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The Journal of investigative dermatology最新文献

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Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: How to Improve the Evaluation of Therapeutic Strategies.
The Journal of investigative dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jid.2024.08.043
Saskia Ingen-Housz-Oro, Lars E French, Pierre Wolkenstein
{"title":"Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: How to Improve the Evaluation of Therapeutic Strategies.","authors":"Saskia Ingen-Housz-Oro, Lars E French, Pierre Wolkenstein","doi":"10.1016/j.jid.2024.08.043","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.043","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosing and Managing Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Adults: Review of Evidence 2017-2023.
The Journal of investigative dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jid.2024.06.1295
Saskia Ingen-Housz-Oro, Ilaria Matei, Antoine Gaillet, Julie Gueudry, Karim Zaghbib, Haudrey Assier, Pierre Wolkenstein, Nicolas de Prost
{"title":"Diagnosing and Managing Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Adults: Review of Evidence 2017-2023.","authors":"Saskia Ingen-Housz-Oro, Ilaria Matei, Antoine Gaillet, Julie Gueudry, Karim Zaghbib, Haudrey Assier, Pierre Wolkenstein, Nicolas de Prost","doi":"10.1016/j.jid.2024.06.1295","DOIUrl":"https://doi.org/10.1016/j.jid.2024.06.1295","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening reactions associated with long-term disabling sequelae. In the acute phase, the best supportive care in expert centers is the cornerstone of treatment. The follow-up is prolonged and multidisciplinary, according to the patient's needs. In this paper, we review the evidence from 2017 to 2023 for the diagnosis and management of SJS/TEN in adults. On the basis of this review and our own experience, we present recommendations for the diagnosis of SJS/TEN in adults, management in the acute phase (best supportive care; prevention of infections; skin, ocular, and other mucosa management; intensive care measures; and etiological treatment), and follow-up. The most frequent sequelae are cutaneous, ocular, and psychological. High-quality studies assessing the efficacy of immunomodulating agents (eg, cyclosporine, corticosteroids, intravenous Igs, and anti-TNF agents) in accelerating healing and reducing mortality are still lacking. In addition, we propose avenues for future studies.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Assessment of Current Clinician- and Patient-Reported Outcome Measures for Acne Scarring and Dyspigmentation: A Scoping Review.
The Journal of investigative dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jid.2025.02.135
James Choe, Rebecca Urbonas, Eric Xia, Allison Yan, Ahana Gaurav, Anne Fladger, John S Barbieri
{"title":"An Assessment of Current Clinician- and Patient-Reported Outcome Measures for Acne Scarring and Dyspigmentation: A Scoping Review.","authors":"James Choe, Rebecca Urbonas, Eric Xia, Allison Yan, Ahana Gaurav, Anne Fladger, John S Barbieri","doi":"10.1016/j.jid.2025.02.135","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.135","url":null,"abstract":"<p><p>Acne-associated scarring and dyspigmentation (i.e. erythema, hyperpigmentation) are common sequelae with significant psychosocial impact, but little is known about what measures are most often used to assess these outcomes. This scoping review evaluates the use of current patient- and clinician-reported outcome measures for acne scars and dyspigmentation. For scars, 7 PROMs and 18 ClinROMs were used, with most being unvalidated. Similarly, for dyspigmentation, 4 PROMs and 8 ClinROMs were identified, but no validated PROMs. These results highlight reliance on unvalidated measures in research and clinical trials and suggest the need for developing high-quality validated measures, particularly PROMs, to improve research quality and develop better treatments.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The miRacle of Epidermal Homeostasis.
The Journal of investigative dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jid.2025.02.003
Enikö Sonkoly
{"title":"The miRacle of Epidermal Homeostasis.","authors":"Enikö Sonkoly","doi":"10.1016/j.jid.2025.02.003","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.003","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Zinc Transporter ZIP13 G289R Variant from Spondylocheirodysplastic Ehlers-Danlos Syndrome Is Associated with Abnormal Hair Quality.
The Journal of investigative dermatology Pub Date : 2025-02-26 DOI: 10.1016/j.jid.2025.02.133
Sofia Brito, Gunwoo Park, Gang Hyoung Lee, Valeria Capra, Gianmaria Viglizzo, Federico Zara, Jeong-Yun Kim, Ji-Hwan Park, Sung Kweon Cho, Beat Steinmann, Byung Mook Weon, Jiyoon Kim, Marcello Scala, Bum-Ho Bin
{"title":"Zinc Transporter ZIP13 G289R Variant from Spondylocheirodysplastic Ehlers-Danlos Syndrome Is Associated with Abnormal Hair Quality.","authors":"Sofia Brito, Gunwoo Park, Gang Hyoung Lee, Valeria Capra, Gianmaria Viglizzo, Federico Zara, Jeong-Yun Kim, Ji-Hwan Park, Sung Kweon Cho, Beat Steinmann, Byung Mook Weon, Jiyoon Kim, Marcello Scala, Bum-Ho Bin","doi":"10.1016/j.jid.2025.02.133","DOIUrl":"10.1016/j.jid.2025.02.133","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional Dynamics of Dendritic Cells in Response to Cutibacteriumacnes Strains Associated with Healthy and Acne-Prone Skin. 树突状细胞对与健康皮肤和痤疮皮肤相关的痤疮杆菌菌株的功能动态响应
The Journal of investigative dermatology Pub Date : 2025-02-26 DOI: 10.1016/j.jid.2025.02.132
Giorgia Del Vecchio, Nam Phuong N Nguyen, Kelsey Ouyang, Collins O Odhiambo, Amanda M Nelson, Min Deng, Matteo Pellegrini, George W Agak
{"title":"Functional Dynamics of Dendritic Cells in Response to Cutibacteriumacnes Strains Associated with Healthy and Acne-Prone Skin.","authors":"Giorgia Del Vecchio, Nam Phuong N Nguyen, Kelsey Ouyang, Collins O Odhiambo, Amanda M Nelson, Min Deng, Matteo Pellegrini, George W Agak","doi":"10.1016/j.jid.2025.02.132","DOIUrl":"10.1016/j.jid.2025.02.132","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Profiling of Genetic and Nongenetic Factors that Influence Skin Traits in Asian Women from 4 Countries. 全面分析影响四个国家亚洲女性皮肤特征的遗传和非遗传因素。
The Journal of investigative dermatology Pub Date : 2025-02-24 DOI: 10.1016/j.jid.2025.02.130
Hyunchae Moon, Minsoo Kim, Hyungtai Sim, Sungjoon Hong, Hyoungseok Jeon, Jinsik Cho, Murim Choi
{"title":"Comprehensive Profiling of Genetic and Nongenetic Factors that Influence Skin Traits in Asian Women from 4 Countries.","authors":"Hyunchae Moon, Minsoo Kim, Hyungtai Sim, Sungjoon Hong, Hyoungseok Jeon, Jinsik Cho, Murim Choi","doi":"10.1016/j.jid.2025.02.130","DOIUrl":"10.1016/j.jid.2025.02.130","url":null,"abstract":"<p><p>Brightness, pore size, wrinkles, color, elasticity, moisture, transepidermal water loss, pH, and sebum are traits that directly affect skin health and aesthetics, which vary substantially among ethnic groups and individuals. Although a complex combination of genetic and environmental factors influences these traits, an accurate estimation of skin phenotypic determination in individuals from Asian countries remains to be determined. In this study, we established the ASTAGR (Asian Skin Traits and Genetics Research) cohort, comprising 2762 female participants from 4 Asian countries (Korea, Vietnam, Thailand, and Indonesia). We documented 26 skin traits and conducted extensive skin-related surveys among the participants. Estimation of the quantitative contribution from whole-genome sequencing-based genotyping, combined with the survey findings, led to a comprehensive documentation of skin trait determination and its variation by country. This approach also revealed major variables affecting each skin trait. Our transethnic GWAS revealed 10 significant associations, 5 of which, to our knowledge, have not been previously reported. This study provides a comprehensive profile of skin traits and their regulation in the 4 Asian countries.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatiotemporal Switches in Progenitor Cell Fate Govern Upper Hair Follicle Growth and Maintenance.
The Journal of investigative dermatology Pub Date : 2025-02-24 DOI: 10.1016/j.jid.2025.01.034
Marianne S Andersen, Svetlana Ulyanchenko, Pawel J Schweiger, Edouard Hannezo, Benjamin D Simons, Kim B Jensen
{"title":"Spatiotemporal Switches in Progenitor Cell Fate Govern Upper Hair Follicle Growth and Maintenance.","authors":"Marianne S Andersen, Svetlana Ulyanchenko, Pawel J Schweiger, Edouard Hannezo, Benjamin D Simons, Kim B Jensen","doi":"10.1016/j.jid.2025.01.034","DOIUrl":"10.1016/j.jid.2025.01.034","url":null,"abstract":"<p><p>The epidermis provides a protective barrier against hostile environments. However, our knowledge of how this barrier forms during development and is subsequently maintained remains incomplete. The infundibulum is a cylindrical epidermal tissue compartment that serves as an outlet for hair follicles protruding from the skin and the excretion of the sebaceous glands that are essential for proper skin function. In this study, we applied quantitative fate mapping to address how infundibulum are maintained during adulthood. We demonstrate that progenitors build and maintain tissues through stochastic cell fate choices. Long-term analysis identified a preferential transient contribution from cells initially located at the bottom of the structure to the maintenance of the tissue, with bursts of local progenitor expansion associated with the phases of hair growth. Beyond providing compartment-wide insights into progenitor cell dynamics in infundibulum, these findings demonstrate how spatiotemporal regulation controls transient progenitor dominance.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Crosstalk between Nets and Keratinocytes in Skin Immunity.
The Journal of investigative dermatology Pub Date : 2025-02-21 DOI: 10.1016/j.jid.2024.07.040
Xiao Zhou, Yi Jin, Yanshan Zhu, Xin Luo, Siying Li, Weiyun Shen, Ruifang Wu
{"title":"The Role of Crosstalk between Nets and Keratinocytes in Skin Immunity.","authors":"Xiao Zhou, Yi Jin, Yanshan Zhu, Xin Luo, Siying Li, Weiyun Shen, Ruifang Wu","doi":"10.1016/j.jid.2024.07.040","DOIUrl":"https://doi.org/10.1016/j.jid.2024.07.040","url":null,"abstract":"<p><p>The skin is the principal barrier against pathogens. Skin-resident cells, especially keratinocytes, play essential roles in skin immunity. Damage to the integrity of the skin barrier triggers the localized release of proinflammatory factors from keratinocytes, which attract neutrophils. These infiltrating neutrophils in turn release cytokines to modulate keratinocyte function, thereby amplifying skin inflammation. In addition, neutrophils produce neutrophil extracellular traps in a process called NETosis. Notably, crosstalk between neutrophils and keratinocytes is a prominent feature of skin infection eradication and autoimmune disorder development. In this paper, we review research progress on neutrophil extracellular traps in cutaneous immunity, with a particular emphasis on their modulation of keratinocytes. Moreover, we discuss the implications of neutrophil heterogeneity for immune defense and disease development and treatment.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Potential role for IL-33 in the amplification of CD8+T cell mediated cytotoxic responses in epidermal necrolysis.
The Journal of investigative dermatology Pub Date : 2025-02-20 DOI: 10.1016/j.jid.2025.02.009
Sophie Lalevée, Mathieu Surenaud, Mubashira Tariq, Saskia Ingen-Housz-Oro, Francette Jean-Louis, Caroline Barau, Barbara Meier-Schiesser, Nicolas De Prost, Pierre Wolkenstein, Lars E French, Nicolas Ortonne, Alexander A Navarini, Yves Lévy, Emmanuel Contassot, Sophie Hüe
{"title":"Potential role for IL-33 in the amplification of CD8<sup>+</sup>T cell mediated cytotoxic responses in epidermal necrolysis.","authors":"Sophie Lalevée, Mathieu Surenaud, Mubashira Tariq, Saskia Ingen-Housz-Oro, Francette Jean-Louis, Caroline Barau, Barbara Meier-Schiesser, Nicolas De Prost, Pierre Wolkenstein, Lars E French, Nicolas Ortonne, Alexander A Navarini, Yves Lévy, Emmanuel Contassot, Sophie Hüe","doi":"10.1016/j.jid.2025.02.009","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.009","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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