The Journal of investigative dermatology最新文献_第3页

Boosting Skin Microcirculation for Androgenetic Alopecia: Does It Work?

The Journal of investigative dermatology Pub Date : 2025-02-04 DOI: 10.1016/j.jid.2024.11.025

Ayman Grada, Naiem Issa

引用次数: 0

Can We Trust Claims-Based Data?

The Journal of investigative dermatology Pub Date : 2025-02-04 DOI: 10.1016/j.jid.2024.12.019

Steven R Feldman, Alan B Fleischer

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Narrowband UVB and Solar-Simulated UV Suppress Systemic Immune Responses Through Different Mechanisms.

The Journal of investigative dermatology Pub Date : 2025-02-03 DOI: 10.1016/j.jid.2024.11.030

Rachael A Ireland, Benita Cy Tse, Anneliese S Ashhurst, Anthony S Don, Scott N Byrne

{"title":"Narrowband UVB and Solar-Simulated UV Suppress Systemic Immune Responses Through Different Mechanisms.","authors":"Rachael A Ireland, Benita Cy Tse, Anneliese S Ashhurst, Anthony S Don, Scott N Byrne","doi":"10.1016/j.jid.2024.11.030","DOIUrl":"https://doi.org/10.1016/j.jid.2024.11.030","url":null,"abstract":"Ultraviolet radiation (UV)-induced immune suppression contributes to skin carcinogenesis but may also explain how sunlight protects from non-skin autoimmune diseases, particularly multiple sclerosis. Narrowband UVB (NBUVB) phototherapy is an effective treatment for some skin diseases, but its mechanism of action and potential for treating diseases away from the skin are not well understood. Solar-simulated UV (ssUV) modulates immune cells in part by altering lipids, but whether NBUVB has the same effect on these cells and molecules is unknown. Exposing mice to an immune-suppressive dose of NBUVB did not affect plasma lipids that were altered following ssUV irradiation. Surprisingly, unlike what occurs after ssUV, dermal mast cells and lymphocyte recirculation were unaffected by NBUVB. NBUVB-irradiated skin had reduced epidermal CD207+ cells and cutaneous CD3+ T cells, and was infiltrated by Ly6G+ neutrophils. There was also an increase in CD4+FoxP3+ T cells in the skin-draining lymph nodes and suppression of antigen-specific CD8+ T cell activity in vivo. Thus, immune-suppressive NBUVB activated some, but not all, pathways responsible for the immune suppressive effects of ssUV. Understanding the wavelength-dependent effects of UV radiation on the immune system is essential for harnessing its immunomodulatory capacity to treat a wider range of diseases.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pemphigus vulgaris autoantibodies induce an ER stress response.

The Journal of investigative dermatology Pub Date : 2025-02-03 DOI: 10.1016/j.jid.2024.12.028

Coryn L Hoffman, Navaneetha Krishnan Bharathan, Yoshitaka Shibata, William Giang, Johann E Gudjonsson, John T Seykora, Stephen M Prouty, Sara N Stahley, Aimee S Payne, Andrew P Kowalczyk

{"title":"Pemphigus vulgaris autoantibodies induce an ER stress response.","authors":"Coryn L Hoffman, Navaneetha Krishnan Bharathan, Yoshitaka Shibata, William Giang, Johann E Gudjonsson, John T Seykora, Stephen M Prouty, Sara N Stahley, Aimee S Payne, Andrew P Kowalczyk","doi":"10.1016/j.jid.2024.12.028","DOIUrl":"10.1016/j.jid.2024.12.028","url":null,"abstract":"Desmosomes are intercellular junctions that mediate cell-cell adhesion and are essential for maintaining tissue integrity. Pemphigus vulgaris (PV) is an autoimmune epidermal blistering disease caused by autoantibodies (IgG) targeting desmoglein 3 (Dsg3), a desmosomal cadherin. PV autoantibodies cause desmosome disassembly and loss of cell-cell adhesion, but the molecular signaling pathways that regulate these processes are not fully understood. Using high-resolution time-lapse imaging of live keratinocytes, we found that ER tubules make frequent and persistent contacts with internalizing Dsg3 puncta in keratinocytes treated with PV patient IgG. Biochemical experiments demonstrated that PV IgG activated ER stress signaling pathways, including both IRE1⍺ and PERK pathways, in cultured keratinocytes. Further, ER stress transcripts were upregulated in PV patient skin. Pharmacological inhibition of ER stress protected against PV IgG-induced desmosome disruption and loss of keratinocyte cell-cell adhesion, suggesting that ER stress may be an important pathomechanism and a therapeutically targetable pathway for PV treatment. These data support a model in which desmosome adhesion is integrated with ER function to serve as a cell adhesion stress sensor that is activated in blistering skin disease.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Research Hotspots and Trends in Psoriasis Literature: Autotuned Topic Modeling with Agent.

The Journal of investigative dermatology Pub Date : 2025-01-31 DOI: 10.1016/j.jid.2024.11.029

Sunsi Wu, Dan Wang, Xinpei Gu, Ruiheng Xiao, Hongzhi Gao, Bo Yang, Yanlan Kang

{"title":"Identifying Research Hotspots and Trends in Psoriasis Literature: Autotuned Topic Modeling with Agent.","authors":"Sunsi Wu, Dan Wang, Xinpei Gu, Ruiheng Xiao, Hongzhi Gao, Bo Yang, Yanlan Kang","doi":"10.1016/j.jid.2024.11.029","DOIUrl":"https://doi.org/10.1016/j.jid.2024.11.029","url":null,"abstract":"The rapid expansion of psoriasis research literature presents challenges for efficient analysis and trend identification, necessitating advanced approaches. We propose AgenTopic, an interactive topic modeling framework that integrates BERT embeddings, dimensionality reduction, clustering, and a language model feedback loop to analyze psoriasis research literature from 2000 to 2023. Applied to PubMed articles, AgenTopic extracted 158 psoriasis-related topics across 8 categories, outperforming traditional methods in handling complex medical literature. Further trend analysis using multiple modeling techniques, including an SVR-Linear model, revealed non-linear patterns in research growth across categories (R2 values 0.75-0.97). Key trends identified include focus on nail psoriasis and spondyloarthritis, shift from TNF-α to IL-17 in pathogenesis understanding, rapid development of biologics and small molecule inhibitors, and increased attention to comorbidities. We developed an interactive web tool to facilitate literature retrieval and trend identification. To our knowledge, this application of an agent-based interactive topic modeling framework to dermatological literature is previously unreported. Using only topic-modeled data, our framework achieved comparable performance to expert manual review in identifying research trends. AgenTopic performed better than several state-of-the-art topic modeling methods and demonstrated the potential of AI in advancing medical literature analysis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle via TRPA1 Activation on Mast Cells in Atopic Dermatitis.

The Journal of investigative dermatology Pub Date : 2025-01-30 DOI: 10.1016/j.jid.2024.12.026

Jiahui Hu, Qiang Zhao, Delu Che, Bin Peng, Xi Wang, Zhuochen CathyWang, Li Li, Songmei Geng

{"title":"Epidermal Mechanical Scratching-Induced ROS Exacerbates the Itch-Scratch Cycle via TRPA1 Activation on Mast Cells in Atopic Dermatitis.","authors":"Jiahui Hu, Qiang Zhao, Delu Che, Bin Peng, Xi Wang, Zhuochen CathyWang, Li Li, Songmei Geng","doi":"10.1016/j.jid.2024.12.026","DOIUrl":"https://doi.org/10.1016/j.jid.2024.12.026","url":null,"abstract":"Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by the itch-scratch cycle. Itching, induced by irritants or allergens that stimulate pruriceptive neurons, triggers uncontrollable mechanical scratching, leading to epidermal barrier disruption, immune response activation, inflammatory mediator release, and further stimulation of pruritus conduction. Although oxidative stress and immune cells can exacerbate this cycle, the correlation between mechanical scratching, epidermal oxidative stress, and dermal mast cell activation in AD remains unclear. Here, by examining clinical specimens of AD, establishing a three-dimensional co-culture system of HaCaT and LAD2 cells, and utilizing a mechanical scratching mouse model of AD, we found that reactive oxygen species produced by mechanically stimulated HaCaT can activate TRPA1 on mast cells presenting tryptase (TPS). Implementing a free radical scavenger and TRPA1 inhibitor can inhibit mast cell activation and type II inflammatory response, thereby alleviating itching and skin lesions in AD. These results indicate that active oxygen scavenging combined with TRPA1 inhibition can inhibit the itch-scratch cycle, which may present a potential approach for the treatment of AD.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum IFNα as a Biomarker for Cutaneous Lupus: Insights into Disease Activity, Severity, Therapeutic Monitoring and Clinical Trial Application.

The Journal of investigative dermatology Pub Date : 2025-01-30 DOI: 10.1016/j.jid.2025.01.003

Touraj Khosravi-Hafshejani, Victoria P Werth

引用次数: 0

Insight into the Relationship between Congenital Large/Giant Melanocytic Nevi and Satellite Nevi.

The Journal of investigative dermatology Pub Date : 2025-01-29 DOI: 10.1016/j.jid.2024.10.620

Jieyu Gu, Boxuan Wei, Ran Duan, Jiamin Jin, Bohan Lai, Jiao Wei, Feng Xie

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Epigenetic Changes Cause Aberrantly High Expression of SOX11, Leading to Systemic Sclerosis.

The Journal of investigative dermatology Pub Date : 2025-01-28 DOI: 10.1016/j.jid.2025.01.016

Yasuhiro Nanri, Satoshi Nunomura, Yuko Honda, Kanako Yokomizo, Hironobu Takedomi, Yukie Yamaguchi, Hidenobu Soejima, Kenji Izuhara

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Multi-omic Sequencing of Intermediate to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.

The Journal of investigative dermatology Pub Date : 2025-01-28 DOI: 10.1016/j.jid.2025.01.015

Shams Nassir, Miranda Yousif, Xing Li, Kevin J Severson, Alysia Hughes, Jake Kechter, Angelina Hwang, Blake Boudreaux, Puneet Bhullar, Nan Zhang, Richard J Butterfield, Tao Ma, Zachary Leibovit-Reiben, Alyssa Stockard, Ewoma Ogbaudu, Collin M Costello, Steven A Nelson, David J DiCaudo, Aleksandar Sekulic, Christian L Baum, Mark R Pittelkow, Aaron R Mangold

{"title":"Multi-omic Sequencing of Intermediate to High-Risk Cutaneous Squamous Cell Carcinoma Identifies Critical Genes and Expression Patterns Associated with Disease and Poor Outcomes.","authors":"Shams Nassir, Miranda Yousif, Xing Li, Kevin J Severson, Alysia Hughes, Jake Kechter, Angelina Hwang, Blake Boudreaux, Puneet Bhullar, Nan Zhang, Richard J Butterfield, Tao Ma, Zachary Leibovit-Reiben, Alyssa Stockard, Ewoma Ogbaudu, Collin M Costello, Steven A Nelson, David J DiCaudo, Aleksandar Sekulic, Christian L Baum, Mark R Pittelkow, Aaron R Mangold","doi":"10.1016/j.jid.2025.01.015","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.015","url":null,"abstract":"Cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in humans and kills as many people annually as melanoma. The understanding of the transcriptional changes with respect to high-risk clinical/histopathological features and outcome is poor. Here, we examine stage-matched, outcome-differentiated cSCC using whole exome and transcriptome sequencing. Exome analysis identified key driver mutations including TP53, CDKN2A, NOTCH1, SHC4, MIIP, CNOT1, C17orf66, LPHN2, and TTC16 and pathway enrichment of driver mutations in replicative senescence, cellular response to UV, cell-cell adhesion, and cell cycle. Transcriptomic analysis identified pathway enrichment of immune signaling/inflammation, cell-cycle pathways, extracellular matrix function, and chromatin function. Integrative analysis identified 183 critical genes in carcinogenesis and were used to develop a gene expression panel (GEP) for outcome. Three outcome-related gene clusters included those involved in keratinization, cell division, and metabolism. We found 16 genes whose expression may be associated with metastasis (risk score ≥ 9 Met & risk score < 9 NoMet) with an AUC of 97.1%, sensitivity 95.5%, specificity 85.7%, and overall accuracy of 90%. Eleven genes were chosen to generate the risk score for Overall Survival (OS) with an OS prediction of 80.8% and each risk gene increasing the risk of death by 2.47 (HR: 2.47; p<0.001).","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0