The journals of gerontology. Series A, Biological sciences and medical sciences最新文献

{"title":"Cardiac Biomarkers, Subclinical Brain Vascular Changes, and Cognitive Decline: Post Hoc Analysis of the SPRINT Trial.","authors":"Wenxin Zhang, Simon B Ascher, Sudipto Dolui, Ilya M Nasrallah, Yuan Lu, Julia Neitzel, Estefania Toledo, Lidia Glodzik, Hossam A Shaltout, Timothy M Hughes, Jarett D Berry, Yuan Ma","doi":"10.1093/gerona/glaf005","DOIUrl":"10.1093/gerona/glaf005","url":null,"abstract":"<p><strong>Background: </strong>The association between subclinical cardiovascular disease (CVD) and cognitive decline in hypertensive adults and the underlying brain pathologies remain unclear. It is also undetermined whether intensifying blood pressure (BP) treatment slows down cognitive decline associated with subclinical CVD.</p><p><strong>Methods: </strong>We conducted a post hoc analysis of the Systolic Blood Pressure Intervention Trial. Subclinical CVD at baseline was identified by elevated levels of high-sensitivity cardiac troponin T (hs-cTnT ≥ 14 ng/L) and N-terminal pro-B-type natriuretic peptide (NT-proBNP ≥ 125 pg/mL). Global cognitive function and domain-specific measures (memory, processing speed, language, and executive function) were assessed at baseline and follow-up (years 2, 4, and 6) in 2 733 participants. White matter lesions, cerebral blood flow, and brain tissue volume were assessed by MRI at baseline and year 4 in a subset of 639 participants.</p><p><strong>Results: </strong>Both elevated hs-cTnT and NT-proBNP levels at baseline were associated with accelerated cognitive decline across all domains after adjusting for potential confounding factors. The group with elevated levels of both cardiac biomarkers showed the fastest decline, with a larger annual decline rate of 0.033 (95% CI: 0.024-0.041) in the z-score of global cognitive function compared with the group with normal levels. Elevated levels of both biomarkers were also associated with a faster progression in white matter lesions, but not with changes in total brain tissue volume or cerebral blood flow. Intensive BP treatment did not attenuate these associations compared with standard treatment.</p><p><strong>Conclusions: </strong>Subclinical CVD may contribute to faster white matter lesion progression and accelerated cognitive decline in patients with hypertension, regardless of intensive BP treatment.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142960916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapamycin alters the feeding preference for amino acids and sugar in female Drosophila.","authors":"Guixiang Yu, Qihao Yang, Qi Wu","doi":"10.1093/gerona/glaf093","DOIUrl":"https://doi.org/10.1093/gerona/glaf093","url":null,"abstract":"<p><p>Rapamycin has demonstrated significant lifespan-extending effects across a variety of model organisms, positioning it as one of the most promising anti-aging agents currently under investigation. Nonetheless, chronic administration of rapamycin may induce diverse adverse reactions, primarily due to its influence on energy metabolism. Here, using Drosophila melanogaster as a model, we show that rapamycin significantly alters feeding behaviors in a dose-dependent manner. Specifically, both long-term and short-term administration of the optimal life-extending dose of rapamycin decreases the protein preference while increasing sugar intake in female flies. Utilizing a chemically defined diet, we identified that these alterations in amino acid and sugar feeding preferences occur as early as the second day of rapamycin exposure, preceding any detectable decline in fecundity. Furthermore, rapamycin also modifies amino acid preference even in taste-blind females, indicating that post-ingestive nutritional learning mechanisms, independent of food taste value, are sufficient to mediate the effects of rapamycin on feeding behavior. However, such changes in macronutrient preferences were absent in males and sterile mutant females. Collectively, our study suggests that the modification of feeding behavior could be a non-negligible side effect of rapamycin treatment, and this effect is influenced by both sex and reproductive status.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated epigenetic aging and prospective morbidity and mortality among U.S. veterans.","authors":"Kyle J Bourassa, Livia Anderson, Sandra Woolson, Paul A Dennis, Melanie E Garrett, Lauren Hair, Michelle Dennis, Karen Sugden, Benjamin Williams, Renate Houts, Patrick S Calhoun, Jennifer C Naylor, Allison E Ashley-Koch, Jean C Beckham, Avshalom Caspi, Gregory A Taylor, Katherine S Hall, Terrie E Moffitt, Nathan A Kimbrel","doi":"10.1093/gerona/glaf088","DOIUrl":"https://doi.org/10.1093/gerona/glaf088","url":null,"abstract":"<p><strong>Background: </strong>Epigenetic aging measures have promise as surrogate health outcomes in randomized control trials and observational cohort studies. The value of these measures, however, will reflect the extent to which they are associated with prospective health outcomes in real-world medical settings.</p><p><strong>Methods: </strong>Using data from 2,216 post-9/11 veterans from the VISN 6 MIRECC's Post-Deployment Mental Health Study, we examined whether accelerated epigenetic aging, assessed by DunedinPACE, was associated with prospective chronic disease morbidity, predicted healthcare costs, and mortality over an average of 13.1 years of electronic health record follow-up.</p><p><strong>Results: </strong>Veterans with faster DunedinPACE aging scores developed more chronic disease over the subsequent 5 years (RR, 1.25; 95% CI, 1.14-1.36), 10 years (RR, 1.31; 95% CI, 1.21-1.40), and 15 years (RR, 1.36; 95% CI, 1.22-1.52). Faster aging scores were also associated with increases in predicted healthcare costs over the next 5 years (β = 0.08; 95% CI, 0.03-0.13), 10 years (β = 0.23, 95% CI, 0.15-0.31), and 15 years (β = 0.21; 95% CI, 0.11-0.30). Faster DunedinPACE aging scores were associated with greater risk for incident myocardial infarction (84%), stroke (38%), diabetes (56%), cancer (25%), liver disease (44%), and renal disease (34%), as well as greater risk of mortality due to all-causes (38%) and chronic disease (74%). These results remained when adjusting for demographic, biomarker, and smoking covariates.</p><p><strong>Conclusions: </strong>Our findings suggest DunedinPACE is a biomarker of accelerated aging that is prospectively associated with chronic disease morbidity and mortality, as assessed using health records from an integrated healthcare system.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Candrive Older Driver Risk Stratification Tool for Assessing Medical Fitness-to-Drive in Older Australian Drivers.","authors":"Judith L Charlton, Sjaan Koppel, Amanda Stephens, Michel Bedard, Jennifer Howcroft, Peteris Darzins, Marilyn Di Stefano, Sylvain Gagnon, Isabelle Gelinas, Malcolm Man-Son-Hing, Anita Myers, Gary Naglie, Michelle M Porter, Mark Rapoport, Brenda Vrkljan, Shawn Marshall","doi":"10.1093/gerona/glaf071","DOIUrl":"https://doi.org/10.1093/gerona/glaf071","url":null,"abstract":"<p><strong>Background: </strong>Assessing older drivers' fitness-to-drive (FTD) is challenging, with decisions impacting mobility and health. This study aimed to validate the Candrive older driver risk stratification tool (RST) for screening medical FTD in an independent cohort of older adults from the Ozcandrive 8-year prospective study.</p><p><strong>Methods: </strong>A convenience sample of drivers aged 75 and older residing in Melbourne, Australia completed the Candrive assessments. Their vehicles were instrumented to collect vehicle and Global Positioning System (GPS) data, including trip distance. The first four years of Ozcandrive data were analysed. The primary outcome measure was self-reported at-fault collisions, adjusted per 10,000 kilometers driven. Collision risk status was modelled using Generalized Estimating Equations with Poisson regression using predetermined Candrive RST predictor variables.</p><p><strong>Results: </strong>A total of 257 older drivers (70.8% male) were recruited with an average age at study enrollment of 79.7 years (Standard Deviation (SD) = 3.5). Of the 755 adjusted person-years of driving, 74.1% were in the Low risk category (vs. original sample, Candrive: 74.8%) and 10.5% were in the Low-Medium risk category (Candrive: 9.3%). Only 15.4% were in the Medium-High risk category (Candrive: 15.9%), where the relative risk for self-reported at-fault collisions was 1.79 (95% confidence interval [CI]= 1.06-3.03) compared to the Low risk category.</p><p><strong>Conclusions: </strong>This study demonstrates an association between self-reported at-fault collisions and Candrive RST scores. This result is promising given the primary outcome measure differed from the original Candrive study that used police-reported, at-fault collisions, and supports Candrive RST's use by healthcare providers when initiating FTD conversations.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motoric cognitive risk syndrome and risk of cardiovascular disease: a population-based study.","authors":"Charlotte Menart, Amber Yaqub, Lisanne Dommershuijsen, M Kamran Ikram, Frank J Wolters, M Arfan Ikram","doi":"10.1093/gerona/glaf070","DOIUrl":"https://doi.org/10.1093/gerona/glaf070","url":null,"abstract":"<p><strong>Background: </strong>To investigate whether differences between motoric cognitive risk syndrome (MCRS) and mild cognitive impairment (MCI) are of vascular origin, we compared the risk of incident cardiovascular disease in both groups in a population-based study.</p><p><strong>Methods: </strong>We included 2710 dementia-free participants of the Rotterdam Study who underwent structured interviews, as well as gait and cognitive assessments. MCRS was defined as subjective cognitive complaints in combination with slow gait speed. MCI was defined as subjective cognitive complaints and objective impairment in one cognitive domain. We used Cox proportional hazards models adjusted for age, sex and cardiovascular risk factors to obtain hazard ratios (HR) for the composite outcome of cardiovascular disease, including coronary heart disease and stroke.</p><p><strong>Results: </strong>Of all 2710 participants (mean age 71 years; 58.5 % women), 221 (8.2%) had MCRS and 148 (5.5%) had MCI. During a median follow-up of 7.6 years, 298 individuals suffered a cardiovascular event, including 167 with coronary heart disease and 147 with stroke. Compared to individuals with neither MRCS nor MCI, MCRS was associated with increased risk of cardiovascular disease (HR=1.54; 95%CI=1.03-2.29), but this could not be confirmed for MCI (HR=0.85; 95%CI=0.46-1.55). Risk of stroke was similar for individuals with MCRS and MCI, whereas associations with coronary heart disease were observed for MCRS only.</p><p><strong>Conclusion: </strong>Motoric cognitive risk syndrome, but not mild cognitive impairment, is associated with increased risk of cardiovascular disease, in particular coronary heart disease. These findings are in line with a predominant vascular underpinning of dementia risk attributed to MCRS.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic Capacity Trajectories: Implications for Subsequent Falls and Hospitalizations Among Older Adults.","authors":"Xiaodong Chen, Lingxiao He, Kewei Shi, Qihui Wen, Qianqian Yu, Mingyue Gao, Ya Fang","doi":"10.1093/gerona/glaf017","DOIUrl":"10.1093/gerona/glaf017","url":null,"abstract":"<p><strong>Background: </strong>Intrinsic capacity (IC) is the composite of an individual's physical and mental capacities. However, the association between IC trajectories and falls and hospitalizations remains uncertain. This study aimed to determine the IC trajectories among older adults, investigating its association with subsequent risk of falls and hospitalizations.</p><p><strong>Methods: </strong>This study enrolled 3 902 older adults aged ≥65 from the National Health and Aging Trends Study (Wave 2015-2019). A bifactor model was used for repeated measurements of the 5 IC domains to generate IC scores for 4 time points (Wave 2015-2018). IC trajectories were identified using group-based trajectory modeling, and modified Poisson regression was used to analyze the associations between IC trajectories and subsequent fall and hospitalization risk.</p><p><strong>Results: </strong>The mean age of the participants was 76.70 years (standard deviation = 6.78), and the majority were female (57.3%). Three IC trajectories were identified, including persistently low (17.86%), persistently moderate (33.96%), and persistently high (48.18%). Compared with the persistently low class, the moderate and high classes have significantly lower fall and hospitalization risks. Multivariate-adjusted rate ratios fall occurrence were 0.87 (95% confidence interval [CI]: 0.78-0.98) and 0.74 (95% CI: 0.65-0.85), for multiple falls were 0.81 (95% CI: 0.68-0.96) and 0.52 (95% CI: 0.41-0.66), for hospitalization occurrence were 0.76 (95% CI: 0.66-0.87) and 0.48 (95% CI: 0.39-0.58), and for multiple hospitalizations were 0.65 (95% CI: 0.53-0.80) and 0.37 (95% CI: 0.28-0.48), respectively.</p><p><strong>Conclusions: </strong>IC trajectories were associated with falls and hospitalizations. Strategies focusing on improving and maintaining IC at a higher level over time could help reduce the subsequent risk of falls and hospitalizations.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Returning Individualized Wearable Sensor Results to Older Adult Research Participants: A Pilot Study.","authors":"Shelby L Bachman, Krista S Leonard-Corzo, Jennifer M Blankenship, Michael A Busa, Corinna Serviente, Matthew W Limoges, Robert T Marcotte, Ieuan Clay, Kate Lyden","doi":"10.1093/gerona/glaf027","DOIUrl":"10.1093/gerona/glaf027","url":null,"abstract":"<p><strong>Background: </strong>Wearable sensors that monitor physical behaviors are increasingly adopted in clinical research. Older adult research participants have expressed interest in tracking and receiving feedback on their physical behaviors. Simultaneously, researchers and clinical trial sponsors are interested in returning results to participants, but the question of how to return individual study results derived from research-grade wearable sensors remains unanswered. In this study, we (1) assessed the feasibility of returning individual physical behavior results to older adult research participants and (2) obtained participant feedback on the returned results.</p><p><strong>Methods: </strong>Older adult participants (N = 20; ages 67-96) underwent 14 days of remote monitoring with 2 wearable sensors. We then used a semiautomated process to generate a 1-page report summarizing each participant's physical behaviors across the 14 days. This report was delivered to each participant via email, and they were asked to evaluate the report.</p><p><strong>Results: </strong>Participants found the reports easy to understand, health-relevant, interesting, and visually pleasing. They had valuable suggestions to improve data interpretability and raised concerns such as comparisons with measures derived from their consumer-grade sensors.</p><p><strong>Conclusions: </strong>We have demonstrated the feasibility of returning individual physical behavior results from research-grade devices to older research participants, and our results indicate that this practice is well-received. Further research to develop more efficient and scalable systems to return results to participants, and to understand the preferences of participants in larger, more representative samples, is warranted.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12004365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Psychotropic Medication Use and Gait and Mobility Impairment in Community-Dwelling Older People: Data From The Irish Longitudinal Study on Ageing (TILDA).","authors":"Desmond O' Donnell, Frank Moriarty, Amanda Lavan, Rose Anne Kenny, Robert Briggs","doi":"10.1093/gerona/glae263","DOIUrl":"10.1093/gerona/glae263","url":null,"abstract":"<p><strong>Background: </strong>Little work to date has quantified the effect of psychotropic medications (antidepressants, benzodiazepines, \"Z\" drugs, antipsychotics, anticholinergics) on mobility and gait in later life. The aim of this study is to examine the relationship between these medications and mobility/gait parameters in a large cohort of community-dwelling older people.</p><p><strong>Methods: </strong>Participants were included if they were aged ≥60 years at TILDA Wave 1 and underwent gait and mobility assessment (Gaitrite system), with follow-up at Wave 3 (4 years). Medication lists were examined for psychotropic medications. Regression models assessed the relationship between psychotropic medications and mobility using the following parameters: Timed Up and Go, gait speed, step length/width, and double support phase. Multilevel modeling assessed trajectories of mobility/gait variables over time by psychotropic use.</p><p><strong>Results: </strong>Of 2620 patients, 12% were prescribed ≥1 psychotropic medication, and 3% prescribed ≥2 psychotropics. Cross-sectionally, psychotropic medication was independently associated with prolonged Timed Up and Go (β = 0.50 [95% confidence interval {CI} 0.27-0.73]; p < .001), slower gait speed (β = -5.65 [95% CI -7.92 to -3.38]; p < .001), shorter step length (β = -2.03 [95% CI -2.93 to -1.42]; p < .001), and increased double support phase (β = 0.47 [95% CI 0.19-0.75]; p = .001). Longitudinally, psychotropic use was independently associated with transition to abnormal Timed Up and Go (odds ratio 2.68 [95% CI 1.55-4.64], p < .001), whereas using ≥2 psychotropics was associated with transition to slower gait speed (odds ratio 2.59 [95% CI 1.01-6.68]; p = .048).</p><p><strong>Conclusions: </strong>Psychotropic use was associated with significantly poorer mobility and gait performance, both cross-sectionally and longitudinally. It is imperative that psychotropic medication use is reviewed as part of a comprehensive geriatric assessment.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12036327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiometabolic Multimorbidity and Dementia Onset Among Middle-Aged and Older Adults: Differences by Race/Ethnicity.","authors":"Siting Chen, Ana R Quiñones, Corey L Nagel, Nicholas J Bishop, Heather G Allore, Jason T Newsom, Jeffrey Kaye, Anda Botoseneanu","doi":"10.1093/gerona/glaf009","DOIUrl":"10.1093/gerona/glaf009","url":null,"abstract":"<p><strong>Background: </strong>Racial/ethnic minoritized groups in the United States have a higher prevalence of cardiometabolic multimorbidity and experience a higher risk of dementia. This study evaluates the relationship between cardiometabolic multimorbidity and dementia onset according to racial/ethnic group in a nationally representative cohort of U.S. middle-aged and older adults.</p><p><strong>Methods: </strong>Data from the Health & Retirement Study (1998-2018, N = 7,960, mean baseline age 59.4 years) and discrete-time survival models were used to estimate differences in the risk of dementia onset, defined by Langa-Weir classification. Models included race/ethnicity (non-Hispanic White, non-Hispanic Black, and Hispanic), chronic disease/multimorbidity categories (no disease, one disease, cardiovascular multimorbidity, metabolic multimorbidity, cardiometabolic multimorbidity, other multimorbidity), age, sex, education, wealth, body-mass index, and proxy status.</p><p><strong>Results: </strong>Over a mean follow-up of 14.6 years, 7.7% of the participants (n = 614) developed dementia. In the fully adjusted model, participants with cardiometabolic multimorbidity had the highest risk of dementia onset (HR:3.27, 95%CI: 2.06, 5.21), followed by metabolic (HR:1.83, 95%CI: 1.14, 2.94), and cardiovascular (HR:1.81, 95%CI: 1.24, 2.64) multimorbidity, relative to participants with no disease. The risk of dementia was significantly greater among Black (HR: 6.40, 95% CI: 3.84, 10.67) and Hispanic participants (HR: 4.90, 95% CI: 2.85, 8.43) with cardiometabolic multimorbidity, compared with White adults with no disease.</p><p><strong>Conclusions: </strong>Individuals from racial/ethnic minoritized groups have a higher risk of dementia. The risk of dementia onset was significantly greater for Black and Hispanic participants experiencing cardiometabolic multimorbidity, highlighting the value of intervening in cardiometabolic conditions among middle-aged and older adults, in particular, those from racial/ethnic minoritized backgrounds to reduce the risk of developing dementia.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12046130/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142981145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workshop Report-Heterogeneity and Successful Aging Part II: Approaches to Investigate Heterogeneity in Aging Research.","authors":"Vivek Kumar, Andrea L Hevener, J Graham Ruby, Paola Sebastiani, George A Kuchel","doi":"10.1093/gerona/glaf021","DOIUrl":"https://doi.org/10.1093/gerona/glaf021","url":null,"abstract":"<p><p>Heterogeneity in aging is a fundamental biological process arising from multifactorial etiologies, including genetic, lifestyle, and socioeconomic factors. Modeling this heterogeneity in animal systems is critical for elucidating the underlying mechanisms of aging and for leveraging these insights in translational research. Here we present part II, a summary of the model organism research presented at the NIA Heterogeneity and Successful Aging workshop, held in May 2023.</p>","PeriodicalId":94243,"journal":{"name":"The journals of gerontology. Series A, Biological sciences and medical sciences","volume":"80 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12010706/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}