The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Advanced brain aging, selective vulnerability in gray matter, and cognition in Parkinson's disease.","authors":"Mengfei Cai, Chentao He, Hao Li, Rui Yang, Siming Rong, Ziqi Gao, Qibing Luo, Zihao Li, Yan Li, Zaiyi Liu, Piao Zhang, Yuhu Zhang","doi":"10.1093/gerona/glaf124","DOIUrl":"https://doi.org/10.1093/gerona/glaf124","url":null,"abstract":"<p><strong>Background: </strong>To identify the most vulnerable brain regions in gray matter attributable to advanced brain aging and examine the cognitive correlates of advanced brain aging in Parkinson's disease (PD).</p><p><strong>Methods: </strong>125 early-stage PD patients with both structural, diffusion MRI and DAT-SPECT data available were included at baseline (year 0) from Parkinson's Progression Markers Initiative (PPMI), with neuroimaging follow-up at year 1, 2, 4. Annual assessment of cognition was performed in 5 years. The relation between brain-predicted age difference (PAD) and free water in cortical and subcortical gray matter, as well as cognition were examined with linear regression and linear mixed effects model. Cox proportional hazards model was used to investigate the relation between brain PAD and the risk of conversion to mild cognitive impairment (MCI).</p><p><strong>Results: </strong>125 PD patients with a mean (SD) chronological age of 60.99 (9.50) years and 82 (65.6%) were men. Brain PAD followed a non-linear progression pattern over time(p = 0.028). Brain PAD was differentially associated with free water in cortical and subcortical gray matter, with the most preferentially vulnerable regions identified as temporal cortex, striatum, hippocampus, and cholinergic basal forebrain. Baseline brain PAD was associated with cognitive deficits and the conversion to mild cognitive impairment during the 5-year follow-up.</p><p><strong>Conclusions: </strong>Our findings suggest that brain PAD offers potential in pinpointing regions most susceptible to accelerated brain aging and identifying patients with Parkinson's disease who are at an increased risk of converting to mild cognitive impairment. .</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of Periodontitis With Biological Aging Among U.S. Adults: An Exploratory Mediation Analysis via Lactate.","authors":"Huan Zhou, Yong Li, Di Miao, Jiayu Zhang, Lisa Yang, An Li, Ruoyan Cao","doi":"10.1093/gerona/glaf061","DOIUrl":"10.1093/gerona/glaf061","url":null,"abstract":"<p><strong>Background: </strong>To investigate the potential role of lactate in the relationship between periodontitis and biological aging.</p><p><strong>Methods: </strong>Cross-sectional data from 9 652 participants in the National Health and Nutrition Examination Survey 2009-2014 were analyzed. Periodontitis was categorized based on the Centers for Disease Control and Prevention and American Academy of Periodontology (CDC/AAP) classification. Biological aging was assessed based on KDM-BA acceleration and PhenoAge acceleration, while lactate levels were assessed using lactate dehydrogenase (LDH). Weighted multivariable linear regression analyses were conducted to examine the association between periodontitis and biological aging. Additionally, exploratory mediation analyses were carried out to determine the mediating effect of LDH on this association.</p><p><strong>Results: </strong>Participants with moderate/severe periodontitis showed accelerated biological aging and higher serum LDH levels. Similarly, mean attachment loss (AL) and probing pocket depth (PPD) were positively associated with biological aging and serum LDH levels. Furthermore, serum LDH was found to mediate 8.4% and 3.8% of the associations between periodontitis and KDM-BA acceleration and PhenoAge acceleration, respectively. LDH also explained 11.0% and 4.4% of the association between mean PPD and KDM-BA acceleration and PhenoAge acceleration, respectively. However, the role of LDH in the relationship between mean AL and biological aging was not observed.</p><p><strong>Conclusions: </strong>These findings indicate that LDH, an enzyme that converts pyruvate to lactate, mediates the association between periodontitis and biological aging. However, additional longitudinal or interventional studies are needed to more effectively assess causality and confirm our findings.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapamycin Alters the Feeding Preference for Amino Acids and Sugar in Female Drosophila.","authors":"Guixiang Yu, Qihao Yang, Qi Wu","doi":"10.1093/gerona/glaf093","DOIUrl":"10.1093/gerona/glaf093","url":null,"abstract":"<p><p>Rapamycin has demonstrated significant lifespan-extending effects across a variety of model organisms, positioning it as one of the most promising antiaging agents currently under investigation. Nonetheless, chronic administration of rapamycin may induce diverse adverse reactions, primarily due to its influence on energy metabolism. Here, using Drosophila melanogaster as a model, we show that rapamycin significantly alters feeding behaviors in a dose-dependent manner. Specifically, both long-term and short-term administration of the optimal life-extending dose of rapamycin decreases the protein preference while increasing sugar intake in female flies. Utilizing a chemically defined diet, we identified that these alterations in amino acid and sugar feeding preferences occur as early as the second day of rapamycin exposure, preceding any detectable decline in fecundity. Furthermore, rapamycin also modifies amino acid preference even in taste-blind females, indicating that postingestive nutritional learning mechanisms, independent of food taste value, are sufficient to mediate the effects of rapamycin on feeding behavior. However, such changes in macronutrient preferences were absent in males and sterile mutant females. Collectively, our study suggests that the modification of feeding behavior could be a non-negligible side effect of rapamycin treatment, and this effect is influenced by both sex and reproductive status.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing the Right for You? intervention to improve engagement in community-based palliative care: A feasibility study and pilot test.","authors":"Elizabeth Luth, Denalee O'Malley, Carlin Brickner, Ruiqi Xue, Kathryn H Bowles","doi":"10.1093/gerona/glaf122","DOIUrl":"https://doi.org/10.1093/gerona/glaf122","url":null,"abstract":"<p><strong>Background: </strong>Community-based palliative care (CBPC) can improve symptom management and quality of life at reduced costs (through hospitalization prevention) for seriously ill older adults. However, CBPC services are underutilized due to multi-level factors including patient perceptions and lack of systematic methods for providers to identify and communicate the potential value of these services.</p><p><strong>Methods: </strong>The purpose of this study is to describe the co-design of Right for You? (R4U?) intervention materials and to present pilot test results of feasibility and preliminary effectiveness testing. R4U? was designed to improve how a CBPC program (offered as part of a Medicare Advantage health plan) is presented to seriously ill older adults and their caregivers.</p><p><strong>Results: </strong>Our findings suggest the co-designed R4U? was acceptable to clinicians and when pilot tested demonstrated preliminary effectiveness with a seven percentage-point increase in enrollment in the CBPC program during the intervention period (May-September 2024).</p><p><strong>Conclusions: </strong>Our preliminary findings support the acceptability and feasibility of using tailored R4U? as a way of increasing interest and enrollment in a CBPC program. Additional research is needed to determine if observed increases in CBPC enrollment are sustainable over time and scalable in other settings to improve enrollment in CBPC.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External Validation of an AI-based Preoperative Frailty Index using Real-World Data.","authors":"Chen Bai, Feifei Xiao, Mohammad Al-Ani, Catherine C Price, Todd M Manini, Mamoun T Mardini","doi":"10.1093/gerona/glaf119","DOIUrl":"https://doi.org/10.1093/gerona/glaf119","url":null,"abstract":"<p><strong>Background: </strong>Preoperative frailty assessment is crucial for surgical risk stratification in older adults. Traditional frailty measurements are often too time-consuming and resource-intensive in preoperative settings. This study aimed to externally validate an artificial intelligence (AI)-based frailty index developed using electronic health records (EHR).</p><p><strong>Methods: </strong>We externally validated an AI-based frailty index, previously developed by our team, on a cohort of 152,364 surgical patients aged 65+ years from the OneFlorida+ Clinical Research Consortium. We examined the association between the predicted frailty and three postoperative outcomes: 30-day mortality, length of hospital stay, and discharge disposition. We also compared the predictive performance of general and service-specific frailty indices (the latter developed using data from patients undergoing specific surgeries) in predicting postoperative outcomes.</p><p><strong>Results: </strong>The AI-based frailty index demonstrated a strong and stepwise association with adverse postoperative outcomes. Patients in the highest frailty level (top 20%) had significantly higher odds of 30-day mortality (OR 4.33, 95% CI 3.91-4.80), longer hospital stays (2.53 times longer, 95% CI 2.47-2.60), and a higher likelihood of unfavorable discharge dispositions compared to the lowest frailty level, after adjusting for demographics and comorbidities. The general frailty index performed comparably to or slightly better than service-specific indices across surgical specialties.</p><p><strong>Conclusion: </strong>The developed preoperative frailty index effectively predicts postoperative outcomes in a large and diverse external cohort. The index's efficiency and predictive performance in stratifying surgical risk can potentially improve surgical care and outcomes.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammation as a Moderator of Air Pollution-Associated Self-Reported Health in Middle-aged and Older Chinese Adults: Evidence from a Nationwide Study.","authors":"Boye Fang, Danyu Li, Zhongwang Wei","doi":"10.1093/gerona/glaf117","DOIUrl":"https://doi.org/10.1093/gerona/glaf117","url":null,"abstract":"<p><p>Prolonged exposure to air pollution and systemic inflammation has both been associated with deteriorating self-reported health (SRH), however, the underlying mechanisms remained poorly understood. This study included 8,292 middle-aged and older adults (≥45 years) from the China Health and Retirement Longitudinal Study (CHARLS). High spatial-temporal gridded air pollution datasets were utilized to estimate individual air pollution exposure at county level. Systemic inflammation was measured using C-reactive protein (CRP) and white blood cell (WBC) numbers from CHARLS blood samples. Generalized linear modeling (GLM) was employed to examine the relationships between air pollution exposure, systemic inflammation, and SRH. After adjusting for confounders, this study found that a 3-year average PM2.5 concentration was associated with a higher risk of poor SRH (OR = 1.005, 95% CI: 1.002-1.009). Elevated CRP and WBC levels were also linked to an increased risk of poor SRH (OR = 1.019, 95% CI: 1.011-1.027; OR = 1.035, 95% CI: 1.010-1.061, respectively). Interaction analysis revealed that elevated CRP levels exacerbated the adverse effect of chronic air pollution exposure on SRH. In addition, residential location and educational attainment influenced how systemic inflammation moderated the relationship between PM2.5 exposure and SRH. Long-term exposure to air pollution was associated with an increased likelihood of poor self-reported health among middle-aged and older adults, with inflammatory markers potentially amplifying this association. Therefore, it is essential to implement multidisciplinary strategies to reduce air pollution and alleviate systemic inflammation in this population.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Racial Disparities in Palliative Care Among Hospitalized Older Adults with Traumatic Brain Injury.","authors":"Jennifer S Albrecht, Justin Price, Chih Chun Tung, Raya Elfadel Kheirbek","doi":"10.1093/gerona/glaf121","DOIUrl":"https://doi.org/10.1093/gerona/glaf121","url":null,"abstract":"<p><strong>Background: </strong>Enhanced understanding of the use of palliative care among older adults with traumatic brain injury (TBI) could help guide development of policy and educational interventions. Our objective was to assess racial and ethnic disparities in the receipt of palliative care among older adults with TBI.</p><p><strong>Methods: </strong>We conducted a cross-sectional study using data from the Premier Database from May 2022-May 2023. We included adults aged 65 and older with an admission diagnosis of TBI who died during hospitalization. We compared characteristics and palliative care receipt across racial/ethnic groups. Logistic regression models were used to estimate the unadjusted and adjusted odds of receiving palliative care as a function of race/ethnicity. The primary outcome was receipt of a palliative care consultation.</p><p><strong>Results: </strong>Of 1,119 included patients,76.4% were Non-Hispanic White, 5.1% were Non-Hispanic Black, 5.5% were Hispanic, 4.4% were Asian, and 8.7% were classified as Other/Unknown. The majority (81.7%) received palliative care. In adjusted models, Non-Hispanic Black patients had the lowest odds of receiving a palliative care consultation compared to Non-Hispanic White patients (odds ratio (OR) 0.42; 95% confidence interval (CI), 0.23-0.76.</p><p><strong>Conclusions: </strong>In a cohort of older adults hospitalized with TBI who died in-hospital, Non-Hispanic Black patients were markedly less likely to receive palliative care compared to their White counterparts. This study underscores the need for future work to identify the extent to which historical mistrust, communication barriers, provider bias, and socioeconomic factors contribute to differences in palliative care access among older TBI patients.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144259810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Peripheral Blood Leukocyte Transcriptome-Based Aging Clock Reveals Acceleration of Aging by Bacterial or Viral Infections.","authors":"Xin Gao, Si-Jia Li, Jian-Ping Cai","doi":"10.1093/gerona/glaf054","DOIUrl":"10.1093/gerona/glaf054","url":null,"abstract":"<p><p>The aging of the population is a global concern. In the post-coronavirus disease 2019 (COVID-19) pandemic era, there are no effective methods to identify aging acceleration due to infection. In this study, we conducted whole-transcriptome sequencing on peripheral blood samples from 35 healthy individuals (22-88 years old). By analyzing the changes in mRNA, lncRNA, and miRNA expression, we investigated the characteristics of transcriptome alterations during the aging process. ceRNA networks were constructed, and 10 genes (CD248, PHGDH, SFXN2, MXRA8, NOG, TTC24, PHYKPL, CACHD1, BPGM, and TWF1) were identified as potential aging markers and used to construct an aging clock. Moreover, our aging clock categorized individuals into slow-, average-, and quick-aging groups, highlighting a link between accelerated aging and infection-related clinical parameters. Pseudotime analysis further revealed 2 distinct aging trajectories, corroborating the variations in the aging rate identified by the aging clock. Furthermore, we validated the results using the OEP001041 data set (277 healthy individuals aged 17-75), and data sets comprising patients with infectious diseases (n = 1 558). Our study revealed that infection accelerates aging via increased inflammation and oxidative stress in infectious disease patients. Besides, the aging clock exhibited alterations after infection, highlighting its potential for assessing the aging rate after patient recovery. In conclusion, our study introduces a novel aging clock to assess the aging rate in healthy individuals and those with infections, revealing a strong link between accelerated aging and infections through inflammation and oxidative stress. These findings offer valuable insights into aging mechanisms and potential strategies for healthy aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There Are Multiple Clocks That Time Us: Cross-Sectional and Longitudinal Associations Among 14 Alternative Indicators of Age and Aging.","authors":"Johanna Drewelies, Jan Homann, Valentin Max Vetter, Sandra Düzel, Simone Kühn, Laura Deecke, Elisabeth Steinhagen-Thiessen, Philippe Jawinski, Sebastian Markett, Ulman Lindenberger, Christina M Lill, Lars Bertram, Ilja Demuth, Denis Gerstorf","doi":"10.1093/gerona/glae244","DOIUrl":"10.1093/gerona/glae244","url":null,"abstract":"<p><p>Aging is a complex process influenced by mechanisms operating at numerous levels of functioning. Multiple biomarkers of age have been identified, yet we know little about how the different alternative age indicators are intertwined. In the Berlin Aging Study II (nmin = 328; nmax = 1 517, women = 51%; 14.27 years of education), we examined how levels and 7-year changes in indicators derived from blood assays, magnetic resonance imaging brain scans, other-ratings, and self-reports converge among older adults. We included 8 epigenetic biomarkers (incl. 5 epigenetic \"clocks\"), a BioAge composite from clinical laboratory parameters, brain age, skin age, subjective age, subjective life expectancy, and subjective health horizon. We found moderate associations within aging domains, both cross-sectionally and longitudinally over 7 years. However, associations across different domains were infrequent and modest. Notably, participants with older BioAge had correspondingly older epigenetic ages. Our results suggest that different aging clocks are only loosely interconnected and that more specific measures are needed to differentiate healthy from unhealthy aging.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142396488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility, and Aging (SOMMA-AT).","authors":"Reichelle X Yeo, Theresa Mau, Zana M Ross, Nicholas P Edenhoffer, Jingfang Liu, Haley N Barnes, Li-Yung Lui, Joshua N Adkins, James A Sanford, Marcus M Seldin, Carlos H Viesi, Mingqi Zhou, Heather L Gregory, Frederico G S Toledo, Maja Stefanovic-Racic, Mary Lyles, Ashlee N Wood, Polly E Mattila, Elizabeth A Blakley, Iva Miljkovic, Peggy M Cawthon, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings, Bret H Goodpaster, Jamie N Justice, Erin E Kershaw, Lauren M Sparks","doi":"10.1093/gerona/glaf015","DOIUrl":"10.1093/gerona/glaf015","url":null,"abstract":"<p><strong>Background: </strong>Age-related changes in adipose tissue affect chronic medical diseases and mobility disability but mechanism remains poorly understood. The goal of this study is to define methods for phenotyping unique characteristics of adipose tissue from older adults.</p><p><strong>Methods: </strong>Older adults enrolled in study of muscle, mobility, and aging selected for the adipose tissue ancillary (SOMMA-AT; N = 210, 52.38% women, 76.12 ± 4.37 years) were assessed for regional adiposity by whole-body magnetic resonance (AMRA) and underwent a needle-aspiration biopsy of abdominal subcutaneous adipose tissue (ASAT). ASAT biopsies were flash frozen, fixed, or processed for downstream applications and deposited at the biorepository. Biopsy yields, qualitative features, adipocyte sizes, and concentration of adipokines secreted in ASAT explant conditioned media were measured. Inter-measure Spearman correlations were determined.</p><p><strong>Results: </strong>Regional, but not total, adiposity differed by sex: women had greater ASAT mass (8.20 ± 2.73 kg, p < .001) and biopsy yield (3.44 ± 1.81 g, p < .001) than men (ASAT = 5.95 ± 2.30 kg, biopsy = 2.30 ± 1.40 g). ASAT mass correlated with leptin (r = 0.54, p < .001) and not resistin (p = .248) and adiponectin (p = .353). Adipocyte area correlated with ASAT mass (r = 0.34, p < .001), BMI (r = 0.33, p < .001), adiponectin (r = -0.22, p = .005) and leptin (r = 0.18, p = .024) but not with resistin (p = .490).</p><p><strong>Conclusion: </strong>In addition to the detailed ASAT biopsy processing in this report, we found that adipocyte area correlated with ASAT mass, and both measures related to some key adipokines in the explant conditioned media. These results, methods, and biological repositories underscore the potential of this unique cohort to impact the understanding of aging adipose biology on disease, disability, and other aging tissues.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}