药物遗传学正在被种族化吗?现代生物医学中种族信仰的重新定义研究。

Theoretical medicine and bioethics Pub Date : 2025-10-01 Epub Date: 2025-08-22 DOI:10.1007/s11017-025-09723-4
Lena Steimle, Christina Schües
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引用次数: 0

摘要

在人类社会和科学史上,种族分类有着复杂而麻烦的过去。它们是种族主义的结果,被用来贬低和贬低非白人。尽管种族的概念已经获得了社会成分,并且基于种族的人的遗传相似性已被证明,但这一类别越来越多地用于药物遗传学研究,以个性化医疗为幌子制造有偏见的研究人群。2005年仅批准用于黑人的心力衰竭药物BiDil尤其臭名昭著。它的种族特异性批准再次引发了关于不同种族的人之间存在基因差异的假设的争论,并导致了“种族”一词进一步的生物政治工具化。尽管种族特异性专利到期,但种族特异性标签仍在研究中发生。本文对药物遗传学的这些种族化进行了研究,解释了它们是如何产生的以及它们是如何保持活力的。最后,本文主张在药物遗传学研究中更好地调节种族。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Is pharmacogenetics being racialized? An investigation into the reinscription of racial beliefs in modern biomedicine.

Racial classifications have a complex and troubled past in the social and scientific history of humankind. They are the result of racism and have been used to devalue and degrade non-White people. Although the concept of race has acquired a social component and the genetic similarity of people based on race has been proven, the category is increasingly used in pharmacogenetic studies to create biased study populations under the guise of personalized medicine. The heart failure drug BiDil, which was only approved for Black people in 2005, gained particular notoriety. Its race-specific approval reignited the debate about the assumption that there are genetic differences between people of different races and led to a further biopolitical instrumentalization of the term 'race'. Despite the expiry of the race-specific patent, race-specific labeling continues to take place in research. In this paper, these racializations of pharmacogenetics are examined, explaining how they arise and how they are kept alive. Finally, this paper argues for better moderation of race in pharmacogenetic studies.

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