The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Intrinsic Capacity Trajectories: Implications for Subsequent Falls and Hospitalizations among Older Adults.","authors":"Xiaodong Chen, Lingxiao He, Kewei Shi, Qihui Wen, Qianqian Yu, Mingyue Gao, Ya Fang","doi":"10.1093/gerona/glaf017","DOIUrl":"https://doi.org/10.1093/gerona/glaf017","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic capacity (IC) is the composite of an individual's physical and mental capacities. However, the association between IC trajectories and falls and hospitalizations remains uncertain. This study aimed to determine the IC trajectories among older adults, investigating its association with subsequent risk of falls and hospitalizations.</p><p><strong>Methods: </strong>This study enrolled 3,902 older adults aged ≥65 from the National Health and Aging Trends Study (NHATS, wave 2015-2019). A bi-factor model was used for repeated measurements of the five IC domains to generate IC scores for four time points (wave 2015-2018). IC trajectories were identified using group-based trajectory modeling (GBTM), and modified Poisson regression was used to analyze the associations between IC trajectories and subsequent fall and hospitalization risk.</p><p><strong>Results: </strong>The mean age of the participants was 76.70 years (SD=6.78), and the majority were female (57.3%). Three IC trajectories were identified, including persistently low (17.86%), persistently moderate (33.96%), and persistently high (48.18%). Compared with the persistently low class, the moderate and high classes have significantly lower fall and hospitalization risk. Multivariate-adjusted RRs for fall occurrence were 0.87 (95% CI:0.78-0.98) and 0.74 (95% CI:0.65-0.85), for multiple falls were 0.81 (95% CI:0.68-0.96) and 0.52 (95% CI:0.41-0.66), for hospitalization occurrence were 0.76 (95% CI:0.66-0.87) and 0.48 (95% CI:0.39-0.58), and for multiple hospitalizations were 0.65 (95% CI:0.53-0.80) and 0.37 (95% CI:0.28-0.48), respectively.</p><p><strong>Conclusions: </strong>IC trajectories were associated with falls and hospitalizations. Strategies focusing on improving and maintaining IC at a higher level over time could help reduce the subsequent risk of falls and hospitalizations.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discussing the interplay of social determinants of health, aging and Alzheimer's biomarkers in U.S. Latinos.","authors":"Jairo E Martinez, Jaime Perales-Puchalt, Miriam J Rodriguez, Monica Rosselli, Christian Salazar, David X Marquez, Melissa Lamar, Clara Vila-Castelar, Katya Rascovsky, Sid O'Bryant, Raul Vintimilla, Mirella Díaz-Santos, Idaly Velez-Uribe, Yakeel T Quiroz, Jorge Llibre-Guerra","doi":"10.1093/gerona/glaf020","DOIUrl":"https://doi.org/10.1093/gerona/glaf020","url":null,"abstract":"<p><p>This perspective examines the impact of Social Determinants of Health (SDoH) on biological age-related decline and Alzheimer's Disease and Related Dementias (ADRD) biomarker trajectories in U.S. Latino populations, emphasizing the need for comprehensive multilevel research frameworks tailored to the community. We discuss the prevailing SDoH among U.S. Latino communities, including economic, educational, and healthcare access inequities that heighten health risks. Subsequently, we examine the pronounced differences in ADRD prevalence and biomarker trajectories among Latinos, suggesting that the interplay between SDoH and biological markers contributes to ADRD risk and progression. Our perspective reflects on the existing research landscape, noting a substantial gap in studies extending beyond identifying and understanding disparities in ADRD, to research incorporating biomarkers and developing actionable interventions to address broader SDoH. This shift is essential for creating a more holistic approach to ADRD research and devising truly effective strategies to mitigate ADRD disparities and improve brain health for older U.S. Latinos.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senolysis by GLS1 Inhibition Ameliorates Kidney Aging by Inducing Excessive mPTP Opening Through MFN1.","authors":"Yuting Chen, Nan Zhao, Yu Zhang, Xueqi Chen, Yi Chen, Yifan Wang, Jianqing Wu, Weihong Zhao","doi":"10.1093/gerona/glae294","DOIUrl":"10.1093/gerona/glae294","url":null,"abstract":"<p><p>Cellular senescence is a pivotal contributor to aging and age-related diseases. The targeted elimination of senescent cells, known as senolysis, has emerged as a promising therapeutic strategy for mitigating these conditions. Glutaminase 1 (GLS1), a key enzyme in the glutaminolysis pathway, has been implicated in various cellular senescence processes. However, its specific role in senescent renal tubular epithelial cells (TECs) remains unclear. This study investigates the role and underlying mechanisms of GLS1 in senescent TECs. Using d-galactose (d-gal)-induced senescence of HK-2 cells, we found that GLS1 inhibition eliminated senescent TECs by promoting excessive mitochondrial permeability transition pore (mPTP) opening. Mechanistically, the excessive mPTP opening is associated with the upregulation of mitofusin 1 (MFN1). Inhibition of GLS1 in d-gal-treated HK-2 cells induced a shift in mitochondrial dynamics from fission to fusion, accompanied by a significant increase in MFN1 expression. Knocking down MFN1 reduced the mPTP opening and the expression of mPTP-related genes (PPIF, VDAC, and BAX) in cells co-treated with d-gal and the GLS1 inhibitor BPTES. Moreover, treatment of aged mice with BPTES specifically eliminated senescent TECs and ameliorated age-associated kidney disease. These findings reveal that GLS1 inhibition eliminate senescent TECs by promoting excessive mPTP opening, suggesting that targeting GLS1 may be a novel senolytic strategy for alleviating aging-related kidney diseases.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11886818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workshop Report-Heterogeneity and Successful Aging Part I: Heterogeneity in Aging-Challenges and Opportunities.","authors":"George A Kuchel, Andrea L Hevener, J Graham Ruby, Paola Sebastiani, Vivek Kumar","doi":"10.1093/gerona/glaf023","DOIUrl":"https://doi.org/10.1093/gerona/glaf023","url":null,"abstract":"<p><p>Historically, aging research has focused primarily on the study of differences in means of varied measures obtained at different ages. However, growing evidence has shown that for many parameters, variability in measurements obtained both between- and within-age groups increases with aging. Moreover, growing heterogeneity may become especially apparent when examined via longitudinal as opposed to cross-sectional aging data. Efforts to deconvolute and better understand such heterogeneity present remarkable translational opportunities for developing targeted and more effective interventions into aging. Here, we present Part I, a summary of the NIA Heterogeneity and Successful Aging workshop virtually held in May 2023.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":"80 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frailty mediated the associations of fine particulate matter with depression and anxiety: Findings from the UK Biobank.","authors":"Xiangying Suo, Junxi Zhang, Jing Guo, Yang Liu, Jie You, Quanjun Lyu, Yacong Bo","doi":"10.1093/gerona/glaf047","DOIUrl":"https://doi.org/10.1093/gerona/glaf047","url":null,"abstract":"<p><strong>Background: </strong>The role of frailty in the associations of fine particulate matter (PM2.5) with depression and anxiety was unknown.</p><p><strong>Methods: </strong>This study is a longitudinal population-based cohort study. A total of 444,094 UK Biobank participants without depression or anxiety at baseline were included. PM2.5 concentrations and frailty phenotype were measured at baseline, while incident depression and anxiety were identified during a median follow-up of 7.8 years. A multivariable cox regression model was utilized to evaluate the prospective relationships between PM2.5/frailty and the risk of depression and anxiety. Mediation analyses were performed to examine whether the associations were mediated by frailty.</p><p><strong>Results: </strong>Both frailty and PM2.5 exposure were associated with a higher risk of depression and anxiety. Each 10 ug/m3 increase in PM2.5 was associated with a 33% and 42% higher risk of depression (HR 1.33, 95%CI: 1.17-1.49) and anxiety (HR 1.42, 95%CI: 1.24-1.67), respectively. Compared with individuals with non-frailty, those with frailty was associated with a higher risk of depression (HR 3.14, 95%CI: 3.01-3.28) and anxiety (HR 2.39, 95%CI: 2.28-2.52), respectively. The estimate of the nature indirect effects (NIEs) of frailty were 1.07 (95%CI: 1.06-1.09) and 1.05 (95%CI: 1.05-1.06), which accounted for 64.6% and 22.4% of the associations between PM2.5 and depression/anxiety, respectively.</p><p><strong>Conclusion: </strong>Our findings suggest that both exposure to PM2.5 and frailty are associated with higher risk of depression and anxiety. The adverse associations between PM2.5 and depression/anxiety are partially mediated through frailty. Targeting frailty management could be a critical strategy for reducing the PM2.5-related psychiatric health burden.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and Acceptability of a Technology Mediated Fall Risk Prevention Intervention for Older Adults with Mild Cognitive Impairment.","authors":"George Demiris, Sean Harrison, Justine Sefcik, Marjorie Skubic, Therese Richmond, Nancy Hodgson","doi":"10.1093/gerona/glaf043","DOIUrl":"https://doi.org/10.1093/gerona/glaf043","url":null,"abstract":"<p><strong>Background: </strong>Falls and fall-related injuries are significant public health issues for adults 65 years of age and older. The annual direct medical costs in the US as a result of falls are estimated to exceed $50 billion, and this estimate does not include the indirect costs of disability, dependence, and decreased quality of life. This project targets community dwelling older adults (OA) with mild cognitive impairment (MCI) who are socially vulnerable and thus at high risk for falling.</p><p><strong>Methods: </strong>We have developed an innovative technology-supported nursing-driven intervention called Sense4Safety to 1) identify escalating risk for falls real-time through in-home passive sensor monitoring (including depth sensors); 2) employ machine learning to inform individualized alerts for fall risk; and 3) link 'at risk' socially vulnerable older adults with a coach who guides them in implementing evidence-based individualized plans to reduce fall-risk. The purpose of this study was to assess the feasibility and acceptability of the Sense4Safety intervention through participant interviews.</p><p><strong>Results: </strong>We recruited a cohort of 11 low-income OA with MCI who received the intervention for 3 months. Our study findings indicate overall feasibility of the intervention with most participants (n=9; 82%) having confidence in the passive monitoring system to effectively predict fall risk and generate actionable and tailored information that informs educational and exercise components.</p><p><strong>Conclusions: </strong>Passive sensing technologies can introduce acceptable platforms for fall prevention for community dwelling older adults with MCI.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Returning individualized wearable sensor results to older adult research participants: A pilot study.","authors":"Shelby L Bachman, Krista S Leonard-Corzo, Jennifer M Blankenship, Michael A Busa, Corinna Serviente, Matthew W Limoges, Robert T Marcotte, Ieuan Clay, Kate Lyden","doi":"10.1093/gerona/glaf027","DOIUrl":"https://doi.org/10.1093/gerona/glaf027","url":null,"abstract":"<p><strong>Background: </strong>Wearable sensors that monitor physical behaviors are increasingly adopted in clinical research. Older adult research participants have expressed interest in tracking and receiving feedback on their physical behaviors. Simultaneously, researchers and clinical trial sponsors are interested in returning results to participants, but the question of how to return individual study results derived from research-grade wearable sensors remains unanswered. In this study, we (1) assessed the feasibility of returning individual physical behavior results to older adult research participants and (2) obtained participant feedback on the returned results.</p><p><strong>Methods: </strong>Older adult participants (N=20; ages 67-96) underwent 14 days of remote monitoring with two wearable sensors. We then used a semi-automated process to generate a 1-page report summarizing each participant's physical behaviors across the 14 days. This report was delivered to each participant via email, and they were asked to evaluate the report.</p><p><strong>Results: </strong>Participants found the reports easy to understand, health-relevant, interesting, and visually pleasing. They had valuable suggestions to improve data interpretability and raised concerns such as comparisons with measures derived from their consumer-grade sensors.</p><p><strong>Conclusions: </strong>We have demonstrated the feasibility of returning individual physical behavior results from research-grade devices to older research participants, and our results indicate that this practice is well-received. Further research to develop more efficient and scalable systems to return results to participants, and to understand the preferences of participants in larger, more representative samples, is warranted.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a hearing intervention on the levels of leisure-time physical activity and T.V. viewing in older adults: results from a secondary analysis of the ACHIEVE trial.","authors":"Pablo Martinez-Amezcua, Wuyang Zhang, Sahar Assi, Heramb Gupta, Erica Twardzik, Alison R Huang, Nicholas S Reed, Jennifer A Deal, Michelle L Arnold, Sheila Burgard, Theresa Chisolm, David Couper, Nancy W Glynn, Theresa Gmelin, Adele M Goman, Lisa Gravens-Mueller, Kathleen M Hayden, Christine M Mitchell, James S Pankow, James Russell Pike, Jennifer A Schrack, Victoria A Sanchez, Kevin J Sullivan, Frank R Lin, Josef Coresh","doi":"10.1093/gerona/glaf033","DOIUrl":"https://doi.org/10.1093/gerona/glaf033","url":null,"abstract":"<p><strong>Background: </strong>Age-related hearing loss is common among older adults and may influence physical activity and sedentary behaviors, such as TV viewing. This study examined whether a hearing intervention could affect these behaviors over three years.</p><p><strong>Methods: </strong>977 participants (mean age of 76.8, 53.5% female, 11.5% Black), recruited from the ARIC study (n=238) and de novo (n=739) with hearing loss (pure-tone average=39.4 dB), were randomized to a hearing intervention or a health education control group. Physical activity, leisurely walking, and TV viewing were interrogated at baseline and three-year follow-up. We used regression models adjusted for demographic and hearing loss severity to examine the impact of the intervention on the change in the frequency of engaging in these activities.</p><p><strong>Results: </strong>At baseline, 57.6% of participants engaged in moderate-to-vigorous physical activity (MVPA), 29.1% in high-frequency leisurely walking, and 46.8% in high-frequency TV viewing. Over three years, MVPA decreased to 48.8%, while leisurely walking and TV viewing increased. After three years, the hearing intervention group had similar odds of engaging in MVPA (ratio of odds ratios [ROR] = 1.03, 95% confidence interval [CI]: 0.93 to 1.14), leisurely walking (ROR = 1.04, 95% CI: 0.93 to 1.17), and TV viewing (ROR = 0.95, 95% CI: 0.87 to 1.02) compared to the control group. Results were consistent across recruitment sources (ARIC and de novo).</p><p><strong>Conclusion: </strong>A hearing intervention did not significantly influence physical activity, walking, or TV viewing behaviors in older adults over three years. Additional strategies may be needed to change physical and sedentary behaviors in this population.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of initiation and continuous adherence to ARBs vs. ACEIs on risk of adjudicated mild cognitive impairment or dementia.","authors":"Catherine G Derington, Ransmond O Berchie, Daniel O Scharfstein, Ryan M Andrews, Tom H Greene, Yizhe Xu, Jordan B King, Mark A Supiano, Joshua A Sonnen, Jeff Williamson, Nicholas M Pajewski, Jeremy Pruzin, Jordana B Cohen, Adam P Bress","doi":"10.1093/gerona/glaf028","DOIUrl":"https://doi.org/10.1093/gerona/glaf028","url":null,"abstract":"<p><strong>Background: </strong>Whether the differing mechanistic effects between angiotensin-2 receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) on the renin-angiotensin system translate to differential effects on clinical cognitive outcomes is unclear.</p><p><strong>Methods: </strong>We employed an active comparator, new-user cohort study to emulate a target trial evaluating the per-protocol effect of initiating and continuously adhering to an ARB vs. ACEI on adjudicated amnestic mild cognitive impairment (MCI) and probable dementia (PD) in the Systolic Blood Pressure Intervention Trial. Inverse probability of treatment and censoring weighted cumulative incidence functions accounted for confounding, the competing risk of death, adherence, and loss to follow-up.</p><p><strong>Results: </strong>Of 9,361 SPRINT participants (mean age 67.1±9.5 years, 36.7% female, 58.7% non-Hispanic White), 710 and 1,289 were new users of an ARB or ACEI. Overall, 291 (41.0%) ARB initiators and 854 (66.3%) ACEI initiators were non-adherent during follow-up. The IP-weighted 4-year probabilities of full adherence and being alive among ARB was 56.0% (95% CI: 52.2%-59.9%) and 30.5% (95% CI: 28.0%-33.1%) for ACEI. The 4-year weighted risk ratios (RR) for amnestic MCI/PD and for amnestic MCI/PD/death with initiation and full adherence to ARB vs. ACEI were 0.94 (95% CI: 0.66-1.29) and 0.79 (95% CI: 0.58-1.06). ARB vs. ACEI initiation and adherence was associated with a weighted RR of 0.36 (95% CI: 0.14-0.76).</p><p><strong>Conclusions: </strong>In this target trial emulation of older adults at high risk for cardiovascular disease, there was insufficient evidence to conclude a beneficial effect of initiating and continuously adhering to an ARB vs. ACEI on adjudicated clinical cognitive outcomes.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testosterone concentration and incident depression in older men: a longitudinal cohort study.","authors":"Malcolm Forbes, Mojtaba Lotfaliany, Cammie Tran, Mohammadreza Mohebbi, Robyn L Woods, John McNeil, Michael Berk","doi":"10.1093/gerona/glaf019","DOIUrl":"https://doi.org/10.1093/gerona/glaf019","url":null,"abstract":"<p><strong>Background: </strong>Testosterone has been implicated in mood regulation, yet its role in the development and treatment of depression remains unclear. This study investigated the association between testosterone concentrations and the incidence of depression in older men.</p><p><strong>Methods: </strong>We utilized data from 4,107 men aged 70 years and older who participated in the Aspirin in Reducing Events in the Elderly (ASPREE) and ASPREE-XT studies. Serum total testosterone concentrations were measured at baseline and year 3. Depressive symptoms were assessed annually using the CES-D-10 scale, with incident depression defined as a CES-D-10 score of ≥ 8. Cox proportional hazards regression models were used to estimate the hazard ratios (HR) for incident depression, adjusted for potential confounders.</p><p><strong>Results: </strong>During a median follow-up of 8.4 years, 1,449 participants experienced an episode of depression. Baseline total testosterone concentrations were not significantly associated with the risk of incident depression, whether treated as continuous variables (HR 1.00, 95% CI 0.99-1.01) or when categorized into quintiles. Similarly, changes in testosterone concentrations from baseline to year 3 did not predict incident depression (aHR 1.03, 95% CI 0.99-1.08). A subgroup analysis focusing on men with biochemical evidence of hypogonadism also found no association with incident depression.</p><p><strong>Conclusions: </strong>Our findings do not support an association between testosterone concentrations and the risk of developing depression in older men. These results suggest that testosterone is not an important factor in the pathogenesis of depression in this population. There may still be individual variability in response to testosterone changes and its potential impact on mood disorders.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}