{"title":"Of rats and humans: rethinking physiological boundaries.","authors":"Ngala Elvis Mbiydzenyuy, Mbawe Zulu","doi":"10.1007/s11017-025-09733-2","DOIUrl":"https://doi.org/10.1007/s11017-025-09733-2","url":null,"abstract":"","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rethinking the nature of medicine: limits of the inquiry thesis through the case of African traditional medicine.","authors":"Likhwa Ncube","doi":"10.1007/s11017-025-09732-3","DOIUrl":"https://doi.org/10.1007/s11017-025-09732-3","url":null,"abstract":"<p><p>This paper critically evaluates Alex Broadbent's Inquiry Thesis, which defines medicine by the core competencies of prediction and understanding. While the thesis seeks to avoid parochialism by identifying features that could apply across traditions, its applicability falters when examined against African traditional medicine (ATM). Using ATM as a test case, this paper demonstrates that legitimate medical systems can operate coherently and enjoy broad social legitimacy without consistently exercising prediction or understanding in Broadbent's sense. This challenges the Inquiry Thesis both as a general account of medicine and as an inclusive framework. Accordingly, this paper tentatively advances a Refined Curative Thesis (RCT), which shifts the unifying criterion from competencies to aims: medicine is defined as the organized, socially recognized effort to restore or maintain health through interventions directed at beneficial change. RCT accommodates epistemic diversity, preserves conceptual discipline, and avoids collapsing into unstructured pluralism. By centring the curative aim, this revised account offers a more inclusive, philosophically robust, and culturally sensitive definition of medicine. The analysis deepens philosophical understanding of medicine while also bearing practical significance for global health policy, intercultural dialogue, and the recognition of diverse medical systems.</p>","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deleuzo-Guattarian de-construction of the mind to re-evaluate undeath.","authors":"Ujjwal Kaur, Preeti Puri","doi":"10.1007/s11017-025-09726-1","DOIUrl":"10.1007/s11017-025-09726-1","url":null,"abstract":"<p><p>This article examines the cases of Jahi McMath and Poe's M. Valdemar to reconceptualize the idea of undeath from a Deleuzo-Guattarian perspective. It builds upon the ambiguity existing in defining a body in the state of 'brain death' after permanent loss of consciousness to analyze how the brain, as Deleuze and Guattari's 'partial object,' facilitates the construction of the mind as a transcendent entity. Evaluated by the presence/lack of consciousness, this transcendent entity becomes the factor defining the health of a body on life-support. In combining aspects of medical science with theoretical abstraction, this article aims to change the negative conception of an 'undead body' as an abjection that disrupts the boundary between the binaries of life and death. Instead, it will re-evaluate such bodies as 'undead assemblages' that exist in liminal spaces of constant flux and possess the potential to be affected by the environment that sustains them. We will further explore how the minor identities of such bodies affect their treatment within the medical community and set off the process of becoming-minor and becoming-patient, as Jahi and Valdemar's marginalized bodies transform into Deleuzian events that challenge the boundaries of life, death, and identity within medical and cultural systems.</p>","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":"399-417"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clarifying the public misrepresentation of transgenerational epigenetic inheritance.","authors":"Tara-Lyn Camilleri","doi":"10.1007/s11017-025-09717-2","DOIUrl":"10.1007/s11017-025-09717-2","url":null,"abstract":"","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":"433-435"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D Micah Hester, Erica K Salter, Kellie R Lang, Douglas S Diekema
{"title":"Parents (of minors) are not surrogates: acknowledging (finally) the unique moral space of parents.","authors":"D Micah Hester, Erica K Salter, Kellie R Lang, Douglas S Diekema","doi":"10.1007/s11017-025-09724-3","DOIUrl":"10.1007/s11017-025-09724-3","url":null,"abstract":"<p><p>A common conflation happens both in everyday discussions in medicine as well as in the medical literature-namely, equating 'parents of minors' with 'surrogate decision makers.' It is important for pediatric clinicians and ethicists to stop using language that confuses and obscures the important difference between surrogates and parents in ways that affect the ethics of decision-making for minors. Specifically, parents of minor children are morally different than surrogates, and by using surrogate language, a misunderstanding arises that distorts the moral space and relevant obligations that pediatric providers, parents of minors, and even pediatric patients find themselves in when making medical decisions.</p>","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":"419-432"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is pharmacogenetics being racialized? An investigation into the reinscription of racial beliefs in modern biomedicine.","authors":"Lena Steimle, Christina Schües","doi":"10.1007/s11017-025-09723-4","DOIUrl":"10.1007/s11017-025-09723-4","url":null,"abstract":"<p><p>Racial classifications have a complex and troubled past in the social and scientific history of humankind. They are the result of racism and have been used to devalue and degrade non-White people. Although the concept of race has acquired a social component and the genetic similarity of people based on race has been proven, the category is increasingly used in pharmacogenetic studies to create biased study populations under the guise of personalized medicine. The heart failure drug BiDil, which was only approved for Black people in 2005, gained particular notoriety. Its race-specific approval reignited the debate about the assumption that there are genetic differences between people of different races and led to a further biopolitical instrumentalization of the term 'race'. Despite the expiry of the race-specific patent, race-specific labeling continues to take place in research. In this paper, these racializations of pharmacogenetics are examined, explaining how they arise and how they are kept alive. Finally, this paper argues for better moderation of race in pharmacogenetic studies.</p>","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":"349-375"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12432089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Orthorexia nervosa: nosographic category or not?","authors":"Fabio Bacchini, Elena Bossini","doi":"10.1007/s11017-025-09722-5","DOIUrl":"10.1007/s11017-025-09722-5","url":null,"abstract":"<p><p>Orthorexia nervosa is defined as an exaggerated and obsessive fixation on healthy eating. In recent years, there has been growing debate over whether orthorexia nervosa should be considered a new psychiatric disorder. This paper discusses the conceptual issues that emerge from the attempt to identify the diagnostic criteria for orthorexia nervosa as opposed to non-pathological cases of healthy eating or 'healthy orthorexia'. The analysis focuses on two main strategies that have been proposed in the literature: using physical impairment (malnutrition) and having recourse to the presence of psychological and psychosocial distress. The first strategy requires fundamental changes in the conceptualization of orthorexia nervosa, while the second risks unacceptably pathologizing uncommon lifestyles devoted to pursuing one specific activity, interest, or plan. Thus, substantial problems undermine the possibility of considering orthorexia nervosa, as it currently stands, as a plausible nosographic category. By proposing an analogy with eco-anxiety, the paper lastly shows that, if one accepts the widespread conceptualization of orthorexia nervosa, this behavior is better interpreted as an adaptive response than as a form of mental disorder.</p>","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":"377-397"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unmasking therapy-speak.","authors":"Carme Isern-Mas, Manuel Almagro","doi":"10.1007/s11017-025-09730-5","DOIUrl":"https://doi.org/10.1007/s11017-025-09730-5","url":null,"abstract":"<p><p>Therapy-speak is the imprecise and superficial integration of psychotherapy language into everyday communication, especially by privileged or wealthy people. Despite the advantages of normalizing psychotherapy language, such as resisting epistemic injustice and enhancing awareness of mental health issues, therapy-speak raises important concerns. On the epistemic front, therapy-speak is susceptible to the erosion of the meaning and relevance of psychotherapy terms, pathologizing, and the risk of self-diagnosis. Regarding its ethical concerns, therapy-speak might be used to discredit individuals, evade responsibilities, and even signal social status, by taking an objective stance. Beyond these epistemic and ethical concerns, therapy-speak can also be weaponized to promote and perpetuate some forms of epistemic injustice, and to generate affective injustice. In particular, we argue that the weaponization of therapy-speak exploits the epistemic authority and the credibility excesses of medical evidence, the conflation between the descriptive and the normative, and the linguistic strategy of deniability to impose a specific way to manage emotions in challenging, and unjust, situations.</p>","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pain-like isn't pain. Reasserting affective attitudes as the boundary of moral life.","authors":"Piotr Grzegorz Nowak","doi":"10.1007/s11017-025-09728-z","DOIUrl":"https://doi.org/10.1007/s11017-025-09728-z","url":null,"abstract":"","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reconsidering affective attitudes in constructivist accounts of moral death: the case of the decerebrate patient.","authors":"Tyrel R Porter","doi":"10.1007/s11017-025-09727-0","DOIUrl":"https://doi.org/10.1007/s11017-025-09727-0","url":null,"abstract":"","PeriodicalId":94251,"journal":{"name":"Theoretical medicine and bioethics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}