Cardiology Research最新文献

{"title":"Partial Pressure of End-Tidal Oxygen and Blood Lactate During Cardiopulmonary Exercise Testing in Healthy Older Participants and Patients at Risk of Cardiac Disease.","authors":"Kazuyuki Kominami, Masatoshi Akino","doi":"10.14740/cr1597","DOIUrl":"10.14740/cr1597","url":null,"abstract":"<p><strong>Background: </strong>The partial pressure of end-tidal oxygen (PETO₂) and end-tidal oxygen concentration (ETO₂) are among the indices that can be measured by exhaled gas analysis. Several observational studies have shown that skeletal muscle function is impaired in patients with cardiac disease; thus, the assessment of skeletal muscle function is important. Additionally, although it has recently been suggested that the difference in PETO₂ from rest to the ventilatory anaerobic threshold (VAT) reflects oxygen availability in peripheral factors, primarily skeletal muscle, the evidence for this is not well established. Therefore, we hypothesized and investigated whether increased blood lactate (BLa) levels, resulting from decreased skeletal muscle and mitochondrial oxygen availability, and PETO₂ dynamics during cardiopulmonary exercise testing (CPET) would be related.</p><p><strong>Methods: </strong>All participants performed the symptomatic limited CPET, and their BLa levels were measured. The difference in PETO₂ and ETO₂ from rest to VAT determined by the V-slope method (ΔPETO₂ and ΔETO₂) was calculated and compared with the increase in BLa due to exercise testing.</p><p><strong>Results: </strong>We recruited 22 healthy older participants (nine males; 69.4 ± 6.8 years) and 11 patients with cardiovascular risk (eight males; 73.0 ± 8.8 years). ΔPETO₂ and ΔETO₂ did not differ between the two groups (P = 0.355 and P = 0.369, respectively), showing no correlation between increase in BLa from rest to VAT, but were significantly correlated with an increase in BLa from rest to the end of exercise (ΔPETO₂, P = 0.030; ΔETO₂, P = 0.029). The correlation was particularly pronounced among those at cardiovascular risk (ΔPETO₂, P = 0.012; ΔETO₂, P = 0.011).</p><p><strong>Conclusions: </strong>ΔPETO₂ and ΔETO₂ from rest to VAT during CPET may be useful as indices reflecting skeletal muscle oxygen utilization capacity.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"15 1","pages":"29-36"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Heart of Rett Syndrome: A Quantitative Analysis of Cardiac Repolarization","authors":"Michael P. Collins, Mark C. Johnson, Robin C. Ryther, Judith L. Weisenberg, Peter T. Heydemann, Colleen M. Buhrfiend, William A. Scott, Dallas Armstrong, Haley M. Kern, Hoang H. Nguyen","doi":"10.14740/cr1580","DOIUrl":"https://doi.org/10.14740/cr1580","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"40 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Anterior Descending Artery Dissection in a Female Patient With History of Chest Radiation Treatment and Separate Ostia of the Left Coronary Arteries","authors":"Christos Papageorgiou, Vaios Tzifos","doi":"10.14740/cr1603","DOIUrl":"https://doi.org/10.14740/cr1603","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"10 3-5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Non-Clinically Apparent Liver Fibrosis and Pulmonary Arterial Hypertension in Hispanic Patients","authors":"M. Kalas, Yacoub Khatab, G. Galura, Haider M Alkhateeb, Debabrata Mukherjee, Hernando García, Marc Zuckerman, N. Nickel","doi":"10.14740/cr1565","DOIUrl":"https://doi.org/10.14740/cr1565","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"4 2-3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of the STIM1/Orai1 Signaling Pathway by Glycine Betaine Mitigates Myocardial Hypertrophy in Spontaneous Hypertension Rats","authors":"Bing Xiao, Yan Zhao, Ke Ke Wang, Xiu Chun Yang, Hai Juan Hu, Yue Li, Yun Fei Xu, Zhen Tian Zhang, Shuai Wang, Jing Chao Lu","doi":"10.14740/cr1583","DOIUrl":"https://doi.org/10.14740/cr1583","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"4 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral Annular Disjunction: Clinical Implications and Surgical Considerations","authors":"Ling Zhu, Y. L. Chua","doi":"10.14740/cr1584","DOIUrl":"https://doi.org/10.14740/cr1584","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"89 5-6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Blood Pressure-Enabled Smartwatch Ready to Drive Precision Medicine? Supporting Findings From a Validation Study","authors":"Wan Ling Lee, Mahmoud Danaee, Adina Abdullah, Li Ping Wong","doi":"10.14740/cr1569","DOIUrl":"https://doi.org/10.14740/cr1569","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"6 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139190306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulseless Electrical Activity and Perioperative Cardiac Arrest Due to Undiagnosed and Asymptomatic Hypothyroidism During Outpatient Surgery in an Adolescent","authors":"Josiane Kerbage, Olamide O. Dairo, Lauren Ketchum, Craig Smith, Joseph D. Tobias","doi":"10.14740/cr1605","DOIUrl":"https://doi.org/10.14740/cr1605","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"62 7","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal Trends in the United States Patent Landscape: Innovation in Cardiology Across Industry and Academia.","authors":"Raoul R Wadhwa, Brenna M McElderry, James Yu, Samir R Kapadia, A Marc Gillinov, Lars G Svensson, Milind Y Desai","doi":"10.14740/cr1417","DOIUrl":"10.14740/cr1417","url":null,"abstract":"<p><strong>Background: </strong>Novel approaches to diagnostics and therapeutics in medical care reflect the scientific community's evolving understanding of disease states and their clinical implications. Marketable and valuable innovations are generally patented for protection of intellectual property. Here, we explore the landscape of cardiology-related patents in the United States.</p><p><strong>Methods: </strong>All United States patents granted between 2005 and 2020 were included in this study. Keywords filtering was used to identify patents related to cardiovascular medicine. Statistical inference was conducted with the Mann-Kendall trend and analysis of variance tests. The results in this report are entirely reproducible with Python and R scripts available in a publicly accessible repository.</p><p><strong>Results: </strong>Of the 4,453,733 patents issued by the USPTO between 2005 and 2020, 31,048 (0.7%) were identified as cardiology-related patents. We identified the top 10 institutions within the for-profit and not-for-profit categories that were assigned the most cardiology-related patents in this time period. Distributions of number of patents per inventor were heavily right-skewed, with a small number of inventors responsible for a large number of patents each. Patents in the cardiac imaging subgroup took the longest to gain approval after submission (median delay: 3.6 years).</p><p><strong>Conclusions: </strong>By studying the patent universe, we are able to identify underexplored areas within cardiovascular medicine. Obstacles such as long delays between patent application and approval can hamper innovation within a field. As a next step, we aim to use these results to predict the next area within cardiovascular medicine to undergo explosive research and innovation.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"14 5","pages":"334-341"},"PeriodicalIF":1.4,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71491093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between the Presence of Coronary Artery Disease or Peripheral Artery Disease and Left Ventricular Mass in Patients Who Have Undergone Coronary Computed Tomography Angiography.","authors":"Tetsuro Tachibana, Yuhei Shiga, Tetsuo Hirata, Kohei Tashiro, Sara Higashi, Yuto Kawahira, Yuta Kato, Takashi Kuwano, Makoto Sugihara, Shin-Ichiro Miura","doi":"10.14740/cr1532","DOIUrl":"10.14740/cr1532","url":null,"abstract":"<p><strong>Background: </strong>Left ventricular mass (LVM) is a critical marker of future cardiovascular risk. We determined the association between LVM measured by coronary computed tomography angiography (CCTA) and the presence of coronary artery disease (CAD) or peripheral artery disease (PAD) in patients who had undergone CCTA for screening of CAD.</p><p><strong>Methods: </strong>We enrolled 1,307 consecutive patients (66 ± 12 years old, 49% males) who underwent CCTA for screening of CAD at the Fukuoka University Hospital (FU-CCTA registry), and either were clinically suspected of having CAD or had at least one cardiovascular risk factor. Patients with coronary stenosis of ≥ 50% by CCTA were diagnosed as CAD. Patients with an ankle brachial pressure index < 0.9 or who had already been diagnosed with PAD were considered to have PAD. Left ventricular mass index (LVMI), left ventricular ejection fraction (LVEF), end-diastolic volume (EDV) and end-systolic volume (ESV) were measured. The patients were divided into CAD (-) and CAD (+) or PAD (-) and PAD (+) groups.</p><p><strong>Results: </strong>The prevalences of CAD and PAD in all patients were 50% and 4.8%, respectively. Age, %males, %hypertension (HTN), %dyslipidemia (DL), %diabetes mellitus (DM), %smoking and %chronic kidney disease in the CAD (+) group were significantly higher than those in the CAD (-) group. Age, %males, %HTN, %DM and %smoking in the PAD (+) group were significantly higher than those in the PAD (-) group. CAD was independently associated with LVMI (odds ratio (OR): 1.01, 95% confidence interval (CI): 1.01 - 1.02, P < 0.01) in addition to age, male, HTN, DL, DM, and smoking. PAD was also independently associated with LVMI (OR: 1.01, 95% CI: 1.0 - 1.02, P = 0.018) in addition to age, DM, and smoking.</p><p><strong>Conclusions: </strong>LVMI determined by CCTA may be useful for predicting atherosclerotic cardiovascular diseases including both CAD and PAD, although there were considerable differences between %CAD and %PAD in all patients.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"14 5","pages":"387-395"},"PeriodicalIF":1.9,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71478249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}