The Journal of investigative dermatology最新文献_第10页

FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2α/GLI2 Signaling Axis. FGF21通过抑制CK2α/GLI2信号轴改善成纤维细胞活化和系统性硬化症

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.026

Yeyi Zheng, Wenjie Gong, Zhaohang Wu, Siyi Zhang, Nan Wang, Zhenyu Hu, Yanni Shou, Tianpeng Xu, Yingjie Shen, Xiaokun Li, Litai Jin, Weitao Cong, Zhongxin Zhu

{"title":"FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2α/GLI2 Signaling Axis.","authors":"Yeyi Zheng, Wenjie Gong, Zhaohang Wu, Siyi Zhang, Nan Wang, Zhenyu Hu, Yanni Shou, Tianpeng Xu, Yingjie Shen, Xiaokun Li, Litai Jin, Weitao Cong, Zhongxin Zhu","doi":"10.1016/j.jid.2024.07.026","DOIUrl":"10.1016/j.jid.2024.07.026","url":null,"abstract":"Systemic sclerosis is a typical fibrotic disease of unknown etiology that is characterized by abnormal fibroblast activation and excessive deposition of extracellular matrix. Unfortunately, effective therapeutic approaches are lacking. FGF21 plays a key role in mediating a variety of biological activities. However, its specific function in systemic sclerosis is unclear. In this study, we found that the expression of FGF21 was significantly downregulated in fibrotic skin tissue and in TGF-β-stimulated fibroblasts. Furthermore, our studies demonstrated that treatment with recombinant FGF21 in the skin significantly alleviated bleomycin-induced and TBRI-activated fibrosis and inhibited the activation of fibroblasts, whereas skin fibrosis was exacerbated by deletion of FGF21. Mechanistically, FGF21 inhibits the activity of CK2α and promotes the degradation of GLI2. In conclusion, these results indicate that FGF21 attenuates skin fibrosis through the CK2α/GLI2 signaling pathway and therefore may be a potential therapeutic target for systemic sclerosis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining Automated Lesion Risk and Change Assessment Improves Melanoma Detection: A Retrospective Accuracy Study. 结合自动病变风险和变化评估可提高黑色素瘤检测率：回顾性准确性研究

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.027

Chantal Rutjes, Adam Mothershaw, Brian M D'Alessandro, Clare A Primiero, Aideen McInerney-Leo, H Peter Soyer, Monika Janda, Brigid Betz-Stablein

引用次数: 0

Resolving 3-Dimensional Genomic Landscape of CD4+ T Cells in the Peripheral Blood of Patients with Psoriasis. 解析银屑病患者外周血中 CD4+ T 细胞的三维基因组图谱。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.08.006

Yueqi Qiu, Wenjuan Jiang, Delong Feng, Yaqin Yu, Huihui Hou, Min Deng, Xiaoyun Chen, Lin Liu, Ruifang Wu, Qianjin Lu, Ming Zhao

{"title":"Resolving 3-Dimensional Genomic Landscape of CD4+ T Cells in the Peripheral Blood of Patients with Psoriasis.","authors":"Yueqi Qiu, Wenjuan Jiang, Delong Feng, Yaqin Yu, Huihui Hou, Min Deng, Xiaoyun Chen, Lin Liu, Ruifang Wu, Qianjin Lu, Ming Zhao","doi":"10.1016/j.jid.2024.08.006","DOIUrl":"10.1016/j.jid.2024.08.006","url":null,"abstract":"A precise regulation of gene expression depends on the accuracy of the 3-dimensional (3D) structure of chromatin; however, the effects of the 3D genome on gene expression in psoriasis remain unknown. In this study, we conducted Hi-C and RNA sequencing on CD4+ T cells collected from 5 patients with psoriasis and 3 healthy controls and constructed a comprehensive 3D chromatin interaction map to delineate the genomic hierarchies, including A/B compartments, topologically associated domains, and chromatin loops. Then, the specific superenhancers related to psoriasis were identified by Hi-C and H3K27ac chromatin immunoprecipitation sequencing data. Subsequently, comprehensive analyses were carried out on the differentially expressed genes that are associated with altered topologically associated domains, loops, and superenhancers in psoriasis. Finally, we screened the candidate target genes and examined the potential functional SNP in psoriasis affected by disruptions of the spatial organization. This study provides a comprehensive reference for examining the 3D genome interactions in psoriasis and elucidating the interplay between spatial organization disruption and gene regulation. We hope that our findings can help clarify the mechanisms underlying the pathogenesis of psoriasis and shed light on the role of 3D genomic structure, therefore informing potential therapeutic approaches.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasoactive Intestinal Peptide Operates as a Negative Regulator of Human Hair Follicle Pigmentation Ex Vivo. 血管活性肠肽（VIP）是人体内毛囊色素沉着的负向调节因子。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.06.1290

Tatiana Gomez Gomez, Jérémy Chéret, Barbara Bedogni, Ramtin Kassir, Marta Bertolini, Ralf Paus

引用次数: 0

Invasion of Human Epidermis by Malassezia furfur Is Strain Dependent. 糠秕马拉色菌侵入人体表皮与菌株有关。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.028

Bastien Tirtiaux, Giuseppe Ianiri, Valérie De Glas, Eléa Denil, Emilie Faway, Yves Poumay

引用次数: 0

Phosphodiesterase-4 Inhibitors Increase Pigment Cell Proliferation and Melanization in Cultured Melanocytes and within a 3-Dimensional Skin Equivalent Model. 磷酸二酯酶-4 抑制剂可增加培养黑色素细胞和三维皮肤等效模型中色素细胞的增殖和黑色素化。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.08.005

Nathaniel B Goldstein, Zachary B K Berk, Landon C Tomb, Junxiao Hu, Laura G Hoaglin, Dennis R Roop, Roni Adiri, Yonghua Zhuang, Juliana M Canosa, Paul Sanders, David A Norris, Karl Nocka, Amy Cha, Stanca A Birlea

{"title":"Phosphodiesterase-4 Inhibitors Increase Pigment Cell Proliferation and Melanization in Cultured Melanocytes and within a 3-Dimensional Skin Equivalent Model.","authors":"Nathaniel B Goldstein, Zachary B K Berk, Landon C Tomb, Junxiao Hu, Laura G Hoaglin, Dennis R Roop, Roni Adiri, Yonghua Zhuang, Juliana M Canosa, Paul Sanders, David A Norris, Karl Nocka, Amy Cha, Stanca A Birlea","doi":"10.1016/j.jid.2024.08.005","DOIUrl":"10.1016/j.jid.2024.08.005","url":null,"abstract":"Vitiligo is a common chronic autoimmune disease characterized by white macules and patches of the skin, having a negative impact on patients' life and without any definitive cure at present. Identification of new compounds to reverse depigmentation is therefore a pressing need for this disease. The pharmacologic compounds phosphodiesterase-4 inhibitors (PDE4is) are small molecules with immunomodulatory properties used for treatment of inflammatory dermatoses. PDE4is have shown repigmentation effects in patients with vitiligo, in some case reports. We characterized the proliferative and melanogenic potential of 2 known PDE4is-crisaborole and roflumilast-and of a more recently designed compound, PF-07038124. We used 2 in vitro model systems-the primary human melanocyte culture and a 3-dimensional cocultured skin model (MelanoDerm)-with an exploratory testing platform composed of complementary assays (spectrophotometry, melanin and proliferation assays, immunostaining, Fontana-Masson staining, RT-qPCR, western blot, and whole-transcriptome RNA sequencing). We identified that treatment with PDE4is was associated with increased melanocyte proliferation and melanization in both in vitro models and with increase in the melanogenic genes and proteins expression in cultured melanocytes. These effects were found to be enhanced by addition of α-melanocyte-stimulating hormone. Our findings support the further evaluation of PDE4is with or without α-melanocyte-stimulating hormone agonists in vitiligo trials.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor RNA Sequencing Identifies a Group of Patients with Mycosis Fungoides with Failure of Skin-Directed Therapies. 肿瘤 RNA 测序确定了一组皮肤导向疗法失败的真菌病患者。

The Journal of investigative dermatology Pub Date : 2024-09-06 DOI: 10.1016/j.jid.2024.06.1292

Marjaana Häyrinen, Hanna-Riikka Teppo, Liisa Väkevä, Annamari Ranki, Henry J Barton, Katja Porvari, Jenni Kiiskilä, Milla E L Kuusisto, Hanne Kuitunen, Siria Lemma, Helka Sahi, Kirsi-Maria Haapasaari, Outi Kuittinen

引用次数: 0

Heterogeneity in keloid scars: influence of mechanical stretching on keloids arising from different anatomical sites. 瘢痕疙瘩的异质性：机械拉伸对不同解剖部位瘢痕疙瘩的影响。

The Journal of investigative dermatology Pub Date : 2024-09-06 DOI: 10.1016/j.jid.2024.08.016

Young In Lee, Yohan Yang, Seoyoon Ham, Jung Eun Shim, Sang Gyu Lee, Si-Hyung Lee, Tae-Gyun Kim, Won Jai Lee, Do-Young Kim, Ju Hee Lee

引用次数: 0

Weak Hydrogen Bonds in Temporary Shape Changes of Curly Human Hair Fibers: Preliminary Evidence. 卷曲人发纤维临时形状变化中的弱氢键：初步证据

The Journal of investigative dermatology Pub Date : 2024-09-05 DOI: 10.1016/j.jid.2024.06.1282

Elsabe Cloete, Malebogo N Ngoepe, Ernesto Ismail, Nonhlanhla P Khumalo

引用次数: 0

The Skin Acid Mantle: An Update on Skin pH. 皮肤酸性外壳：皮肤酸碱度的最新进展。

The Journal of investigative dermatology Pub Date : 2024-09-05 DOI: 10.1016/j.jid.2024.07.009

Sarah G Brooks, Rami H Mahmoud, Rachel R Lin, Joachim W Fluhr, Gil Yosipovitch

引用次数: 0