Cardiology Research最新文献

{"title":"Hemodynamic Response to Exercise Training in Heart Failure With Reduced Ejection Fraction Patients.","authors":"Marine Kirsch, Marie-Christine Iliou, Damien Vitiello","doi":"10.14740/cr1591","DOIUrl":"10.14740/cr1591","url":null,"abstract":"<p><strong>Background: </strong>Supervised exercise training decreases total and cardiac mortality and increases quality of life of heart failure with reduced ejection fraction (HFrEF) patients. However, response to training is variable from one patient to another and factors responsible for a positive response to training remain unclear. The aims of the study were to compare cardiac hemodynamic changes after an exercise training program in responders (R) versus non-responders (NR) HFrEF patients, and to compare different discriminators used to assess response to training.</p><p><strong>Methods: </strong>Seventy-six HFrEF patients (86% males, 57 ± 12 years) completed an exercise training program for 4 weeks. Patients underwent cardiopulmonary exercise testing (CPET) on a cycle ergometer before and after training. Cardiac hemodynamics were measured by impedance cardiography during CPET. The R and NR groups were classified using the median change in peak oxygen uptake (V̇O_2peak).</p><p><strong>Results: </strong>There were statistically significant differences in V̇O_2peak (+35% vs. -1%, P < 0.0001) and in peaks of ventilation (+30% vs. +2%, P < 0.0001), cardiac output (CO_peak) (+25% vs. +4%, P < 0.01), systolic blood pressure (+12% vs. +2%, P < 0.05), diastolic blood pressure (+9% vs. +4%, P < 0.05) and heart rate (+8% vs. +1%, P < 0.01) between R and NR after the training program. V̇O_2peak was the best discriminator between R and NR (receiver operating characteristic (ROC) area under the curve (AUC) = 0.83, P < 0.0001), followed by CO_peak (ROC AUC = 0.77, P < 0.0001).</p><p><strong>Conclusion: </strong>V̇O_2peak is the best discriminator between HFrEF R and NR patients after the training program. Responders showed improvements in peak hemodynamic parameters. These results pave the way for other studies to determine how the individualization of exercise training programs and peak hemodynamic parameters potentially linked to a better positive response status.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"15 1","pages":"18-28"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Respiratory Muscle Strength and Overall Function in Patients With Cardiovascular Disease Through Rehabilitation Hospitals.","authors":"Tomohiro Matsuo, Tomoyuki Morisawa, Takuro Ohtsubo, Katsuhiro Ueno, Shuichi Kozawa","doi":"10.14740/cr1616","DOIUrl":"10.14740/cr1616","url":null,"abstract":"<p><strong>Background: </strong>The prevalence of respiratory sarcopenia and its effect on respiratory muscle strength (RMS) in patients with cardiovascular disease (CVD), who are transferred to a convalescent rehabilitation hospital after acute care and require continuous cardiac rehabilitation (CR), is currently unclear. This study aimed to assess changes in RMS, physical function, and activities of daily living (ADL) before and after CR performed in a rehabilitation hospital.</p><p><strong>Methods: </strong>Of 50 consecutive patients transferred to a rehabilitation hospital for ongoing CR, 30 fulfilled the inclusion criteria. Maximal inspiratory and expiratory pressures (MIP and MEP, respectively) were measured at transfer, and patients with decreased RMS were diagnosed with respiratory sarcopenia. RMS, physical function, exercise tolerance, ADL ability, and health-related quality of life (HR-QoL) were measured and compared at transfer and discharge.</p><p><strong>Results: </strong>The prevalence of respiratory sarcopenia at the time of transfer to the rehabilitation hospital was 93.3%. RMS assessments at transfer and discharge demonstrated significant improvements in %MIP (from 46.3±26.1% to 63.6±33.7%) and %MEP (from 44.8±17.3% to 56.6±21.8%). Short physical performance battery, gait speed, handgrip strength, and knee extension muscle strength significantly improved, along with significant prolongation of 6-min walking distance as a measure of exercise tolerance. ADL assessment using the functional independence measure revealed significant improvement, as did HR-QoL assessed according to the five-dimension, five-level, EuroQoL instrument, following CR.</p><p><strong>Conclusions: </strong>Although respiratory sarcopenia was highly prevalent among patients with CVD who required transfer to a rehabilitation hospital after acute care, continuous CR significantly improved RMS, ADL, physical function, and exercise tolerance. These findings support the continued expansion of CR, particularly in dedicated rehabilitation hospitals.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"15 1","pages":"56-66"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Experience With Remimazolam for Procedural Sedation and as an Adjunct to General Anesthesia During Diagnostic and Interventional Cardiac Procedures.","authors":"Holly Gillis, Christopher McKee, Kristin Chenault, Marco Corridore, Joseph D Tobias","doi":"10.14740/cr1595","DOIUrl":"10.14740/cr1595","url":null,"abstract":"<p><strong>Background: </strong>Remimazolam is a benzodiazepine which, like midazolam, has sedative, anxiolytic, and amnestic properties. Ester metabolism results in a half-life of 5 - 10 min, a limited context sensitive half-life, and rapid recovery when the infusion is discontinued.</p><p><strong>Methods: </strong>Following the Institutional Review Board (IRB) approval, we performed a retrospective chart review of patients who received remimazolam in the cardiac catheterization, cardiac magnetic resonance imaging (MRI), and electrophysiology suites. The primary objective was to assess efficacy and safety. The secondary objective was to describe bolus and infusion dosing of remimazolam and the need for adjunctive agents to optimize procedural sedation conditions.</p><p><strong>Results: </strong>The study cohort included 26 patients with a median age of 18 years and a total of 33 anesthetic encounters. The most common procedures were endomyocardial biopsy or isolated hemodynamic assessment (right or left heart catheterization). Remimazolam was the primary agent for sedation in 82% of the procedures. The majority of cases (25 encounters, 76%) included a bolus dose of remimazolam prior to the start of an infusion. For those patients who received a starting bolus dose, dosing typically ranged between 30 and 110 µg/kg. Continuous infusion rates of remimazolam varied from 5 to 20 µg/kg/min. No adverse hemodynamic or respiratory effects were noted. Midazolam, fentanyl, and dexmedetomidine were the most frequently used adjunctive agents. One patient required transition to general anesthesia due to the need for a surgical intervention based on the findings of the cardiac catheterization. All other patients were effectively sedated.</p><p><strong>Conclusions: </strong>Our preliminary experience demonstrates that remimazolam effectively provided sedation for diagnostic and therapeutic cardiovascular procedures. Future studies are needed to further define dosing parameters for both bolus dosing and continuous infusion as well as to compare remimazolam to other commonly used for procedural sedation in patients with congenital and acquired heart disease.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"15 1","pages":"12-17"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partial Pressure of End-Tidal Oxygen and Blood Lactate During Cardiopulmonary Exercise Testing in Healthy Older Participants and Patients at Risk of Cardiac Disease.","authors":"Kazuyuki Kominami, Masatoshi Akino","doi":"10.14740/cr1597","DOIUrl":"10.14740/cr1597","url":null,"abstract":"<p><strong>Background: </strong>The partial pressure of end-tidal oxygen (PETO₂) and end-tidal oxygen concentration (ETO₂) are among the indices that can be measured by exhaled gas analysis. Several observational studies have shown that skeletal muscle function is impaired in patients with cardiac disease; thus, the assessment of skeletal muscle function is important. Additionally, although it has recently been suggested that the difference in PETO₂ from rest to the ventilatory anaerobic threshold (VAT) reflects oxygen availability in peripheral factors, primarily skeletal muscle, the evidence for this is not well established. Therefore, we hypothesized and investigated whether increased blood lactate (BLa) levels, resulting from decreased skeletal muscle and mitochondrial oxygen availability, and PETO₂ dynamics during cardiopulmonary exercise testing (CPET) would be related.</p><p><strong>Methods: </strong>All participants performed the symptomatic limited CPET, and their BLa levels were measured. The difference in PETO₂ and ETO₂ from rest to VAT determined by the V-slope method (ΔPETO₂ and ΔETO₂) was calculated and compared with the increase in BLa due to exercise testing.</p><p><strong>Results: </strong>We recruited 22 healthy older participants (nine males; 69.4 ± 6.8 years) and 11 patients with cardiovascular risk (eight males; 73.0 ± 8.8 years). ΔPETO₂ and ΔETO₂ did not differ between the two groups (P = 0.355 and P = 0.369, respectively), showing no correlation between increase in BLa from rest to VAT, but were significantly correlated with an increase in BLa from rest to the end of exercise (ΔPETO₂, P = 0.030; ΔETO₂, P = 0.029). The correlation was particularly pronounced among those at cardiovascular risk (ΔPETO₂, P = 0.012; ΔETO₂, P = 0.011).</p><p><strong>Conclusions: </strong>ΔPETO₂ and ΔETO₂ from rest to VAT during CPET may be useful as indices reflecting skeletal muscle oxygen utilization capacity.</p>","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"15 1","pages":"29-36"},"PeriodicalIF":1.9,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10923256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140093387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Heart of Rett Syndrome: A Quantitative Analysis of Cardiac Repolarization","authors":"Michael P. Collins, Mark C. Johnson, Robin C. Ryther, Judith L. Weisenberg, Peter T. Heydemann, Colleen M. Buhrfiend, William A. Scott, Dallas Armstrong, Haley M. Kern, Hoang H. Nguyen","doi":"10.14740/cr1580","DOIUrl":"https://doi.org/10.14740/cr1580","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"40 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left Anterior Descending Artery Dissection in a Female Patient With History of Chest Radiation Treatment and Separate Ostia of the Left Coronary Arteries","authors":"Christos Papageorgiou, Vaios Tzifos","doi":"10.14740/cr1603","DOIUrl":"https://doi.org/10.14740/cr1603","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"10 3-5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Non-Clinically Apparent Liver Fibrosis and Pulmonary Arterial Hypertension in Hispanic Patients","authors":"M. Kalas, Yacoub Khatab, G. Galura, Haider M Alkhateeb, Debabrata Mukherjee, Hernando García, Marc Zuckerman, N. Nickel","doi":"10.14740/cr1565","DOIUrl":"https://doi.org/10.14740/cr1565","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"4 2-3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139194931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of the STIM1/Orai1 Signaling Pathway by Glycine Betaine Mitigates Myocardial Hypertrophy in Spontaneous Hypertension Rats","authors":"Bing Xiao, Yan Zhao, Ke Ke Wang, Xiu Chun Yang, Hai Juan Hu, Yue Li, Yun Fei Xu, Zhen Tian Zhang, Shuai Wang, Jing Chao Lu","doi":"10.14740/cr1583","DOIUrl":"https://doi.org/10.14740/cr1583","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"4 1","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139195864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitral Annular Disjunction: Clinical Implications and Surgical Considerations","authors":"Ling Zhu, Y. L. Chua","doi":"10.14740/cr1584","DOIUrl":"https://doi.org/10.14740/cr1584","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"89 5-6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139189768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the Blood Pressure-Enabled Smartwatch Ready to Drive Precision Medicine? Supporting Findings From a Validation Study","authors":"Wan Ling Lee, Mahmoud Danaee, Adina Abdullah, Li Ping Wong","doi":"10.14740/cr1569","DOIUrl":"https://doi.org/10.14740/cr1569","url":null,"abstract":"","PeriodicalId":9424,"journal":{"name":"Cardiology Research","volume":"6 3","pages":""},"PeriodicalIF":1.9,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139190306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}