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The Journal of investigative dermatology最新文献

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INTER-RATER AND INTRA-RATER RELIABILITY OF THE CUTANEOUS LUPUS ACTIVITY-INVESTIGATOR GLOBAL ASSESSMENT-REVISED (CLA-IGA-R) INSTRUMENT.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2025.01.020
Joseph F Merola, Arianna J Zhang, Beth A Childs, Mingyue Li, Jeffrey S Smith, Benjamin F Chong, Alice B Gottlieb, Victoria P Werth, Scott A Elman, Lourdes M Pérez-Chada
{"title":"INTER-RATER AND INTRA-RATER RELIABILITY OF THE CUTANEOUS LUPUS ACTIVITY-INVESTIGATOR GLOBAL ASSESSMENT-REVISED (CLA-IGA-R) INSTRUMENT.","authors":"Joseph F Merola, Arianna J Zhang, Beth A Childs, Mingyue Li, Jeffrey S Smith, Benjamin F Chong, Alice B Gottlieb, Victoria P Werth, Scott A Elman, Lourdes M Pérez-Chada","doi":"10.1016/j.jid.2025.01.020","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.020","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Truncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-κB signaling.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2024.02.042
Éva Ádám, Balázs Leitgeb, Judit Danis, Anita Hajdu, Evelyn Kelemen, Margit Pál, Nóra Belső, István Balázs Németh, Neil Rajan, Nikoletta Nagy, Márta Széll
{"title":"Truncating CYLD pathogenic variants in CYLD cutaneous syndrome distinctly influence CYLD proteostasis and NF-κB signaling.","authors":"Éva Ádám, Balázs Leitgeb, Judit Danis, Anita Hajdu, Evelyn Kelemen, Margit Pál, Nóra Belső, István Balázs Németh, Neil Rajan, Nikoletta Nagy, Márta Széll","doi":"10.1016/j.jid.2024.02.042","DOIUrl":"https://doi.org/10.1016/j.jid.2024.02.042","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secreted Phosphoprotein 1-CD44s Axis Downregulation Promotes Melanocyte Senescence through ROS Generation.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2025.01.017
Yul Hee Kim, So Yeon Myeong, Yeongeun Kim, Jieun Maeng, Jin Cheol Kim, Soon Sang Park, Hyun Jung Kim, Tae Jun Park, Hee Young Kang
{"title":"Secreted Phosphoprotein 1-CD44s Axis Downregulation Promotes Melanocyte Senescence through ROS Generation.","authors":"Yul Hee Kim, So Yeon Myeong, Yeongeun Kim, Jieun Maeng, Jin Cheol Kim, Soon Sang Park, Hyun Jung Kim, Tae Jun Park, Hee Young Kang","doi":"10.1016/j.jid.2025.01.017","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.017","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Filaggrinopathies-FLG/FLG2: Diagnostic Complexities and Immunotherapy.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2024.12.008
Zahra Nouri, Sajjad Biglari, Mohammad Amin Tabatabaiefar, Fatemeh Vahidnezhad, Amir Hozhabrpour, Michael E March, David J Margolis, Johann E Gudjonsson, Hakon Hakonarson, Hassan Vahidnezhad
{"title":"Filaggrinopathies-FLG/FLG2: Diagnostic Complexities and Immunotherapy.","authors":"Zahra Nouri, Sajjad Biglari, Mohammad Amin Tabatabaiefar, Fatemeh Vahidnezhad, Amir Hozhabrpour, Michael E March, David J Margolis, Johann E Gudjonsson, Hakon Hakonarson, Hassan Vahidnezhad","doi":"10.1016/j.jid.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.jid.2024.12.008","url":null,"abstract":"<p><p>FLG and FLG2 proteins are expressed in the outer layers of the epidermis, where they are vital in epidermal differentiation and skin barrier formation. Filaggrinopathies involving dysfunctions in these proteins are associated with a spectrum of phenotypic presentations, from monogenic to multifactorial conditions. This review examines biosynthesis and function of FLG and FLG2 proteins and evaluates their molecular pathogenesis in filaggrinopathies. Moreover, genotype-phenotype correlations are assessed, emphasizing genetic diagnosis complexities and diverse immune dysregulation patterns. Finally, it examines ongoing immunotherapeutic approaches by targeting different cytokines as promising treatment options for filaggrinopathies management.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143384489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transfer of Oncologic Signals from Melanoma Cells to Benign Melanocytes by Circulating Tumor-Derived Extracellular Vesicles.
The Journal of investigative dermatology Pub Date : 2025-02-07 DOI: 10.1016/j.jid.2025.01.004
Theresa L Whiteside
{"title":"Transfer of Oncologic Signals from Melanoma Cells to Benign Melanocytes by Circulating Tumor-Derived Extracellular Vesicles.","authors":"Theresa L Whiteside","doi":"10.1016/j.jid.2025.01.004","DOIUrl":"10.1016/j.jid.2025.01.004","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genotype-Phenotype Correlation in Junctional Epidermolysis Bullosa-Signposts to Severity: Enamel Phenotype.
The Journal of investigative dermatology Pub Date : 2025-02-06 DOI: 10.1016/j.jid.2024.10.618
Susanne Krämer, Sebastián Véliz
{"title":"Genotype-Phenotype Correlation in Junctional Epidermolysis Bullosa-Signposts to Severity: Enamel Phenotype.","authors":"Susanne Krämer, Sebastián Véliz","doi":"10.1016/j.jid.2024.10.618","DOIUrl":"https://doi.org/10.1016/j.jid.2024.10.618","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143451349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melatonin and the Skin: Current Progress and Perspectives for Human Health.
The Journal of investigative dermatology Pub Date : 2025-02-06 DOI: 10.1016/j.jid.2024.11.012
Andrzej T Slominski, Tae-Kang Kim, Zorica Janjetovic, Radomir M Slominski, Gitali Ganguli-Indra, Mohammad Athar, Arup K Indra, Russel J Reiter, Konrad Kleszczyński
{"title":"Melatonin and the Skin: Current Progress and Perspectives for Human Health.","authors":"Andrzej T Slominski, Tae-Kang Kim, Zorica Janjetovic, Radomir M Slominski, Gitali Ganguli-Indra, Mohammad Athar, Arup K Indra, Russel J Reiter, Konrad Kleszczyński","doi":"10.1016/j.jid.2024.11.012","DOIUrl":"https://doi.org/10.1016/j.jid.2024.11.012","url":null,"abstract":"<p><p>Skin has the capacity to produce and metabolize melatonin into biologically active metabolites. These metabolites exert phenotypic activities through receptor-dependent and receptor-independent action, including direct antioxidant activity, interaction with regulatory proteins, and regulation of mitochondrial function. They can act on G-protein-coupled melatonin receptors (MT1 and MT2) as well as nuclear aryl hydrocarbon receptor and peroxisome proliferator-activated receptor γ receptors. These metabolic pathways, together with receptor- and nonreceptor-mediated phenotypic activities of its intermediates, has been identified as a cutaneous melatoninergic system. Its pharmacological modulation and topical application of melatonin or its metabolites can be used to prevent and treat skin disorders and cutaneous aging.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5-Aminolevulinic Acid Photodynamic Therapy Modulates Lipid Production by Akt/JunD-mediated NR4A1 Activation in the Treatment of Acne Vulgaris.
The Journal of investigative dermatology Pub Date : 2025-02-06 DOI: 10.1016/j.jid.2025.01.018
Yun Wu, Xiaojing Liu, Linglin Zhang, Peiru Wang, Haiyan Zhang, Jia Yan, Yu Yan, Pei Liu, Jingjun Zhao, Qingyu Zeng, Xiuli Wang
{"title":"5-Aminolevulinic Acid Photodynamic Therapy Modulates Lipid Production by Akt/JunD-mediated NR4A1 Activation in the Treatment of Acne Vulgaris.","authors":"Yun Wu, Xiaojing Liu, Linglin Zhang, Peiru Wang, Haiyan Zhang, Jia Yan, Yu Yan, Pei Liu, Jingjun Zhao, Qingyu Zeng, Xiuli Wang","doi":"10.1016/j.jid.2025.01.018","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.018","url":null,"abstract":"<p><p>Severe acne vulgaris is a prevalent chronic inflammatory skin condition affecting individuals worldwide, with abnormal sebaceous gland function closely linked to its pathogenesis. 5-Aminolevulinic acid photodynamic therapy (ALA-PDT) effectively and safely treats severe acne; however, the mechanisms underlying its effects remain unclear. In this study, we first noted a decrease in lipid production following ALA-PDT in patients with clinical acne, acne-like mouse models, and the human immortalized sebocyte cell line XL-i-20. Through RNA sequencing, we identified significant upregulation of the transcription factor nuclear receptor 4A1(NR4A1) after ALA-PDT. Further confirmation of NR4A1 upregulation and its nuclear translocation under ALA-PDT was obtained in vitro and in vivo. Both the knockdown and overexpression of NR4A1 were shown to reverse or enhance the suppressive effect of ALA-PDT on lipid production. Following findings suggest that ALA-PDT inhibits the Akt signaling pathway, resulting in the activation of JunD, which subsequently enhances NR4A1 transcription and facilitates its inhibitory effect on lipid production. Overall, our findings highlight the crucial role of NR4A1 in regulating sebaceous lipids, elucidate the mechanism by which ALA-PDT treats acne, and lay the groundwork for enhancing the clinical applications of ALA-PDT.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemistry to monitor skin barrier: a proof-of-concept study on skin differentiation compared to corneometry, TEWL measurement, and High-Performance Liquid Chromatography.
The Journal of investigative dermatology Pub Date : 2025-02-06 DOI: 10.1016/j.jid.2024.11.031
William Richard, Alain Moga, Gilles Genain, Nicolas Amalric, Mélissa Eveillard, Jason Shourick, Sophie Le Tanneur, Elisa Funck-Brentano, Charbel Skayem, Stanislas Vandier, Tu Anh Duong
{"title":"Electrochemistry to monitor skin barrier: a proof-of-concept study on skin differentiation compared to corneometry, TEWL measurement, and High-Performance Liquid Chromatography.","authors":"William Richard, Alain Moga, Gilles Genain, Nicolas Amalric, Mélissa Eveillard, Jason Shourick, Sophie Le Tanneur, Elisa Funck-Brentano, Charbel Skayem, Stanislas Vandier, Tu Anh Duong","doi":"10.1016/j.jid.2024.11.031","DOIUrl":"https://doi.org/10.1016/j.jid.2024.11.031","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143375121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIF-1 Un-LOX Mechanical Mechanisms in Psoriasis.
The Journal of investigative dermatology Pub Date : 2025-02-05 DOI: 10.1016/j.jid.2025.01.005
Boris Hinz
{"title":"HIF-1 Un-LOX Mechanical Mechanisms in Psoriasis.","authors":"Boris Hinz","doi":"10.1016/j.jid.2025.01.005","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.005","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143367061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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