The Journal of investigative dermatology最新文献

Toward Pharmacogenomic Approaches to Hidradenitis Suppurativa. 化脓性汗腺炎的药物基因组学研究。

The Journal of investigative dermatology Pub Date : 2025-05-29 DOI: 10.1016/j.jid.2025.05.001

Richie Jeremian, Vincent Piguet

引用次数: 0

Specific, High Avidity Transient Receptor Potential Ion Channel Inhibitors Demonstrate An Approach To Keratoderma Therapy. 特异性，高亲和力瞬时受体电位离子通道抑制剂证明了一种治疗角膜炎的方法。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.04.039

Ephraim Brener, Tal Mashriki, Ezra Ella, Maya Moran, Dov Terkieltaub, Doron Eren, Boris Vaisman, Shelly Leibman Barak, David Aviezer, Nili Schutz, Liora Braiman

引用次数: 0

Spatial Transcriptome Analysis Reveals Factors Involved in Actinic Cheilosis Transformation to Squamous Cell Carcinoma of the Lip. 空间转录组分析揭示了光化性唇裂向鳞状细胞癌转化的相关因素。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.04.037

Myoung Eun Choi, Hee Joo Yang, Joon Min Jung, Woo Jin Lee, Mi Woo Lee, Chong Hyun Won

{"title":"Spatial Transcriptome Analysis Reveals Factors Involved in Actinic Cheilosis Transformation to Squamous Cell Carcinoma of the Lip.","authors":"Myoung Eun Choi, Hee Joo Yang, Joon Min Jung, Woo Jin Lee, Mi Woo Lee, Chong Hyun Won","doi":"10.1016/j.jid.2025.04.037","DOIUrl":"https://doi.org/10.1016/j.jid.2025.04.037","url":null,"abstract":"Lip squamous cell carcinoma (SCC) often arise from actinic cheilitis. However, factors driving oncogenic transformation and determinants of lip SCC differentiation are unclear. This study investigated differences between lip SCC and premalignant actinic cheilitis and factors related to tumor differentiation. We included patients who received biopsies for actinic cheilitis that later progressed to lip SCC. Moreover, well-differentiated lip SCC and moderately-to-poorly differentiated lip SCC were selected for spatial transcriptomic analysis, using PanCK and CD45 as morphology markers. In PanCK+ tumor areas, we detected 5 upregulated differentially expressed genes (DEGs) (KLK13, MGST1, LNX1, NDRGZ, and HMOX1) and 1 downregulated DEG (HOXD11) in lip SCCs compared with premalignant lesions. Endosomal transport, lysosomal transport, macroautophagy, and wound healing pathways were significantly upregulated in lip SCC compared to actinic cheilitis. Furthermore, proteolysis- and hypoxia-related DEGs were found in moderately-to-poorly differentiated lip SCC compared to well-differentiated lip SCC. General cancer-associated fibroblast markers (p = 0.021) were increased in actinic cheilitis preceding moderately-to-poorly differentiated lip SCCs compared to actinic cheilitis preceding well-differentiated lip SCCs, which was validated in immunohistochemical staining. This observation could expand our understanding of the changes in the microenvironment composition during lip SCC carcinogenesis and according to lip SCC differentiation.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo CRISPRi screen reveals lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth. 体内CRISPRi筛选揭示了皮肤鳞状细胞癌肿瘤生长至关重要的lncRNA组合。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.04.038

Gyuhyeon Kim, Zurab Siprashvili, Xue Yang, Jordan M Meyers, Andrew Ji, Paul A Khavari, Luca Ducoli

{"title":"In vivo CRISPRi screen reveals lncRNA portfolio crucial for cutaneous squamous cell carcinoma tumor growth.","authors":"Gyuhyeon Kim, Zurab Siprashvili, Xue Yang, Jordan M Meyers, Andrew Ji, Paul A Khavari, Luca Ducoli","doi":"10.1016/j.jid.2025.04.038","DOIUrl":"https://doi.org/10.1016/j.jid.2025.04.038","url":null,"abstract":"Cutaneous squamous cell carcinoma (cSCC) accounts for 20% of all skin cancer mortality globally, making it the second-highest subtype of skin cancer. The high prevalence of cSCC in humans highlights the need to uncover alternative actors and mechanisms influencing skin cancer development. Significant advances have been made to better understand some key factors in cSCC growth. However, little is known about the role of noncoding RNAs, particularly of a specific subclass termed long noncoding RNA (lncRNA). By performing pseudobulk analysis of single-cell sequencing data from normal and cSCC human skin tissues, we determined a global portfolio of lncRNAs specifically expressed in keratinocyte subpopulations. Integration of CRISPR interference screens in vitro and the xenograft model identified several lncRNAs impacting the growth of cSCC cancer lines both in vitro and in vivo. Among these, we further validated LINC00704 and LINC01116 as proliferation-regulating lncRNAs in cSCC lines and potential biomarkers of cSCC growth. Taken together, our study provides a comprehensive signature of lncRNAs with roles in regulating cSCC growth.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma Incidence and Survival: A SEER Database Study. 黑色素瘤的发病率和生存率：一项SEER数据库研究。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.011

Olivia M Burke, Fangchao Ma, Jason Huang, Robert S Kirsner

引用次数: 0

CD8⁺ Skin-Resident Memory T Cells Require TCR Signaling for their Persistence in a Mouse Model of Allergic Contact Dermatitis. 在小鼠过敏性接触性皮炎模型中，CD8+皮肤驻留记忆T细胞需要TCR信号才能持续存在。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.012

Anders Boutrup Funch, Julie Friis Weber, Veronika Mraz, Martin Kongsbak-Wismann, Rebecca Kitt Davidson Lohmann, Mia Hamilton Jee, Helen Vaher, Kelvin Yeung, Anne-Sofie Østergaard Gadsbøll, Niels Ødum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menné Bonefeld

{"title":"CD8+ Skin-Resident Memory T Cells Require TCR Signaling for their Persistence in a Mouse Model of Allergic Contact Dermatitis.","authors":"Anders Boutrup Funch, Julie Friis Weber, Veronika Mraz, Martin Kongsbak-Wismann, Rebecca Kitt Davidson Lohmann, Mia Hamilton Jee, Helen Vaher, Kelvin Yeung, Anne-Sofie Østergaard Gadsbøll, Niels Ødum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menné Bonefeld","doi":"10.1016/j.jid.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.012","url":null,"abstract":"Epidermal-resident memory CD8+ T (TRM) cells play a significant role in fighting off pathogens. However, CD8+ TRM cells are also central in the pathogenesis of a variety of inflammatory skin diseases. It is unclear whether the generation and persistence of CD8+ TRM cells are dependent on the presence of cognate antigen and T cell receptor (TCR) signaling. The purpose of this study was to determine whether TCR signaling is required for the generation and persistence of epidermal CD8+ TRM cells in a mouse model for allergic contact dermatitis. We examined the responses to four different contact allergens in combination with adoptive transfer and prime-pull experiments. We determined the presence of contact allergen in the skin by Western blot analysis. We found that epidermal CD8+ TRM cells can develop in the absence of the cognate antigen and TCR signaling as determined by Nur77 induction, whereas persistence of epidermal CD8+ TRM cells requires presence of the cognate antigen and correlates with Nur77 expression. In the presence of contact allergen, a selective expansion of specific TCR clonotypes was seen. In conclusion, this study supports that cognate antigen and TCR signaling are required for the persistence of allergen-specific CD8+ TRM cells in the skin.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting RORγt Inhibition in Plaque Psoriasis: Lessons Learned from BI 730357. 重新研究斑块型银屑病的rr γt抑制：BI 730357的经验教训

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.03.036

Hossein Akbarialiabad, Christopher G Bunick

引用次数: 0

Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective and Potent Allosteric TYK2 Inhibitor. Zasocitinib （TAK-279）的药理特性：一种口服、高选择性和有效的变构TYK2抑制剂。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.014

Shailly Mehrotra, Yasuyo Sano, Petro Halkowycz, Elizabeth Wilson, Chandra Durairaj, Kok-Fai Kong, Guliang Xia, Faith Dunbar, Taylor Spector, Graham A Heap, Christopher G Bunick, Iain B McInnes

{"title":"Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective and Potent Allosteric TYK2 Inhibitor.","authors":"Shailly Mehrotra, Yasuyo Sano, Petro Halkowycz, Elizabeth Wilson, Chandra Durairaj, Kok-Fai Kong, Guliang Xia, Faith Dunbar, Taylor Spector, Graham A Heap, Christopher G Bunick, Iain B McInnes","doi":"10.1016/j.jid.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.014","url":null,"abstract":"Zasocitinib (TAK-279) is an investigational, oral, highly selective and potent allosteric tyrosine kinase 2 (TYK2) inhibitor. This study assessed the TYK2 inhibitory potency and selectivity of zasocitinib versus licensed TYK2 and JAK inhibitors. Binding affinities were determined using homogenous time-resolved fluorescence. In vitro concentration-percent inhibition curves for IL-23-phosphorylated signal transducer and activator of transcription (pSTAT) 3, type I IFN-pSTAT3, IL-12-pSTAT4, IL-2-pSTAT5 and thrombopoietin-pSTAT3 pathways were established using human whole blood assays. Relationships between concentration and percent inhibition were determined to estimate half-maximal inhibitory concentration (IC50). Time above IC50 and percent daily inhibition were modeled from simulated clinical concentrations. Zasocitinib bound the TYK2 Janus homology 2 domain with a inhibitory constant of 0.0087nM, demonstrating more than 1 millionfold selectivity over JAK1. Zasocitinib potently inhibited TYK2 signaling, with IC50s for IL-23-pSTAT3, type I IFN-pSTAT3 and IL-12-pSTAT4 of 48.2nM (95% confidence interval [CI]: 36.8-63.1nM), 21.6nM (95% CI: 17.3-26.9nM) and 57.0nM (95% CI: 44.2-73.4nM), respectively; zasocitinib showed no inhibition of JAK1/2/3. Simulated clinical concentrations of zasocitinib 30 mg once daily exceeded the TYK2 IC50 for 24 hours, maintaining >90% daily inhibition, with no JAK1/2/3 inhibition. The distinct potent and selective inhibition profile of zasocitinib defines it as a next-generation TYK2 inhibitor.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Translational Regulation of Transcription Factor KROX20 in Epithelial Stem Cells. 转录因子KROX20在上皮干细胞中的翻译后调控

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.009

Elnaz Ghotbi, Edem Tchegnon, Yumeng Zhang, Renee M McKay, Lu Q Le

引用次数: 0

Rosacea as a Neurocutaneous Disorder: In Vivo Corneal Confocal Microscopy Reveals Neurologic Alterations. 酒渣鼻作为一种神经皮肤疾病：体内角膜共聚焦显微镜显示神经系统改变。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.04.003

Kexin Liao, Timo Buhl

引用次数: 0