The Journal of investigative dermatology最新文献_第9页

HIF-1 Un-LOX Mechanical Mechanisms in Psoriasis.

The Journal of investigative dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jid.2025.01.005

Boris Hinz

引用次数: 0

Boosting Skin Microcirculation for Androgenetic Alopecia: Does It Work?

The Journal of investigative dermatology Pub Date : 2025-02-04 DOI: 10.1016/j.jid.2024.11.025

Ayman Grada, Naiem Issa

引用次数: 0

Comment on "Does Sex Matter? Temporal Analyses of Melanoma Trends among Men and Women Suggest Etiologic Heterogeneity." 关于 "性别是否重要？对男性和女性黑色素瘤趋势的时间分析表明了病因的异质性"。

The Journal of investigative dermatology Pub Date : 2025-02-04 DOI: 10.1016/j.jid.2024.11.023

Zhen Yu Wong, Kai Qi Ou, Zhen Ning Wong, Ryan Faderani, Muholan Kanapathy, Afshin Mosahebi

引用次数: 0

Can We Trust Claims-Based Data?

The Journal of investigative dermatology Pub Date : 2025-02-04 DOI: 10.1016/j.jid.2024.12.019

Steven R Feldman, Alan B Fleischer

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Narrowband UVB and Solar-Simulated UV Suppress Systemic Immune Responses through Different Mechanisms.

The Journal of investigative dermatology Pub Date : 2025-02-03 DOI: 10.1016/j.jid.2024.11.030

Rachael A Ireland, Benita C Y Tse, Anneliese S Ashhurst, Anthony S Don, Scott N Byrne

{"title":"Narrowband UVB and Solar-Simulated UV Suppress Systemic Immune Responses through Different Mechanisms.","authors":"Rachael A Ireland, Benita C Y Tse, Anneliese S Ashhurst, Anthony S Don, Scott N Byrne","doi":"10.1016/j.jid.2024.11.030","DOIUrl":"10.1016/j.jid.2024.11.030","url":null,"abstract":"UV-induced immune suppression contributes to skin carcinogenesis and may also explain how sunlight protects against nonskin autoimmune diseases, particularly multiple sclerosis. Narrowband UVB (NBUVB) phototherapy is an effective treatment for some skin diseases; however, its mechanism of action and its potential for treating diseases away from the skin are not well-understood. Solar-simulated UV modulates immune cells, in part, by altering lipids. However, whether NBUVB has the same effect on these cells and molecules is unknown. Exposure of mice to an immunosuppressive dose of NBUVB did not affect plasma lipid levels, which were altered after solar-simulated UV irradiation. Surprisingly, unlike what occurs after solar-simulated UV irradiation, dermal mast cells and lymphocyte recirculation were unaffected by NBUVB. NBUVB-irradiated skin showed a reduced number of epidermal CD207+ cells and cutaneous CD3+ T cells, and was infiltrated by Ly6G+ neutrophils. There was also an increase in the number of CD4+FoxP3+ T cells in the skin-draining lymph nodes and suppression of antigen-specific CD8+ T-cell activity in vivo. Thus, immunosuppressive NBUVB activates some but not all the pathways responsible for the immunosuppressive effects of solar-simulated UV. Understanding the wavelength-dependent effects of UVR on the immune system is essential to harness its immunomodulatory capacity to treat a wide range of diseases.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response.

The Journal of investigative dermatology Pub Date : 2025-02-03 DOI: 10.1016/j.jid.2024.12.028

Coryn L Hoffman, Navaneetha Krishnan Bharathan, Yoshitaka Shibata, William Giang, Johann E Gudjonsson, John T Seykora, Stephen M Prouty, Sara N Stahley, Aimee S Payne, Andrew P Kowalczyk

{"title":"Pemphigus Vulgaris Autoantibodies Induce an Endoplasmic Reticulum Stress Response.","authors":"Coryn L Hoffman, Navaneetha Krishnan Bharathan, Yoshitaka Shibata, William Giang, Johann E Gudjonsson, John T Seykora, Stephen M Prouty, Sara N Stahley, Aimee S Payne, Andrew P Kowalczyk","doi":"10.1016/j.jid.2024.12.028","DOIUrl":"10.1016/j.jid.2024.12.028","url":null,"abstract":"Desmosomes are intercellular junctions that mediate cell-cell adhesion and are essential for maintaining tissue integrity. Pemphigus vulgaris (PV) is an autoimmune epidermal blistering disease caused by autoantibodies (IgG) targeting desmoglein 3, a desmosomal cadherin. PV autoantibodies cause desmosome disassembly and loss of cell-cell adhesion; however, the molecular signaling pathways that regulate these processes are not fully understood. Using high-resolution time-lapse imaging of live keratinocytes, we found that endoplasmic reticulum (ER) tubules make frequent and persistent contacts with internalizing desmoglein 3 puncta in keratinocytes treated with IgG of patients with PV. Biochemical experiments demonstrated that PV IgG activated ER stress signaling pathways, including both IRE1⍺ and PERK pathways, in cultured keratinocytes. Furthermore, ER stress transcripts were upregulated in the skin of patients with PV. Pharmacological inhibition of ER stress protects against PV IgG-induced desmosome disruption and loss of keratinocyte cell-cell adhesion, suggesting that ER stress may be an important pathomechanism and a therapeutically targetable pathway for PV treatment. These data support a model in which desmosome adhesion is integrated with ER function to serve as a cell adhesion stress sensor that is activated in blistering skin diseases.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Research Hotspots and Trends in Psoriasis Literature: Autotuned Topic Modeling with Agent.

The Journal of investigative dermatology Pub Date : 2025-01-31 DOI: 10.1016/j.jid.2024.11.029

Sunsi Wu, Dan Wang, Xinpei Gu, Ruiheng Xiao, Hongzhi Gao, Bo Yang, Yanlan Kang

{"title":"Identifying Research Hotspots and Trends in Psoriasis Literature: Autotuned Topic Modeling with Agent.","authors":"Sunsi Wu, Dan Wang, Xinpei Gu, Ruiheng Xiao, Hongzhi Gao, Bo Yang, Yanlan Kang","doi":"10.1016/j.jid.2024.11.029","DOIUrl":"10.1016/j.jid.2024.11.029","url":null,"abstract":"The rapid expansion of psoriasis research presents challenges in efficient analysis and trend identification, necessitating advanced approaches. We propose AgenTopic, an interactive topic modeling framework that integrates Bidirectional Encoder Representations from Transformers embeddings, dimensionality reduction, clustering, and a language model feedback loop to analyze the psoriasis research literature from 2000 to 2023. Applied to PubMed articles, AgenTopic extracted 158 psoriasis-related topics across 8 categories, outperforming traditional methods in handling complex medical literature. Further trend analysis using multiple modeling techniques, including a support vector regression-Linear model, revealed nonlinear patterns in research growth across categories (R2 values = 0.75-0.97). Key trends identified include focus on nail psoriasis and spondyloarthritis, shift from TNF-α to IL-17 in pathogenesis understanding, rapid development of biologics and small-molecule inhibitors, and increased attention to comorbidities. We developed an interactive web tool to facilitate literature retrieval and identification of trends. To the best of our knowledge, this application of an agent-based interactive topic modeling framework to dermatological literature has not been previously reported. Using only topic-modeled data, our framework achieved a performance comparable with that of expert manual reviews in identifying research trends. AgenTopic performed better than several state-of-the-art topic modeling methods and demonstrated the potential of artificial intelligence for advancing medical literature analyses.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle via TRPA1 Activation on Mast Cells in Atopic Dermatitis.

The Journal of investigative dermatology Pub Date : 2025-01-30 DOI: 10.1016/j.jid.2024.12.026

Jiahui Hu, Qiang Zhao, Delu Che, Bin Peng, Xi Wang, Zhuochen CathyWang, Li Li, Songmei Geng

{"title":"Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle via TRPA1 Activation on Mast Cells in Atopic Dermatitis.","authors":"Jiahui Hu, Qiang Zhao, Delu Che, Bin Peng, Xi Wang, Zhuochen CathyWang, Li Li, Songmei Geng","doi":"10.1016/j.jid.2024.12.026","DOIUrl":"https://doi.org/10.1016/j.jid.2024.12.026","url":null,"abstract":"Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the itch-scratch cycle. Itching, induced by irritants or allergens that stimulate pruriceptive neurons, triggers uncontrollable mechanical scratching, leading to epidermal barrier disruption, immune response activation, inflammatory mediator release, and further stimulation of pruritus conduction. Although oxidative stress and immune cells can exacerbate this cycle, the correlation between mechanical scratching, epidermal oxidative stress, and dermal mast cell activation in AD remains unclear. Here, by examining clinical specimens of AD, establishing a three-dimensional co-culture system of HaCaT and LAD2 cells, and utilizing a mechanical scratching mouse model of AD, we found that reactive oxygen species produced by mechanically stimulated HaCaT can activate TRPA1 on mast cells presenting tryptase (TPS). Implementing a free radical scavenger and TRPA1 inhibitor can inhibit mast cell activation and type II inflammatory response, thereby alleviating itching and skin lesions in AD. These results indicate that active oxygen scavenging combined with TRPA1 inhibition can inhibit the itch-scratch cycle, which may present a potential approach for the treatment of AD.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum IFNα as a Biomarker for Cutaneous Lupus: Insights into Disease Activity, Severity, Therapeutic Monitoring and Clinical Trial Application.

The Journal of investigative dermatology Pub Date : 2025-01-30 DOI: 10.1016/j.jid.2025.01.003

Touraj Khosravi-Hafshejani, Victoria P Werth

引用次数: 0

Insight into the Relationship between Congenital Large/Giant Melanocytic Nevi and Satellite Nevi.

The Journal of investigative dermatology Pub Date : 2025-01-29 DOI: 10.1016/j.jid.2024.10.620

Jieyu Gu, Boxuan Wei, Ran Duan, Jiamin Jin, Bohan Lai, Jiao Wei, Feng Xie

引用次数: 0