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The Journal of investigative dermatology最新文献

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Autosomal Dominant Lamellar Ichthyosis Keeps Surprising Us. 常染色体显性片状鱼鳞病不断给我们带来惊喜。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-07-11 DOI: 10.1016/j.jid.2024.05.008
Heiko Traupe
{"title":"Autosomal Dominant Lamellar Ichthyosis Keeps Surprising Us.","authors":"Heiko Traupe","doi":"10.1016/j.jid.2024.05.008","DOIUrl":"10.1016/j.jid.2024.05.008","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2616-2617"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus. 在丘疹性荨麻疹中，脱丝体过度粘附会影响对脱丝蛋白相互作用的直接抑制。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-04-26 DOI: 10.1016/j.jid.2024.03.042
Letyfee Steinert, Michael Fuchs, Anna M Sigmund, Dario Didona, Christoph Hudemann, Christian Möbs, Michael Hertl, Takashi Hashimoto, Jens Waschke, Franziska Vielmuth
{"title":"Desmosomal Hyper-Adhesion Affects Direct Inhibition of Desmoglein Interactions in Pemphigus.","authors":"Letyfee Steinert, Michael Fuchs, Anna M Sigmund, Dario Didona, Christoph Hudemann, Christian Möbs, Michael Hertl, Takashi Hashimoto, Jens Waschke, Franziska Vielmuth","doi":"10.1016/j.jid.2024.03.042","DOIUrl":"10.1016/j.jid.2024.03.042","url":null,"abstract":"<p><p>During differentiation, keratinocytes acquire a strong, hyper-adhesive state, where desmosomal cadherins interact calcium ion independently. Previous data indicate that hyper-adhesion protects keratinocytes from pemphigus vulgaris autoantibody-induced loss of intercellular adhesion, although the underlying mechanism remains to be elucidated. Thus, in this study, we investigated the effect of hyper-adhesion on pemphigus vulgaris autoantibody-induced direct inhibition of desmoglein (DSG) 3 interactions by atomic force microscopy. Hyper-adhesion abolished loss of intercellular adhesion and corresponding morphological changes of all pathogenic antibodies used. Pemphigus autoantibodies putatively targeting several parts of the DSG3 extracellular domain and 2G4, targeting a membrane-proximal domain of DSG3, induced direct inhibition of DSG3 interactions only in non-hyper-adhesive keratinocytes. In contrast, AK23, targeting the N-terminal extracellular domain 1 of DSG3, caused direct inhibition under both adhesive states. However, antibody binding to desmosomal cadherins was not different between the distinct pathogenic antibodies used and was not changed during acquisition of hyper-adhesion. In addition, heterophilic DSC3-DSG3 and DSG2-DSG3 interactions did not cause reduced susceptibility to direct inhibition under hyper-adhesive condition in wild-type keratinocytes. Taken together, the data suggest that hyper-adhesion reduces susceptibility to autoantibody-induced direct inhibition in dependency on autoantibody-targeted extracellular domain but also demonstrate that further mechanisms are required for the protective effect of desmosomal hyper-adhesion in pemphigus vulgaris.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2682-2694.e10"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keratinocytes Listen, Respond, and Actively Contribute to Crosstalk in the Epidermal Community and Beyond. 角质形成细胞倾听、回应并积极促进表皮群落内外的串联。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-07-09 DOI: 10.1016/j.jid.2024.03.045
Sara J Brown
{"title":"Keratinocytes Listen, Respond, and Actively Contribute to Crosstalk in the Epidermal Community and Beyond.","authors":"Sara J Brown","doi":"10.1016/j.jid.2024.03.045","DOIUrl":"10.1016/j.jid.2024.03.045","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2628-2630"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetic Study of Psoriasis Highlights its Close Link with Socioeconomic Status and Affective Symptoms. 对银屑病的遗传研究突出表明，银屑病与社会经济地位和情感症状密切相关。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-05-18 DOI: 10.1016/j.jid.2024.03.043
Anni Heikkilä, Eeva Sliz, Laura Huilaja, Kadri Reis, Priit Palta, Abdelrahman G Elnahas, Anu Reigo, Tõnu Esko, Triin Laisk, Maris Teder-Laving, Kaisa Tasanen, Johannes Kettunen
{"title":"Genetic Study of Psoriasis Highlights its Close Link with Socioeconomic Status and Affective Symptoms.","authors":"Anni Heikkilä, Eeva Sliz, Laura Huilaja, Kadri Reis, Priit Palta, Abdelrahman G Elnahas, Anu Reigo, Tõnu Esko, Triin Laisk, Maris Teder-Laving, Kaisa Tasanen, Johannes Kettunen","doi":"10.1016/j.jid.2024.03.043","DOIUrl":"10.1016/j.jid.2024.03.043","url":null,"abstract":"<p><p>Psoriasis is an inflammatory skin disease with an estimated heritability of around 70%. Previous GWASs have detected several risk loci for psoriasis. To further improve the understanding of the genetic risk factors impacting the disease, we conducted a discovery GWAS in FinnGen and a subsequent replication and meta-analysis with data from the Estonian Biobank and the UK Biobank; the study sample included 925,649 individuals (22,659 cases and 902,990 controls), the largest sample for psoriasis yet. In addition, we conducted downstream analyses to find out more about psoriasis' cross-trait genetic correlations and causal relationships. We report 6 risk loci, which, to our knowledge, are previously unreported, most of which harbor genes related to NF-κB signaling pathway and overall immunity. Genetic correlations highlight the relationship between psoriasis and smoking, higher body weight, and lower education level. In addition, we report causal relationships between psoriasis and mood symptoms as well as 2-directioned causal relationship between psoriasis and lower education level. Our results provide further knowledge on psoriasis risk factors, which may be useful in the development of future treatment strategies.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2719-2729"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mystery of Melanotransferrin in Melanoma. 黑色素瘤中黑色素转铁蛋白的奥秘。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-09-14 DOI: 10.1016/j.jid.2024.07.024
Gagan Chhabra, Nihal Ahmad
{"title":"Mystery of Melanotransferrin in Melanoma.","authors":"Gagan Chhabra, Nihal Ahmad","doi":"10.1016/j.jid.2024.07.024","DOIUrl":"10.1016/j.jid.2024.07.024","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2619-2622"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psoriasis: Disease Modification Today, Cure Tomorrow. 牛皮癣：今天改变疾病，明天治愈疾病。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1016/j.jid.2024.10.004
Joel M Gelfand
{"title":"Psoriasis: Disease Modification Today, Cure Tomorrow.","authors":"Joel M Gelfand","doi":"10.1016/j.jid.2024.10.004","DOIUrl":"10.1016/j.jid.2024.10.004","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2614-2615"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142515679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Essential Role of Macrophages in Contact Hypersensitivity-Induced Hair Regeneration. 巨噬细胞在接触过敏诱导的毛发再生中发挥着重要作用。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-06-25 DOI: 10.1016/j.jid.2024.05.022
Kai-Rong Huang, Sabrina Mai-Yi Fan, Kang-Yu Tai, Jian-Da Lin, Che-Feng Chang, Kai-Chien Yang, Sung-Jan Lin
{"title":"Essential Role of Macrophages in Contact Hypersensitivity-Induced Hair Regeneration.","authors":"Kai-Rong Huang, Sabrina Mai-Yi Fan, Kang-Yu Tai, Jian-Da Lin, Che-Feng Chang, Kai-Chien Yang, Sung-Jan Lin","doi":"10.1016/j.jid.2024.05.022","DOIUrl":"10.1016/j.jid.2024.05.022","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2805-2809"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SERPINB3/B4 Is Increased in Psoriasis and Rosacea Lesions and Has Proinflammatory Effects in Mouse Models of these Diseases. 银屑病和红斑痤疮皮损中的 SERPINB3/B4 增加，并在这些疾病的小鼠模型中具有促炎作用。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-05-10 DOI: 10.1016/j.jid.2024.04.011
Wenqin Xiao, Ke Sha, Mei Wang, Zixin Tan, Yunying Wang, San Xu, Zhixiang Zhao, Qian Wang, Hongfu Xie, Mengting Chen, Zhili Deng, Ji Li
{"title":"SERPINB3/B4 Is Increased in Psoriasis and Rosacea Lesions and Has Proinflammatory Effects in Mouse Models of these Diseases.","authors":"Wenqin Xiao, Ke Sha, Mei Wang, Zixin Tan, Yunying Wang, San Xu, Zhixiang Zhao, Qian Wang, Hongfu Xie, Mengting Chen, Zhili Deng, Ji Li","doi":"10.1016/j.jid.2024.04.011","DOIUrl":"10.1016/j.jid.2024.04.011","url":null,"abstract":"<p><p>Psoriasis and rosacea are both chronic inflammatory skin disorders resulted from aberrant keratinocyte-immune cell crosstalk, but the common molecular foundations for these 2 conditions are poorly understood. In this study, we reveal that both patients with psoriasis and those with rosacea as well as their mouse models have significantly elevated expressions of SERPINB3/B4 (members of serine protease inhibitor) in the lesional skin. Skin inflammation in mice that resembles both psoriasis and rosacea is prevented by SERPINB3/B4 deficiency. Mechanistically, we demonstrate that SERPINB3/B4 positively induces NF-κB signaling activation, thereby stimulating disease-characteristic inflammatory chemokines and cytokines production in keratinocytes and promoting the chemotaxis of CD4<sup>+</sup> T cells. Our results suggest that in keratinocytes, SERPINB3/B4 may be involved in the pathogenesis of both psoriasis and rosacea by stimulating NF-κB signaling, and they indicate a possible treatment overlap between these 2 diseases.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2706-2718.e6"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140913619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking the Vicious Cycle of Staphylococcal aureus Skin Colonization and Progression of Cutaneous T-Cell Lymphoma. 打破金黄色葡萄球菌皮肤定植与皮肤 T 细胞淋巴瘤恶化的恶性循环
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-07-14 DOI: 10.1016/j.jid.2024.05.021
Marshall E Kadin, Robert G Hamilton
{"title":"Breaking the Vicious Cycle of Staphylococcal aureus Skin Colonization and Progression of Cutaneous T-Cell Lymphoma.","authors":"Marshall E Kadin, Robert G Hamilton","doi":"10.1016/j.jid.2024.05.021","DOIUrl":"10.1016/j.jid.2024.05.021","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2617-2619"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141604724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A European Roundtable "Addressing Under-Prioritized Skin Diseases: Policy Responses to High-Burden Conditions". 欧洲圆桌会议 "应对未被充分重视的皮肤病：2024 年 2 月 6 日，欧洲圆桌会议 "应对未被充分重视的皮肤病：高负担疾病的对策"。
The Journal of investigative dermatology Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI: 10.1016/j.jid.2024.05.019
Yalchin Mammadov, Jennifer Austin, Tammi Shipowick, Karin Veldman, Sabine Eming, Andrea Szegedi, Eli Sprecher, Curdin Conrad
{"title":"A European Roundtable \"Addressing Under-Prioritized Skin Diseases: Policy Responses to High-Burden Conditions\".","authors":"Yalchin Mammadov, Jennifer Austin, Tammi Shipowick, Karin Veldman, Sabine Eming, Andrea Szegedi, Eli Sprecher, Curdin Conrad","doi":"10.1016/j.jid.2024.05.019","DOIUrl":"10.1016/j.jid.2024.05.019","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":"2631-2633"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141636270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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