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The Journal of investigative dermatology最新文献

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Tumor-Infiltrating Lymphocyte Therapy for Melanoma Has Arrived (at Last).
The Journal of investigative dermatology Pub Date : 2025-03-27 DOI: 10.1016/j.jid.2024.04.039
Alexandra M Haugh, David E Fisher, Donald P Lawrence
{"title":"Tumor-Infiltrating Lymphocyte Therapy for Melanoma Has Arrived (at Last).","authors":"Alexandra M Haugh, David E Fisher, Donald P Lawrence","doi":"10.1016/j.jid.2024.04.039","DOIUrl":"https://doi.org/10.1016/j.jid.2024.04.039","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An overview of data analysis approaches and biases in unveiling the impact of COVID 19 on melanoma diagnosis.
The Journal of investigative dermatology Pub Date : 2025-03-25 DOI: 10.1016/j.jid.2025.03.009
Lejie Zheng, H Peter Soyer, Monika Janda, Dilki Jayasinghe
{"title":"An overview of data analysis approaches and biases in unveiling the impact of COVID 19 on melanoma diagnosis.","authors":"Lejie Zheng, H Peter Soyer, Monika Janda, Dilki Jayasinghe","doi":"10.1016/j.jid.2025.03.009","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.009","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrin α11β1 as a Key Collagen Receptor in Human Skin Dermis: Insight into Fibroblast Function and Skin Dermal Aging. 整合素α11β1是人类皮肤真皮层中的关键胶原蛋白受体：洞察成纤维细胞功能和皮肤真皮层老化。
The Journal of investigative dermatology Pub Date : 2025-03-24 DOI: 10.1016/j.jid.2025.03.006
Taihao Quan, Zhaoping Qin, Tianyuan He, Gary J Fisher
{"title":"Integrin α11β1 as a Key Collagen Receptor in Human Skin Dermis: Insight into Fibroblast Function and Skin Dermal Aging.","authors":"Taihao Quan, Zhaoping Qin, Tianyuan He, Gary J Fisher","doi":"10.1016/j.jid.2025.03.006","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.006","url":null,"abstract":"<p><p>Collagen-binding integrins play a crucial role in facilitating fibroblast-collagen interactions and regulating cellular functions. In this study, we identified that among four collagen-binding integrins, integrin α11 (α11) as the predominant integrin in human skin dermal fibroblasts, and loss α11 expression contributes to skin dermal aging. α11β1 is critical for regulating fibroblast-collagen interactions, including cell adhesion, spreading, morphology, mechanical tension, and the production of collagenous extracellular matrix (ECM). Transforming growth factor-beta (TGF-β) is recognized as the primary regulator of α11 expression. Notably, dermal fibroblasts in aged human skin demonstrate impaired TGF-β signaling, which coincides with a loss of α11 expression, while the expression of other collagen-binding integrins remains unchanged. Similarly, in senescent dermal fibroblasts in vitro, impaired TGF-β signaling is associated with a significant reduction in α11 expression, whereas other collagen-binding integrins are upregulated or unaffected. Furthermore, collapsed dermal fibroblasts, a key characteristic of dermal fibroblasts in aged human skin, specifically downregulate α11, while other collagen-binding integrins are upregulated or remain unchanged. These findings suggest a negative feedback loop in which an impaired TGF-β- α11β1 axis and fibroblast collapse promote dermal aging in human skin. This self-reinforcing cycle reflects the progressive and unidirectional nature of biological aging.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Emotional Distress and Atopic Dermatitis: A Cross-Sectional Study. 情绪困扰与特应性皮炎之间的关系：一项横断面研究
The Journal of investigative dermatology Pub Date : 2025-03-24 DOI: 10.1016/j.jid.2025.03.007
Hanyi Zhang, Siding Tang, Xiang Chen, Mi Wang, Juan Su
{"title":"Association Between Emotional Distress and Atopic Dermatitis: A Cross-Sectional Study.","authors":"Hanyi Zhang, Siding Tang, Xiang Chen, Mi Wang, Juan Su","doi":"10.1016/j.jid.2025.03.007","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.007","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-throughput drug screening in a cellular model of KRAS-driven arteriovenous malformations.
The Journal of investigative dermatology Pub Date : 2025-03-21 DOI: 10.1016/j.jid.2025.02.151
Fanourios Michailidis, Davide Zecchin, Mohammad Rabii, Ignacio Del Valle Torres, Aimie Sauvadet, Ming Jiang, Michael Howell, Dale Bryant, Satyamaanasa Polubothu, Veronica A Kinsler
{"title":"High-throughput drug screening in a cellular model of KRAS-driven arteriovenous malformations.","authors":"Fanourios Michailidis, Davide Zecchin, Mohammad Rabii, Ignacio Del Valle Torres, Aimie Sauvadet, Ming Jiang, Michael Howell, Dale Bryant, Satyamaanasa Polubothu, Veronica A Kinsler","doi":"10.1016/j.jid.2025.02.151","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.151","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
National Institutes of Health Dermatology Funding Trends: 2020-2024.
The Journal of investigative dermatology Pub Date : 2025-03-19 DOI: 10.1016/j.jid.2025.03.004
Aditya Joshi, Lauren Gawey, Morgan Harrison, Kyla N Price, Raveena Ghanshani, David J Griego, Jennifer L Hsiao, Vivian Y Shi
{"title":"National Institutes of Health Dermatology Funding Trends: 2020-2024.","authors":"Aditya Joshi, Lauren Gawey, Morgan Harrison, Kyla N Price, Raveena Ghanshani, David J Griego, Jennifer L Hsiao, Vivian Y Shi","doi":"10.1016/j.jid.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.004","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143675117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Topical Steroid Withdrawal: Addressing a Controversial Dermatological Condition.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.01.035
Parisut Kimkool, Helen A Brough
{"title":"Topical Steroid Withdrawal: Addressing a Controversial Dermatological Condition.","authors":"Parisut Kimkool, Helen A Brough","doi":"10.1016/j.jid.2025.01.035","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.035","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bullous Pemphigoid-Associated S. aureus Increases Protease Activity from Keratinocytes and Promotes Unique BP180 Cleavage.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.03.001
Annaliese M Hersom, Liam F Peterson, Patrick M Schlievert, Alice P Pentland, Matthew G Brewer
{"title":"Bullous Pemphigoid-Associated S. aureus Increases Protease Activity from Keratinocytes and Promotes Unique BP180 Cleavage.","authors":"Annaliese M Hersom, Liam F Peterson, Patrick M Schlievert, Alice P Pentland, Matthew G Brewer","doi":"10.1016/j.jid.2025.03.001","DOIUrl":"https://doi.org/10.1016/j.jid.2025.03.001","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical observational study utilizing teledermatology in bullous pemphigoid.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.149
Olive Osuoji, Taylor Adkins, Jason Barron, Yixin Chen, Shuyang Yue, Yuan Liu, Jazmine Stokes, Bridget Bradley, Suephy Chen, Howa Yeung, Emily F Cole, Ron J Feldman
{"title":"Clinical observational study utilizing teledermatology in bullous pemphigoid.","authors":"Olive Osuoji, Taylor Adkins, Jason Barron, Yixin Chen, Shuyang Yue, Yuan Liu, Jazmine Stokes, Bridget Bradley, Suephy Chen, Howa Yeung, Emily F Cole, Ron J Feldman","doi":"10.1016/j.jid.2025.02.149","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.149","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Free Flow Cytometry for Sézary Cells Identification and Quantification.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.03.003
Van Anh Ta, Caroline Ram-Wolff, Elissa Annabi, Clémentine Chauvel, Adèle de Masson, Marie Beylot-Barry, Jean Soulier, Martine Bagot, Jean-Philippe Vial, Richard Veyrat-Masson, Hélène Moins-Teisserenc
{"title":"Computational Free Flow Cytometry for Sézary Cells Identification and Quantification.","authors":"Van Anh Ta, Caroline Ram-Wolff, Elissa Annabi, Clémentine Chauvel, Adèle de Masson, Marie Beylot-Barry, Jean Soulier, Martine Bagot, Jean-Philippe Vial, Richard Veyrat-Masson, Hélène Moins-Teisserenc","doi":"10.1016/j.jid.2025.03.003","DOIUrl":"10.1016/j.jid.2025.03.003","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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