The Journal of investigative dermatology最新文献_第9页

Cutaneous Neuroanatomical and Cellular Response to Dupilumab Treatment in Atopic Dermatitis. 杜匹单抗治疗特应性皮炎的皮肤神经解剖学和细胞反应。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-22 DOI: 10.1016/j.jid.2025.08.012

Henning Wiegmann, Felix Witte, Lina Renkhold, Jaana Westmeier, Verena K Raker, Christa Hohoff, Lea-Sophie Stahl, Svenja Royeck, Claudia Zeidler, Konstantin Agelopoulos, Sonja Ständer

{"title":"Cutaneous Neuroanatomical and Cellular Response to Dupilumab Treatment in Atopic Dermatitis.","authors":"Henning Wiegmann, Felix Witte, Lina Renkhold, Jaana Westmeier, Verena K Raker, Christa Hohoff, Lea-Sophie Stahl, Svenja Royeck, Claudia Zeidler, Konstantin Agelopoulos, Sonja Ständer","doi":"10.1016/j.jid.2025.08.012","DOIUrl":"10.1016/j.jid.2025.08.012","url":null,"abstract":"Itch is the dominant symptom in atopic dermatitis. Cutaneous neuronal alterations underlying this symptom are still poorly understood. Therefore, we aimed at deciphering cutaneous neuronal alterations during atopic dermatitis treatment with dupilumab. Skin biopsies and blood from 49 adult patients with severe atopic dermatitis receiving 300 mg dupilumab subcutaneously every 2 weeks over a period of 16 weeks were analyzed at initial assessment and at follow-up for intraepidermal nerve fiber density, alloknesis, and biomarkers. Decreased intraepidermal nerve fiber density and increased alloknesis in pruritic lesional and nonpruritic nonlesional skin at initial assessment improved after dupilumab treatment. Formation of tight junctions (claudin-1 staining) was correlated with the epidermal level of intraepidermal nerve fiber growth. Expressions of targeted IL receptors (IL4R, IL13RA1, IL13RA2) and mediators related to innervation density (NGF, SEMA3A) were increased in pruritic lesion skin at initial assessment compared with those in nonpruritic nonlesional skin at initial assessment and former pruritic lesional skin/healed at follow-up. Blood CD8+ central memory T cells and CD4+ CD25+ CD127- cells, including regulatory T cells, increased at follow-up; CD8 T-effector cells and CLA+ activated CD4+ cells decreased. In conclusion, treatment with an IL4Rα antibody is paralleled by an improvement of neuroanatomy and a reduction of neuronal sensitization, paralleled by relevant biomarker improvement.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endothelin-2 from Keratinocytes and Its Association with Itch in Skin Diseases. 角质形成细胞的内皮素-2及其与皮肤病瘙痒的关系。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-22 DOI: 10.1016/j.jid.2025.07.030

Yumeng Dong, Mrinal K Sarkar, Yuntian Wu, Xianying Xing, Matthew T Patrick, Bo Duan, Mehrnaz Gharaee-Kermani, Valerie Julia, Stephan Weidinger, J Michelle Kahlenberg, Johann E Gudjonsson, Lam C Tsoi

引用次数: 0

Immune and Biological Changes during Treatment in Patients with Nonsegmental Vitiligo and their Relation to Repigmentation. 非节段性白癜风治疗期间的免疫和生物学变化及其与色素重沉着的关系。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-21 DOI: 10.1016/j.jid.2025.07.029

Wouter Ouwerkerk, Vidhya S Narayan, Saskia Chielie, Nathalie O P van Uden, Martin A Schneider, Rainer Hillenbrand, Swann Gaulis, Rasmus B Kjellerup, Christian Loesche, Malika Hanser, Elizabeth McNamara, Marcel W Bekkenk, Albert Wolkerstorfer, Rosalie M Luiten

{"title":"Immune and Biological Changes during Treatment in Patients with Nonsegmental Vitiligo and their Relation to Repigmentation.","authors":"Wouter Ouwerkerk, Vidhya S Narayan, Saskia Chielie, Nathalie O P van Uden, Martin A Schneider, Rainer Hillenbrand, Swann Gaulis, Rasmus B Kjellerup, Christian Loesche, Malika Hanser, Elizabeth McNamara, Marcel W Bekkenk, Albert Wolkerstorfer, Rosalie M Luiten","doi":"10.1016/j.jid.2025.07.029","DOIUrl":"10.1016/j.jid.2025.07.029","url":null,"abstract":"The treatment of nonsegmental vitiligo remains challenging and poorly understood. The aim of this study was to evaluate protein differences in lesional and nonlesional skin and changes of cellular and proteomic markers early in treatment in lesional skin and blood in relation to clinical response. This prospective exploratory study was conducted in 30 patients with nonsegmental vitiligo, 11 starting with standard-of-care topical therapy and 19 starting in combination with narrow-band UVB phototherapy. We identified 53 proteins that differed between blister fluids from lesional and nonlesional skin before treatment. After 3 months of therapy, CD3+, CD8+ T, and tissue-resident memory (CD69+CD103-) cell populations decreased in skin biopsies, together with changes in 47 blister fluid proteins. Percentages of circulating follicular T helper type 17, CD336+Nkbright, type 1 regulatory T (Tr1), and IL-10-secreting Tr1 cells decreased in blood. Decreases in tissue-resident memory, Tr1, and IL-10-secreting Tr1 cells and fatty acid-binding protein 4 were associated with repigmentation, measured by Vitiligo Extent Score at baseline and 6 months. Differences in lesional and nonlesional skin prior to treatment do not reflect changes in lesional skin early in therapy nor associations with clinical repigmentation response. We found an association between decreasing fatty acid-binding protein 4 and tissue-resident memory cells in the skin and IL-10-secreting Tr1 cells in the blood and repigmentation response to treatment of vitiligo.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Human Factor: Unpacking Biopsy Decision Variability that Artificial Intelligence Cannot Predict. 人为因素：解开人工智能无法预测的活检决策变异性。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-21 DOI: 10.1016/j.jid.2025.08.009

Justin W Ng, Kyra L Diehl, Tracy C Petrie, Tayler N Tobey, Elizabeth R Stoos, Emile J Latour, Joanna N Ludzik, Victoria E Orfaly, Jacob H Nelson, Jordan R Gillespie, Emilie A Foltz, Elizabeth G Berry, Alexandra Verdieck, Clara Curiel-Lewandrowski, Kelly C Nelson, Emily H Smith, Susan M Swetter, Sancy A Leachman

引用次数: 0

Overexpression of Neuropeptide Y Leads to Progressive, Cutaneous Inflammatory Fibrotic Responses in Mouse Skin. NPY的过度表达导致小鼠皮肤的进行性皮肤炎性纤维化反应。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-20 DOI: 10.1016/j.jid.2025.08.007

Noha Ahmed, Alex D Dawson, Zoya T Anderson, Joseph W Palmer, Misgana I Idris, Megha Ghanta, Kelly Barajas, Jennifer Proctor, Dezhi Wang, Andrzej T Slominski, Melissa L Harris

引用次数: 0

Exploring the Role of Fibroblast Heterogeneity from Different Skin Types in Epidermal Regeneration In Vitro. 探讨不同皮肤类型成纤维细胞异质性在体外表皮再生中的作用。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-19 DOI: 10.1016/j.jid.2025.08.006

Sarah Girardeau-Hubert, Hervé Pageon, Rabab Label, Hakima Abdessadeq, Sylvie Ricois, Inês Sequeira, Xavier Marat

{"title":"Exploring the Role of Fibroblast Heterogeneity from Different Skin Types in Epidermal Regeneration In Vitro.","authors":"Sarah Girardeau-Hubert, Hervé Pageon, Rabab Label, Hakima Abdessadeq, Sylvie Ricois, Inês Sequeira, Xavier Marat","doi":"10.1016/j.jid.2025.08.006","DOIUrl":"10.1016/j.jid.2025.08.006","url":null,"abstract":"In human skin, dermal fibroblasts play a crucial role in epidermal regeneration and homeostasis. Despite literature highlighting fibroblast heterogeneity, physiological diversity in skin of color may impact in vitro approaches to investigating skin regeneration. We have investigated the functionality of human adult fibroblasts from different skin types in the morphogenesis of the epidermis in vitro. Primary papillary dermal fibroblasts and keratinocytes from donors with both darker (of African descent) and lighter (of European descent) skin types were used to reconstruct skin in vitro. Autologous skin models from the same donor were generated and compared with mixed skin models combining keratinocytes from one skin type with fibroblasts from the other. Papillary fibroblasts from African descent expressed a reduced amount of types IV and VII collagens at the dermal-epidermal junction in vitro. Morphogenesis of the reconstructed epidermis was differently regulated by the underlying papillary fibroblasts. European-descent fibroblasts increased the commitment of keratinocytes to a differentiated state in vitro, whereas African-descent fibroblasts maintained the proliferation of basal keratinocytes. Altogether, this study highlights how the skin type origin of fibroblasts can drive the phenotype of in vitro skin models. This sheds light on the heterogeneity of the superficial dermal layer and its specific dermal-epidermal crosstalk, providing insights into the cutaneous physiology of different skin types.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative Fragmentation of Collagen in Skin: Relevance to Skin Aging and Skin Diseases. 皮肤中胶原蛋白的氧化断裂-与皮肤老化和皮肤病有关。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-19 DOI: 10.1016/j.jid.2025.08.005

Vendula Paculová, Ankush Prasad, Pavel Pospíšil

引用次数: 0

Could Intracellular Transport Systems of Epidermal Lamellar Bodies Be Novel Therapeutic Targets in Skin Diseases? 表皮层状体的细胞内转运系统能否成为治疗皮肤病的新靶点？

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-19 DOI: 10.1016/j.jid.2025.06.1587

Akemi Ishida-Yamamoto

引用次数: 0

A Comprehensive Review of GWASs of Human Hair Traits. 人类毛发特征GWASs研究综述。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-19 DOI: 10.1016/j.jid.2025.07.004

Carli D Needle, Anna L Brinks, Olivia D Perez, Jerry Shapiro, Kristen I Lo Sicco, Aristotelis Tsirigos, Lynn Petukhova

引用次数: 0

Primary Cutaneous Melanoma Microbiome Is Associated with Overall Survival and Recurrence. 原发性皮肤黑色素瘤微生物组与总体生存和复发相关。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-18 DOI: 10.1016/j.jid.2025.07.028

Alfred A Chan, Juliana Noguti, Natalia Maverakis Ramirez, Marian Navarrete, Delphine J Lee

{"title":"Primary Cutaneous Melanoma Microbiome Is Associated with Overall Survival and Recurrence.","authors":"Alfred A Chan, Juliana Noguti, Natalia Maverakis Ramirez, Marian Navarrete, Delphine J Lee","doi":"10.1016/j.jid.2025.07.028","DOIUrl":"10.1016/j.jid.2025.07.028","url":null,"abstract":"Melanoma contributes to the highest deaths from skin cancer. The primary melanoma intratumoral microbiome association with clinical outcomes has not been described. We hypothesized that specific microbes may be associated with clinical outcomes as found in other cancers. We performed 16S V1-V3 ribosomal RNA gene-based microbial profiling of primary melanoma formalin-fixed paraffin-embedded specimens and found that the bacterial composition of cutaneous melanoma (β-diversity analysis) was associated with both overall survival and recurrence (P = .024 and P = .025), and a higher effective number of species (α-diversity) was associated with both worse overall survival (P = .048; hazard ratio = 2.13, 95% confidence interval = 1.15-6.02) and earlier time to recurrence (P = .016; hazard ratio = 2.13, 95% confidence interval = 1.15-3.94). Cutibacterium granulosum was associated with better overall survival and lower recurrence. Lower recurrence was also associated with C acnes, Corynebacterium kefirresidentii, and an unclassified Corynebacterium. Conversely, both higher recurrence and worse overall survival were associated with Leuconostoc inhae, Streptococcus salivarius, Collinsella sp900764415, and an unclassified Porphyromonas. Although the bacterial microbiome for nasal and oral melanomas was not associated with clinical outcomes, 5 bacterial operational taxonomic units were significantly associated with recurrence versus no recurrence by supervised β-diversity analysis (P = .023). These findings highlight a potential role of microbes in the pathophysiology of melanoma.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0