The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Mental exertion causes impairments in multi-finger force deficit during a hand grip strength task in older adults.","authors":"Narges Kazemi, Hamidreza Barzegarpoor, Hamid Rajabi, Brian C Clark, Rana Fayazmilani","doi":"10.1093/gerona/glaf141","DOIUrl":"https://doi.org/10.1093/gerona/glaf141","url":null,"abstract":"<p><strong>Background: </strong>There has been growing interest in the interrelationship between age-related reductions in cognitive and motor function. To advance the understanding of this interrelationship, we sought to determine whether a mentally fatiguing task differentially effects hand grip motor function in older versus younger adults.</p><p><strong>Methods: </strong>Young (n = 10, 33 ± 3 years) and older adults (n = 15, 69 ± 3 years) free of overt neurological disease and who did not report chronic fatigue symptoms participated in two testing sessions. During both sessions, participants had their composite grip strength (GS) and their multi-finger force deficit (MFFD) measured. The MFFD assays the degree of neural inactivation observed during a composite grip strength test. During one session participants completed a series of psychomotor vigilance tasks (PVT) to induce mental fatigue. The other session served as a control condition.</p><p><strong>Results: </strong>Older adults exhibited an ∼18% reduction in composite GS associated with mental effort, which was significantly greater than that observed in young adults. Indirect neural activation, assessed via the MFFD, was reduced by approximately 22% in older adults during mental effort, which was significantly greater than the reduction observed in young adults.</p><p><strong>Conclusions: </strong>: These findings indicate that mental exertion/fatigue results in decreased composite GS and increasing impairments in neural activation in older adults. No effect on indices of neuromuscular performance were observed in young adults. These findings suggest that neural mechanisms are heavily involved in the regulation of composite grip strength, and that the relative contribution of neural and muscular mechanisms of handgrip strength are state dependent in older adults.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144510192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent impact of sarcopenia and cognitive impairment on walking recovery after rehabilitation following hip fracture surgery.","authors":"Seung-Kyu Lim, Younji Kim, Jae-Young Lim","doi":"10.1093/gerona/glaf137","DOIUrl":"https://doi.org/10.1093/gerona/glaf137","url":null,"abstract":"<p><strong>Background: </strong>Cognitive impairment and sarcopenia each negatively impact functional recovery after hip fracture, yet their combined effects remain underexplored. This study investigated the influence of these conditions on 1-year independent walking recovery in older adults undergoing post-fracture rehabilitation.</p><p><strong>Methods: </strong>This secondary analysis used data from the Fragility Fracture Integrated Rehabilitation Management (FIRM) clinical trial, a parallel-group, single-blind, multicenter superiority RCT, and its preliminary feasibility study. A total of 114 patients aged ≥65 years from three tertiary hospitals in South Korea were included. Patients were classified into four groups based on the presence of cognitive impairment and/or sarcopenia. Walking ability was assessed over a 12-month period. Kaplan-Meier analysis and multivariate Cox regression were used to evaluate independent ambulation rates and associated factors.</p><p><strong>Results: </strong>Patients with sarcopenia had lower independent ambulation rates than those without (71.9% vs. 84.4%; p = 0.025), as did those with cognitive impairment (65.2% vs. 89.1%; p = 0.010). The lowest rate was in patients with both conditions (60.8%, p = 0.022) and the highest in those without either (90.2%). Post hoc pairwise comparisons confirmed significant differences (p = 0.011). Cox regression showed cognitive impairment reduced independent ambulation likelihood by 45.8% (HR: 0.542, 95% CI: 0.340-0.865, p = 0.010), while both conditions together lowered it by 57% (HR: 0.431, 95% CI: 0.233-0.798, p = 0.007).</p><p><strong>Conclusions: </strong>Cognitive impairment, especially with sarcopenia, significantly hinders walking recovery after hip fracture. Targeted rehabilitation strategies are crucial to addressing their combined impact in older adults.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling the Relationship Between Metabolic Syndrome and Epigenetic Aging: Evidence from NHANES 1999-2002 and Mendelian Randomization Study.","authors":"Yujun Zhang, Jiawei Gui, JingJing Song, Benjie Li, Qixian Wang, Xinmeng Lv, Chong Li, Guoyang Zhang, Zaihua Cheng, Xiao Huang","doi":"10.1093/gerona/glaf134","DOIUrl":"https://doi.org/10.1093/gerona/glaf134","url":null,"abstract":"<p><strong>Background: </strong>Epigenetic age acceleration (EAA), reflecting the difference between biological and chronological age, serves as a novel biomarker for biological aging. Evidence shows metabolic syndrome (MetS) affects aging-related physiology, but the relationship between MetS and EAA remains unclear and warrants further investigation.</p><p><strong>Methods: </strong>We analyzed data from 1,972 individuals in the National Health and Nutrition Examination Survey (NHANES) 1999-2002. EAAs were determined from the residuals of 13 epigenetic clocks regressed on chronological age. Weighted logistic regression, linear regression, and restricted cubic spline (RCS) models were utilized to investigate correlations between EAAs and MetS. Genetic correlation and two-sample Mendelian randomization (MR) analyses were performed to assess causal associations, complemented by summary-data-based MR (SMR) and bioinformatics analyses to explore gene regulation related to these associations.</p><p><strong>Results: </strong>Participants with MetS exhibited significantly higher levels of EAAs, with DNA methylation PhenoAge acceleration (PhenoAgeAccel) increasing by 0.84 years (95% CI: 0.04-1.64), DNA methylation GrimAge acceleration (GrimAgeAccel) increasing by 0.83 years (95% CI: 0.32-1.34), and DNA methylation Grim2Age acceleration (GrimAge2Accel) increasing by 1.33 years (95% CI: 0.77-1.89). Elevated EAAs were significantly associated with increased risks of MetS, a correlation further substantiated by RCS models. Genetic correlation and MR analyses revealed significant associations between MetS and GrimAgeAccel. SMR identified shared risk genes between MetS and GrimAgeAccel. Subsequent bioinformatics analyses showed that these genes were associated with phenotypes such as glucose-dependent proinsulinotropic peptide levels.</p><p><strong>Conclusion: </strong>We established a causal relationship between MetS and EAAs, indicating that MetS may provide new strategies for personalized aging prevention and intervention.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Accelerometer-Estimated Sleep with Cardiorespiratory Fitness and Energetic Efficiency among Middle-Aged and Older Adults.","authors":"Daniel D Callow, Yiwei Yue, Idiatou Diallo, Jill A Rabinowitz, Yang An, Alfonso J Alfini, Mark N Wu, Sarah K Wanigatunga, Amal A Wanigatunga, Luigi Ferrucci, Eleanor M Simonsick, Jennifer A Schrack, Adam P Spira","doi":"10.1093/gerona/glaf130","DOIUrl":"https://doi.org/10.1093/gerona/glaf130","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbances and cardiovascular disease are common and often co-occur in middle-aged and older adults, but less is known about associations of sleep with cardiorespiratory fitness and energy efficiency in these populations. We examined cross-sectional associations of accelerometer-derived sleep metrics with cardiorespiratory fitness, walking energetics, and resting metabolic rate, and explored whether associations were moderated by age, sex, and race.</p><p><strong>Methods: </strong>We studied 263 participants from the Baltimore Longitudinal Study of Aging (mean age 72.7 ± 10.1 years, 53.6% women). Predictors included total sleep time (TST), sleep efficiency (SE), sleep onset latency (SOL), wake after sleep onset (WASO), and average wake bout length (WBL). Outcomes included measures of cardiorespiratory fitness (ie, maximal oxygen consumption (VO2peak)) and energetic efficiency (ie, energetic cost of walking (ECW) and resting metabolic rate (RMR)).</p><p><strong>Results: </strong>After adjusting for demographics, comorbidities, and self-reported physical activity, longer WBL was associated with lower VO2peak (B=-1.01 ml/kg/min, p < 0.01) and higher RMR (B = 43.25 kcal, p < 0.05), lower SE was associated with lower VO2peak (B = 1.07 ml/kg/min, p < 0.01), and shorter TST was associated with lower VO2peak (B = 0.33 ml/kg/min, p < 0.05). Higher SE was associated with lower RMR among middle-aged adults but not older adults (interaction p-value < 0.05).</p><p><strong>Conclusion: </strong>Shorter TST, longer WBL, and lower SE are associated with poorer cardiorespiratory fitness and energetic efficiency among middle-aged and older adults. Longitudinal studies are needed to understand the temporality of these associaitons and potential targets for interventions in these populations.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise and Cognitive Aging: A Meta-Analysis of Macrovascular Cerebral Blood Flow and Cognitive Function in Older Adults.","authors":"Wang Li, Peiyou Chen, Guoyi Li, Jinhao Zhang, Gongxiang Chen, Fan Zhang, Zhijian Wu","doi":"10.1093/gerona/glaf133","DOIUrl":"https://doi.org/10.1093/gerona/glaf133","url":null,"abstract":"<p><strong>Background: </strong>Cognitive decline is a major public health challenge in aging populations, closely linked to cerebral blood flow (CBF) reductions. While exercise is suggested to improve cognitive function and cerebrovascular health, its precise effects remain unclear.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted on studies published up to January 2024 using PubMed, Web of Science, ScienceDirect, Embase, Cochrane, PsycINFO, ClinicalTrials.gov. A total of 57 studies on cognitive function and 12 on CBF were included, focusing on randomized controlled trials (RCTs) or controlled trials. Standardized mean differences (SMDs) and weighted mean differences (WMDs) were calculated using fixed- or random-effects models. Regression analysis examined the association between CBF and cognitive outcomes.</p><p><strong>Results: </strong>Exercise interventions significantly improved cognitive function (SMD = 0.52, 95% CI [0.31, 0.74], p < .001), particularly in inhibitory control, switching function, memory, and verbal fluency. Additionally, exercise increased middle cerebral artery velocity (WMD = 1.88, 95% CI [0.08, 3.67], p < .05) while reducing resting heart rate and pulse index. Higher CBF was positively correlated with cognitive performance, particularly memory and verbal fluency.</p><p><strong>Conclusion: </strong>Exercise enhances cognitive function in older adults by improving macrovascular cerebral blood flow and cardiovascular efficiency. The positive effects of exercise on macrovascular cerebral blood flow, as demonstrated by increased MCAv and reduced PI, play a crucial role in promoting cognitive health in the elderly. These findings support structured exercise programs as a non-pharmacological intervention for promoting brain health and delaying cognitive decline.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship Between Pain, Cognition, and Chronic Conditions: Insights from the HAALSI Study in Rural South Africa.","authors":"Camryn Dixon, Tamara P Taporoski, F Xavier Gomez-Olive Casas, Stephen M Tollman, Lisa F Berkman, Darina T Bassil","doi":"10.1093/gerona/glaf131","DOIUrl":"https://doi.org/10.1093/gerona/glaf131","url":null,"abstract":"<p><strong>Background: </strong>Research on cognition and pain is limited in Low and Middle-income Countries (LMICs) and understanding how chronic conditions and pain treatment may moderate this association is underexplored. This study aimed to explore the relationship between pain and cognition and the moderating effect of hypertension, diabetes, HIV, pain treatment, and depressive symptoms.</p><p><strong>Methods: </strong>We analyzed data from 3803 individuals enrolled in the HAALSI Study, a longitudinal population study of older adults in Agincourt, South Africa. Pain was measured with the Brief Pain Inventory. Cognition was assessed using a composite of orientation questions, a memory test, and the Trails Making Test B. Chronic conditions were assessed using biological measures, and depressive symptoms were measured using the CES-D scale. Linear regression models were used to investigate the relationship.</p><p><strong>Results: </strong>Baseline and longitudinal pain were significantly associated with poorer episodic memory (ß= -0.17 [p < 0.001]; ß= -0.18 [p < 0.001]). Hypertension amplified the negative effect of pain on episodic memory, while diabetes and HIV did not moderate the relationship between pain and cognition (ß = -0.10[.006]). Pain treatment was associated with poorer cognitive performance. Depressive symptoms moderated the relationship between pain and both cognition and executive function (p = 0.02). The negative effect of pain on episodic memory was observed in individuals with both acute and persisting pain, while it only affected executive function in those with acute pain.</p><p><strong>Conclusions: </strong>These findings highlight the importance of examining factors that may moderate the relationship between pain and cognition and strategies to mitigate the effect pain has on cognition, particularly in LMICs.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom Trajectories After COVID Hospitalization and Risk Factors for Symptom Burden in Older Persons: a Longitudinal Cohort Study.","authors":"Yulu Pan, Gawon Cho, Mary Geda, Thomas M Gill, Andrew B Cohen, Lauren E Ferrante, Alexandra M Hajduk, Brienne Miner","doi":"10.1093/gerona/glaf132","DOIUrl":"https://doi.org/10.1093/gerona/glaf132","url":null,"abstract":"<p><strong>Background: </strong>Little is known about how psychosocial factors and geriatric conditions contribute to persistent post-COVID symptoms among older adults. We evaluated symptom burden following COVID-19 hospitalization and identified risk factors for persistent symptoms among community-dwelling older adults.</p><p><strong>Methods: </strong>This prospective study recruited 281 older persons (mean age 70.6 years) hospitalized for SARS-CoV-2 infection between June 2020 and June 2021 from Yale-New Haven Health System. Post-COVID symptoms were assessed using a modified Edmonton Symptom Assessment System during hospitalization, and at 1, 3, and 6 months post-discharge. Trajectory analysis identified three symptom trajectories. Multinomial logistic regression evaluated associations between characteristics (sociodemographic, clinical, psychosocial factors, and geriatric conditions) obtained during hospitalization and trajectory membership.</p><p><strong>Results: </strong>Three symptom burden trajectory groups were identified: low (n = 70; 24.9%; reference); moderate (n = 149; 53.0%); and high (62; 22.1%). Female sex (adjusted odds ratio (adjOR)_moderate = 3.10 [95%CI = 1.68- 5.72]; adjOR_high = 5.76 [2.70-12.27]), higher depression/anxiety (adjOR_moderate = 1.47 [1.24- 1.74]; adjOR_high =1.72 [1.43-2.07]), and less social support (adjOR_moderate=0.91 [0.83, 0.99]; adjOR_high = 0.86 [0.78-0.95]) were associated with moderate and high symptom burden. Geriatric conditions, including delirium (adjOR_high = 7.74 [1.56- 38.26]), frailty (adjOR_high = 5.26 [1.77-15.68]), impairment of physical function (adjOR_high = 1.18 [1.00-1.40]), and vision impairment (adjOR_high = 4.63 [1.33-16.11]), were associated with high symptom burden.</p><p><strong>Conclusions: </strong>In older persons hospitalized with COVID-19, female sex, psychosocial factors, and geriatric conditions were associated with higher symptom burden over six months. Future work should investigate the biopsychosocial mechanisms through which psychosocial factors and geriatric conditions contribute to post-COVID symptom burden.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large extension of C. elegans lifespan in diluted axenic medium: a balancing act between different survival responses.","authors":"Ping Wu, Lieselot Vandemeulebroucke, Kevin Rey A Guiritan, Bart P Braeckman","doi":"10.1093/gerona/glaf129","DOIUrl":"https://doi.org/10.1093/gerona/glaf129","url":null,"abstract":"<p><p>Axenic dietary restriction (ADR) represents a powerful and unique DR regimen for C. elegans as it robustly extends lifespan independently of well-known key genes associated with DR, such as those of insulin/IGF-1 signaling, skn-1, and pha-4. Here, we analyze C. elegans survival in a dilution series of axenic medium to explore the dependency of lifespan extension on nutrient availability. We find a non-linear relationship between lifespan and axenic nutrient levels with a four-fold axenic dilution yielding peak longevity. Notably, lifespan extension at specific dilutions permits maintenance of reproductive potential and survivability after bacterial reintroduction, indicating a partial reliance on adult reproductive diapause mechanisms. Genetic analyses found the involvement of AMPK/aak-2, sir-2.1, and cbp-1 in mediating lifespan extension across the axenic dilution spectrum, the essential role of daf-16 and hlh-30 under severe nutrient scarcity, and the specific contribution of bli-4 to standard ADR longevity. These findings elucidate that C. elegans lifespan extension under different levels of nutrient restriction is governed by overlapping yet distinct genetic pathways.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Associations Between Medication Use and Phenotypic Aging: Insights from the Baltimore Longitudinal Study of Aging.","authors":"Bowen Tang, Perry Kuo, Ann Zenobia Moore, Madhav Thambisetty, Luigi Ferrucci, Sara Hägg","doi":"10.1093/gerona/glaf128","DOIUrl":"https://doi.org/10.1093/gerona/glaf128","url":null,"abstract":"<p><strong>Background: </strong>Limited population-based data exist on the association between medication use and changes in phenotypic aging. This study investigated these associations using data from the Baltimore Longitudinal Study of Aging.</p><p><strong>Methods: </strong>Phenotypic aging (PA) markers were constructed using the Klemera-Doubal (KD) method across four domains: body composition (structural and metabolic changes), energetics (energy generation and utilization capacity), homeostatic mechanisms (internal stability maintenance), and neuroplasticity/neurodegeneration (nervous system function and decline). Associations between 27 common drug categories and changes in these PA markers were analyzed using conditional generalized estimating equations (cGEE), focusing on within-individual variation to control for genetics and early-life factors, with additional adjustments for time-varying covariates.</p><p><strong>Results: </strong>Five drug categories were associated with significant reductions in PA markers. Vitamin D, bisphosphonates, and proton pump inhibitors were linked to decreases in body composition (Beta = -0.73 years, 95% CI: -1.35 to - 0.10), energetics (Beta = -2.05, 95% CI: -3.98 to - 0.13), and neuroplasticity/neurodegeneration (Beta = -1.00, 95% CI: -2.02 to - 0.03), respectively. Thyroid hormones showed reductions in body composition (Beta = -1.75, 95% CI: -3.24 to - 0.26) and neuroplasticity/neurodegeneration (Beta = -1.04, 95% CI: -1.96 to - 0.12). Thiazides were associated with decreases across body composition (Beta = -1.55, 95% CI: -2.94 to - 0.16), energetics (Beta = -2.36, 95% CI: -4.30 to - 0.42), and homeostatic mechanisms (Beta = -3.83, 95% CI: -6.71 to - 0.96).</p><p><strong>Conclusions: </strong>These findings suggest potential protective effects of certain medications on phenotypic aging. Further research is needed to validate these results, particularly with data from other populations.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep, Carotid Intima-Media Thickness and Arterial Stiffness: Results from a Large Longitudinal Cohort Study.","authors":"Ruirui Wang, Mengyao Shi, Xiangyan Yin, Yi Chen, Xiaoxiao Wang, Zhengbao Zhu, Tan Xu, Yonghong Zhang","doi":"10.1093/gerona/glaf126","DOIUrl":"https://doi.org/10.1093/gerona/glaf126","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the associations of sleep health with carotid intima-media thickness (CIMT) and arterial stiffness.</p><p><strong>Methods: </strong>A total of 41,465 UK Biobank participants were included. Sleep traits were assessed at baseline via self-reported questionnaires, and a composite sleep score was constructed based on six factors: sleep duration, snoring, insomnia, chronotype, daytime napping, and daytime sleepiness, with higher scores indicating poorer sleep health. CIMT and arterial stiffness were measured at follow-up. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between sleep score and study outcomes, adjusting for baseline demographics, socioeconomic status, physical measurements, and medication use.</p><p><strong>Results: </strong>The mean age of the study population was 55.08 years (SD = 7.57), with 52.91% females and 96.99% Whites. Compared with those for participants with a sleep score of 0, the multivariate-adjusted ORs (95% CI) for those with sleep scores of 1, 2, 3, 4, and 5-6 were 1.04 (0.93, 1.16), 1.09 (0.98, 1.21), 1.17 (1.05, 1.30), 1.15 (1.02, 1.29), and 1.18 (1.03, 1.35) for CIMT thickening, respectively, and 1.04 (0.92, 1.18), 1.13 (1.00, 1.27), 1.25 (1.08, 1.40), 1.23 (1.08, 1.40), and 1.31 (1.12, 1.53) for arterial stiffness, respectively. Poor sleep health was associated with an increased risk of CIMT thickening within all genetic risk categories, and no interaction between the sleep and genetic risk scores was found.</p><p><strong>Conclusion: </strong>This study highlighted the importance of healthy sleep behaviors in slowing the progression of subclinical cardiovascular disease, regardless of individual's genetic risk status.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144277204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}