通过对比增强超声造影评估缺血性脑卒中患者体内残留胆固醇和颈动脉斑块内新生血管的情况

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2024-06-01 Epub Date: 2024-06-25 DOI:10.14740/cr1634

Yan Song, Ying Dang, Jun Feng, Li Tao Ruan

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引用次数: 0

摘要

背景：我们研究了缺血性脑卒中患者体内残余胆固醇与造影剂增强超声成像（CEUS）评估的颈动脉斑块内新生血管（IPN）之间的关系：这是一项单中心研究。残余胆固醇的计算方法是总胆固醇减去低密度脂蛋白胆固醇（LDL-C）再减去高密度脂蛋白胆固醇（HDL-C）。所有患者均接受 CEUS 检查。根据每个斑块内微气泡的存在和位置对 IPN 进行分级：结果：研究对象包括 110 名缺血性中风患者。与 IPN 分级 < 2 的患者相比，IPN 分级为 2 的患者甘油三酯（TG）、非高密度脂蛋白胆固醇（HDL-C）和残余胆固醇浓度更高（TG：1.45 ± 0.69 vs. 0.96 ± 0.69）。69 vs. 0.96 ± 0.24 mmol/L，P < 0.001；非高密度脂蛋白胆固醇：2.63 ± 0.85 vs. 2.31 ± 0.64 mmol/L，P = 0.037；残余胆固醇：0.57 ± 0.23 vs. 0.44 ± 0.07 mmol/L，P < 0.001）。在具有最佳低密度脂蛋白胆固醇浓度的患者子集中，残余胆固醇的多变量调整赔率比（95% 置信区间）为 27.728 (2.714 - 283.253)，IPN 分级为 2：结论：在低密度脂蛋白胆固醇浓度达到最佳水平的缺血性脑卒中患者中，残余胆固醇浓度与CEUS上的颈动脉IPN显著相关。残余胆固醇可能是缺血性脑卒中患者风险分层的一个重要指标。

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Remnant Cholesterol and Carotid Intraplaque Neovascularization Assessed by Contrast-Enhanced Ultrasonography in Patients With Ischemic Stroke.

Background: We investigated the relationship between remnant cholesterol and carotid intraplaque neovascularization (IPN) assessed by contrast-enhanced ultrasonography (CEUS) in patients with ischemic stroke.

Methods: This was a single-center study. Remnant cholesterol is calculated as total cholesterol minus low-density lipoprotein cholesterol (LDL-C) minus high-density lipoprotein cholesterol (HDL-C). All patients underwent CEUS. IPN is graded according to the presence and location of microbubbles within each plaque.

Results: The cohort included 110 patients with ischemic stroke. Patients with an IPN grading of 2 had higher triglyceride (TG), non-HDL-C, and remnant cholesterol concentrations than those with an IPN grading of < 2 (TG: 1.45 ± 0.69 vs. 0.96 ± 0.24 mmol/L, P < 0.001; non-HDL-C: 2.63 ± 0.85 vs. 2.31 ± 0.64 mmol/L, P = 0.037; remnant cholesterol: 0.57 ± 0.23 vs. 0.44 ± 0.07 mmol/L, P < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for remnant cholesterol was 27.728 (2.714 - 283.253) for an IPN grading of 2 in the subset of patients with an optimal LDL-C concentration.

Conclusions: The remnant cholesterol concentration is significantly associated with carotid IPN on CEUS in patients with ischemic stroke with an optimal LDL-C concentration. Remnant cholesterol may be an important indicator of risk stratification in patients with ischemic stroke.

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.