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The Journal of investigative dermatology最新文献

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High-throughput drug screening in a cellular model of KRAS-driven arteriovenous malformations.
The Journal of investigative dermatology Pub Date : 2025-03-21 DOI: 10.1016/j.jid.2025.02.151
Fanourios Michailidis, Davide Zecchin, Mohammad Rabii, Ignacio Del Valle Torres, Aimie Sauvadet, Ming Jiang, Michael Howell, Dale Bryant, Satyamaanasa Polubothu, Veronica A Kinsler
{"title":"High-throughput drug screening in a cellular model of KRAS-driven arteriovenous malformations.","authors":"Fanourios Michailidis, Davide Zecchin, Mohammad Rabii, Ignacio Del Valle Torres, Aimie Sauvadet, Ming Jiang, Michael Howell, Dale Bryant, Satyamaanasa Polubothu, Veronica A Kinsler","doi":"10.1016/j.jid.2025.02.151","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.151","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National Institutes of Health Dermatology Funding Trends: 2020-2024.
The Journal of investigative dermatology Pub Date : 2025-03-19 DOI: 10.1016/j.jid.2025.03.004
Aditya Joshi, Lauren Gawey, Morgan Harrison, Kyla N Price, Raveena Ghanshani, David J Griego, Jennifer L Hsiao, Vivian Y Shi
{"title":"National Institutes of Health Dermatology Funding Trends: 2020-2024.","authors":"Aditya Joshi, Lauren Gawey, Morgan Harrison, Kyla N Price, Raveena Ghanshani, David J Griego, Jennifer L Hsiao, Vivian Y Shi","doi":"10.1016/j.jid.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.004","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical Steroid Withdrawal: Addressing a Controversial Dermatological Condition.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.01.035
Parisut Kimkool, Helen A Brough
{"title":"Topical Steroid Withdrawal: Addressing a Controversial Dermatological Condition.","authors":"Parisut Kimkool, Helen A Brough","doi":"10.1016/j.jid.2025.01.035","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.035","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous Pemphigoid-Associated S. aureus Increases Protease Activity from Keratinocytes and Promotes Unique BP180 Cleavage.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.03.001
Annaliese M Hersom, Liam F Peterson, Patrick M Schlievert, Alice P Pentland, Matthew G Brewer
{"title":"Bullous Pemphigoid-Associated S. aureus Increases Protease Activity from Keratinocytes and Promotes Unique BP180 Cleavage.","authors":"Annaliese M Hersom, Liam F Peterson, Patrick M Schlievert, Alice P Pentland, Matthew G Brewer","doi":"10.1016/j.jid.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.001","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical observational study utilizing teledermatology in bullous pemphigoid.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.149
Olive Osuoji, Taylor Adkins, Jason Barron, Yixin Chen, Shuyang Yue, Yuan Liu, Jazmine Stokes, Bridget Bradley, Suephy Chen, Howa Yeung, Emily F Cole, Ron J Feldman
{"title":"Clinical observational study utilizing teledermatology in bullous pemphigoid.","authors":"Olive Osuoji, Taylor Adkins, Jason Barron, Yixin Chen, Shuyang Yue, Yuan Liu, Jazmine Stokes, Bridget Bradley, Suephy Chen, Howa Yeung, Emily F Cole, Ron J Feldman","doi":"10.1016/j.jid.2025.02.149","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.149","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational free flow cytometry for Sézary cells identification and quantification.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.03.003
Van Anh Ta, Caroline Ram-Wolff, Elissa Annabi, Clémentine Chauvel, Adèle de Masson, Marie Beylot-Barry, Jean Soulier, Martine Bagot, Jean-Philippe Vial, Richard Veyrat-Masson, Hélène Moins-Teisserenc
{"title":"Computational free flow cytometry for Sézary cells identification and quantification.","authors":"Van Anh Ta, Caroline Ram-Wolff, Elissa Annabi, Clémentine Chauvel, Adèle de Masson, Marie Beylot-Barry, Jean Soulier, Martine Bagot, Jean-Philippe Vial, Richard Veyrat-Masson, Hélène Moins-Teisserenc","doi":"10.1016/j.jid.2025.03.003","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.003","url":null,"abstract":"<p><p>Although robust, these methods rely on highly standardized procedures that encompass all steps of FC, prior characterization of normal CD4+ T-cells from healthy donors and/or CTCL patients, and the use of multiparametric panels requirements typically only supported by reference centers. In this context, simplified FC strategy has been proposed, utilizing computationally enhanced data files (Seheult et al. 2024). However, the remarkable heterogeneity of SS, particularly the variability in the phenotype of SCs, which can evolve over time as the disease progresses, underscores the necessity of using more specific markers for their identification. This dynamic nature of SCs, characterized by shifts in immunophenotypic expression and clonal diversity, presents a challenge for accurate diagnosis and monitoring, making the application of advanced flow cytometry techniques and computational analysis crucial in clinical practice.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review of Metabolic Dysregulation in Lymphocytic Cicatricial Alopecia: Exploring the Connections and Therapeutic Implications.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.01.036
Aaron Bao, Lindsey A Bordone, Crystal Aguh
{"title":"A Review of Metabolic Dysregulation in Lymphocytic Cicatricial Alopecia: Exploring the Connections and Therapeutic Implications.","authors":"Aaron Bao, Lindsey A Bordone, Crystal Aguh","doi":"10.1016/j.jid.2025.01.036","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.036","url":null,"abstract":"<p><p>Lymphocytic primary cicatricial alopecia (LPCA) is an inflammatory disorder characterized by permanent hair follicle destruction and fibrosis. Recent evidence suggests a significant link between LPCA and metabolic dysregulation, particularly diabetes and dyslipidemia. This review examines the emerging role of metabolism in LPCA pathogenesis and its implications for novel therapeutic approaches. Epidemiologic studies demonstrate increased prevalence of metabolic disorders among patients with LPCA, whereas molecular investigations reveal altered metabolic pathways in affected hair follicles, including disruptions in peroxisome proliferator-activated receptor γ signaling and adenosine monophosphate-activated protein kinase activation, mechanisms that parallel those observed in other fibrotic diseases. These pathways appear to precede inflammatory changes, suggesting metabolic dysfunction as a primary trigger rather than a secondary effect. Preliminary treatments targeting these pathways, such as pioglitazone and metformin, have shown promising results in normalizing lipid metabolism and reducing inflammation, although their clinical efficacy across LPCA subtypes requires further investigation. The review also explores emerging therapeutic possibilities, including glucagon-like peptide-1 agonists. Understanding the interplay between metabolic disturbances, fibrosis, and inflammation in the pathogenesis of LPCA offers new avenues for both research and treatment. This paradigm shift suggests the need for metabolic screening in patients with LPCA and highlights the potential for developing more comprehensive, metabolism-targeted therapies to improve outcomes in these challenging hair disorders.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TIE-2 expressing monocytic myeloid-derived suppressor cells are involved in resistance to anti-PD-1 therapy mediated by angiopoietin 2 in melanoma patients.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.150
Amélie Marguier, Jessica Mathiot, Babacar NDao, Mylène Wespiser, Victor Pereira, Benoît Lecoester, Laura Boullerot, Marine Malfroy, Caroline Laheurte, François Aubin, Olivier Adotevi, Charlée Nardin
{"title":"TIE-2 expressing monocytic myeloid-derived suppressor cells are involved in resistance to anti-PD-1 therapy mediated by angiopoietin 2 in melanoma patients.","authors":"Amélie Marguier, Jessica Mathiot, Babacar NDao, Mylène Wespiser, Victor Pereira, Benoît Lecoester, Laura Boullerot, Marine Malfroy, Caroline Laheurte, François Aubin, Olivier Adotevi, Charlée Nardin","doi":"10.1016/j.jid.2025.02.150","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.150","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial Dysfunction in Keloid Formation and Therapeutic Insights.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.134
Junxian Wen, Zhijin Li, Yingrou Tan, Hong Liang Tey, Nanze Yu, Xiaojun Wang
{"title":"Endothelial Dysfunction in Keloid Formation and Therapeutic Insights.","authors":"Junxian Wen, Zhijin Li, Yingrou Tan, Hong Liang Tey, Nanze Yu, Xiaojun Wang","doi":"10.1016/j.jid.2025.02.134","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.134","url":null,"abstract":"<p><p>Keloids are benign fibroproliferative tumors that cause significant physical and mental morbidity owing to their disfiguring appearance, chronic symptoms, and resistance to treatment. Although fibroblast hyperproliferation and excessive extracellular matrix deposition have been extensively studied, less attention has been paid to the role of vascular dysregulation and endothelial dysfunction (ED) in keloid pathogenesis. Emerging evidence highlights abnormal angiogenesis, vascular irregularities, and endothelial injury as critical drivers of fibrosis in keloids. This review explores the direct and indirect mechanisms of ED in keloid progression, including endothelial-to-mesenchymal transition, inflammation, immune cell crosstalk, and hypoxia. In addition, various treatment strategies targeting angiogenesis and ED, such as drugs, radiotherapy, hyperbaric oxygen therapy, compression, and laser treatments, are comprehensively reviewed. This review explores keloids through the lens of vasculature and endothelium, emphasizing the critical roles of vascular dysregulation and ED. It aims to provide insights into the mechanisms of keloid formation and serve as a reference for developing future therapeutic strategies.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial transcriptomics reveals differential inflammatory pathways in discoid lupus erythematosus and lichen planus.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.148
Michal Kidacki, Christina Cho, Francesc Lopez-Giraldez, Rachel Breidbart, Anjali Jaiswal, Morten Lee, Shanin Chowdhury, William Damsky, Lieping Chen, Matthew D Vesely
{"title":"Spatial transcriptomics reveals differential inflammatory pathways in discoid lupus erythematosus and lichen planus.","authors":"Michal Kidacki, Christina Cho, Francesc Lopez-Giraldez, Rachel Breidbart, Anjali Jaiswal, Morten Lee, Shanin Chowdhury, William Damsky, Lieping Chen, Matthew D Vesely","doi":"10.1016/j.jid.2025.02.148","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.148","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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