The Journal of investigative dermatology最新文献_第3页

Cutibacterium Adaptation to Life on Humans Provides a Potential C. acnes Infection Biomarker. 皮肤细菌对人类生命的适应提供了一个潜在的痤疮杆菌感染的生物标志物。

The Journal of investigative dermatology Pub Date : 2025-05-26 DOI: 10.1016/j.jid.2025.03.048

Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H McCoy

{"title":"Cutibacterium Adaptation to Life on Humans Provides a Potential C. acnes Infection Biomarker.","authors":"Md Shafiuddin, Wen-Chi Huang, Gabriel William Prather, Jeffrey Ryan Anton, Andrew Lawrence Martin, Sydney Brianna Sillart, Jonathan Z Tang, Michael R Vittori, Michael J Prinsen, Jessica Jane Ninneman, Chandrashekhara Manithody, Jeffrey P Henderson, Alexander W Aleem, Ma Xenia Garcia Ilagan, William H McCoy","doi":"10.1016/j.jid.2025.03.048","DOIUrl":"10.1016/j.jid.2025.03.048","url":null,"abstract":"Propionibacteriaceae appear to have adapted to life on humans during the domestication of cattle. These microbial immigrants formed the genus Cutibacterium, and a descendent of those microbial trailblazers (C. acnes) now dominates 25% of human skin. C. acnes colonization of human skin requires the protein RoxP. While all Cutibacteria encode this adaptation to life on humans, nothing like RoxP has been found in any other organism. Herein, we report an extensive assessment of twenty-one RoxP orthologs, which identified conserved molecular surfaces linked to heme-dependent oligomerization and low pH stability. Our investigation suggests how RoxP helps C. acnes dominant sebaceous skin, and it identified an ortholog associated with the emergence of an acne vulgaris-associated, pathobiont subspecies. C. acnes is also an emerging pathogen that frequently infects joint prostheses and other medical devices. These infections are often missed, because there is no test to confirm a C. acnes infection. To address this clinical need, we developed immunoassays that can assess RoxP in human biofluids commonly infected by C. acnes. This study's findings and assays will help shed light on the consequences of Neolithic Age livestock domestication, the evolution of skin commensals into pathogens, and how to identify infections of human \"replacement parts.\"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improving Adverse Event Reporting in Dermatology Trials. 改善皮肤病学试验不良事件报告。

The Journal of investigative dermatology Pub Date : 2025-05-26 DOI: 10.1016/j.jid.2025.03.015

Hossein Akbarialiabad, Ayman Grada

引用次数: 0

ScRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR T Cells in Tertiary Lymphoid Structures(TLS) in Pemphigus. ScRNA+TCR-seq揭示天疱疮三级淋巴结构（TLS）中双TCR T细胞的比例和特征。

The Journal of investigative dermatology Pub Date : 2025-05-24 DOI: 10.1016/j.jid.2025.05.008

Kai Quan, Ying Yang, Chunming Li, Xinsheng Yao

{"title":"ScRNA+TCR-seq Reveals the Proportion and Characteristics of Dual TCR T Cells in Tertiary Lymphoid Structures(TLS) in Pemphigus.","authors":"Kai Quan, Ying Yang, Chunming Li, Xinsheng Yao","doi":"10.1016/j.jid.2025.05.008","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.008","url":null,"abstract":"The origin, characteristics, and the effects/mechanisms of lymphocytes within tertiary lymphoid structures (TLS) in pemphigus pathological skin tissue, as well as their role in pemphigus pathogenesis, remain unclear. Using scRNA+TCR-seq analysis, this study revealed that pemphigus TLS (P_TLS) contain a higher proportion of dual T-cell receptor (TCR) T cells compared to chronic idiopathic erythroderma (CIE) and healthy control (HC) skin tissues. Notably, P_TLS exhibit a unique enrichment of clonally expanded dual TCR CXCL13+CD4+ T cells, while the proportions of dual TCR Treg and dual TCR CD8+ T cells are reduced. However, CXCR5 is significantly upregulated in dual TCR Treg cells within P_TLS. The dual TCR T cells within P_TLS exhibit significant heterogeneity in their top 10 mRNA expressions compared to HC and CIE. For instance, P_TLS shows high expression of IL-17F, among others. There is also substantial heterogeneity in shared CDR3 (Complementarity Determining Region 3) sequences and V gene usage among single and dual TCR T cells across HC, P_TLS, and CIE. These findings provide insights and a basis for further exploring TLS formation, the origin, effects, and mechanisms of potential novel T-cell subsets in pemphigus pathogenesis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory Inputs Orchestrate Key Epidermal Functions. 感觉输入协调关键的表皮功能。

The Journal of investigative dermatology Pub Date : 2025-05-24 DOI: 10.1016/j.jid.2024.12.029

Mitsuhiro Denda, Peter M Elias

引用次数: 0

Differentiating the Role of Inflammation in Hidradenitis Suppurativa from that in Other Inflammatory Skin Diseases. 辨析化脓性汗腺炎与其他炎性皮肤病炎症的作用。

The Journal of investigative dermatology Pub Date : 2025-05-24 DOI: 10.1016/j.jid.2025.04.009

Angel S Byrd, Joshua M Moreau, Lynn Petukhova, John Frew

引用次数: 0

Integrative Molecular Analysis of Skin Tumors from CYLD Cutaneous Syndrome Patients. CYLD皮肤综合征患者皮肤肿瘤的综合分子分析。

The Journal of investigative dermatology Pub Date : 2025-05-22 DOI: 10.1016/j.jid.2025.05.006

Andrey A Yurchenko, Hiba Sharkhith, Fatemeh Rajabi, Sofia Bogiatzi, Jinxin Wang, Marcel Huber, Daniel Hohl, Sergey Nikolaev

{"title":"Integrative Molecular Analysis of Skin Tumors from CYLD Cutaneous Syndrome Patients.","authors":"Andrey A Yurchenko, Hiba Sharkhith, Fatemeh Rajabi, Sofia Bogiatzi, Jinxin Wang, Marcel Huber, Daniel Hohl, Sergey Nikolaev","doi":"10.1016/j.jid.2025.05.006","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.006","url":null,"abstract":"CYLD cutaneous syndrome (CCS) is a rare genetic disorder caused by germline CYLD mutations, leading to multiple benign skin tumors, including cylindromas, spiradenomas, and trichoepitheliomas. While these tumors are well-characterized histologically, their molecular landscape remains unclear, and no targeted treatments exist. To comprehensively analyze the molecular features of CCS tumors, we integrated newly generated and publicly available data using multiomic approaches. We profiled 24 CCS tumors through whole-exome/genome sequencing, RNA-seq, immunohistochemistry, and methylation arrays. To enhance statistical power, we incorporated existing CCS tumor datasets, forming a cohort of 50 tumors. CCS tumors exhibited a low mutational burden and scarce UV damage. The driver landscape was defined by mutations in CYLD, DNMT3A, and BCOR. The tumor microenvironment of cylindromas was rich in CD8+ T cells. Methylation profiling identified two groups: cylindromas, which appeared to originate from apocrine sweat glands, and trichoepitheliomas, which clustered with basal cell carcinoma. RNA sequencing revealed specific activation of the non-canonical NF-κB pathway in cylindromas, a finding confirmed by immunohistochemistry. This pathway may drive tumor formation, highlighting a potential therapeutic target for CCS. Our study provides insights into CCS tumor biology and suggests that targeting the non-canonical NF-κB pathway could be explored as a treatment strategy.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOD2-induced IκBζ mediates a protective host response against epicutaneous Staphylococcus aureus infection. nod2诱导的κ b ζ介导对表皮金黄色葡萄球菌感染的保护性宿主反应。

The Journal of investigative dermatology Pub Date : 2025-05-22 DOI: 10.1016/j.jid.2025.04.036

Berenice Fischer, Antonia Kolb, Enrico Focaccia, Tanja Kübelbeck, Matthias Klein, Dagmar Löck, Francesca Bork, Franziska Engelmann, Martina Casari, Elisa Mazza, Carsten Deppermann, Alexander N R Weber, Miriam Wittmann, Birgit Schittek, Klaus Schulze-Osthoff, Daniela Kramer

{"title":"NOD2-induced IκBζ mediates a protective host response against epicutaneous Staphylococcus aureus infection.","authors":"Berenice Fischer, Antonia Kolb, Enrico Focaccia, Tanja Kübelbeck, Matthias Klein, Dagmar Löck, Francesca Bork, Franziska Engelmann, Martina Casari, Elisa Mazza, Carsten Deppermann, Alexander N R Weber, Miriam Wittmann, Birgit Schittek, Klaus Schulze-Osthoff, Daniela Kramer","doi":"10.1016/j.jid.2025.04.036","DOIUrl":"https://doi.org/10.1016/j.jid.2025.04.036","url":null,"abstract":"IκBζ, an atypical and largely unknown member of the IκB family, is a transcriptional coactivator of selective immune functions. Here, we investigated the role of keratinocyte-derived IκBζ upon infection with a multidrug-resistant S. aureus strain. Infection of keratinocytes rapidly induced IκBζ expression, leading to an elevated expression of antimicrobial peptides, IL-17/IL-36-responsive genes, and proteins involved in skin barrier function. Conversely, loss of IκBζ resulted in increased S. aureus internalization, epidermal tissue damage, and severe skin infections in vivo. This impaired host defense upon IκBζ depletion was characterized by reduced antimicrobial peptide expression, and diminished recruitment of neutrophils and CD4+ T-cells. Importantly, S. aureus-induced IκBζ expression required the internalization of the bacteria and its sensing by the intracellular receptor NOD2, which triggered IκBζ and its target gene expression. Thus, we identified NOD2-IκBζ signaling as a novel pathway acting as a key mediator for a protective host defense against pathogenic S. aureus infections in the skin.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Proteomic Profiling Reveals Increased Levels of Cholesterol Synthesis Proteins in Psoriasis Vulgaris. 空间蛋白质组学分析揭示寻常型银屑病中胆固醇合成蛋白水平升高。

The Journal of investigative dermatology Pub Date : 2025-05-22 DOI: 10.1016/j.jid.2025.05.002

Line B P Møller, Bjørn Kromann, Sonja Kabatnik, Johanne Hatorp Hjortlund, Morten Bahrt Haulrig, Julie B K Sølberg, Michael Bzorek, Rachael A Clark, Lone Skov, Matthias Mann, Marianne Bengtson Løvendorf, Beatrice Dyring-Andersen

{"title":"Spatial Proteomic Profiling Reveals Increased Levels of Cholesterol Synthesis Proteins in Psoriasis Vulgaris.","authors":"Line B P Møller, Bjørn Kromann, Sonja Kabatnik, Johanne Hatorp Hjortlund, Morten Bahrt Haulrig, Julie B K Sølberg, Michael Bzorek, Rachael A Clark, Lone Skov, Matthias Mann, Marianne Bengtson Løvendorf, Beatrice Dyring-Andersen","doi":"10.1016/j.jid.2025.05.002","DOIUrl":"https://doi.org/10.1016/j.jid.2025.05.002","url":null,"abstract":"Psoriasis arises from a combination of genetic and environmental factors, triggering inflammatory circuits involving innate and adaptive immune responses. While the associated histological changes are well described, the changes on the protein level associated with the inflammation and tissue remodeling have only been characterized to a limited extent and with a low degree of spatial information. Therefore, we aimed to to explore skin layer-specific proteomic changes in psoriatic plaques. Using laser-capture microdissection, we divided skin biopsies from patients with psoriasis (N=8) and healthy controls (N=8) into four layers (stratum corneum, inner epidermis, dermis, and subcutis) and analyzed the protein composition of each layer using mass spectrometry. A total of 7,236 proteins were identified and 1,649 proteins were differentially expressed in lesional versus non-lesional inner epidermis. Several of the upregulated proteins related to innate immunity and cholesterol biosynthesis. Stratum corneum showed a more complex protein composition in psoriatic lesions compared to controls, while dermis exhibited upregulation of proteins involved in IL-17 signaling and neutrophil chemotaxis. No differences were detected in subcutis. Our findings highlight the inner epidermis as central to psoriasis pathology, driven by both innate and adaptive immune mechanisms that are potentially enhanced by an increased cholesterol production.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Microbial Shield: Interactions between UVR, cis-Urocanic Acid, and the Skin Microbiome. 微生物屏蔽：紫外线辐射、顺式尿酸和皮肤微生物群之间的相互作用。

The Journal of investigative dermatology Pub Date : 2025-05-22 DOI: 10.1016/j.jid.2025.04.010

Emanuela Camera, Anna Di Nardo

引用次数: 0

The Visceral Relationship of Psoriasis and Obesity. 银屑病与肥胖的内脏关系。

The Journal of investigative dermatology Pub Date : 2025-05-21 DOI: 10.1016/j.jid.2025.04.013

Joel M Gelfand

引用次数: 0