The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Exploring the Relationship Between Pain, Cognition, and Chronic Conditions: Insights from the HAALSI Study in Rural South Africa.","authors":"Camryn Dixon, Tamara P Taporoski, F Xavier Gomez-Olive Casas, Stephen M Tollman, Lisa F Berkman, Darina T Bassil","doi":"10.1093/gerona/glaf131","DOIUrl":"https://doi.org/10.1093/gerona/glaf131","url":null,"abstract":"<p><strong>Background: </strong>Research on cognition and pain is limited in Low and Middle-income Countries (LMICs) and understanding how chronic conditions and pain treatment may moderate this association is underexplored. This study aimed to explore the relationship between pain and cognition and the moderating effect of hypertension, diabetes, HIV, pain treatment, and depressive symptoms.</p><p><strong>Methods: </strong>We analyzed data from 3803 individuals enrolled in the HAALSI Study, a longitudinal population study of older adults in Agincourt, South Africa. Pain was measured with the Brief Pain Inventory. Cognition was assessed using a composite of orientation questions, a memory test, and the Trails Making Test B. Chronic conditions were assessed using biological measures, and depressive symptoms were measured using the CES-D scale. Linear regression models were used to investigate the relationship.</p><p><strong>Results: </strong>Baseline and longitudinal pain were significantly associated with poorer episodic memory (ß= -0.17 [p < 0.001]; ß= -0.18 [p < 0.001]). Hypertension amplified the negative effect of pain on episodic memory, while diabetes and HIV did not moderate the relationship between pain and cognition (ß = -0.10[.006]). Pain treatment was associated with poorer cognitive performance. Depressive symptoms moderated the relationship between pain and both cognition and executive function (p = 0.02). The negative effect of pain on episodic memory was observed in individuals with both acute and persisting pain, while it only affected executive function in those with acute pain.</p><p><strong>Conclusions: </strong>These findings highlight the importance of examining factors that may moderate the relationship between pain and cognition and strategies to mitigate the effect pain has on cognition, particularly in LMICs.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom Trajectories After COVID Hospitalization and Risk Factors for Symptom Burden in Older Persons: a Longitudinal Cohort Study.","authors":"Yulu Pan, Gawon Cho, Mary Geda, Thomas M Gill, Andrew B Cohen, Lauren E Ferrante, Alexandra M Hajduk, Brienne Miner","doi":"10.1093/gerona/glaf132","DOIUrl":"https://doi.org/10.1093/gerona/glaf132","url":null,"abstract":"<p><strong>Background: </strong>Little is known about how psychosocial factors and geriatric conditions contribute to persistent post-COVID symptoms among older adults. We evaluated symptom burden following COVID-19 hospitalization and identified risk factors for persistent symptoms among community-dwelling older adults.</p><p><strong>Methods: </strong>This prospective study recruited 281 older persons (mean age 70.6 years) hospitalized for SARS-CoV-2 infection between June 2020 and June 2021 from Yale-New Haven Health System. Post-COVID symptoms were assessed using a modified Edmonton Symptom Assessment System during hospitalization, and at 1, 3, and 6 months post-discharge. Trajectory analysis identified three symptom trajectories. Multinomial logistic regression evaluated associations between characteristics (sociodemographic, clinical, psychosocial factors, and geriatric conditions) obtained during hospitalization and trajectory membership.</p><p><strong>Results: </strong>Three symptom burden trajectory groups were identified: low (n = 70; 24.9%; reference); moderate (n = 149; 53.0%); and high (62; 22.1%). Female sex (adjusted odds ratio (adjOR)_moderate = 3.10 [95%CI = 1.68- 5.72]; adjOR_high = 5.76 [2.70-12.27]), higher depression/anxiety (adjOR_moderate = 1.47 [1.24- 1.74]; adjOR_high =1.72 [1.43-2.07]), and less social support (adjOR_moderate=0.91 [0.83, 0.99]; adjOR_high = 0.86 [0.78-0.95]) were associated with moderate and high symptom burden. Geriatric conditions, including delirium (adjOR_high = 7.74 [1.56- 38.26]), frailty (adjOR_high = 5.26 [1.77-15.68]), impairment of physical function (adjOR_high = 1.18 [1.00-1.40]), and vision impairment (adjOR_high = 4.63 [1.33-16.11]), were associated with high symptom burden.</p><p><strong>Conclusions: </strong>In older persons hospitalized with COVID-19, female sex, psychosocial factors, and geriatric conditions were associated with higher symptom burden over six months. Future work should investigate the biopsychosocial mechanisms through which psychosocial factors and geriatric conditions contribute to post-COVID symptom burden.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large extension of C. elegans lifespan in diluted axenic medium: a balancing act between different survival responses.","authors":"Ping Wu, Lieselot Vandemeulebroucke, Kevin Rey A Guiritan, Bart P Braeckman","doi":"10.1093/gerona/glaf129","DOIUrl":"https://doi.org/10.1093/gerona/glaf129","url":null,"abstract":"<p><p>Axenic dietary restriction (ADR) represents a powerful and unique DR regimen for C. elegans as it robustly extends lifespan independently of well-known key genes associated with DR, such as those of insulin/IGF-1 signaling, skn-1, and pha-4. Here, we analyze C. elegans survival in a dilution series of axenic medium to explore the dependency of lifespan extension on nutrient availability. We find a non-linear relationship between lifespan and axenic nutrient levels with a four-fold axenic dilution yielding peak longevity. Notably, lifespan extension at specific dilutions permits maintenance of reproductive potential and survivability after bacterial reintroduction, indicating a partial reliance on adult reproductive diapause mechanisms. Genetic analyses found the involvement of AMPK/aak-2, sir-2.1, and cbp-1 in mediating lifespan extension across the axenic dilution spectrum, the essential role of daf-16 and hlh-30 under severe nutrient scarcity, and the specific contribution of bli-4 to standard ADR longevity. These findings elucidate that C. elegans lifespan extension under different levels of nutrient restriction is governed by overlapping yet distinct genetic pathways.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Associations Between Medication Use and Phenotypic Aging: Insights from the Baltimore Longitudinal Study of Aging.","authors":"Bowen Tang, Perry Kuo, Ann Zenobia Moore, Madhav Thambisetty, Luigi Ferrucci, Sara Hägg","doi":"10.1093/gerona/glaf128","DOIUrl":"https://doi.org/10.1093/gerona/glaf128","url":null,"abstract":"<p><strong>Background: </strong>Limited population-based data exist on the association between medication use and changes in phenotypic aging. This study investigated these associations using data from the Baltimore Longitudinal Study of Aging.</p><p><strong>Methods: </strong>Phenotypic aging (PA) markers were constructed using the Klemera-Doubal (KD) method across four domains: body composition (structural and metabolic changes), energetics (energy generation and utilization capacity), homeostatic mechanisms (internal stability maintenance), and neuroplasticity/neurodegeneration (nervous system function and decline). Associations between 27 common drug categories and changes in these PA markers were analyzed using conditional generalized estimating equations (cGEE), focusing on within-individual variation to control for genetics and early-life factors, with additional adjustments for time-varying covariates.</p><p><strong>Results: </strong>Five drug categories were associated with significant reductions in PA markers. Vitamin D, bisphosphonates, and proton pump inhibitors were linked to decreases in body composition (Beta = -0.73 years, 95% CI: -1.35 to - 0.10), energetics (Beta = -2.05, 95% CI: -3.98 to - 0.13), and neuroplasticity/neurodegeneration (Beta = -1.00, 95% CI: -2.02 to - 0.03), respectively. Thyroid hormones showed reductions in body composition (Beta = -1.75, 95% CI: -3.24 to - 0.26) and neuroplasticity/neurodegeneration (Beta = -1.04, 95% CI: -1.96 to - 0.12). Thiazides were associated with decreases across body composition (Beta = -1.55, 95% CI: -2.94 to - 0.16), energetics (Beta = -2.36, 95% CI: -4.30 to - 0.42), and homeostatic mechanisms (Beta = -3.83, 95% CI: -6.71 to - 0.96).</p><p><strong>Conclusions: </strong>These findings suggest potential protective effects of certain medications on phenotypic aging. Further research is needed to validate these results, particularly with data from other populations.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, Carotid Intima-Media Thickness and Arterial Stiffness: Results from a Large Longitudinal Cohort Study.","authors":"Ruirui Wang, Mengyao Shi, Xiangyan Yin, Yi Chen, Xiaoxiao Wang, Zhengbao Zhu, Tan Xu, Yonghong Zhang","doi":"10.1093/gerona/glaf126","DOIUrl":"https://doi.org/10.1093/gerona/glaf126","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the associations of sleep health with carotid intima-media thickness (CIMT) and arterial stiffness.</p><p><strong>Methods: </strong>A total of 41,465 UK Biobank participants were included. Sleep traits were assessed at baseline via self-reported questionnaires, and a composite sleep score was constructed based on six factors: sleep duration, snoring, insomnia, chronotype, daytime napping, and daytime sleepiness, with higher scores indicating poorer sleep health. CIMT and arterial stiffness were measured at follow-up. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between sleep score and study outcomes, adjusting for baseline demographics, socioeconomic status, physical measurements, and medication use.</p><p><strong>Results: </strong>The mean age of the study population was 55.08 years (SD = 7.57), with 52.91% females and 96.99% Whites. Compared with those for participants with a sleep score of 0, the multivariate-adjusted ORs (95% CI) for those with sleep scores of 1, 2, 3, 4, and 5-6 were 1.04 (0.93, 1.16), 1.09 (0.98, 1.21), 1.17 (1.05, 1.30), 1.15 (1.02, 1.29), and 1.18 (1.03, 1.35) for CIMT thickening, respectively, and 1.04 (0.92, 1.18), 1.13 (1.00, 1.27), 1.25 (1.08, 1.40), 1.23 (1.08, 1.40), and 1.31 (1.12, 1.53) for arterial stiffness, respectively. Poor sleep health was associated with an increased risk of CIMT thickening within all genetic risk categories, and no interaction between the sleep and genetic risk scores was found.</p><p><strong>Conclusion: </strong>This study highlighted the importance of healthy sleep behaviors in slowing the progression of subclinical cardiovascular disease, regardless of individual's genetic risk status.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomics-Based Identification and Validation of the Creatine Precursor Guanidinoacetic Acid for Frailty in Older Adults.","authors":"Yin Yuan, Xiaoming Huang, Siyang Lin, Wenwen Lin, Feng Huang, Pengli Zhu","doi":"10.1093/gerona/glaf127","DOIUrl":"https://doi.org/10.1093/gerona/glaf127","url":null,"abstract":"<p><strong>Backgound: </strong>Subtle biological changes related to frailty may be undetected by standard clinical methods, and reliable biomarkers for frailty are still under investigation. This study was conducted to profile plasma metabolite patterns associated with frailty and validate the most significant metabolite for identifying and predicting frailty in cross-sectional and longitudinal analyses.</p><p><strong>Methods: </strong>The \"Fujian Prospective Aging Cohort\" (ChiCTR 2000032949) enrolled 2,265 community-dwelling individuals aged 60 and above in 2020. Plasma metabolites were analyzed using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Frailty was assessed using Fried's phenotype and the Frailty Index.</p><p><strong>Results: </strong>Widely targeted metabolomic analysis identified 889 metabolites. GAA was identified as the top frailty-associated candidate by ROC analysis and validated in a large cross-sectional cohort (AUC = 0.670). This cohort (N = 1,972) confirmed that subjects with lower GAA levels had a higher prevalence of frailty (P < 0.001). Multinomial logistic regression showed that higher GAA levels were significantly associated with lower odds of prefrailty and frailty, the ORs were 0.46 (95% CI: 0.32-0.66), and 0.15 (95% CI: 0.07-0.33) in the highest quartile, both P < 0.001). Over a three-year follow-up period, a group-based trajectory model identified three Frailty Index trajectories: low-elevated (59.6%), moderate-elevated (34.1%), and high-elevated (6.3%). Subjects in the highest GAA quartile had a 36% and 66% lower likelihood of following moderate-elevated and high-elevated Frailty Index trajectories (P = 0.016 and P = 0.022).</p><p><strong>Conclusions: </strong>This study identifies GAA as a potential metabolic biomarker for frailty. Higher GAA levels are associated with lower frailty odds and provide predictive value for a lower likelihood of frailty progression.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty and Physical Activity: Are all Physical Activity Variables Equal?","authors":"Mariana Wingood, Byron C Jaeger, Jason Fanning, Kathryn E Callahan","doi":"10.1093/gerona/glaf125","DOIUrl":"https://doi.org/10.1093/gerona/glaf125","url":null,"abstract":"<p><strong>Background: </strong>Frailty, defined as diminished physiological and functional reserve, is linked to negative health outcomes such as falls, fractures, and disability. Physical activity dose plays a significant role in preventing and reducing physical frailty, but the influence of different PA variables on deficit accumulation (ie, frailty index [FI]) is not fully understood. Thus, we examined the relationship between physical activity variables and FI among older adults.</p><p><strong>Methods: </strong>We utilized Round 11 (2021) data from the National Health and Aging Trends Study, a longitudinal study of Medicare beneficiaries aged 65 and older in the USA. Our participants included 726 community-dwelling older adults who had at least 3 valid days of accelerometer data and all data needed to calculate FI. Demographic variables, health conditions, and physical function were assessed through standardized interviews and objective assessments. We completed regression and Poisson models to estimate FI value and prevalence ratios for frailty.</p><p><strong>Results: </strong>Participants spent 339 daily minutes performing physical activity. The activity was accumulated over 88 bouts averaging 3.8 minutes. Those with frailty have lower levels of activity, higher levels of non-activity and sleep, higher activity fragmentation, fewer bouts, shorter bouts, and lower intensity over 10 consecutive minutes (ps < 0.001). After adjusting for all activity metrics, activity fragmentation (B = 1.32) and intensity of the most-active 10-minute bout (B=-0.46) remained significantly associated with FI (p ≤ 0.04).</p><p><strong>Conclusions: </strong>Low-intensity and fragmented physical activity is linked to frailty. Further research should explore the role of sustained activity and fragmentation in monitoring and guiding interventions for frailty.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Associations of Depression and Diabetes with Alzheimer's Disease and Related Dementias Risk among American Indian and Alaska Native Peoples.","authors":"R Turner Goins, Yuxi Shi, Maria M Corrada, Spero M Manson, Joan O'Connell, Luohua Jiang","doi":"10.1093/gerona/glaf123","DOIUrl":"https://doi.org/10.1093/gerona/glaf123","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease and related dementias (ADRD) research worldwide indicate that it is more common in Indigenous than in non-Indigenous populations. We examined the relationship of depression and diabetes, alone and together, with incident ADRD in a large sample of American Indian and Alaska Native (AI/AN) peoples.</p><p><strong>Methods: </strong>We examined a sample of 65,801 AI/AN peoples aged ≥ 45 years in fiscal year 2007 who were ADRD free between FY2007-09. Cox proportional hazard models were employed to estimate associations between ADRD risk and baseline depression and diabetes, adjusting for potential confounding variables.</p><p><strong>Results: </strong>We found 2.3% received an ADRD diagnosis during FY2010-13. Compared to persons with neither depression nor diabetes, the fully adjusted hazard ratio (HR) for those aged ≥ 45 years with depression and diabetes was 1.82 (95% CI 1.53-2.16) for ADRD and those with depression only had a hazard ratio of 1.70 (95% CI 1.44-2.00). A significant relationship was not found between diabetes only and ADRD risk. Compared with women without depression, the adjusted risk of ADRD was 50% higher (HR = 1.50, 95% CI 1.30-1.73) for women with depression, while 115% higher (HR = 2.15, 95% CI 1.76-2.61) for men with depression.</p><p><strong>Conclusions: </strong>Depression is associated with a substantially higher risk of ADRD among adult AI/AN peoples. This association varies by sex and age, with the strongest association observed among relatively young men. Helpful future efforts include ensuring clinical and behavioral services for AI/AN peoples provide regular mental health screening and any needed treatment.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term air pollutants exposure on risk of psoriasis: the mediating role of accelerated biological aging among 284,544 participants.","authors":"Jie Gao, Jiarong He, Wenbo Zhao, Jing Cui, Qi Zhang, Ping Yang, Fan Yang, Yuquan Chen, Mingming Zhang","doi":"10.1093/gerona/glaf118","DOIUrl":"https://doi.org/10.1093/gerona/glaf118","url":null,"abstract":"<p><p>Psoriasis burdens children and adults, but the impact of air pollution and aging is unclear. This study examines the association between air pollution exposure and psoriasis risk, considering the mediating role of biological aging. A prospective cohort study of 284,544 adults (51.3% female, mean age 56.26 ± 8.10 years) from the UK Biobank examined long-term exposure to air pollutants (PM2.5, PM10, PM2.5-10, NO2, and NOX). Biological aging was assessed using phenotypic age algorithms. Cox proportional hazards models were constructed to analyze the relationships with the risk of psoriasis, adjusting for demographic, socioeconomic, and health-related factors. Mediation analysis explored the role of biological aging. During a median follow-up of 15.58 years, 3,446 (1.21%) participants developed psoriasis. After adjusting for all confounders, each ten-unit increase (10 μg/m³) in PM2.5, PM10, NO2, and NOx, corresponded to the significantly increased risk of psoriasis by 95.7% (HR = 1.957, 95% CI 1.435-2.671), 19.7% (HR = 1.197, 95% CI 1.006-1.426), 9.0% (HR = 1.090, 95% CI 1.043-1.138) and 4.4% (HR = 1.044, 95% CI 1.024-1.066), respectively. Moreover, all air pollutants are significantly associated with biologically aging, while each one-year increase in PhenoAge was associated with a 5.0% higher risk of psoriasis (HR = 1.050, 95% CI 1.045-1.056). Finally, accelerated biological aging partially mediated 5.96%-13.86% of these air pollutants. Long-term exposure to air pollution significantly affects psoriasis risk, with biological aging as a partial mediator. Reducing pollution may lower the risk of psoriasis by slowing biological aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease.","authors":"Mengfei Cai, Chentao He, Hao Li, Rui Yang, Siming Rong, Ziqi Gao, Qibing Luo, Zihao Li, Yan Li, Zaiyi Liu, Piao Zhang, Yuhu Zhang","doi":"10.1093/gerona/glaf124","DOIUrl":"https://doi.org/10.1093/gerona/glaf124","url":null,"abstract":"<p><strong>Background: </strong>To identify the most vulnerable brain regions in gray matter attributable to advanced brain aging and examine the cognitive correlates of advanced brain aging in Parkinson's disease (PD).</p><p><strong>Methods: </strong>125 early-stage PD patients with both structural, diffusion MRI and DAT-SPECT data available were included at baseline (year 0) from Parkinson's Progression Markers Initiative (PPMI), with neuroimaging follow-up at year 1, 2, 4. Annual assessment of cognition was performed in 5 years. The relation between brain-predicted age difference (PAD) and free water in cortical and subcortical gray matter, as well as cognition were examined with linear regression and linear mixed effects model. Cox proportional hazards model was used to investigate the relation between brain PAD and the risk of conversion to mild cognitive impairment (MCI).</p><p><strong>Results: </strong>125 PD patients with a mean (SD) chronological age of 60.99 (9.50) years and 82 (65.6%) were men. Brain PAD followed a non-linear progression pattern over time(p = 0.028). Brain PAD was differentially associated with free water in cortical and subcortical gray matter, with the most preferentially vulnerable regions identified as temporal cortex, striatum, hippocampus, and cholinergic basal forebrain. Baseline brain PAD was associated with cognitive deficits and the conversion to mild cognitive impairment during the 5-year follow-up.</p><p><strong>Conclusions: </strong>Our findings suggest that brain PAD offers potential in pinpointing regions most susceptible to accelerated brain aging and identifying patients with Parkinson's disease who are at an increased risk of converting to mild cognitive impairment. .</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}