The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Human Peripheral Blood Leukocyte Transcriptome-Based Aging Clock Reveals Acceleration of Aging by Bacterial or Viral Infections.","authors":"Xin Gao, Si-Jia Li, Jian-Ping Cai","doi":"10.1093/gerona/glaf054","DOIUrl":"10.1093/gerona/glaf054","url":null,"abstract":"<p><p>The aging of the population is a global concern. In the post-coronavirus disease 2019 (COVID-19) pandemic era, there are no effective methods to identify aging acceleration due to infection. In this study, we conducted whole-transcriptome sequencing on peripheral blood samples from 35 healthy individuals (22-88 years old). By analyzing the changes in mRNA, lncRNA, and miRNA expression, we investigated the characteristics of transcriptome alterations during the aging process. ceRNA networks were constructed, and 10 genes (CD248, PHGDH, SFXN2, MXRA8, NOG, TTC24, PHYKPL, CACHD1, BPGM, and TWF1) were identified as potential aging markers and used to construct an aging clock. Moreover, our aging clock categorized individuals into slow-, average-, and quick-aging groups, highlighting a link between accelerated aging and infection-related clinical parameters. Pseudotime analysis further revealed 2 distinct aging trajectories, corroborating the variations in the aging rate identified by the aging clock. Furthermore, we validated the results using the OEP001041 data set (277 healthy individuals aged 17-75), and data sets comprising patients with infectious diseases (n = 1 558). Our study revealed that infection accelerates aging via increased inflammation and oxidative stress in infectious disease patients. Besides, the aging clock exhibited alterations after infection, highlighting its potential for assessing the aging rate after patient recovery. In conclusion, our study introduces a novel aging clock to assess the aging rate in healthy individuals and those with infections, revealing a strong link between accelerated aging and infections through inflammation and oxidative stress. These findings offer valuable insights into aging mechanisms and potential strategies for healthy aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal Muscle Aging: Lessons From Teleosts.","authors":"Tuyen K Quach, Megan F Taylor, Peter D Currie, Nir Eynon, Avnika A Ruparelia","doi":"10.1093/gerona/glae052","DOIUrl":"10.1093/gerona/glae052","url":null,"abstract":"<p><p>Aging is the greatest risk factor for a multitude of age-related diseases including sarcopenia-the loss of skeletal muscle mass and strength-which occurs at remarkable rates each year. There is an unmet need not only to understand the mechanisms that drive sarcopenia but also to identify novel therapeutic strategies. Given the ease and affordability of husbandry, along with advances in genomics, genome editing technologies, and imaging capabilities, teleost models are increasingly used for aging and sarcopenia research. Here, we explain how teleost species such as zebrafish, African turquoise killifish, and medaka recapitulate many of the classical hallmarks of sarcopenia, and discuss the various dietary, pharmacological, and genetic approaches that have been used in teleosts to understand the mechanistic basis of sarcopenia.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12080710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139898413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility, and Aging (SOMMA-AT).","authors":"Reichelle X Yeo, Theresa Mau, Zana M Ross, Nicholas P Edenhoffer, Jingfang Liu, Haley N Barnes, Li-Yung Lui, Joshua N Adkins, James A Sanford, Marcus M Seldin, Carlos H Viesi, Mingqi Zhou, Heather L Gregory, Frederico G S Toledo, Maja Stefanovic-Racic, Mary Lyles, Ashlee N Wood, Polly E Mattila, Elizabeth A Blakley, Iva Miljkovic, Peggy M Cawthon, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings, Bret H Goodpaster, Jamie N Justice, Erin E Kershaw, Lauren M Sparks","doi":"10.1093/gerona/glaf015","DOIUrl":"10.1093/gerona/glaf015","url":null,"abstract":"<p><strong>Background: </strong>Age-related changes in adipose tissue affect chronic medical diseases and mobility disability but mechanism remains poorly understood. The goal of this study is to define methods for phenotyping unique characteristics of adipose tissue from older adults.</p><p><strong>Methods: </strong>Older adults enrolled in study of muscle, mobility, and aging selected for the adipose tissue ancillary (SOMMA-AT; N = 210, 52.38% women, 76.12 ± 4.37 years) were assessed for regional adiposity by whole-body magnetic resonance (AMRA) and underwent a needle-aspiration biopsy of abdominal subcutaneous adipose tissue (ASAT). ASAT biopsies were flash frozen, fixed, or processed for downstream applications and deposited at the biorepository. Biopsy yields, qualitative features, adipocyte sizes, and concentration of adipokines secreted in ASAT explant conditioned media were measured. Inter-measure Spearman correlations were determined.</p><p><strong>Results: </strong>Regional, but not total, adiposity differed by sex: women had greater ASAT mass (8.20 ± 2.73 kg, p < .001) and biopsy yield (3.44 ± 1.81 g, p < .001) than men (ASAT = 5.95 ± 2.30 kg, biopsy = 2.30 ± 1.40 g). ASAT mass correlated with leptin (r = 0.54, p < .001) and not resistin (p = .248) and adiponectin (p = .353). Adipocyte area correlated with ASAT mass (r = 0.34, p < .001), BMI (r = 0.33, p < .001), adiponectin (r = -0.22, p = .005) and leptin (r = 0.18, p = .024) but not with resistin (p = .490).</p><p><strong>Conclusion: </strong>In addition to the detailed ASAT biopsy processing in this report, we found that adipocyte area correlated with ASAT mass, and both measures related to some key adipokines in the explant conditioned media. These results, methods, and biological repositories underscore the potential of this unique cohort to impact the understanding of aging adipose biology on disease, disability, and other aging tissues.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone Concentration and Incident Depression in Older Men: A Longitudinal Cohort Study.","authors":"Malcolm Forbes, Mojtaba Lotfaliany, Cammie Tran, Mohammadreza Mohebbi, Robyn L Woods, John J McNeil, Michael Berk","doi":"10.1093/gerona/glaf019","DOIUrl":"10.1093/gerona/glaf019","url":null,"abstract":"<p><strong>Background: </strong>Testosterone has been implicated in mood regulation, yet its role in the development and treatment of depression remains unclear. This study investigated the association between testosterone concentrations and the incidence of depression in older men.</p><p><strong>Methods: </strong>We utilized data from 4 107 men aged 70 years and older who participated in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE-XT studies. Serum total testosterone concentrations were measured at baseline and year 3. Depressive symptoms were assessed annually using the CES-D-10 scale, with incident depression defined as a CES-D-10 score of ≥8. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) for incident depression, adjusted for potential confounders.</p><p><strong>Results: </strong>During a median follow-up of 8.4 years, 1 449 participants experienced an episode of depression. Baseline total testosterone concentrations were not significantly associated with the risk of incident depression, whether treated as continuous variables (HR 1.00, 95% CI 0.99-1.01) or when categorized into quintiles. Similarly, changes in testosterone concentrations from baseline to year 3 did not predict incident depression (aHR 1.03, 95% CI 0.99-1.08). A subgroup analysis focusing on men with biochemical evidence of hypogonadism also found no association with incident depression.</p><p><strong>Conclusions: </strong>Our findings do not support an association between testosterone concentrations and the risk of developing depression in older men. These results suggest that testosterone is not an important factor in the pathogenesis of depression in this population. There may still be individual variability in response to testosterone changes and its potential impact on mood disorders.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Association Between Multimorbidity, Participating Activity, and Cognitive Function: Cross-lagged Mediation Analysis.","authors":"Shuojia Wang, Zikuan Yang, Yilin Chen, Jing Zhu, Lin Kang, Lixin Cheng","doi":"10.1093/gerona/glaf062","DOIUrl":"10.1093/gerona/glaf062","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have reported an association between multimorbidity and cognitive function; however, the specific direction and underlying mechanism remain unclear. The study aimed to explore the direction of this association and to examine the role of physical activity and leisure activity among older adults.</p><p><strong>Methods: </strong>Data from 5 546 dementia-free Americans aged 60 or above of 2008 (T1) and 2016 (T2) of the Health and Retirement Study were used. Multimorbidity was measured by the multimorbidity weight index. Cognitive function was measured by the Telephone Interview of Cognitive Status. We used cross-lagged panel models to determine the associations between multimorbidity and cognitive function and examine the mediation effect of physical and leisure activity.</p><p><strong>Results: </strong>There was a bidirectional association between multimorbidity and cognitive function. More severe multimorbidity predicted worse cognitive function (β = -0.064, SE = 0.016) and vice versa (β = -0.024, SE = 0.009). Paths from multimorbidity to cognitive function were stronger than those from cognitive function to multimorbidity. Physical and leisure activity mediated the association between multimorbidity (T1) and cognitive function (T2), and the association between cognitive function (T1) and multimorbidity (T2). The bidirectional association between multimorbidity and cognitive function was only observed in APOE ε4 noncarriers.</p><p><strong>Conclusions: </strong>A negative bidirectional association was observed between multimorbidity and cognitive function. Additionally, the association is mediated by physical and leisure activity.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty Mediated the Associations of Fine Particulate Matter With Depression and Anxiety: Findings From the UK Biobank.","authors":"Xiangying Suo, Junxi Zhang, Jing Guo, Yang Liu, Jie You, Quanjun Lyu, Yacong Bo","doi":"10.1093/gerona/glaf047","DOIUrl":"10.1093/gerona/glaf047","url":null,"abstract":"<p><strong>Background: </strong>The role of frailty in the associations of fine particulate matter (PM2.5) with depression and anxiety was unknown.</p><p><strong>Methods: </strong>This study is a longitudinal population-based cohort study. A total of 444 094 UK Biobank participants without depression or anxiety at baseline were included. PM2.5 concentrations and frailty phenotype were measured at baseline, while incident depression and anxiety were identified during a median follow-up of 7.8 y. A multivariable Cox regression model was utilized to evaluate the prospective relationships between PM2.5/frailty and the risk of depression and anxiety. Mediation analyses were performed to examine whether the associations were mediated by frailty.</p><p><strong>Results: </strong>Both frailty and PM2.5 exposure were associated with a higher risk of depression and anxiety. Each 10 μg/m3 increase in PM2.5 was associated with a 33% and 42% higher risk of depression (hazard ration [HR] 1.33, 95% CI: 1.17-1.49) and anxiety (HR 1.42, 95% CI: 1.24-1.67), respectively. Compared with individuals with nonfrailty, those with frailty was associated with a higher risk of depression (HR 3.14, 95% CI: 3.01-3.28) and anxiety (HR 2.39, 95% CI: 2.28-2.52), respectively. The estimate of the nature indirect effects of frailty was 1.07 (95% CI: 1.06-1.09) and 1.05 (95% CI: 1.05-1.06), which accounted for 64.6% and 22.4% of the associations between PM2.5 and depression/anxiety, respectively.</p><p><strong>Conclusions: </strong>Our findings suggest that both exposure to PM2.5 and frailty are associated with higher risk of depression and anxiety. The adverse associations between PM2.5 and depression/anxiety are partially mediated through frailty. Targeting frailty management could be a critical strategy for reducing the PM2.5-related psychiatric health burden.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulating Brain Activity to Improve Goal-directed Physical Activity in Older Adults: A Pilot Randomized Controlled Trial.","authors":"On-Yee Lo, Levi Ask, Melike Kahya, Thomas Travison, Lewis A Lipsitz, Brad Manor","doi":"10.1093/gerona/glaf039","DOIUrl":"10.1093/gerona/glaf039","url":null,"abstract":"<p><strong>Background: </strong>Insufficient physical activity in older adults remains a global health issue. Several interrelated factors contributing to inactivity are linked to the prefrontal cortex. We conducted a pilot study to assess the feasibility, acceptability, and effects of combining transcranial direct current stimulation (tDCS) and behavior counseling to improve physical activity in older adults.</p><p><strong>Methods: </strong>Inactive older adults living in subsidized housing participated in this randomized controlled trial. Baseline physical activity (daily steps) was measured with a Fitbit for 2 weeks. Participants then received an 8-week intervention, including 10 daily sessions of tDCS or Sham stimulation during the first 2 weeks, along with 4 biweekly behavior sessions. Functional outcomes were assessed at baseline, poststimulation, and after the entire intervention. Step counts were measured throughout the intervention and a 12-week retention period.</p><p><strong>Results: </strong>Twenty-eight participants completed the study. Compliance was 97%, 93%, and 92% for brain stimulation, behavior sessions, and follow-up assessments, respectively. Fitbit adherence was 96% and 71% during the intervention and retention periods. The tDCS arm, compared to Sham, exhibited greater increase in average daily steps (p .001). Participants increased 1 179 (+ 22%) and 550 (+ 15%) steps/day from baseline in the tDCS and Sham arms, respectively. Motivation (p .03) and self-reported walking performance (p .02) were also improved in the tDCS arm compared to Sham.</p><p><strong>Conclusions: </strong>Combining tDCS and personalized behavior counseling to improve physical activity was feasible, acceptable, and appeared to be effective in a cohort of inactive older adults living within subsidized housing. Larger and more definitive studies are warranted.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12051861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Hearing Intervention on the Levels of Leisure-Time Physical Activity and T.V. Viewing in Older Adults: Results from a Secondary Analysis of the ACHIEVE Study.","authors":"Pablo Martinez-Amezcua, Wuyang Zhang, Sahar Assi, Heramb Gupta, Erica Twardzik, Alison R Huang, Nicholas S Reed, Jennifer A Deal, Michelle L Arnold, Sheila Burgard, Theresa Chisolm, David Couper, Nancy W Glynn, Theresa Gmelin, Adele M Goman, Lisa Gravens-Mueller, Kathleen M Hayden, Christine M Mitchell, James S Pankow, James Russell Pike, Jennifer A Schrack, Victoria A Sanchez, Kevin J Sullivan, Frank R Lin, Josef Coresh","doi":"10.1093/gerona/glaf033","DOIUrl":"10.1093/gerona/glaf033","url":null,"abstract":"<p><strong>Background: </strong>Age-related hearing loss is common among older adults and may influence physical activity and sedentary behaviors, such as TV viewing. This study examined whether a hearing intervention could affect these behaviors over 3 years.</p><p><strong>Methods: </strong>A total of 977 participants (mean age of 76.8, 53.5% female, 11.5% Black), recruited from the ARIC study (n = 238) and de novo (n = 739) with hearing loss (pure-tone average = 39.4 dB), were randomized to a hearing intervention or a health education control group. Physical activity, leisurely walking, and TV viewing were interrogated at baseline and 3-year follow-up. We used regression models adjusted for demographic and hearing loss severity to examine the impact of the intervention on the change in the frequency of engaging in these activities.</p><p><strong>Results: </strong>At baseline, 57.6% of participants engaged in moderate-to-vigorous physical activity (MVPA), 29.1% in high-frequency leisurely walking, and 46.8% in high-frequency TV viewing. Over 3 years, MVPA decreased to 48.8%, whereas leisurely walking and TV viewing increased. After 3 years, the hearing intervention group had similar odds of engaging in MVPA (ratio of odds ratios [ROR] = 1.03, 95% confidence interval [CI], 0.93-1.14), leisurely walking (ROR = 1.04, 95% CI, 0.93-1.17), and TV viewing (ROR = 0.95, 95% CI, 0.87-1.02) compared with the control group. Results were consistent across recruitment sources (ARIC and de novo).</p><p><strong>Conclusion: </strong>A hearing intervention did not significantly influence physical activity, walking, or TV viewing behaviors in older adults over 3 years. Additional strategies may be needed to change physical and sedentary behaviors in this population.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethics From the Outset: Incorporating Ethical Considerations into the Artificial Intelligence and Technology Collaboratories for Aging Research Pilot Projects.","authors":"Emily A Largent, Yungjee Kim, Jason Karlawish, Anna Wexler","doi":"10.1093/gerona/glaf035","DOIUrl":"10.1093/gerona/glaf035","url":null,"abstract":"<p><p>There is an urgent need to develop tools to enable older adults to live healthy, independent lives for as long as possible. To address this need, the National Institute on Aging (NIA) Artificial Intelligence and Technology Collaboratories (AITCs) for Aging Research were created to identify, develop, evaluate, commercialize, and disseminate innovative technologies and artificial intelligence (AI) methods to promote healthy aging and to support persons with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). In 2023, AITC pilot grant applicants were required to answer questions about how, if at all, they would safeguard older adults' data privacy and confidentiality, advance health equity, address bias, and protect vulnerable participants. Our team analyzed applicants' answers to these ethics-focused questions using a constructivist grounded theory approach. In this article, we present what we learned and discuss modifications to our approach moving forward.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Acceptability of a Technology-Mediated Fall Risk Prevention Intervention for Older Adults With Mild Cognitive Impairment.","authors":"George Demiris, Sean Harrison, Justine Sefcik, Marjorie Skubic, Therese S Richmond, Nancy A Hodgson","doi":"10.1093/gerona/glaf043","DOIUrl":"10.1093/gerona/glaf043","url":null,"abstract":"<p><strong>Background: </strong>Falls and fall-related injuries are significant public health issues for adults 65 years of age and older. The annual direct medical costs in the United States as a result of falls are estimated to exceed $50 billion, and this estimate does not include the indirect costs of disability, dependence, and decreased quality of life. This project targets community-dwelling older adults (OA) with mild cognitive impairment (MCI) who are socially vulnerable and thus at high risk for falling.</p><p><strong>Methods: </strong>We have developed an innovative technology-supported nursing-driven intervention called Sense4Safety to (a) identify escalating risk for falls real time through in-home passive sensor monitoring (including depth sensors); (b) employ machine learning to inform individualized alerts for fall risk; and (c) link \"at risk\" socially vulnerable OA with a coach who guides them in implementing evidence-based individualized plans to reduce fall risk. The purpose of this study was to assess the feasibility and acceptability of the Sense4Safety intervention through participant interviews.</p><p><strong>Results: </strong>We recruited a cohort of 11 low-income OA with MCI who received the intervention for 3 months. Our study findings indicate the overall feasibility of the intervention with most participants (n = 9; 82%) having confidence in the passive monitoring system to effectively predict fall risk and generate actionable and tailored information that informs educational and exercise components.</p><p><strong>Conclusions: </strong>Passive sensing technologies can introduce acceptable platforms for fall prevention for community-dwelling OA with MCI.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}