The Journal of investigative dermatology最新文献_第10页

Repeated Temperature Fluctuation Exposure Causes Prolonged Skin Barrier Dysfunction. 反复的温度波动暴露导致长期的皮肤屏障功能障碍。

The Journal of investigative dermatology Pub Date : 2025-03-28 DOI: 10.1016/j.jid.2025.02.154

Jessica W Hui-Beckman, Byung Eui Kim, Taras Lyubchenko, Clifton F Hall, Olivia Xiao, Kyle Gallik, David Baraghoshi, Matthew Strand, Seungyeon Annie Paik, Elena Goleva, Donald Y M Leung

引用次数: 0

Development of an Artificial Intelligence-Based Model to Precisely Measure Body Surface Area in Psoriasis. 基于人工智能的银屑病体表面积精确测量模型的开发。

The Journal of investigative dermatology Pub Date : 2025-03-28 DOI: 10.1016/j.jid.2025.03.013

Yiyi Wang, Xuhao Wang, Xinran Ming, Yuanxia Gu, Qian Wang, Mingzheng Zhu, Lin Qin, Furong Li, Yue Xiao, Hongxiang Hu, Chenlin Du, Yue Zhang, Mingyue Zhang, Ranjie Hu, Wei Li

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Expression of Glandular Genes in the Tunnel Epithelium of Hidradenitis Suppurativa. 化脓性汗腺炎隧道上皮腺体基因的表达。

The Journal of investigative dermatology Pub Date : 2025-03-28 DOI: 10.1016/j.jid.2025.03.010

Meng-Ju Lin, Meaghan Marohn, Ernest S Chiu, Catherine P Lu

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Advances in Pediatric Dermatology Research from the 2024 PeDRA Annual Conference. 来自 2024 年 PeDRA 年会的儿科皮肤病研究进展。

The Journal of investigative dermatology Pub Date : 2025-03-28 DOI: 10.1016/j.jid.2025.02.143

Hannah R Chang, Leslie Castelo-Soccio, Colleen H Cotton, Dawn Z Eichenfield, Maria Teresa García Romero, Elena B Hawryluk, Kalyani S Marathe, Harper N Price, Dawn H Siegel, Michael Siegel, JiaDe Yu, Esteban Fernández Faith

引用次数: 0

Uncovering Disparities in Skin Tone Representation among Artificial Intelligence Vision-Language Models. 人工智能视觉语言模型（VLMs）肤色表征差异的揭示。

The Journal of investigative dermatology Pub Date : 2025-03-28 DOI: 10.1016/j.jid.2025.03.011

Vivian B Yang, Clarence M Sams, Shanika N Francis, Roxana Daneshjou, Jenna C Lester

引用次数: 0

Blood Single-Cell Transcriptomic and Proteomic Signatures of Paradoxical Eczema in Patients with Psoriasis Treated with Biologics. 用生物制剂治疗银屑病患者的血液单细胞转录组学和蛋白质组学特征

The Journal of investigative dermatology Pub Date : 2025-03-27 DOI: 10.1016/j.jid.2025.02.153

Ali Al-Janabi, Paul Martin, Catherine Simpson, Hefin Rhys, Adnan R Khan, Steve Eyre, Maria Christofi, Amy C Foulkes, Andrew Skelton, Sebastien Viatte, Anne Barton, Andrew P Morris, Catherine H Smith, Christopher E M Griffiths, Richard B Warren

{"title":"Blood Single-Cell Transcriptomic and Proteomic Signatures of Paradoxical Eczema in Patients with Psoriasis Treated with Biologics.","authors":"Ali Al-Janabi, Paul Martin, Catherine Simpson, Hefin Rhys, Adnan R Khan, Steve Eyre, Maria Christofi, Amy C Foulkes, Andrew Skelton, Sebastien Viatte, Anne Barton, Andrew P Morris, Catherine H Smith, Christopher E M Griffiths, Richard B Warren","doi":"10.1016/j.jid.2025.02.153","DOIUrl":"10.1016/j.jid.2025.02.153","url":null,"abstract":"Biologics targeting the TNF and IL-17/23 axis are highly effective treatments for psoriasis but can result in cutaneous adverse events. The pathogenesis of paradoxical eczema, the occurrence of an atopic dermatitis phenotype after biologic initiation in people with psoriasis, is unknown. Using single-cell RNA sequencing and mass cytometry, we found increased expression of TNF, IFN-γ, and IFN-α and their signaling pathways in paradoxical eczema case cell clusters compared with that in matched psoriasis controls. Genetic variants influencing the expression of chemokine signaling and TNF pathway genes were associated with paradoxical eczema in a separate genotyped cohort, and this association was independent of known atopic risk loci. This suggests that paradoxical eczema has a predominantly type 1 systemic inflammatory signature and that genetic susceptibility to aberrant chemokine and TNF pathway signaling could contribute to development of this phenotype during biologic treatment.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suberythemal Sun and the Skin. 红斑下的太阳和皮肤。

The Journal of investigative dermatology Pub Date : 2025-03-27 DOI: 10.1016/j.jid.2025.02.141

Jiayue Gu, Richard Weller

引用次数: 0

Progress on Multiomics Research on Acne Vulgaris: A Literature Review. 寻常痤疮多组学研究进展

The Journal of investigative dermatology Pub Date : 2025-03-27 DOI: 10.1016/j.jid.2025.02.012

Yangfan Lai, Mengjie Fan, Xiaoyao Fan, Jin Chen, Leihong Flora Xiang, Ying Ma

引用次数: 0

An Overview of Data Analysis Approaches and Biases in Unveiling the Impact of COVID-19 on Melanoma Diagnosis. 概述揭示COVID - 19对黑色素瘤诊断影响的数据分析方法和偏见。

The Journal of investigative dermatology Pub Date : 2025-03-25 DOI: 10.1016/j.jid.2025.03.009

Lejie Zheng, H Peter Soyer, Monika Janda, Dilki Jayasinghe

引用次数: 0

Integrin α11β1 as a Key Collagen Receptor in Human Skin Dermis: Insight into Fibroblast Function and Skin Dermal Aging. 整合素α11β1是人类皮肤真皮层中的关键胶原蛋白受体：洞察成纤维细胞功能和皮肤真皮层老化。

The Journal of investigative dermatology Pub Date : 2025-03-24 DOI: 10.1016/j.jid.2025.03.006

Taihao Quan, Zhaoping Qin, Tianyuan He, Gary J Fisher

{"title":"Integrin α11β1 as a Key Collagen Receptor in Human Skin Dermis: Insight into Fibroblast Function and Skin Dermal Aging.","authors":"Taihao Quan, Zhaoping Qin, Tianyuan He, Gary J Fisher","doi":"10.1016/j.jid.2025.03.006","DOIUrl":"10.1016/j.jid.2025.03.006","url":null,"abstract":"Collagen-binding integrins play a crucial role in facilitating fibroblast-collagen interactions and regulating cellular functions. In this study, we identified that among 4 collagen-binding integrins, integrin α11 was the predominant type in human skin dermal fibroblasts and that loss of integrin α11 expression contributed to skin dermal aging. Integrin α11β1 was critical for regulating fibroblast-collagen interactions, including cell adhesion, spreading, morphology, mechanical tension, and the production of collagenous extracellular matrix. TGF-β was recognized as the primary regulator of integrin α11 expression. Notably, dermal fibroblasts in aged human skin demonstrated impaired TGF-β signaling, which coincided with a loss of integrin α11 expression, whereas the expression of other collagen-binding integrins remained unchanged. Similarly, in senescent dermal fibroblasts in vitro, impaired TGF-β signaling was associated with a significant reduction in integrin α11 expression, whereas other collagen-binding integrins were upregulated or unaffected. Furthermore, collapsed dermal fibroblasts, a key characteristic of dermal fibroblasts in aged human skin, specifically downregulated integrin α11, whereas other collagen-binding integrins were upregulated or remained unchanged. These findings suggest a negative feedback loop in which an impaired TGF-β-integrin α11β1 axis and fibroblast collapse promote dermal aging in human skin. This self-reinforcing cycle reflects the progressive and unidirectional nature of biological aging.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0