The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Implementing the WHO ICOPE Program in Clinical Practice: Three Years of Lessons From Monitoring 27 082 Participants Using the ICOPE Monitor Digital Tool.","authors":"Caroline Berbon, Catherine Takeda, Laurent Balardy, Christine Lafont, Néda Tavassoli, Isabelle Carrie, Sophie Guyonnet, Justine de Kerimel, Céline Mathieu, Delphine Pennetier, Véronique Bezombes, Fatemeh Nourhashemi, Bruno Vellas, Sandrine Andrieu, Maria-Eugenia Soto-Martin","doi":"10.1093/gerona/glae278","DOIUrl":"10.1093/gerona/glae278","url":null,"abstract":"<p><strong>Background: </strong>To describe the implementation of the ICOPE program in France using a digital tool in order to: (1) describe the characteristics of people completing the screener, identifying differences across assessors (healthcare professionals (HCPs), non-HCPs, or self-assessment); (2) describe the characteristics of follow-up and assessments for people with abnormal screening test; and (3) describe the recommendations in the intervention care plans for people with a decline in intrinsic capacity.</p><p><strong>Methods: </strong>A descriptive study, presenting the results at initial screening, as well as at assessment when needed, and the recommendations issued during Step 3. We compared these results based on whether the participant was enrolled by an HCP, by a non-HCP, or by self-assessment.</p><p><strong>Results: </strong>A total of 27 082 participants were enrolled. 67.9% were registered by HCPs. 90.8% participants screened positive at Step 1. Participants who completed the self-assessment were significantly younger (70.9 years vs 76.4 for HCPs or 77.9 for non-HCPs, p < .01) and less frequently had alerts in Step 1 (83.8% vs 90.8% for HCPs or 94.8% for non-HCPs). Step 2 in-depth assessments were carried out for 8.9% of the participants. In Step 2, only the SPPB showed significantly better motor abilities in individuals enrolled through self-assessment (median and IQR: 11 (10-12) vs 10 (8-12) for HCPs and 10 (7-12) for non-HCPs). Prevention care plans were proposed, mainly physical activity (n = 833, 33.7%) and nutrition counseling (n = 1 233, 51.7%).</p><p><strong>Conclusions: </strong>This study highlights the major role of HCPs in the implementation of the ICOPE program. Self-assessment enables the enrollment of more robust seniors, allowing for an early detection and treatment.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meeting 24-Hour Movement Guidelines and Mortality Risk in Older Adults: Cross-Sectional and Longitudinal Pooled Analysis in the Seniors-ENRICA Cohorts.","authors":"Miguel Angelo Duarte Junior, Salud Pintos-Carrillo, Alba Hernández-Martínez, José Francisco López-Gil, Auxiliadora Graciani, José Ramón Banegas, Fernando Rodríguez-Artalejo, Verónica Cabanas-Sánchez, David Martinez-Gomez","doi":"10.1093/gerona/glae291","DOIUrl":"10.1093/gerona/glae291","url":null,"abstract":"<p><strong>Background: </strong>We assessed the association of adherence to the guidelines and subsequent changes over time in adherence with all-cause mortality.</p><p><strong>Methods: </strong>We used data from 3 518 and 3 273 older adults, aged 60-96 years at baseline, from Seniors-ENRICA 1 and 2 cohorts, respectively. Adherence to 24-hour movement guidelines was defined as ≥150 min/wk of moderate-to-vigorous physical activity (MVPA), sedentary behavior (SB) ≤8 h/d (including ≤3 h/d of recreational screen time), and 7-9 h/d of sleep if aged 18-64 years or 7-8 h/d if aged ≥65 years. All-cause mortality was ascertained up to January 31, 2024. Analyses were performed using Cox regression adjusted for the main confounders.</p><p><strong>Results: </strong>Of the 6 613 participants with complete data, 1 353 died during a mean follow-up of 10.1 (standard deviation [SD] = 4.0) years. Meeting MVPA (hazard ratio [HR] 0.73; 95% confidence interval [CI] 0.65-0.82), SB (HR 0.89; 95% CI 0.80-0.99), and sleep (HR 0.89; 95% CI 0.80-0.99) recommendations were associated with lower mortality. Also, we noticed a reduction in mortality in meeting MVPA combined with both SB (34%) and sleep (12%), sleep and SB combined (23%), and meeting all 24-hour movement guidelines (40%). Changes in meeting 24-hour movement guidelines occurred between a mean follow-up of 2.8 (0.6) years. Meeting 24-hour movement guidelines at baseline and follow-up is associated with lower mortality (HR 0.69; 95% CI 0.47-0.99), compared to not meet them at both examinations.</p><p><strong>Conclusions: </strong>This prospective cohort study underscores the critical impact of adhering to and maintaining adherence to the 24-hour movement guidelines in reducing mortality risk among older adults.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Has Muscle Power Better Discriminative Capacity Compared to Muscle Strength in Predicting Worsening Disability in Older Adults?","authors":"Silvia Travaglini, Maria Bonvicini, Stefania Bandinelli, Luigi Ferrucci, Raffaele Antonelli Incalzi, Claudio Pedone","doi":"10.1093/gerona/glaf003","DOIUrl":"10.1093/gerona/glaf003","url":null,"abstract":"<p><strong>Background: </strong>Poor muscle strength is a risk factor for disability; nonetheless, its discriminative capacity in identifying people who will become disabled is poor. We evaluated whether muscle power, which also is a risk factor for disability, has better discriminative capacity compared to muscle strength.</p><p><strong>Methods: </strong>We used data from the population-based InCHIANTI study. Our outcome measure was the loss of at least 1 basic or instrumental activity of daily living between baseline and 3-year follow-up visit. Body weight standardized knee isometric strength and leg power (power rig) were used as exposure variables. Discriminative capacity was estimated using the area under the receiver-operating curves. Both strength and power were dichotomized as below versus equal of above sex-specific first quartile. Sensitivity, specificity, and positive/negative predictive values (PPV, NPV) were calculated.</p><p><strong>Results: </strong>We included 763 participants (415 women), with a mean age of 73.5 years (standard deviation: 6.4). In men, using muscle strength we obtained an area under the curve (AUC) of 0.70, with sensitivity = 0.45, specificity = 0.80, PPV = 0.27, and NPV = 0.90; using muscle power we obtained an AUC of 0.82, sensitivity = 0.73, specificity = 0.86, PPV = 0.46, and NPV = 0.95. In women, using muscle strength we obtained an AUC of 0.62, with sensitivity = 0.39, specificity = 0.81, PPV = 0.39, and NPV = 0.81; using muscle power we obtained an AUC = 0.69, sensitivity = 0.40, specificity = 0.83, PPV = 0.42, and NPV = 0.82.</p><p><strong>Conclusions: </strong>We found that in men muscle power had better discriminative capacity, especially higher sensitivity, compared to muscle strength for prediction of worsening disability. No meaningful difference in overall discriminative capacity was found in women.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809250/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in the Association Between 24-hour Rest-Activity Rhythms and Frailty Among U.S. Older Adults: Findings From NHANES 2011-2014.","authors":"Jisu Kim, Jonathan Kenyon, Lana Sargent, Danielle L Kirkman, Youngdeok Kim","doi":"10.1093/gerona/glae281","DOIUrl":"10.1093/gerona/glae281","url":null,"abstract":"<p><strong>Background: </strong>Little is known as to how rest-activity rhythms are associated with frailty and how this relationship differs by sex. This study examined the relationship between rest-activity rhythms and frailty in a nationally representative sample of U.S. older adults, focusing on the moderating role of sex.</p><p><strong>Methods: </strong>2 531 participants aged ≥60 years (females: 55.2%; frail: 5.15% [4.02-6.29]; pre-frail: 33.49% [31.29-35.68]) were included using the 2011-2014 National Health and Nutrition Examination Survey. Nonparametric rest-activity rhythms parameters, including inter-daily stability, intra-daily variability, relative amplitude, most active 10-hour, and least active 5-hour, were estimated from wrist-worn actigraphy data. Frailty status was assessed using a modified version of frailty phenotype (range: 0-5): frail (≥3), pre-frail (1,2), and non-frail (0). Multinomial logistic regression models were used to examine the interest of associations, adjusting for potential confounders.</p><p><strong>Results: </strong>Frail and pre-frail older adults exhibited significantly lower relative amplitude, inter-daily stability, higher intra-daily variability, and phase delay when compared with non-frail older adults (p's < .05). Particularly, older adults with low relative amplitude had significantly greater odds of being frail and pre-frail (aOR [95% confidence intervals]; frailty: 5.60 [2.61-12.04]; pre-frailty: 1.58 [1.13-2.20]). Significant sex-interaction was observed (p < .01), with this association being greater in females than in males (aOR [95% confidence intervals]; females: 7.78 [2.98-20.30] for frailty, 2.31 [1.60-3.32] for pre-frailty; males: 4.48 [1.38-14.54] for frailty, 1.12 [0.61-2.07] for pre-frailty).</p><p><strong>Conclusion: </strong>Weakened rest-activity rhythms strength is unfavorably associated with frailty, particularly in females. Rest-activity rhythms may be a useful indicator associated with frailty in older adults, but sex-specific differences should be considered. Further longitudinal research is necessary to investigate the bidirectionality of their association.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of OLR1 Reduces SASP of Nucleus Pulposus Cells by Targeting Autophagy-GATA4 Axis.","authors":"Jia-Wei Gao, Hang Shi, Fu-Ping Gao, Zhi-Min Zhou, Xin Peng, Rui Sun, Vladmir Lenine Ferreira Cabral, Jian Li, Yun-Tao Wang, Xiao-Hu Wang, Xiao-Tao Wu","doi":"10.1093/gerona/glae204","DOIUrl":"10.1093/gerona/glae204","url":null,"abstract":"<p><p>Targeting cellular senescence and senescence associated secretory phenotype (SASP) through autophagy has emerged as a promising intervertebral disc (IVD) degeneration (IDD) treatment strategy in recent years. This study aimed to clarify the role and mechanism of autophagy in preventing IVD SASP. Methods involved in vitro experiments with nucleus pulposus (NP) tissues from normal and IDD patients, as well as an in vivo IDD animal model. GATA4's regulatory role in SASP was validated both in vitro and in vivo, while autophagy modulators were employed to assess their impact on GATA4 and SASP. Transcriptomic sequencing identified oxidized low-density lipoprotein receptor 1 (OLR1) as a key regulator of autophagy and GATA4. A series of experiments manipulated OLR1 expression to investigate associated effects. Results demonstrated significantly increased senescent NP cells (NPCs) and compromised autophagy in IDD patients and animal models, with SASP closely linked to IDD progression. The aged disc milieu impeded autophagic GATA4 degradation, leading to elevated SASP expression in senescent NPCs. Restoring autophagy reversed senescence by degrading GATA4, hence disrupting the SASP cascade. Moreover, OLR1 was identified for its regulation of autophagy and GATA4 in senescent NPCs. Silencing OLR1 enhanced autophagic activity, suppressing GATA4-induced senescence, and SASP expression in senescent NPCs. In conclusion, OLR1 was found to control autophagy-GATA4 and SASP, with targeted OLR1 inhibition holding promise in alleviating GATA4-induced senescence and SASP expression while delaying extracellular matrix degradation, offering a novel therapeutic approach for IDD management.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142038108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study in Murine Model: Is There a Relationship Between Presbycusis and Frailty?","authors":"Rosalía Fátima Heredia-Molina, Juan Ignacio Riestra-Ayora, Joaquín Yanes-Díaz, Israel John Thuissard Vasallo, Cristina Andreu-Vázquez, Iria de la Osa Subtil, Ricardo Sanz-Fernández, Carolina Sánchez-Rodríguez","doi":"10.1093/gerona/glae273","DOIUrl":"10.1093/gerona/glae273","url":null,"abstract":"<p><p>Age-related hearing loss, or Presbycusis, is the most frequent sensory deficiency in older adults and is associated with comorbidities such as falls, cognitive decline, and frailty. Frailty is related to poor health outcomes in old age. Recent research suggested that age-related hearing loss may be a potentially modifiable risk factor for frailty, although inconclusive. The use of animal models to study the correlation between age-related hearing loss and frailty is important to test future interventions to be translated into clinical practice. The aim of this study was to determine if there is an association between age-related hearing loss and frailty in experimental animals based on the human frailty phenotype. This research studied male and female C57Bl/6J mice at different ages (6, 14, and 22 months). Auditory steady-state response threshold shifts were measured at different frequencies. To assess frailty status, we were based on the \"Valence Score,\" which consists of measuring: weakness, weight loss, low level of activity, slowness, and little resistance. We found that hearing is significantly lower in older age groups. The mice become frail as they age. The worsening in auditory steady-state responses threshold shifts with age correlates significantly with an increasing frailty. No significant differences were found between both sexes. Our research is, to our knowledge, the first carried out in experimental animals to establish the association between age-related hearing loss and frailty, which would provide a useful tool to evaluate future interventions in mice before translating them into clinical practice.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Relationship Between Weekend Catch-Up Sleep and Phenotypic Age Acceleration: Insights From a Cross-Sectional Study.","authors":"Dongmei Liu, Chen Wang, Ben Huang, Jun Qiu, Zheng Zhang","doi":"10.1093/gerona/glae295","DOIUrl":"10.1093/gerona/glae295","url":null,"abstract":"<p><strong>Background: </strong>Phenotypic age acceleration (PhenoAgeAccel) is a potential aging biomarker. While weekend catch-up sleep (WCS) is commonly practiced to compensate for weekday sleep deficits, its relationship with PhenoAgeAccel remains unclear.</p><p><strong>Methods: </strong>In this cross-sectional study, we analyzed data from 7 683 participants in the National Health and Nutrition Examination Survey. WCS duration was calculated as weekend sleep duration minus weekday sleep duration, and WCS was further defined as WCS duration >0 hour. Multivariable logistic regression adjusted for confounders and subgroup analyses by weekday sleep duration were employed to examine the relationship of WCS with PhenoAgeAccel.</p><p><strong>Results: </strong>WCS is associated with a modulated risk of PhenoAgeAccel, contingent on the amount of WCS and regular weekday sleep. Specifically, engaging in 0-1 hour of WCS was associated with significantly lower odds of PhenoAgeAccel (odds ratio = 0.80, 95% confidence interval: 0.68-0.94, p = .007) compared to no WCS, particularly among individuals who averaged 7-8 hours of sleep on weekdays (odds ratio = 0.67, 95% confidence interval: 0.49-0.93, p = .016). Conversely, those sleeping less than 6 hours on weekdays benefited from extending WCS beyond 2 hours (odds ratio = 0.65, 95% confidence interval: 0.44-0.97, p = .036). No benefits were observed for those with more than 8 hours of weekday sleep.</p><p><strong>Conclusions: </strong>WCS is associated with a reduced likelihood of PhenoAgeAccel among individuals with inadequate weekday sleep, particularly those sleeping less than 6 hours or between 7 and 8 hours on weekdays.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Deficit Accumulation Frailty and Baseline Markers of Lifestyle in the U.S. POINTER Trial.","authors":"Mark A Espeland, Yitbarek N Demesie, KayLoni Olson, Samuel N Lockhart, Sarah E Tomaszewski Farias, Maryjo L Cleveland, Christy C Tangney, Lucia Crivelli, Heather M Snyder, Michele K York, Laura D Baker, Rachel A Whitmer, Rena R Wing, Katelyn R Garcia, Kathryn E Callahan","doi":"10.1093/gerona/glae279","DOIUrl":"10.1093/gerona/glae279","url":null,"abstract":"<p><strong>Background: </strong>Multidomain lifestyle interventions may have the potential to slow biological aging as captured by deficit accumulation frailty indices. We describe the distribution and composition of the 49-component frailty index developed by the U.S. POINTER clinical trial team of investigators and assess its cross-sectional associations with sociodemographic factors and markers chosen to be representative of behaviors targeted by the trial's multidomain interventions.</p><p><strong>Methods: </strong>We draw baseline data from the 2 111 volunteers enrolled in U.S. POINTER who were ages 60-79 years and at increased risk for cognitive decline. Frailty components were grouped into 9 domains. Associations that frailty index scores and their domains had with behavioral markers were described with correlations and canonical correlation.</p><p><strong>Results: </strong>The 25th, 50th, and 75th percentiles of the frailty index score distribution were 0.153, 0.189, and 0.235. Higher frailty scores tended to occur among individuals who were older, male, and living in areas of greater deprivation (all p < .001). They were also associated with poorer self-reported diet, less physical activity, and higher Framingham risk scores (all p < .001). Associations were diffusely distributed among the frailty component domains, indicating that no individual domain was dominating associations.</p><p><strong>Conclusions: </strong>The U.S. POINTER deficit accumulation frailty index had expected relationships with sociodemographic factors and sensitivity to the behaviors targeted by the trial's interventions. Our analysis supports its use as a secondary outcome to assess whether the multidomain interventions differentially impact an established marker of biological aging. ClinicalTrials.gov Identifier: NCT03688126.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Response to Diet Enriched With Glutathione Precursors in the Aging Heart.","authors":"Aude Angelini, Grecia Garcia Marquez, Anna Malovannaya, Marta L Fiorotto, Alexander Saltzman, Antrix Jain, JoAnn Trial, George E Taffet, Katarzyna A Cieslik","doi":"10.1093/gerona/glae258","DOIUrl":"10.1093/gerona/glae258","url":null,"abstract":"<p><p>Common features of the aging heart are dysregulated metabolism, inflammation, and fibrosis. Elevated oxidative stress is another hallmark of cardiac aging that can exacerbate each of these conditions. We hypothesize that by increasing natural antioxidant levels (glutathione), we will improve cardiac function. Twenty-one-month-old mice were fed glycine and N-acetyl cysteine (GlyNAC; glutathione precursors)-supplemented or control diets for 12 weeks. Heart function was monitored longitudinally, and the exercise performance was determined at the end of the study. We found that the GlyNAC diet was beneficial for old male but not old female mice, leading to an increase of Ndufb8 expression (a subunit of the mitochondrial respiratory chain complex), and higher enzymatic activity for CPT1b and CrAT, 2 carnitine acyltransferases that are critical to cardiomyocyte metabolism. Although no quantifiable change of collagen turnover was detected, hearts from GlyNAC-fed old males exhibited a slight but significant enrichment in Fmod, a protein that can inhibit collagen fibril formation, possibly reducing extracellular matrix stiffness and thus improving diastolic function. Cardiac diastolic function was modestly improved in males but not females, and surprisingly GlyNAC-fed female mice showed a decline in exercise performance. In summary, our work supports the concept that aged male and female hearts are phenotypically different. These basic differences may affect the response to pharmacological and diet interventions, including antioxidants.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11788829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between APOE, Type 2 Diabetes, and Cardiovascular Disease in Postmenopausal Women.","authors":"Michelle M Dunk, Ira Driscoll, Mark A Espeland, Kathleen M Hayden, Simin Liu, Rami Nassir, Ginny Natale, Aladdin H Shadyab, JoAnn E Manson","doi":"10.1093/gerona/glae246","DOIUrl":"10.1093/gerona/glae246","url":null,"abstract":"<p><strong>Background: </strong>The apolipoprotein E (APOE) ε4 allele, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD) are well-established risk factors for dementia. Relationships between APOE and incidence of T2DM and CVD are not fully understood but may shed light on the mechanisms underlying dementia pathogenesis.</p><p><strong>Methods: </strong>Postmenopausal women (N = 6 795) from the Women's Health Initiative hormone therapy clinical trial with APOE genotyping and no prior diagnosis of T2DM or CVD were included. We examined associations of APOE status (APOE2+ [ε2/ε2, ε2/ε3], APOE3 [ε3/ε3], and APOE4+ [ε4/ε4, ε3/ε4] carriers) with incidence of T2DM, coronary heart disease, stroke, and total CVD events using Cox regression. CVD outcomes were examined in baseline non-statin users and adjusted for statin initiation over follow-up to account for possible confounding by statins.</p><p><strong>Results: </strong>Among all participants (mean age 66.7 ± 6.5 years, 100% non-Hispanic White), 451 (6.6%) were using statins at baseline. Over the follow-up (mean 14.9 and 16.0 years for T2DM and CVD, respectively), 1 564 participants developed T2DM and 1 578 developed CVD. T2DM incidence did not differ significantly by APOE status (ps ≥ .09). Among non-statin users, APOE4+ had higher incidence of total CVD (hazard ratio [95% confidence interval] = 1.18 [1.02-1.38], p = .03) compared with APOE3 carriers, but risks for coronary heart disease (1.09 [0.87-1.36], p = .47) and stroke (1.14 [0.91-1.44], p = .27) were not significantly elevated when examined individually. CVD outcomes did not differ between APOE2+ and APOE3 carriers (ps ≥ 0.11).</p><p><strong>Conclusions: </strong>T2DM risk did not differ by APOE status among postmenopausal women, but APOE4+ carriers not using statins had an increased risk of total CVD events.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775828/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}