The Journal of investigative dermatology最新文献_第2页

Melanoma Incidence and Survival: A SEER Database Study. 黑色素瘤的发病率和生存率：一项SEER数据库研究。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.011

Olivia M Burke, Fangchao Ma, Jason Huang, Robert S Kirsner

引用次数: 0

CD8⁺ Skin-Resident Memory T Cells Require TCR Signaling for their Persistence in a Mouse Model of Allergic Contact Dermatitis. 在小鼠过敏性接触性皮炎模型中，CD8+皮肤驻留记忆T细胞需要TCR信号才能持续存在。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.012

Anders Boutrup Funch, Julie Friis Weber, Veronika Mraz, Martin Kongsbak-Wismann, Rebecca Kitt Davidson Lohmann, Mia Hamilton Jee, Helen Vaher, Kelvin Yeung, Anne-Sofie Østergaard Gadsbøll, Niels Ødum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menné Bonefeld

{"title":"CD8+ Skin-Resident Memory T Cells Require TCR Signaling for their Persistence in a Mouse Model of Allergic Contact Dermatitis.","authors":"Anders Boutrup Funch, Julie Friis Weber, Veronika Mraz, Martin Kongsbak-Wismann, Rebecca Kitt Davidson Lohmann, Mia Hamilton Jee, Helen Vaher, Kelvin Yeung, Anne-Sofie Østergaard Gadsbøll, Niels Ødum, Anders Woetmann, Jeanne Duus Johansen, Carsten Geisler, Charlotte Menné Bonefeld","doi":"10.1016/j.jid.2025.05.012","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.012","url":null,"abstract":"Epidermal-resident memory CD8+ T (TRM) cells play a significant role in fighting off pathogens. However, CD8+ TRM cells are also central in the pathogenesis of a variety of inflammatory skin diseases. It is unclear whether the generation and persistence of CD8+ TRM cells are dependent on the presence of cognate antigen and T cell receptor (TCR) signaling. The purpose of this study was to determine whether TCR signaling is required for the generation and persistence of epidermal CD8+ TRM cells in a mouse model for allergic contact dermatitis. We examined the responses to four different contact allergens in combination with adoptive transfer and prime-pull experiments. We determined the presence of contact allergen in the skin by Western blot analysis. We found that epidermal CD8+ TRM cells can develop in the absence of the cognate antigen and TCR signaling as determined by Nur77 induction, whereas persistence of epidermal CD8+ TRM cells requires presence of the cognate antigen and correlates with Nur77 expression. In the presence of contact allergen, a selective expansion of specific TCR clonotypes was seen. In conclusion, this study supports that cognate antigen and TCR signaling are required for the persistence of allergen-specific CD8+ TRM cells in the skin.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting RORγt Inhibition in Plaque Psoriasis: Lessons Learned from BI 730357. 重新研究斑块型银屑病的rr γt抑制：BI 730357的经验教训

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.03.036

Hossein Akbarialiabad, Christopher G Bunick

引用次数: 0

Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective and Potent Allosteric TYK2 Inhibitor. Zasocitinib （TAK-279）的药理特性：一种口服、高选择性和有效的变构TYK2抑制剂。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.014

Shailly Mehrotra, Yasuyo Sano, Petro Halkowycz, Elizabeth Wilson, Chandra Durairaj, Kok-Fai Kong, Guliang Xia, Faith Dunbar, Taylor Spector, Graham A Heap, Christopher G Bunick, Iain B McInnes

{"title":"Pharmacological Characterization of Zasocitinib (TAK-279): An Oral, Highly Selective and Potent Allosteric TYK2 Inhibitor.","authors":"Shailly Mehrotra, Yasuyo Sano, Petro Halkowycz, Elizabeth Wilson, Chandra Durairaj, Kok-Fai Kong, Guliang Xia, Faith Dunbar, Taylor Spector, Graham A Heap, Christopher G Bunick, Iain B McInnes","doi":"10.1016/j.jid.2025.05.014","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.014","url":null,"abstract":"Zasocitinib (TAK-279) is an investigational, oral, highly selective and potent allosteric tyrosine kinase 2 (TYK2) inhibitor. This study assessed the TYK2 inhibitory potency and selectivity of zasocitinib versus licensed TYK2 and JAK inhibitors. Binding affinities were determined using homogenous time-resolved fluorescence. In vitro concentration-percent inhibition curves for IL-23-phosphorylated signal transducer and activator of transcription (pSTAT) 3, type I IFN-pSTAT3, IL-12-pSTAT4, IL-2-pSTAT5 and thrombopoietin-pSTAT3 pathways were established using human whole blood assays. Relationships between concentration and percent inhibition were determined to estimate half-maximal inhibitory concentration (IC50). Time above IC50 and percent daily inhibition were modeled from simulated clinical concentrations. Zasocitinib bound the TYK2 Janus homology 2 domain with a inhibitory constant of 0.0087nM, demonstrating more than 1 millionfold selectivity over JAK1. Zasocitinib potently inhibited TYK2 signaling, with IC50s for IL-23-pSTAT3, type I IFN-pSTAT3 and IL-12-pSTAT4 of 48.2nM (95% confidence interval [CI]: 36.8-63.1nM), 21.6nM (95% CI: 17.3-26.9nM) and 57.0nM (95% CI: 44.2-73.4nM), respectively; zasocitinib showed no inhibition of JAK1/2/3. Simulated clinical concentrations of zasocitinib 30 mg once daily exceeded the TYK2 IC50 for 24 hours, maintaining >90% daily inhibition, with no JAK1/2/3 inhibition. The distinct potent and selective inhibition profile of zasocitinib defines it as a next-generation TYK2 inhibitor.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-Translational Regulation of Transcription Factor KROX20 in Epithelial Stem Cells. 转录因子KROX20在上皮干细胞中的翻译后调控

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.05.009

Elnaz Ghotbi, Edem Tchegnon, Yumeng Zhang, Renee M McKay, Lu Q Le

引用次数: 0

Rosacea as a Neurocutaneous Disorder: In Vivo Corneal Confocal Microscopy Reveals Neurologic Alterations. 酒渣鼻作为一种神经皮肤疾病：体内角膜共聚焦显微镜显示神经系统改变。

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.04.003

Kexin Liao, Timo Buhl

引用次数: 0

Why Cold Gas Plasma Technology for Wound Healing? 为什么低温气体等离子体技术用于伤口愈合？

The Journal of investigative dermatology Pub Date : 2025-05-27 DOI: 10.1016/j.jid.2025.04.002

Sander Bekeschus, Steffen Emmert, Lars Boeckmann

引用次数: 0

Cutaneous Exposure to Per- and Polyfluoroalkyl Substances: Cause for Concern? 皮肤接触全氟烷基和多氟烷基物质：值得关注的原因？

The Journal of investigative dermatology Pub Date : 2025-05-26 DOI: 10.1016/j.jid.2025.03.030

Thomas Haarmann-Stemmann, Charlotte Esser

引用次数: 0

Cutibacterium Adaptation to Life on Humans Provides a Potential C. acnes Infection Biomarker. 皮肤细菌对人类生命的适应提供了一个潜在的痤疮杆菌感染的生物标志物。

The Journal of investigative dermatology Pub Date : 2025-05-26 DOI: 10.1016/j.jid.2025.03.048

Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H McCoy

{"title":"Cutibacterium Adaptation to Life on Humans Provides a Potential C. acnes Infection Biomarker.","authors":"Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H McCoy","doi":"10.1016/j.jid.2025.03.048","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.048","url":null,"abstract":"Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C. acnes) now dominates 25% of human skin. C. acnes colonization of human skin requires the protein RoxP. While all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. Herein, we report an extensive assessment of twenty-one RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C. acnes dominant sebaceous skin, and it identified an ortholog associated with the emergence of an acne vulgaris-associated, pathobiont subspecies. C. acnes is also an emerging pathogen that frequently infects joint prostheses and other medical devices. These infections are often missed, because there is no test to confirm a C. acnes infection. To address this clinical need, we developed immunoassays that can assess RoxP in human biofluids commonly infected by C. acnes. This study's findings and assays will help shed light on the consequences of Neolithic Age livestock domestication, the evolution of skin commensals into pathogens, and how to identify infections of human \"replacement parts.\"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Adverse Event Reporting in Dermatology Trials. 改善皮肤病学试验不良事件报告。

The Journal of investigative dermatology Pub Date : 2025-05-26 DOI: 10.1016/j.jid.2025.03.015

Hossein Akbarialiabad, Ayman Grada

引用次数: 0