Partial Pressure of End-Tidal Oxygen and Blood Lactate During Cardiopulmonary Exercise Testing in Healthy Older Participants and Patients at Risk of Cardiac Disease.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Cardiology Research Pub Date : 2024-02-01 Epub Date: 2024-02-28 DOI:10.14740/cr1597
Kazuyuki Kominami, Masatoshi Akino
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引用次数: 0

Abstract

Background: The partial pressure of end-tidal oxygen (PETO2) and end-tidal oxygen concentration (ETO2) are among the indices that can be measured by exhaled gas analysis. Several observational studies have shown that skeletal muscle function is impaired in patients with cardiac disease; thus, the assessment of skeletal muscle function is important. Additionally, although it has recently been suggested that the difference in PETO2 from rest to the ventilatory anaerobic threshold (VAT) reflects oxygen availability in peripheral factors, primarily skeletal muscle, the evidence for this is not well established. Therefore, we hypothesized and investigated whether increased blood lactate (BLa) levels, resulting from decreased skeletal muscle and mitochondrial oxygen availability, and PETO2 dynamics during cardiopulmonary exercise testing (CPET) would be related.

Methods: All participants performed the symptomatic limited CPET, and their BLa levels were measured. The difference in PETO2 and ETO2 from rest to VAT determined by the V-slope method (ΔPETO2 and ΔETO2) was calculated and compared with the increase in BLa due to exercise testing.

Results: We recruited 22 healthy older participants (nine males; 69.4 ± 6.8 years) and 11 patients with cardiovascular risk (eight males; 73.0 ± 8.8 years). ΔPETO2 and ΔETO2 did not differ between the two groups (P = 0.355 and P = 0.369, respectively), showing no correlation between increase in BLa from rest to VAT, but were significantly correlated with an increase in BLa from rest to the end of exercise (ΔPETO2, P = 0.030; ΔETO2, P = 0.029). The correlation was particularly pronounced among those at cardiovascular risk (ΔPETO2, P = 0.012; ΔETO2, P = 0.011).

Conclusions: ΔPETO2 and ΔETO2 from rest to VAT during CPET may be useful as indices reflecting skeletal muscle oxygen utilization capacity.

健康老年参与者和有心脏病风险的患者进行心肺运动测试时的潮气末氧分压和血乳酸。
背景:潮气末氧分压(PETO2)和潮气末氧浓度(ETO2)是可以通过呼出气体分析测量的指标之一。多项观察性研究表明,心脏病患者的骨骼肌功能会受损;因此,骨骼肌功能的评估非常重要。此外,虽然最近有人认为 PETO2 从静息到通气无氧阈值(VAT)的差异反映了外周因素(主要是骨骼肌)的氧气可用性,但这方面的证据并不充分。因此,我们假设并研究了骨骼肌和线粒体氧可用性降低导致的血乳酸(BLa)水平升高与心肺运动测试(CPET)期间 PETO2 动态是否相关:方法:所有参与者都进行了有症状的有限 CPET,并测量了他们的 BLa 水平。方法:所有参与者都进行了无症状限制性 CPET,并测量了他们的 BLa 水平。通过 V 斜率法(ΔPETO2 和 ΔETO2)计算出 PETO2 和 ETO2 从静息状态到 VAT 的差异,并与运动测试导致的 BLa 增加进行比较:我们招募了 22 名健康的老年参与者(9 名男性;69.4 ± 6.8 岁)和 11 名心血管风险患者(8 名男性;73.0 ± 8.8 岁)。两组之间的 ΔPETO2 和 ΔETO2 没有差异(分别为 P = 0.355 和 P = 0.369),从静息到 VAT 的 BLa 增加之间没有相关性,但与从静息到运动结束的 BLa 增加显著相关(ΔPETO2,P = 0.030;ΔETO2,P = 0.029)。结论:ΔPETO2 和 ΔETO2 从静息到 CPET 期间的 VAT,可能是反映骨骼肌氧利用能力的有用指标。
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来源期刊
Cardiology Research
Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.50
自引率
0.00%
发文量
42
期刊介绍: Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.
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