The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"The influence of accelerated aging-related cardiac remodeling on cardiovascular outcomes: an observational study.","authors":"Zhi Lv, Kexin Li, Chang Liu, Peiqi Liu, Zi Kou, Mingjuan Zhang, Dengfeng Gao","doi":"10.1093/gerona/glag098","DOIUrl":"10.1093/gerona/glag098","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the associations between phenotypic age acceleration (PhenoAgeAccel) and different CVD outcomes and mortality, examine its relationship with cardiac structure and function using cardiac magnetic resonance imaging (CMR), and explore potential mediating pathways involving cardiac remodeling and cardiometabolic diseases.</p><p><strong>Methods: </strong>PhenoAgeAccel was defined as the residual of PhenoAge, derived from 9 biomarkers, regressed on chronological age. We included 31 722 UK Biobank participants (mean age 54.6 years; 48.1% male) with complete baseline biomarker and CMR data. Multiple Cox proportional hazards models were used to assess associations with CVD outcomes and mortality. Multivariable linear regression examined associations with CMR-derived cardiac measures, and multiple mediation analyses were performed to evaluate potential mediating roles.</p><p><strong>Results: </strong>Higher PhenoAgeAccel was independently associated with increased risks of any CVD, ischemic heart disease (IHD), heart failure, all-cause mortality, and CVD mortality. Each standard deviation increase in PhenoAgeAccel (4.63 years) was associated with 7%, 9%, 29%, 14%, and 16% higher risks of these outcomes, respectively, but not with arrhythmias or cerebrovascular disease. Associations with any CVD, IHD, and CVD mortality were stronger in women. Higher PhenoAgeAccel was also associated with adverse cardiac remodeling, including lower left ventricular volume, stroke volume, mass, LVGFI, and ejection fraction. Cardiac remodeling and cardiometabolic diseases partially mediated these associations.</p><p><strong>Conclusions: </strong>Our study examines the association between accelerated aging and cardiac phenotypes and their important independent mediating role in the accelerated aging-cardiovascular outcome relationship. Improving cardiac remodeling and metabolic health may mitigate the effects of biological aging on CVD risk.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding the turning point in aging: a comparison of physical, cognitive, and psychological trajectories among centenarians and non-centenarians.","authors":"Erfei Zhao, Jennifer A Ailshire, Jung Ki Kim, Eileen M Crimmins","doi":"10.1093/gerona/glag116","DOIUrl":"10.1093/gerona/glag116","url":null,"abstract":"<p><strong>Background: </strong>Centenarians tend to delay age-related decline until very late life and generally experience slower deterioration across health domains. However, timing and pace of decline across physical, cognitive, and psychological domains among centenarians, compared to other long-lived groups, remain poorly characterized.</p><p><strong>Methods: </strong>Using the nationally representative Health and Retirement Study (1993-2022), we modeled trajectories of disease burden, physical functioning, psychological wellbeing, and cognition among participants born before 1922 (N = 7237), followed up to 29 years. Participants were categorized by survival groups: centenarians (100+), nonagenarians (90-99), octogenarians (80-89), and septuagenarians (73-79). Joinpoint regression identified ages at which decline accelerated and quantified rates of change.</p><p><strong>Results: </strong>Those who lived to older ages-nonagenarian and centenarian decedents-maintained higher levels of physical/cognitive functioning into later life but showed sharp accelerations thereafter. Across physical functioning and cognition, onset of accelerated decline shifted later among those who survived longer, with centenarians showing the latest age at acceleration. Prior to acceleration, activities of daily living/instrumental activities of daily living limitations increased by approximately 0.04-0.05 points per year, rising to 0.20-0.34 points per year thereafter, while prevalence of cognitive impairment accelerated from roughly 1% to 4%-6% per year. Individuals who survived longer also maintained lower depressive symptoms and disease burden into advanced ages, although cardiovascular conditions continued to rise.</p><p><strong>Conclusions: </strong>Exceptional longevity is marked by preserved physical and cognitive function followed by rapid late-life declines. Pinpointing when this tipping point occurs offers a quantitative basis for targeting interventions-medical, behavioral, and social-that sustains function and delay deterioration at the population level.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of high-intensity interval training versus continuous moderate-intensity exercise on body composition among older adults with HIV.","authors":"Grace L Kulik, Vitor H F Oliveira, Melissa P Wilson, Vincent Khuu, Catherine M Jankowski, Stephanie Dillon, Paul Cook, Samantha MaWhinney, Debashis Ghosh, Allison R Webel, Kristine M Erlandson","doi":"10.1093/gerona/glag113","DOIUrl":"10.1093/gerona/glag113","url":null,"abstract":"<p><p>We compared two exercise intensities on lean and fat mass among older people with HIV (PWH). The High Intensity Exercise to Attenuate Limitations and Train Habits (HEALTH) randomized sedentary PWH ≥50 years to 16 weeks of high-intensity interval training (HIIT) or continuous moderate-intensity exercise (CME), both with resistance exercise. Body composition was measured using dual-energy x-ray absorptiometry (DXA) at baseline and week 16. The primary outcome was the percent change in body fat percentage (ratio of fat mass to total mass). Secondary outcomes included percent change in lean, fat, appendicular lean (ALM), and total mass. Linear regression models examined between- and within-group changes from baseline to week 16. Of the 95 participants with pre- and post-DXA scans, the median (interquartile range [IQR]) age was 58 [54-61] years, 14% female, 14% Black, and 14% Hispanic. Fat percentage decreased by -3.3% (95% confidence interval [CI]: -5.2, -1.6) in HIIT and -3.3% (95% CI: -5.3, -1.6) in CME. Fat mass decreased by -3.5% (95% CI: -5.9, -1.0) in HIIT and -3.8% (95% CI: -6.3, -1.3) in CME. Lean mass increased by 1.7% (95% CI: 0.7, 2.7) and ALM by 3.3% (95% CI: 1.3, 5.3) in HIIT and 1.2% (95% CI: 0.2, 2.2) and ALM by 2.6% (95% CI: 0.6, 4.6) in CME. Although both arms had significant improvements compared to baseline, no between-arm comparisons were statistically significant. Supervised HIIT or CME combined with resistance training for 16 weeks is an effective strategy for improving body composition in previously sedentary older PWH. Clinicaltrials.gov: NCT04550676.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13211981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147825321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing and internally validating AI-based aging resilience biomarkers in non-human primates.","authors":"Robert F Bennett, Jaime L Speiser, John D Olson, George W Schaaf, Thomas C Register, Laura A Cox, J Mark Cline, Ellen E Quillen","doi":"10.1093/gerona/glag112","DOIUrl":"10.1093/gerona/glag112","url":null,"abstract":"<p><p>Quantifying biological aging is crucial for understanding functional decline before the onset of morbidity. While many accelerated aging and frailty measures based on clinical data exist for humans and several for rodent models of aging, there are few options for non-human primates (NHPs). NHP clinical data has several unique features including a lack of clinically delineated normative values for features and variability in data collection over long lifespans. There are also wide discrepancies in the number of available clinical measures and the number of animals across data sets. To address these challenges, we developed and validated \"aging resilience\" (AR) metrics using longitudinal, routine clinical data from two distinct non-human primate cohorts: 4328 baboons and 281 rhesus macaques. We trained five computational models-including Linear Mixed-Effects Models, Random Forest, and Recurrent Neural Networks (RNN)-to predict chronological age, subsequently deriving AR metrics that represent the velocity (rate of aging) and cumulative burden (normalized cumulative aging) of physiological deviation. While linear models achieved high precision in predicting chronological age (test R2 up to 0.99), they correlated poorly with actual lifespan. In contrast, AR metrics derived from non-linear models (RNN and Random Forest) displayed strong predictive validity for mortality (Pearson's r > 0.8). These findings highlight a critical paradox: models that best predict chronological age do not necessarily capture the biological resilience determining healthspan. This study establishes a scalable framework for monitoring biological aging in translational models using standard veterinary records.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13195804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147848425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A genome-wide association study identified 10 novel genomic loci associated with intrinsic capacity.","authors":"","doi":"10.1093/gerona/glag092","DOIUrl":"10.1093/gerona/glag092","url":null,"abstract":"","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":"81 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125877/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147793573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substituting blood-based biomarkers for imaging measures in Alzheimer's disease studies: implications for sample size and bias.","authors":"Sarah F Ackley, Renaud La Joie, Michelle Caunca, Shubhabrata Mukherjee, Seo-Eun Choi, Emily H Trittschuh, Paul K Crane, Eleanor Hayes-Larson","doi":"10.1093/gerona/glag068","DOIUrl":"10.1093/gerona/glag068","url":null,"abstract":"<p><strong>Background: </strong>Blood-based biomarkers for Alzheimer's disease (AD) pathology are appealing options in large population-based studies due to their low cost, minimal invasiveness, and feasibility of collection in non-clinical settings. Despite these benefits, blood-based biomarkers have lower test-retest reliability than neuroimaging measures like amyloid positron emission tomography (amyloid-PET) Centiloids; trade-offs in power and bias remain unexplored.</p><p><strong>Methods: </strong>We use data from Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) studies, which include both amyloid-PET and blood-based measures, to assess differences in statistical power, required sample size, and bias when replacing a neuroimaging measure with a blood-based measure. We use simulations parameterized based on these studies to show potential implications of using plasma p-tau 181 or p-tau 217, blood-based AD biomarkers, in place of Centiloids from amyloid-PET, when the biomarker is either the exposure or the outcome in an analysis of interest.</p><p><strong>Results: </strong>We demonstrated that substituting amyloid-PET Centiloids with a blood-based measure of p-tau can substantially reduce power, requiring 1.5-6.5 times the sample size to achieve 80% power compared to amyloid-PET. In addition, using a blood-based biomarker as the exposure can introduce significant regression dilution bias, attenuating estimated associations.</p><p><strong>Conclusions: </strong>While blood-based biomarkers are lower cost and easier to collect than neuroimaging measures, their use as proxies for AD pathology may introduce substantial methodological challenges, depending on the p-tau isoform. Consideration of the sample sizes they necessitate and their potential for bias is critical for the design and interpretation of studies employing these biomarkers.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13071402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of blood-based DNA methylation scores reveals associations with shared cohabitation duration in cohabiting pairs.","authors":"Joshua Stevenson-Hoare, Martin Stoffel, Ben Schöttker, Bernd Holleczek, Judith Zaugg, Beate Ditzen, Hermann Brenner","doi":"10.1093/gerona/glag036","DOIUrl":"10.1093/gerona/glag036","url":null,"abstract":"<p><p>Individuals who share their environment for long periods of time, that is, spouses, are likely to share behaviors and exposures, and longer spouse-pair cohabitation durations have been suggested to increase methylation pattern similarity on a methylome-wide scale. Risk scores and aging clocks based on blood DNA methylation use subsets of the methylome that share functional associations with disease and phenotype outcomes to estimate exposure and disease-specific epigenetic effects. By using the CpG sites contained within methylation risk scores and aging clocks, it is possible to examine functionally-linked methylation patterns of long-term shared exposure effects. In a population cohort of paired adults, we observed that methylation disease and phenotype risk scores show no significant correlation between partners, and neither do aging clocks after adjustment for age, which is already correlated in pairs. We also did not find evidence of an absolute difference in scores being significantly associated with cohabitation duration. However, when we examined the correlation in normalized methylation values between partners, we observed that correlations were higher in pairs with longer cohabitation durations for many, but not all, functionally-linked CpG sets. This supports the hypothesis that shared cohabitation's association with methylome-wide similarity in pairs is the result of many shared exposures, not a generic effect of cohabitation. Further research is required to establish the precise exposure-methylation links implicated.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atlas of human cerebellar aging: nonlinear molecular trajectories reveal multidimensional mechanisms underlying cognitive and motor function regulation.","authors":"Xiuling Ma, Likun Zhao, Hongxin Pan, Zhongwen Feng, Jianlin Lin, Junjun Ji, Junrong Li, Xiaoxia Liu, Jinfeng Wang, Xijun Tang, Kefeng Li","doi":"10.1093/gerona/glag022","DOIUrl":"10.1093/gerona/glag022","url":null,"abstract":"<p><p>The cerebellum, traditionally recognized for motor coordination, may also contribute to cognitive and emotional regulation, as recent evidence indicates. However, the molecular and structural changes in the human cerebellum during healthy aging remain poorly understood. This study systematically investigated the molecular trajectories and structural alterations in the human cerebellum across the adult lifespan (20-80 years) by integrating cerebella transcriptomic data from 456 non-disease brains and MRI structural neuroimaging data from 264 disease-free subjects. Fuzzy clustering analyses uncovered nonlinear expression trajectories involving synaptic plasticity, metabolic regulation, and protein homeostasis, highlighting multiple critical biological turning points across different age periods. Differential gene expression analyses identified early downregulation of immediate early genes (eg, FOS, NPAS4, EGR1-3) and sustained activation of stress-response pathways changes that precede observable functional decline. Moreover, we identified an integrated \"synaptic plasticity-stress homeostasis\" module, where immediate early genes and heat shock proteins exhibit coordinated regulation whose efficiency progressively declines with age. MRI analyses showed a pronounced acceleration of cerebellar gray matter (GM) loss after age 70, with multiple subregions affected, highlighting the nonlinear trajectory of cerebellar structural aging. In combination with the transcriptomic findings, these results indicate that cerebellar aging comprises complex, stage-dependent molecular alterations accompanied by GM reductions in later decades. This collective evidence advances our understanding of cerebellar aging biology and highlights the synaptic-stress module as a promising molecular axis that may inform future strategies to support cerebellar function in older adults.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of common infections with frailty and mortality in two UK cohort studies.","authors":"Demelza Smeeth, Charlotte Warren-Gash, Rebecca E Green, Julia Butt, Tim Waterboer, Alun D Hughes, Nishi Chaturvedi, Dylan M Williams","doi":"10.1093/gerona/glag046","DOIUrl":"10.1093/gerona/glag046","url":null,"abstract":"<p><strong>Background: </strong>Some common infections are associated with poorer age-related health outcomes; however, findings are limited to a small number of pathogens and frequently inconclusive. This study aimed to expand the range of pathogens investigated in relation to frailty and mortality in older age.</p><p><strong>Methods: </strong>We investigated relationships between seropositivity for 18 viruses, bacteria and protozoa with concurrent frailty and prospective mortality in middle-aged and older adults within two UK population-based cohorts: UK Biobank (N = 9427; aged 40-70 years) and Medical Research Council National Survey of Health and Development (N = 1791; aged 60-65 years). Multiplex serological assays were used to identify seropositivity for each pathogen and frailty was assessed using a frailty index measuring the accumulation of age-related health deficits. Mortality was determined from linked administrative records.</p><p><strong>Results: </strong>Adjusting for sex, age, income and education, previous infection with Toxoplasma gondii ((β = 0.77%; 95% CI, 0.42-1.11) and Helicobacter pylori (0.63%; 95% CI, 0.28-0.97) were associated with higher frailty equivalent to 3.8 or 3.1 years of aging, as was inflammation-weighted pathogen burden (0.41%/SD, 95% CI, 0.25-0.57; 0.42%/SD, 95% CI, 0.26-0.58). Previous infection with Chlamydia trachomatis, human herpes simplex virus 1 and cytomegalovirus were associated with increased frailty after adjustment for sex and age, although relationships were confounded by socioeconomic circumstances. No common infections were robustly associated with mortality.</p><p><strong>Conclusions: </strong>Our results indicate that infection with H. pylori and T. gondii, and the combined burden of infection may detrimentally impact ageing health. These pathogens may warrant targeting beyond current clinical measures to mitigate the development of frailty.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13031002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity and healthy aging in the United Kingdom and Brazil: a coordinated analysis of 2 population-based cohort studies.","authors":"Laiss Bertola, Yu-Tzu Wu, Márlon Juliano R Aliberti, Andrew Kingston, Marcel Hiratsuka, Eduardo Ferriolli, Matthew Prina, Claudia K Suemoto","doi":"10.1093/gerona/glag033","DOIUrl":"10.1093/gerona/glag033","url":null,"abstract":"<p><strong>Background: </strong>Although intrinsic capacity (IC) is a multidimensional marker of healthy aging, cross-country validation in diverse cultural and socioeconomic contexts remains limited. We study aimed to harmonize the operationalization of IC and examine its associations with sociodemographic characteristics and health outcomes in the United Kingdom and Brazil.</p><p><strong>Methods: </strong>Nationally representative cohorts of community-dwelling older adults in both countries, aged ≥60 years from the English Longitudinal Study of Ageing (n = 3392) and Brazilian Longitudinal Study of Ageing (n = 3580). IC was derived using bi-factor models comprising locomotor, cognition, psychological, sensory, and vitality measures, standardized to a 0-100 scale. Linear regressions assessed IC associations with sociodemographic factors. Logistic regressions examined IC associations with poor/fair self-rated health and disability in basic activities of daily living (ADL) and instrumental ADL (IADL). We tested whether education and wealth modified these associations.</p><p><strong>Results: </strong>Mean IC scores were lower in women than in men, with differences of 3.06 points (95% confidence interval [CI] = 2.30-3.82) in the United Kingdom and 8.14 (95% CI = 7.40-8.90) in Brazil. Older age, non-White race/ethnicity, less education, and lower wealth were also linked to lower IC scores. Higher IC was associated with lower odds of poor/fair self-rated health in the United Kingdom (odds ratio [OR] = 0.32; 95% CI = 0.29-0.35) and Brazil (OR = 0.54; 95% CI = 0.48-0.61). Higher IC was also linked to lower odds of ADL and IADL disability in both cohorts. No significant interactions were found.</p><p><strong>Conclusions: </strong>IC showed consistent associations with sociodemographic factors and health outcomes both countries. IC may inform equitable, person-cent red healthy aging policies for older adults in diverse contexts.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146204571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}