Nazif Yalçın, Fatih Kahraman, Mehmet Ali Astarcıoğlu, Taner Şen
{"title":"Local Anesthetic-Related Methemoglobinemia During Cardiac Device Implantation; A Retrospective Registry: The LAMDA Study-Uncorrected Proof.","authors":"Nazif Yalçın, Fatih Kahraman, Mehmet Ali Astarcıoğlu, Taner Şen","doi":"10.5543/tkda.2025.62884","DOIUrl":"https://doi.org/10.5543/tkda.2025.62884","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to determine the frequency of methemoglobin development and identify associated factors in patients undergoing Implantable Cardioverter-Defibrillator (ICD) and Cardiac Resynchronization Therapy (CRT) procedures with the local anesthetic prilocaine.</p><p><strong>Method: </strong>Data from 64 patients were analyzed. The patients' methemoglobin levels before and after the procedure were measured and compared. The relationships between the results and factors such as creatinine, hemoglobin, BMI, and the amount of prilocaine used were examined. Exclusion criteria included: age under 18 years, pregnancy, breastfeeding, malignancy, chemotherapy, hemoglobin chain disorders, liver failure, and renal failure (GFR <60 ml/min), chronic obstructive pulmonary disease, other hypoxic lung diseases and smoker patients.</p><p><strong>Results: </strong>Methemoglobin levels were significantly higher in the first hour after the procedure (p < 0.001). Oxygen saturation levels were significantly lower during the first hour post-procedure (p < 0.001). In the group with elevated methemoglobin levels after the procedure, creatinine levels were significantly higher (p < 0.001), while BMI (p < 0.001) and hemoglobin levels (p < 0.001) were significantly lower. No significant relationship was found with ALT levels (p = 0.425).</p><p><strong>Conclusion: </strong>While significant methemoglobin elevation was observed following ICD/CRT procedures with prilocaine, clinically significant methemoglobinemia cases are rare. A significant relationship was identified between methemoglobin elevation and BMI, hemoglobin, and creatinine.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koray Kalenderoğlu, Mert İlker Hayıroğlu, Melih Öz, Kadir Gürkan
{"title":"A Rare Anatomical Variant: Cryoballoon Ablation of Accessory Pulmonary Vein Originating from the Left Atrial Roof: A Case Report.","authors":"Koray Kalenderoğlu, Mert İlker Hayıroğlu, Melih Öz, Kadir Gürkan","doi":"10.5543/tkda.2025.35324","DOIUrl":"https://doi.org/10.5543/tkda.2025.35324","url":null,"abstract":"<p><p>We administered cryoballoon ablation to a 61-year-old female patient for recurrent paroxysmal atrial fibrillation. Contrast-enhanced CT angiography used to assess the patient's pulmonary vein anatomy prior to cryoballoon ablation revealed an accessory pulmonary vein emanating from the left atrial roof. Cryoballoon ablation was successfully performed on this accessory vein, which is rarely seen in the literature for the first time.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to Recognize Cardiac Amyloidosis: Explaining With Clinical Case.","authors":"Shafag Mustafaeva, Uzeyir Rahimov, Emin Karimli, Khatira Abdulalimova, Shahla Shabanova","doi":"10.5543/tkda.2024.79810","DOIUrl":"https://doi.org/10.5543/tkda.2024.79810","url":null,"abstract":"<p><p>Cardiac amyloidosis is a rare systemic condition in which amyloid proteins accumulate outside the cells of the heart. These proteins can be deposited in various parts of the heart, including the valves, endocardium, myocardium and pericardium. This abnormal protein deposition can disrupt normal heart function, leading to a range of symptoms and complications, including heart failure, arrhythmias, and even sudden cardiac death. Diagnosis of cardiac amyloidosis is suspected based on characteristic findings, electrocardiogram abnormalities, and echocardiographic features, which prompt further evaluation and confirmation. We present the case of a 57-year-old female who was hospitalized due to significant exertional dyspnea, hypotension, lower extremity edema, and proteinuria. The aim of this case report is to augment clinicians' understanding of this condition and to minimize the interval between symptom onset and diagnosis, thereby potentially improving the prognosis of affected patients.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emine Altuntaş, Kadriye Memiç Sancar, Begüm Uygur, İffet Doğan
{"title":"Uninvited Guest in the Left Ventricle: Lipomade.","authors":"Emine Altuntaş, Kadriye Memiç Sancar, Begüm Uygur, İffet Doğan","doi":"10.5543/tkda.2025.35332","DOIUrl":"https://doi.org/10.5543/tkda.2025.35332","url":null,"abstract":"<p><p>Cardiac lipoma is a rare primary tumour of the heart, and as diagnostic and treatment methods have improved, more cases have been reported. This situation suggests that the clinical presentation, previously thought to have classic features, may in fact have atypical manifestations. In this case report is presented a case of a 28-year-old female with progressive exertional dyspnea. Trans thoracic and transesophageal echocardiography showed a huge mass in the left ventricle that originated from posteromedial papillary muscle, had a low-density focus with a clear boundary and regular shape, and had no fortunately significant effect on the valves and hemodynamics. After cardiac magnetic resonans, cardiac lipoma was diagnosed. The lipoma excision surgery was offered to the patient, however the patient refused the operation. The most patients diagnosed with cardiac lipoma in the heart chambers manifest no symptoms. Therefore they are diagnosed accidentally. The utilization of multimodality imaging would facilitate the diagnosis. Echocardiography is a suitable modality for subsequent monitoring.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Paradoxical Cerebral and Coronary Embolism in a Young Patient Due to Right Atrial Appendage Aneurysm: A Case Report.","authors":"Songül Usalp, Safiye Sanem Dereli Bulut, Filiz Çelebi, Emine Altuntaş","doi":"10.5543/tkda.2024.36737","DOIUrl":"https://doi.org/10.5543/tkda.2024.36737","url":null,"abstract":"<p><p>A 32-year-old male patient was admitted to the hospital due to an ischemic stroke. Transesophageal echocardiography demonstrated the presence of an echogenic structure consistent with a thrombus within the aneurysm of the right atrium, along with a foramen ovale (PFO) within the interatrial septum. Cardiac MRI revealed the presence of a right atrial appendage aneurysm (RAAA) with a thrombus. Coronary angiography demonstrated that the circumflex artery was occluded. Concurrently, the antiphospholipid syndrome was identified. Given the presence of a PFO, paradoxical embolism was postulated as the aetiology of both coronary and cerebral artery occlusion. Antithrombotic and anticoagulant medical treatment was initiated, and surgical intervention for RAAA and PFO was advised. However, the patient declined surgical treatment, and thus, his medical management was continued. The patient has been attending regular visits for about two years and is being followed up without any problems.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to Letter to the Editor: Artificial Intelligence in Cardiac Rehabilitation: Evaluating ChatGPT's Knowledge Level and Responses to Clinical Scenarios-Uncorrected Proof.","authors":"Muhammet Geneş","doi":"10.5543/tkda.2025.77137","DOIUrl":"https://doi.org/10.5543/tkda.2025.77137","url":null,"abstract":"","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144593283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mustafa Bilal Özbay, Serhat Değirmen, Ayşenur Güllü, Bede Nnaemeka Nriagu, Yasin Özen, Çağrı Yayla
{"title":"Association of CRP Albumin Ratio with No-Reflow Phenomenon After PCI: A Systematic Review and Meta-Analysis.","authors":"Mustafa Bilal Özbay, Serhat Değirmen, Ayşenur Güllü, Bede Nnaemeka Nriagu, Yasin Özen, Çağrı Yayla","doi":"10.5543/tkda.2025.17257","DOIUrl":"https://doi.org/10.5543/tkda.2025.17257","url":null,"abstract":"<p><strong>Objective: </strong>No-reflow (NR), a complication of percutaneous coronary intervention (PCI), is associated with poor cardiovascular outcomes. Identifying reliable predictors of NR is crucial for risk stratification and improving clinical outcomes. The CRP-albumin ratio (CAR), a marker of systemic inflammation, has been suggested as a potential predictor of NR. This systematic review and meta-analysis aimed to evaluate the relationship of CAR with the NR after PCI.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in Cochrane, Embase and PubMed databases, following PRISMA 2020 guidelines. Studies evaluating the predictive value of CAR for NR were included. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Heterogeneity was assessed using Cochrane's Q and I² statistics.</p><p><strong>Results: </strong>Four studies comprising 2,068 patients were included. The pooled analysis showed a significant association between higher CAR and an increased risk of NR (OR: 2.34; 95% CI: 1.19-4.60; p = 0.01; I² = 96%).</p><p><strong>Conclusion: </strong>We found that elevated CAR is associated with NR after PCI, suggesting its potential utility as a prognostic biomarker. However, high heterogeneity underscores the need for large-scale studies to validate its clinical applicability.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Total Occlusion of The Infrarenal Aorta by Cardiac Myxoma: Emergent Surgical Management.","authors":"Şeyda Çelebi, Rıfat Özmen, Aydın Tunçay, Gülden Sarı, Özlem Canöz, Nevzat Herdem","doi":"10.5543/tkda.2024.23771","DOIUrl":"https://doi.org/10.5543/tkda.2024.23771","url":null,"abstract":"<p><p>Cardiac myxomas are the most common primary tumor of the heart, and they cause systemic embolization if they are located in the left atrium. We present a rare case of a left atrial myxoma resulting in total occlusion of the infrarenal abdominal aorta. A 60-year-old man was admitted to the hospital because of back pain with paresthesia in the lower extremities, and subsequent development of paraplegia. Computed tomography (CT) showed evidence of total occlusion of the infrarenal aorta. Emergent surgery was performed. Intraoperative specimen removed from the aorta was histologically found to be a myxomatous-like material. Transthoracic echocardiography (TTE) revealed a mass located in the left atrium. Despite the second surgery for the removal of cardiac mass, embolism attacks caused by myxoma could not be prevented. Prompt diagnosis and therefore prompt treatment can improve clinical outcomes by preventing embolization-related complications.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of Meteorin-like Protein Infusion vs. Moderate-Intensity Exercise on Cardiac Mast Cell and Plasma Cell Dynamics and Musclin Levels in Female Rats.","authors":"Nazife Ülker Ertuğrul, Ebru Gökdere, Feyza Keskin, Nurcan Delice, Tuğrul Ertuğrul, Gökçen Sevilgen, Şerife Tütüncü, Sinan Canpolat","doi":"10.5543/tkda.2025.80886","DOIUrl":"https://doi.org/10.5543/tkda.2025.80886","url":null,"abstract":"<p><strong>Objective: </strong>Moderate-intensity exercise modulates the immunological response in cardiac tissue. Meteorin-like protein (metrnl) is a myokine secreted by muscle cells during exercise and is involved in immune response regulation. However, the effects of metrnl on mast cells and plasma cells in cardiac tissue are not fully understood. This study was designed to assess the effects of exogenous metrnl infusion on the cardiac mast cells and plasma cells. In addition, serum levels of musclin, an exercise-responsive factor, were evaluated during the effects of moderate-intensity exercise on cardiac immune cells.</p><p><strong>Method: </strong>Twenty-seven female rats were randomly divided into three groups (n=9 each): control (deionized water), exercise (moderate-intensity swimming exercise) and metrnl (1 µg/day). For histological studies, hematoxylin-eosin, toluidine blue and methyl green-pyronin staining were performed on heart tissues. Musclin levels were measured in serum samples using the ELISA method.</p><p><strong>Results: </strong>Metrnl infusion increased cardiac mast cell and plasma cell numbers in female rats like moderate-intensity exercise. In addition, the increase in cardiac mast cell count was greater in the exercise group, whereas musclin concentration decreased in female rats subjected to moderate-intensity exercise.</p><p><strong>Conclusion: </strong>Our data suggests that moderate-intensity exercise's effects on the cardiac immune system may be mediated, by downregulating musclin and metrnl-dependent upregulating cardiac mast cells and plasma cells. Thus, exercise-induced metrnl may affect the cardiac immune response by modulating cardiac immune cells.</p>","PeriodicalId":94261,"journal":{"name":"Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144586040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}