{"title":"Symptomatic Severe Bradycardia during Pazopanib Treatment.","authors":"Cafer Zorkun, Öykü Alara Eren","doi":"10.5543/tkda.2024.03788","DOIUrl":"https://doi.org/10.5543/tkda.2024.03788","url":null,"abstract":"<p><p>Pazopanib, a tyrosine kinase inhibitor that targets growth factor receptors, is associated with various side effects, including bradycardia. We report a severe case of symptomatic bradycardia, with a heart rate dropping to 28 beats per minute, in a patient with cardiac angiosarcoma treated with 800 mg/day of pazopanib. Reducing the dosage to 600 mg/day improved the heart rate to 53 beats per minute. This case highlights the risk of severe bradycardia associated with pazopanib, emphasizing the need for vigilant heart rate monitoring.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"140-142"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Spyridon-Filippos Papadopoulos, Emmanouela Peteinidou, Konstantinos C Theodoropoulos, Matthaios Didagelos, Athanasios Samaras, Aristi Boulmpou, Thomas Gossios, Antonios Kouparanis, George Kassimis, Antonios Ziakas
{"title":"Cangrelor Monotherapy Bridging for Cardiac and Non-Cardiac Surgery Following Percutaneous Coronary Intervention.","authors":"Spyridon-Filippos Papadopoulos, Emmanouela Peteinidou, Konstantinos C Theodoropoulos, Matthaios Didagelos, Athanasios Samaras, Aristi Boulmpou, Thomas Gossios, Antonios Kouparanis, George Kassimis, Antonios Ziakas","doi":"10.5543/tkda.2024.86987","DOIUrl":"https://doi.org/10.5543/tkda.2024.86987","url":null,"abstract":"<p><p>Managing dual antiplatelet therapy (DAPT) perioperatively is challenging, especially in patients who have recently undergone percutaneous coronary intervention (PCI). Intravenous antiplatelet agents are recommended in these cases. This case series describes the perioperative management of two high bleeding risk patients with recent PCI undergoing cardiac and non-cardiac surgeries using cangrelor monotherapy.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"143-147"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hülya Yılmaz Ak, Mustafa Yıldız, Ahmet Yıldız, Sait Mesut Doğan, Ziya Salihoğlu, Kerem Erkalp, Emir Özgür Barış Ökçün, Yasemin Özşahin
{"title":"Adaptation of the Enhanced Recovery After Surgery (ERAS®) Protocol in Transcatheter Aortic Valve Replacement Patients.","authors":"Hülya Yılmaz Ak, Mustafa Yıldız, Ahmet Yıldız, Sait Mesut Doğan, Ziya Salihoğlu, Kerem Erkalp, Emir Özgür Barış Ökçün, Yasemin Özşahin","doi":"10.5543/tkda.2024.98566","DOIUrl":"https://doi.org/10.5543/tkda.2024.98566","url":null,"abstract":"<p><p>Enhanced Recovery After Surgery (ERAS®) is a multimodal, multidisciplinary care and recovery protocol designed to facilitate faster recovery for patients undergoing surgery during the perioperative period. These programs aim to encourage an earlier return to normal activities by reducing complications. While ERAS® protocols have become standard practice in many surgical specialties, their application in the transcatheter aortic valve replacement (TAVI) procedure is relatively recent. TAVI patients are often high-risk and medically fragile. We believe that managing these patients with a multidisciplinary approach, such as the ERAS® protocol, during the preoperative and postoperative periods will reduce morbidity and mortality, enhance patient satisfaction, and lower hospital costs.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"127-133"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mehmet Özyaşar, Mustafa Doğduş, Ahmet Yılmaz, Mehmet Sait Altıntaş, Ertan Yetkin
{"title":"Reply to the Letter to the Editor: 'Coronary Atherosclerosis Burden and Coronary Artery Tortuosity'.","authors":"Mehmet Özyaşar, Mustafa Doğduş, Ahmet Yılmaz, Mehmet Sait Altıntaş, Ertan Yetkin","doi":"10.5543/tkda.2025.92377","DOIUrl":"https://doi.org/10.5543/tkda.2025.92377","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"154"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emir Baskovski, İrem Cenan Büyükçakır, Timuçin Altın, Ömer Akyürek
{"title":"Utilization of Coronary Venous Ethanol Ablation for Intramural Ventricular Arrhythmias in Two Different Scenarios: A How-To Approach.","authors":"Emir Baskovski, İrem Cenan Büyükçakır, Timuçin Altın, Ömer Akyürek","doi":"10.5543/tkda.2024.21859","DOIUrl":"https://doi.org/10.5543/tkda.2024.21859","url":null,"abstract":"<p><p>Catheter-based radiofrequency (RF) ablation is a recommended treatment modality for various ventricular arrhythmias. However, challenging sites that may not be accessible due to anatomical reasons, as well as intramural sites, where RF energy penetration may be limited, pose challenges that limit the success rate of RF ablation. Ethanol ablation may be an alternative option for treatment of ventricular arrhythmias that are not amenable to treatment by RF ablation. This report describes two cases of successful venous alcohol ablation for refractory ventricular tachycardia to standard RF ablation procedure. In the first case, a patient with a ventricular tachycardia (VT) originating from intramural outflow tract, having failed an endocardial ablation, underwent a successful ethanol ablation, via a double balloon technique. In the second case, we describe a patient with a history of transcatheter aortic valve replacement and premature ventricular complexes (PVCs) originating from intramural outflow tract. Radiofrequency ablation in this patient was limited by both the far-field appearing signals and the proximity prosthetic valve to the site of these signals. Therefore, this patient also underwent successful ethanol ablation of annular vein with the over the wire system after venography of coronary sinus. No complications were observed in both patients. In conclusion, coronary venous ethanol ablation may be a safe and successful technique for ablation of intramural ventricular arrhythmias in different clinical scenarios.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"134-139"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aykut Demirkıran, Cihan Aydın, Aydın Akyüz, Şeref Alpsoy
{"title":"Ten-Year Outcomes Following Revascularization Strategies for Non-ST-Segment Elevation Myocardial Infarction and Multivessel Disease.","authors":"Aykut Demirkıran, Cihan Aydın, Aydın Akyüz, Şeref Alpsoy","doi":"10.5543/tkda.2024.59839","DOIUrl":"https://doi.org/10.5543/tkda.2024.59839","url":null,"abstract":"<p><strong>Objective: </strong>There remain conflicting recommendations regarding revascularization strategies for patients with non-ST-segment elevation myocardial infarction (NSTEMI) and multivessel disease (MVD). This study aimed to compare the long-term outcomes of different revascularization strategies.</p><p><strong>Method: </strong>Patients with similar characteristics were categorized into three groups: immediate complete revascularization (ICR), staged complete revascularization (SCR), and non-complete revascularization (NCR). The SCR group was further divided based on the time interval between the index and staged procedures: SCR ≤ 24 hours and SCR > 24 hours. Cardiac composite outcomes included the total number of cardiac deaths and recurrent myocardial infarction during the follow-up period.</p><p><strong>Results: </strong>Out of 14,511 screened patients, 316 were included in the analysis. The results showed a significant difference in risk between SCR and ICR (hazard ratio [HR] (95% confidence interval [CI]): 0.27 (0.15-0.47); P = 0.001). There was no significant difference between NCR and SCR (HR (95% CI): 1.06 (0.61-1.84); P = 0.832). The SCR group was divided into two groups based on the time interval from the first to the second procedure (time interval [TI] ≤ 24 hours in the SCR1 group, and TI > 24 hours in the SCR2 group). The frequency of cardiac composite outcomes was lower in SCR1 compared to SCR2 (16.7% vs. 47.1%; P = 0.038).</p><p><strong>Conclusion: </strong>Our findings support the use of ICR and SCR completed within 24 hours due to their favorable long-term outcomes in patients with MVD and NSTEMI.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"93-99"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Percutaneous Extraction of Catheter Trapped in the Right Ventricle.","authors":"Ramin Eskandari, Yousef Rezaei","doi":"10.5543/tkda.2024.29608","DOIUrl":"10.5543/tkda.2024.29608","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 2","pages":"152"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Levent Pay, Ahmet Çağdaş Yumurtaş, Tuğba Çetin, Tufan Çınar, Mert İlker Hayıroğlu
{"title":"Comparative Evaluation of Chatbot Responses on Coronary Artery Disease.","authors":"Levent Pay, Ahmet Çağdaş Yumurtaş, Tuğba Çetin, Tufan Çınar, Mert İlker Hayıroğlu","doi":"10.5543/tkda.2024.78131","DOIUrl":"https://doi.org/10.5543/tkda.2024.78131","url":null,"abstract":"<p><strong>Objective: </strong>Coronary artery disease (CAD) is the leading cause of morbidity and mortality globally. The growing interest in natural language processing chatbots (NLPCs) has driven their inevitable widespread adoption in healthcare. The purpose of this study was to evaluate the accuracy and reproducibility of responses provided by NLPCs, such as ChatGPT, Gemini, and Bing, to frequently asked questions about CAD.</p><p><strong>Methods: </strong>Fifty frequently asked questions about CAD were asked twice, with a one-week interval, on ChatGPT, Gemini, and Bing. Two cardiologists independently scored the answers into four categories: comprehensive/correct (1), incomplete/partially correct (2), a mix of accurate and inaccurate/misleading (3), and completely inaccurate/irrelevant (4). The accuracy and reproducibility of each NLPC's responses were assessed.</p><p><strong>Results: </strong>ChatGPT's responses were scored as 14% incomplete/partially correct and 86% comprehensive/correct. In contrast, Gemini provided 68% comprehensive/correct responses, 30% incomplete/partially correct responses, and 2% a mix of accurate and inaccurate/misleading information. Bing delivered 60% comprehensive/correct responses, 26% incomplete/partially correct responses, and 8% a mix of accurate and inaccurate/misleading information. Reproducibility scores were 88% for ChatGPT, 84% for Gemini, and 70% for Bing.</p><p><strong>Conclusion: </strong>ChatGPT demonstrates significant potential to improve patient education about coronary artery disease by providing more sensitive and accurate answers compared to Bing and Gemini.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 1","pages":"35-43"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akın Torun, Şahhan Kılıç, Süha Asal, Mert Babaoğlu, Samet Yavuz, Cumaali Demirtaş, Serkan Dilmen, Ahmet Lutfullah Orhan, Mehmet Uzun
{"title":"Effect of Sacubitril/Valsartan and Dapagliflozin on Cardiac Functions and Exercise Capacity of Rats.","authors":"Akın Torun, Şahhan Kılıç, Süha Asal, Mert Babaoğlu, Samet Yavuz, Cumaali Demirtaş, Serkan Dilmen, Ahmet Lutfullah Orhan, Mehmet Uzun","doi":"10.5543/tkda.2024.74353","DOIUrl":"https://doi.org/10.5543/tkda.2024.74353","url":null,"abstract":"<p><strong>Objective: </strong>Recent studies have demonstrated the positive effects of sacubitril/valsartan and dapagliflozin on cardiac prognosis and performance. These drugs have the potential to be misused as doping agents by professional athletes. This study aimed to evaluate the effects of sacubitril/valsartan and dapagliflozin on athletic performance.</p><p><strong>Methods: </strong>In this study, swimming performance was assessed in three groups of rats divided into control, sacubitril/valsartan, and dapagliflozin groups. Echocardiography, weight, and rotarod performance were also evaluated during follow-up.</p><p><strong>Results: </strong>In comparisons between the sacubitril/valsartan and control groups, a statistical difference was observed in the 13th, 19th, and 20th swimming sessions. For total and median swimming times, the P values were 0.115 and 0.015, respectively. In comparisons between the dapagliflozin and control groups, a statistical difference was observed starting from the 10th swimming session, with P values of < 0.001 for both total and median swimming times. In a three-group analysis, statistical differences were observed from the ninth swimming session until the end of the experiment. Additionally, rotarod results showed a significant difference for both sacubitril/valsartan and dapagliflozin compared to baseline (P < 0.001 and P = 0.011, respectively).</p><p><strong>Conclusion: </strong>This study demonstrated a limited positive effect of sacubitril/valsartan on athletic performance, while the impact of dapagliflozin on athletic performance was particularly significant.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 1","pages":"13-21"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hüseyin Bozbaş, Savaş Aksüyek Çelebi, Mohamed Asfour, Basri Amasyalı, Cem Barçın
{"title":"Percutaneous Mitral Valve-in-Ring Procedure in a Case of Severe Mitral Regurgitation Repaired with a Surgical Flexible Ring: A Step-by-Step Description.","authors":"Hüseyin Bozbaş, Savaş Aksüyek Çelebi, Mohamed Asfour, Basri Amasyalı, Cem Barçın","doi":"10.5543/tkda.2024.41877","DOIUrl":"https://doi.org/10.5543/tkda.2024.41877","url":null,"abstract":"<p><p>Severe mitral regurgitation (MR) following surgical repair of the mitral valve poses a significant clinical challenge. Patients who have undergone surgery are typically at high risk for a second operation. This report details the case of a 54-year-old male who underwent aortic valve replacement and mitral valve repair using a 34-ring, 14 years prior. The patient presented with severe MR, severe left ventricular (LV) dilation, and a reduced ejection fraction of 20%. A Sovering 34 ring, characterized by its oval, radio-opaque, and flexible nature and completely encircling the annulus, was used. After comprehensive assessment utilizing cardiac computed tomography (CT) and the Valve-in-Valve (ViV) application, a 32 mm balloon-expandable transcatheter heart valve was chosen. The selected valve was the 32 mm Myval (Meril) valve, the largest size available globally. Following careful alignment (left atrium/left ventricle ratio (LA/LV) ratio 20/80) and under rapid pacing, the valve was successfully implanted within the ring. Subsequent transesophageal echocardiography confirmed the valve's functionality, and left ventriculography showed no paravalvular regurgitation. The Mitral Valve-in-Ring (MVIR) procedure emerges as a promising therapeutic option for patients with a history of mitral valve repair and severe MR. This procedure is preferred in centers where structural heart interventions are performed by an experienced team.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":"53 1","pages":"68-72"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}