"291-295"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}