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The Journal of investigative dermatology最新文献

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Effect of Repeated Low Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers and Vitamin D in Healthy Adults.
The Journal of investigative dermatology Pub Date : 2025-02-14 DOI: 10.1016/j.jid.2025.01.024
Florentine de Boer, Sanja Kezic, Ghislaine van der Lelie, Ehsan Motazedi, Thomas Rustemeyer, Arjan van Dijk, Mitra Almasian, Ivone Jakasa, Henk F van der Molen
{"title":"Effect of Repeated Low Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers and Vitamin D in Healthy Adults.","authors":"Florentine de Boer, Sanja Kezic, Ghislaine van der Lelie, Ehsan Motazedi, Thomas Rustemeyer, Arjan van Dijk, Mitra Almasian, Ivone Jakasa, Henk F van der Molen","doi":"10.1016/j.jid.2025.01.024","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.024","url":null,"abstract":"<p><p>Ultraviolet radiation (UVR) can cause photoaging, skin burns and skin cancer. The skin counters these effects through photoadaptation, which involves melanin production, skin thickening and immune responses. This study investigated the effects of repeated, sub-erythemal low-dose UVR on the skin's inflammation threshold, assessed as minimal erythema dose (MED), across different skin phototypes (FP). Additionally, epidermal and stratum corneum (SC) thickness, melanin index (MI), erythema index (EI), skin and blood levels of immunological biomarkers and blood 25(OH)D3 were measured. Over nine-weeks, 31 subjects were exposed to UVR (0.8 standard erythema dose), on the lower back three times per week. Results showed a 50% increase in MED, with a stronger effect in lighter phototypes. Increase in MED was paralleled by an increase in EI. MI and SC thickness increased significantly 12% and 34%, respectively, with melanin having a stronger effect on the MED increase. Vitamin D levels rose by 21%, adjusting for seasonal decline. Immunological markers of Th1/Th2 response and vascular markers declined, indicating local immunosuppression, though no systemic changes in immunological markers were observed. These findings suggest that even low UVR doses are sufficient to induce photoadaptation. Further research is needed to evaluate the long-term benefits and risks of this exposure.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143434857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated analysis of proteomic and dermoscopy imaging data improves non-invasive classification of benign nevi and melanoma.
The Journal of investigative dermatology Pub Date : 2025-02-13 DOI: 10.1016/j.jid.2025.01.022
Ali Azimi, Lei Bi, Anila Bonfil, Rachel Teh, Helena Collgros, Jinman Kim, Pablo Fernandez-Penas
{"title":"Integrated analysis of proteomic and dermoscopy imaging data improves non-invasive classification of benign nevi and melanoma.","authors":"Ali Azimi, Lei Bi, Anila Bonfil, Rachel Teh, Helena Collgros, Jinman Kim, Pablo Fernandez-Penas","doi":"10.1016/j.jid.2025.01.022","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.022","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out of this World: Wound Healing on Earth and in Space.
The Journal of investigative dermatology Pub Date : 2025-02-13 DOI: 10.1016/j.jid.2024.12.024
Nathan C Balukoff, Garrett Houk, Tammy Gonzalez, Yael Berton, Vincent Ronfard, Irena Pastar, Marjana Tomic-Canic
{"title":"Out of this World: Wound Healing on Earth and in Space.","authors":"Nathan C Balukoff, Garrett Houk, Tammy Gonzalez, Yael Berton, Vincent Ronfard, Irena Pastar, Marjana Tomic-Canic","doi":"10.1016/j.jid.2024.12.024","DOIUrl":"https://doi.org/10.1016/j.jid.2024.12.024","url":null,"abstract":"<p><p>Impaired wound healing is a significant concern for humans in space, where the unique microgravity environment poses challenges to the natural healing processes of the body. Similar to chronic wounds on earth, such as diabetic foot ulcers and venous leg ulcers, wounds inflicted in space exhibit delayed or impaired healing responses. These wounds share common features, including dysregulated cellular signaling, altered cytokine profiles, and impaired tissue regeneration. Little is known about the mechanisms underlying wound healing under microgravity. In this review, we focused on exploring the parallels between wound healing in space and chronic wounds on earth as a fundamental approach for developing effective countermeasures to promote healing and mitigate associated health risks during long-space missions.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Whole-Genome Structural Variations Study in a Severe Acne Family.
The Journal of investigative dermatology Pub Date : 2025-02-12 DOI: 10.1016/j.jid.2025.01.023
Jiaqi Feng, Mingmin Xu, Jue Qi, Wenjuan Wu, Minsheng Peng, Li He
{"title":"Whole-Genome Structural Variations Study in a Severe Acne Family.","authors":"Jiaqi Feng, Mingmin Xu, Jue Qi, Wenjuan Wu, Minsheng Peng, Li He","doi":"10.1016/j.jid.2025.01.023","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.023","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possible role of IL-23 inhibition in reduction of circulating IL-17A+ CD103+ memory CD8 T cells in psoriasis.
The Journal of investigative dermatology Pub Date : 2025-02-11 DOI: 10.1016/j.jid.2025.01.021
Yutaka Matsumura, Miki Kume, Junichi Furuta, Hanako Koguchi-Yoshioka, Manabu Fujimoto, Rei Watanabe
{"title":"Possible role of IL-23 inhibition in reduction of circulating IL-17A<sup>+</sup> CD103<sup>+</sup> memory CD8 T cells in psoriasis.","authors":"Yutaka Matsumura, Miki Kume, Junichi Furuta, Hanako Koguchi-Yoshioka, Manabu Fujimoto, Rei Watanabe","doi":"10.1016/j.jid.2025.01.021","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.021","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143416635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Voice of the American Dermatological Association: 2025 Official Policy Statement on Climate Change.
The Journal of investigative dermatology Pub Date : 2025-02-10 DOI: 10.1016/j.jid.2024.12.015
Eva Rawlings Parker, Misha Rosenbach, Mark Denis P Davis
{"title":"The Voice of the American Dermatological Association: 2025 Official Policy Statement on Climate Change.","authors":"Eva Rawlings Parker, Misha Rosenbach, Mark Denis P Davis","doi":"10.1016/j.jid.2024.12.015","DOIUrl":"https://doi.org/10.1016/j.jid.2024.12.015","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Changing Landscape of Clinical Research in Pyoderma Gangrenosum.
The Journal of investigative dermatology Pub Date : 2025-02-08 DOI: 10.1016/j.jid.2024.12.023
Sarah L Becker, Alex G Ortega-Loayza
{"title":"The Changing Landscape of Clinical Research in Pyoderma Gangrenosum.","authors":"Sarah L Becker, Alex G Ortega-Loayza","doi":"10.1016/j.jid.2024.12.023","DOIUrl":"https://doi.org/10.1016/j.jid.2024.12.023","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Checkpoint Agonists for Inflammatory Skin Diseases.
The Journal of investigative dermatology Pub Date : 2025-02-08 DOI: 10.1016/j.jid.2025.01.008
Matthew D Vesely, Paul F Lizzul, Paul Klekotka, Nicole Joller, Adam Raff
{"title":"Immune Checkpoint Agonists for Inflammatory Skin Diseases.","authors":"Matthew D Vesely, Paul F Lizzul, Paul Klekotka, Nicole Joller, Adam Raff","doi":"10.1016/j.jid.2025.01.008","DOIUrl":"10.1016/j.jid.2025.01.008","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INTER-RATER AND INTRA-RATER RELIABILITY OF THE CUTANEOUS LUPUS ACTIVITY-INVESTIGATOR GLOBAL ASSESSMENT-REVISED (CLA-IGA-R) INSTRUMENT.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2025.01.020
Joseph F Merola, Arianna J Zhang, Beth A Childs, Mingyue Li, Jeffrey S Smith, Benjamin F Chong, Alice B Gottlieb, Victoria P Werth, Scott A Elman, Lourdes M Pérez-Chada
{"title":"INTER-RATER AND INTRA-RATER RELIABILITY OF THE CUTANEOUS LUPUS ACTIVITY-INVESTIGATOR GLOBAL ASSESSMENT-REVISED (CLA-IGA-R) INSTRUMENT.","authors":"Joseph F Merola, Arianna J Zhang, Beth A Childs, Mingyue Li, Jeffrey S Smith, Benjamin F Chong, Alice B Gottlieb, Victoria P Werth, Scott A Elman, Lourdes M Pérez-Chada","doi":"10.1016/j.jid.2025.01.020","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.020","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Truncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-κB signaling.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2024.02.042
Éva Ádám, Balázs Leitgeb, Judit Danis, Anita Hajdu, Evelyn Kelemen, Margit Pál, Nóra Belső, István Balázs Németh, Neil Rajan, Nikoletta Nagy, Márta Széll
{"title":"Truncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-κB signaling.","authors":"Éva Ádám, Balázs Leitgeb, Judit Danis, Anita Hajdu, Evelyn Kelemen, Margit Pál, Nóra Belső, István Balázs Németh, Neil Rajan, Nikoletta Nagy, Márta Széll","doi":"10.1016/j.jid.2024.02.042","DOIUrl":"https://doi.org/10.1016/j.jid.2024.02.042","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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