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The Journal of investigative dermatology最新文献

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A Review of Metabolic Dysregulation in Lymphocytic Cicatricial Alopecia: Exploring the Connections and Therapeutic Implications.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.01.036
Aaron Bao, Lindsey A Bordone, Crystal Aguh
{"title":"A Review of Metabolic Dysregulation in Lymphocytic Cicatricial Alopecia: Exploring the Connections and Therapeutic Implications.","authors":"Aaron Bao, Lindsey A Bordone, Crystal Aguh","doi":"10.1016/j.jid.2025.01.036","DOIUrl":"https://doi.org/10.1016/j.jid.2025.01.036","url":null,"abstract":"<p><p>Lymphocytic primary cicatricial alopecia (LPCA) is an inflammatory disorder characterized by permanent hair follicle destruction and fibrosis. Recent evidence suggests a significant link between LPCA and metabolic dysregulation, particularly diabetes and dyslipidemia. This review examines the emerging role of metabolism in LPCA pathogenesis and its implications for novel therapeutic approaches. Epidemiologic studies demonstrate increased prevalence of metabolic disorders among patients with LPCA, whereas molecular investigations reveal altered metabolic pathways in affected hair follicles, including disruptions in peroxisome proliferator-activated receptor γ signaling and adenosine monophosphate-activated protein kinase activation, mechanisms that parallel those observed in other fibrotic diseases. These pathways appear to precede inflammatory changes, suggesting metabolic dysfunction as a primary trigger rather than a secondary effect. Preliminary treatments targeting these pathways, such as pioglitazone and metformin, have shown promising results in normalizing lipid metabolism and reducing inflammation, although their clinical efficacy across LPCA subtypes requires further investigation. The review also explores emerging therapeutic possibilities, including glucagon-like peptide-1 agonists. Understanding the interplay between metabolic disturbances, fibrosis, and inflammation in the pathogenesis of LPCA offers new avenues for both research and treatment. This paradigm shift suggests the need for metabolic screening in patients with LPCA and highlights the potential for developing more comprehensive, metabolism-targeted therapies to improve outcomes in these challenging hair disorders.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TIE-2 expressing monocytic myeloid-derived suppressor cells are involved in resistance to anti-PD-1 therapy mediated by angiopoietin 2 in melanoma patients.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.150
Amélie Marguier, Jessica Mathiot, Babacar NDao, Mylène Wespiser, Victor Pereira, Benoît Lecoester, Laura Boullerot, Marine Malfroy, Caroline Laheurte, François Aubin, Olivier Adotevi, Charlée Nardin
{"title":"TIE-2 expressing monocytic myeloid-derived suppressor cells are involved in resistance to anti-PD-1 therapy mediated by angiopoietin 2 in melanoma patients.","authors":"Amélie Marguier, Jessica Mathiot, Babacar NDao, Mylène Wespiser, Victor Pereira, Benoît Lecoester, Laura Boullerot, Marine Malfroy, Caroline Laheurte, François Aubin, Olivier Adotevi, Charlée Nardin","doi":"10.1016/j.jid.2025.02.150","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.150","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial Dysfunction in Keloid Formation and Therapeutic Insights.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.134
Junxian Wen, Zhijin Li, Yingrou Tan, Hong Liang Tey, Nanze Yu, Xiaojun Wang
{"title":"Endothelial Dysfunction in Keloid Formation and Therapeutic Insights.","authors":"Junxian Wen, Zhijin Li, Yingrou Tan, Hong Liang Tey, Nanze Yu, Xiaojun Wang","doi":"10.1016/j.jid.2025.02.134","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.134","url":null,"abstract":"<p><p>Keloids are benign fibroproliferative tumors that cause significant physical and mental morbidity owing to their disfiguring appearance, chronic symptoms, and resistance to treatment. Although fibroblast hyperproliferation and excessive extracellular matrix deposition have been extensively studied, less attention has been paid to the role of vascular dysregulation and endothelial dysfunction (ED) in keloid pathogenesis. Emerging evidence highlights abnormal angiogenesis, vascular irregularities, and endothelial injury as critical drivers of fibrosis in keloids. This review explores the direct and indirect mechanisms of ED in keloid progression, including endothelial-to-mesenchymal transition, inflammation, immune cell crosstalk, and hypoxia. In addition, various treatment strategies targeting angiogenesis and ED, such as drugs, radiotherapy, hyperbaric oxygen therapy, compression, and laser treatments, are comprehensively reviewed. This review explores keloids through the lens of vasculature and endothelium, emphasizing the critical roles of vascular dysregulation and ED. It aims to provide insights into the mechanisms of keloid formation and serve as a reference for developing future therapeutic strategies.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus.
The Journal of investigative dermatology Pub Date : 2025-03-18 DOI: 10.1016/j.jid.2025.02.148
Michal Kidacki, Christina Cho, Francesc Lopez-Giraldez, Rachel Breidbart, Anjali Jaiswal, Morten Lee, Shanin Chowdhury, William Damsky, Lieping Chen, Matthew D Vesely
{"title":"Spatial Transcriptomics Reveals Differential Inflammatory Pathways in Discoid Lupus Erythematosus and Lichen Planus.","authors":"Michal Kidacki, Christina Cho, Francesc Lopez-Giraldez, Rachel Breidbart, Anjali Jaiswal, Morten Lee, Shanin Chowdhury, William Damsky, Lieping Chen, Matthew D Vesely","doi":"10.1016/j.jid.2025.02.148","DOIUrl":"10.1016/j.jid.2025.02.148","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of IL-17 Antibody in Psoriasis on Brain Structural Morphology Reveals Significant Changes in the Precuneus.
The Journal of investigative dermatology Pub Date : 2025-03-13 DOI: 10.1016/j.jid.2025.02.147
Hideki Mochizuki, Sarah G Brooks, Rami H Mahmoud, Luis F Andrade, Ju Teresa, Neda Ghiam, Gil Yosipovitch
{"title":"The Effect of IL-17 Antibody in Psoriasis on Brain Structural Morphology Reveals Significant Changes in the Precuneus.","authors":"Hideki Mochizuki, Sarah G Brooks, Rami H Mahmoud, Luis F Andrade, Ju Teresa, Neda Ghiam, Gil Yosipovitch","doi":"10.1016/j.jid.2025.02.147","DOIUrl":"10.1016/j.jid.2025.02.147","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating Adverse Event Reporting in Parallel-Group Randomized Trials Published in Dermatology-Specific Journals: A Methodological Systematic Review.
The Journal of investigative dermatology Pub Date : 2025-03-13 DOI: 10.1016/j.jid.2025.02.144
Zexing Song, Justin Pymento, Tessa Bortoluzzi, Manav V Vyas, Elizabeth M Uleryk, An-Wen Chan
{"title":"Evaluating Adverse Event Reporting in Parallel-Group Randomized Trials Published in Dermatology-Specific Journals: A Methodological Systematic Review.","authors":"Zexing Song, Justin Pymento, Tessa Bortoluzzi, Manav V Vyas, Elizabeth M Uleryk, An-Wen Chan","doi":"10.1016/j.jid.2025.02.144","DOIUrl":"10.1016/j.jid.2025.02.144","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Significance of Prognostic Factors across Tumor Thicknesses in Melanoma: A National Cohort Study.
The Journal of investigative dermatology Pub Date : 2025-03-12 DOI: 10.1016/j.jid.2025.02.146
Kevin Ma, Neha Shafique, Gabriella Tortorello, Anushka Dheer, Luke J Keele, Giorgos C Karakousis, Michael E Ming
{"title":"Significance of Prognostic Factors across Tumor Thicknesses in Melanoma: A National Cohort Study.","authors":"Kevin Ma, Neha Shafique, Gabriella Tortorello, Anushka Dheer, Luke J Keele, Giorgos C Karakousis, Michael E Ming","doi":"10.1016/j.jid.2025.02.146","DOIUrl":"10.1016/j.jid.2025.02.146","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Beauty of Fibroblasts Is Several Skin Layers Deep and Much Deeper.
The Journal of investigative dermatology Pub Date : 2025-03-10 DOI: 10.1016/j.jid.2025.02.010
R Wilder Scott
{"title":"The Beauty of Fibroblasts Is Several Skin Layers Deep and Much Deeper.","authors":"R Wilder Scott","doi":"10.1016/j.jid.2025.02.010","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.010","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Changing Landscape of Photodermatology. 不断变化的光皮肤病学。
The Journal of investigative dermatology Pub Date : 2025-03-10 DOI: 10.1016/j.jid.2025.02.008
David X Gao, Henry W Lim
{"title":"The Changing Landscape of Photodermatology.","authors":"David X Gao, Henry W Lim","doi":"10.1016/j.jid.2025.02.008","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.008","url":null,"abstract":"","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Formyl Peptide Receptor 2 and Toll-Like Receptor 2 in Skin Barrier Function and Atopic Dermatitis.
The Journal of investigative dermatology Pub Date : 2025-03-09 DOI: 10.1016/j.jid.2025.02.002
Marco Lebtig, Andreas Peschel, Dorothee Kretschmer
{"title":"Role of Formyl Peptide Receptor 2 and Toll-Like Receptor 2 in Skin Barrier Function and Atopic Dermatitis.","authors":"Marco Lebtig, Andreas Peschel, Dorothee Kretschmer","doi":"10.1016/j.jid.2025.02.002","DOIUrl":"https://doi.org/10.1016/j.jid.2025.02.002","url":null,"abstract":"<p><p>The skin acts as a barrier against external threats and plays an important role in tissue repair. Skin cells, including keratinocytes, sense microbe-associated molecular pattern molecules released by members of the bacterial microbiome, and the cellular responses control central processes of skin homeostasis or inflammation. How the combination and amount of different microbe-associated molecular patterns modulate skin cell functions is not yet fully understood. Here, we review the current knowledge of the responses of skin cells to microbe-associated molecular patterns, focusing on Toll-like receptor 2 and formyl peptide receptor 2, two of the most important receptors for sensing the skin microbiome.</p>","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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