The Journal of investigative dermatology最新文献

Vitiligo and Depression in Western versus South Asian Countries: Cultural Background Should Be Considered. 西方与南亚国家的白癜风和抑郁症：应考虑文化背景。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-24 DOI: 10.1016/j.jid.2025.09.021

Shahnawaz Towheed, Zaakir Hamzavi, Viktoria Eleftheriadou, Khaled Ezzedine

{"title":"Vitiligo and Depression in Western versus South Asian Countries: Cultural Background Should Be Considered.","authors":"Shahnawaz Towheed, Zaakir Hamzavi, Viktoria Eleftheriadou, Khaled Ezzedine","doi":"10.1016/j.jid.2025.09.021","DOIUrl":"https://doi.org/10.1016/j.jid.2025.09.021","url":null,"abstract":"Reported psychosocial outcomes in vitiligo vary considerably across geographic and cultural contexts, yet no comprehensive review has compared these differences. In this study, we aimed to review the psychological and social impact of vitiligo, with a comparative focus on South Asia and Western countries. In this review, Western countries were defined as Europe, the United States, Canada, and Australia, whereas South Asian countries included India, Pakistan, Bangladesh, Sri Lanka, and Nepal. This narrative review was conducted using PubMed, Scopus, Web of Science, and PsycINFO, including English- and French-language publications from 2000 to 2025. Evidence was categorized across 5 thematic domains: (i) psychological outcomes, (ii) social consequences, (iii) skin phototype and visibility, (iv) health system and policy factors, and (v) cultural and religious frameworks. Psychiatric morbidity was highest in South Asian populations, with depression and anxiety rates reaching up to 60%, compared with 15-30% in European cohorts and 20-30% in North American and Australian samples. Stigma in India was exacerbated by cultural beliefs related to contagion, impurity, karma, and dietary taboos, especially among individuals with darker skin phototypes. Western patients more often reported issues related to self-image and social withdrawal but faced fewer institutional or interpersonal barriers. Future research should prioritize longitudinal and community-based studies to inform interventions that shift vitiligo from a socially disabling condition to a manageable chronic difference.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145357404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Polygenic Architecture of Human Diseases Affecting the Hair Follicle. 影响毛囊的人类疾病的多基因结构

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-24 DOI: 10.1016/j.jid.2025.09.012

Anna L Brinks, Carli D Needle, Olivia D Perez, Jerry Shapiro, Kristen I Lo Sicco, Michael A Occidental, Aristotelis Tsirigos, Lynn Petukhova

引用次数: 0

The Role of Mast Cells in the Pathophysiology of Chronic Prurigo. 肥大细胞在慢性瘙痒病病理生理中的作用。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-24 DOI: 10.1016/j.jid.2025.09.365

Manuel P Pereira, Monique Butze, Carolina Vera Ayala, Pavel Kolkhir, Martin Metz

引用次数: 0

Fibroblast-Specific Deletion of Tgfbr2 in Mouse Skin Recapitulates Human Skin Dermal Aging by Suppressing Collagen Production. 小鼠皮肤中Tgfbr2的成纤维细胞特异性缺失通过抑制胶原蛋白的产生再现了人类皮肤的老化。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-21 DOI: 10.1016/j.jid.2025.10.541

Tianyuan He, Ingrid L Bergin, Jun Young Kim, Chunfang Guo, Cong-Qiu Chu, Gary J Fisher, John J Voorhees, Taihao Quan

引用次数: 0

Dupilumab's Effects on Itch Sensitization in Atopic Dermatitis. 杜匹单抗对特应性皮炎瘙痒致敏的影响。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-21 DOI: 10.1016/j.jid.2025.09.017

Laurent Misery, Matthieu Talagas, Christelle Le Gall-Ianotto

引用次数: 0

A Long Stretch: IL-11 Drives Skin Regeneration. 长时间伸展：IL-11促进皮肤再生。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-18 DOI: 10.1016/j.jid.2025.09.018

Steven O'Reilly

引用次数: 0

Cutaneous Immune Memory: A Double-Edged Sword in Skin Repair and Fibrosis. 皮肤免疫记忆：皮肤修复和纤维化的双刃剑。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-17 DOI: 10.1016/j.jid.2025.09.006

Zeinab Ghasemishahrestani, Nonhlanhla P Khumalo, Hayley Ipp, Ardeshir Bayat

{"title":"Cutaneous Immune Memory: A Double-Edged Sword in Skin Repair and Fibrosis.","authors":"Zeinab Ghasemishahrestani, Nonhlanhla P Khumalo, Hayley Ipp, Ardeshir Bayat","doi":"10.1016/j.jid.2025.09.006","DOIUrl":"https://doi.org/10.1016/j.jid.2025.09.006","url":null,"abstract":"The skin, the body's largest and most immunologically dynamic organ, functions as both a protective barrier and an active immune interface. Tissue-resident memory T cells (TRMs) are pivotal in orchestrating localized immune responses, enabling rapid antigen-specific reactions, tissue repair, and immune cell recruitment. However, dysregulated TRM activity can drive chronic inflammation and fibrosis, complicating repair processes. This review examines the dual roles of TRMs and innate immune memory in wound healing and pathogen defense, emphasizing their interplay within cutaneous immune memory. This unique memory system integrates adaptive and innate immunity to enhance skin defense and repair but can contribute to pathologies, such as chronic wounds and keloids, when dysregulated. We discuss promising interventions, including cytokine delivery, biomaterial-based scaffolds, and epigenetic modulators, to enhance healing while mitigating pathology. These strategies aim to harness cutaneous immune memory for improved outcomes in conditions such as diabetic ulcers and recurrent infections. A key challenge is balancing protective and pathological immune responses, underscoring the need for personalized, skin-targeted immunotherapies with demonstrated long-term efficacy. By synthesizing recent advances, this review highlights novel therapeutic opportunities to modulate cutaneous immune memory, addressing critical knowledge gaps to guide future research and clinical translation.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145314441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PD-L1 negative macrophages associate with poor outcomes and high grade irAE development in melanoma patients receiving anti-PD-1 immunotherapy. 在接受抗pd -1免疫治疗的黑色素瘤患者中，PD-L1阴性巨噬细胞与不良预后和高级别irAE发展相关。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-16 DOI: 10.1016/j.jid.2025.09.379

Xin Ming M Zhou, Kaitlin Williams, Elizabeth Will, Daniel Jimenez-Sanchez, Janis M Taube, Joel C Sunshine

引用次数: 0

Dermal IgA is rare in Celiac Disease and relatives, and lacks Dermatitis Herpetiformis-type co-localization with Transglutaminase 3. 皮肤IgA在乳糜泻及其亲属中罕见，缺乏与谷氨酰胺转胺酶3的皮炎疱疹型共定位。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-16 DOI: 10.1016/j.jid.2025.09.380

Elli Turjanmaa, Helka Kaunisto, Esko Kemppainen, Noora Nilsson, Kaisa Hervonen, Iida Mankki, Juha Jernman, Päivi Saavalainen, Johanna Lempainen, Anna Alakoski, Luigina De Leo, Fabiana Ziberna, Timo Reunala, Katri Kaukinen, Katri Lindfors, Teea Salmi

引用次数: 0

Randomized Controlled Trial of the Topical JAK Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia. 局部JAK抑制剂Delgocitinib乳膏治疗额部纤维化性脱发的随机对照试验。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-10-14 DOI: 10.1016/j.jid.2025.09.375

Aubrey Martin, Neda Shokrian, Kristen J Kelley, Joel Correa da Rosa, Ester Del-Duca, Robert Bissonnette, Ole E Sørensen, Anders Bacher Nielsen, Emma Guttman-Yassky, Maryanne Makredes Senna

{"title":"Randomized Controlled Trial of the Topical JAK Inhibitor Delgocitinib Cream in Patients with Frontal Fibrosing Alopecia.","authors":"Aubrey Martin, Neda Shokrian, Kristen J Kelley, Joel Correa da Rosa, Ester Del-Duca, Robert Bissonnette, Ole E Sørensen, Anders Bacher Nielsen, Emma Guttman-Yassky, Maryanne Makredes Senna","doi":"10.1016/j.jid.2025.09.375","DOIUrl":"https://doi.org/10.1016/j.jid.2025.09.375","url":null,"abstract":"Background: Frontal fibrosing alopecia (FFA) is a cicatricial alopecia with generally poor prognosis if untreated, and no approved treatment options.Objective: To evaluate changes in the molecular signature of FFA lesions after application of delgocitinib cream. Safety, tolerability and efficacy were also investigated.Methods: This was a phase 2a, randomized, double-blind, exploratory trial of delgocitinib cream 20 mg/g (2%) versus cream vehicle in patients with FFA.Results: A total of 30 adult females with FFA were randomized to delgocitinib cream (n=15) or cream vehicle (n=15). After 12 weeks, expression of the T helper 1-related biomarker CXCL9 was significantly downregulated (-3.10; p<0.05) while there were non-significant reductions in CXCL10 (-2.60; p<0.1), and interferon-γ (-1.49; p=0.22) in lesions treated with delgocitinib cream but not cream vehicle. Delgocitinib-treated lesions had a small but significant mean improvement in transcriptomic profile (4%; p<0.001) whereas lesions treated with cream vehicle worsened (33%). Delgocitinib cream was well tolerated and associated with improvements in exploratory clinical severity endpoints.Limitations: Limitations of the trial include small sample size, biomarker analyses only being conducted to week 12, and the exploratory nature of efficacy endpoints.Conclusion: Delgocitinib cream resulted in an improvement in the transcriptomic profile of lesions and may have potential as a topical treatment for FFA.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0