{"title":"Suppression of Recurrent Ventricular Fibrillation Associated with J-Wave Syndrome Using Cilostazol.","authors":"Uğur Canpolat, Kudret Aytemir","doi":"10.5543/tkda.2025.48409","DOIUrl":"https://doi.org/10.5543/tkda.2025.48409","url":null,"abstract":"<p><p>Sudden cardiac death (SCD) survivors should be carefully evaluated for primary electrical diseases of the heart, including early repolarization syndrome (ERS). Early repolarization patterns in some patients may be hindered by depolarization or intermittent, making it difficult to diagnose. Besides implantable cardioverter defibrillator (ICD) implantation for secondary prevention, pharmacological agents like quinidine and phosphodiesterase-III inhibitors (e.g., cilostazol) are recommended to prevent or reduce recurrent VF episodes. We presented an SCD survivor, a young female patient with a documented VF and ICD implantation, who was admitted after Home Monitoring detected multiple short-coupled PVC-induced VF episodes and was successfully treated with cilostazol.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Fici, Nicolas Roberto Robles, Istemihan Tengiz, Guido Grassi
{"title":"New Drugs for Resistant Hypertension: Pending Issue?","authors":"Francesco Fici, Nicolas Roberto Robles, Istemihan Tengiz, Guido Grassi","doi":"10.5543/tkda.2025.74304","DOIUrl":"https://doi.org/10.5543/tkda.2025.74304","url":null,"abstract":"<p><p>Antihypertensive pharmacological treatment, based on currently available drugs, has been shown to reduce the cardiovascular risk profile of the treated hypertensive patients by lowering elevated blood pressure values. However, the risk of the treated hypertensive patients remains elevated. This represents the rationale for developing new antihypertensive drugs capable to normalize cardiovascular risk related to uncontrolled high blood pressure. This paper is designed at reviewing new antihypertensive drugs for the treatment of drug-resistant hypertension. The review will focus in particular on the results obtained with non-steroidal mineralcorticoid receptors antagonists, aldosterone synthase inhibitors, brain renin-angiotensin blockers, hepatic angiotensinogen inhibitors, atrial natriuretic peptides and endothelin 1 receptors antagonists.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Burcunur Karayiğit, Orhan Karayiğit, Ahmet Balun, Hamdi Temel
{"title":"Reply to the Letter to the Editor: 'Uric Acid/Albumin Ratio: Beyond Risk Stratification to Therapeutic Guidance in Hypertension'.","authors":"Burcunur Karayiğit, Orhan Karayiğit, Ahmet Balun, Hamdi Temel","doi":"10.5543/tkda.2025.30971","DOIUrl":"https://doi.org/10.5543/tkda.2025.30971","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hacı Ali Kürklü, Türkan Seda Tan, Nil Özyüncü, Kerim Esenboğa, İrem Dinçer
{"title":"Association Between Right Ventricular Echocardiographic Parameters and HFA-PEFF Score in Heart Failure with Preserved Ejection Fraction.","authors":"Hacı Ali Kürklü, Türkan Seda Tan, Nil Özyüncü, Kerim Esenboğa, İrem Dinçer","doi":"10.5543/tkda.2025.25905","DOIUrl":"https://doi.org/10.5543/tkda.2025.25905","url":null,"abstract":"<p><strong>Objective: </strong>Heart failure with preserved ejection fraction (HFpEF) is a leading clinical syndrome, accounting for more than 50% of hospitalizations due to heart failure. The HFA-PEFF algorithm, used for the diagnosis of HFpEF, also has prognostic value. The primary purpose of this work was to explore the relationship between the HFA-PEFF score and right ventricular (RV) echocardiographic parameters.</p><p><strong>Methods: </strong>127 patients diagnosed with HFpEF between January 2021 and November 2024, with adequate transthoracic echocardiography (TTE) images, were retrospectively evaluated. Patients were categorized into three prognostic risk groups based on their HFA-PEFF scores: low (0-2), intermediate (3-4) and high (5-6). RV function was assessed using Tricuspid annular plane systolic excursion (TAPSE), tricuspid annular S' velocity and RV free wall longitudinal strain (RVFW GLS). The relationship between the HFA-PEFF score and RV parameters was evaluated using One-way ANOVA and Spearman correlation analysis.</p><p><strong>Results: </strong>Patients with high HFA-PEFF scores showed significant deterioration in TAPSE and RV GLS values. A moderate negative correlation was observed between HFA-PEFF score and RVFW GLS (r = 0.50, P < 0.001), while a mild negative correlation was found with TAPSE (r = -0.35, P < 0.001).</p><p><strong>Conclusion: </strong>In HFpEF patients with poor prognosis as identified by the HFA-PEFF score, there was a marked deterioration in RV parameters, particularly RVFW 2D GLS and TAPSE. These findings suggest that incorporating RV parameters into HFpEF diagnostic and prognostic algorithms might provide additional clinical value.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Murat Akçay, Ahmet Çınar, Aydın Can Ulusoy, Fatma Rumeysa Karaçeşme, Metin Çoksevim
{"title":"Left Anterior Descending Artery to Right Coronary Artery Bifurcation Stenting with Culotte Technique in Acute Inferior Myocardial Infarction.","authors":"Murat Akçay, Ahmet Çınar, Aydın Can Ulusoy, Fatma Rumeysa Karaçeşme, Metin Çoksevim","doi":"10.5543/tkda.2024.77257","DOIUrl":"https://doi.org/10.5543/tkda.2024.77257","url":null,"abstract":"<p><p>Coronary artery anomalies are described as abnormal origin, course, or termination of any of the three main epicardial coronary arteries. They are generally not seen in cardiac complaints and are detected incidentally. However, some may be related to an increased risk of myocardial infarction, syncope, ventricular arrhythmias, and exercise-induced sudden cardiac death. Single coronary artery anomaly is very rare in coronary artery anomalies and provides a large myocardial perfusion area. Here we described an unusual very rare single coronary artery anomaly that the right coronary artery (RCA) originates from the middle left anterior descending coronary artery (LAD), presented with acute inferior myocardial infarction, and underwent LAD/RCA bifurcation stenting with the Culotte technique.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cemalettin Yılmaz, İsmail Üngan, Enes Arslan, Emrah Çitil, Ömer Uluuysal, Muhammet Mücahit Tiryaki, Doğan Şen, Ahmet Karaduman, Regayip Zehir
{"title":"The HALP Score's Prognostic Value for the Elderly (≥75 years) Patients Following Percutaneous Coronary Intervention for Acute Myocardial Infarction.","authors":"Cemalettin Yılmaz, İsmail Üngan, Enes Arslan, Emrah Çitil, Ömer Uluuysal, Muhammet Mücahit Tiryaki, Doğan Şen, Ahmet Karaduman, Regayip Zehir","doi":"10.5543/tkda.2025.45606","DOIUrl":"https://doi.org/10.5543/tkda.2025.45606","url":null,"abstract":"<p><strong>Objective: </strong>Despite the fact that percutaneous coronary intervention (PCI) lowers mortality following acute myocardial infarction (AMI), older patients (≥75 years) are still at high risk of mortality. The purpose of this study was to evaluate the prognostic significance of the HALP score, which reflects the inflammatory and nutritional status, in this population.</p><p><strong>Method: </strong>We retrospectively included 128 elderly patients who had PCI at our institution between 2019 and 2022. The primary endpoint of the study was long-term all-cause mortality. The study population was categorized into two distinct groups based on survival status: survivors and non-survivors. A multivariable Cox regression analysis was conducted to identify independent predictors of long-term all-cause mortality.</p><p><strong>Results: </strong>The median follow-up time was 49.9 (35.6-62.74) months. In multivariable analysis, the HALP score and CRP independently predicted all-cause mortality at long-term follow-up (hazard ratio (HR): 0.96, 95% confidence interval (CI): 0.94-0.99, p=0.003; HR: 1.04, 95% CI: 1.01-1.07, p=0.020; respectively). Receiver operating characteristic curve analysis identified 26.252 as the optimal HALP score cut-off for predicting mortality (area under the curve (AUC): 0.764; 95% CI: 0.672-0.855; p< 0.001), with 73% sensitivity and 70.3% specificity. The HALP score demonstrated a higher AUC value, indicating better discriminative power compared to its individual components. In Kaplan-Meier analysis, patients with HALP score< 26.252 had a greater follow-up death (log rank p< 0.0001).</p><p><strong>Conclusion: </strong>The HALP score is an independent predictor of long-term all-cause death in older AMI patients following PCI.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Dilemma of Edoxaban Interruption and Heparin Bridging Before Upgrading to Cardiac Resynchronization Therapy in an Older Patient with Atrial Fibrillation, Chronic Kidney Disease, and Mitral Bioprosthesis.","authors":"Mert Doğan, Uğur Canpolat","doi":"10.5543/tkda.2024.86907","DOIUrl":"https://doi.org/10.5543/tkda.2024.86907","url":null,"abstract":"<p><p>The peri-procedural management of novel oral anticoagulants (NOAC) should be individualized based on the patient (age, body weight, renal function, medications, previous thromboembolic/bleeding event, presence of prosthetic valve) and procedural (bleeding risk) characteristics. Less invasive procedures carry a relatively low bleeding risk and may be performed under minimally- or uninterrupted NOAC therapy. However, upgrading from implantable cardioverter defibrillator (ICD) to cardiac resynchronization therapy (CRT) is more complex than the initial implantation procedure. Thus, the timing of the last NOAC intake before an elective procedure requires judgment based on the individual benefit/risk ratio. Herein, we presented the management of an elderly patient with atrial fibrillation, grade IIIb chronic renal disease, low body weight, and bioprosthetic mitral valve who underwent upgrading from ICD to CRT-D procedure, experienced a bioprosthetic valve thrombosis 24 hours after an interruption of edoxaban therapy without heparin bridging, and successfully treated with ultraslow tPA therapy.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}