The Journal of investigative dermatology最新文献_第4页

The Acid Mantle Reimagined: Unveiling the Role of Stepwise pH Zonation in the Stratum Corneum.

The Journal of investigative dermatology Pub Date : 2025-03-09 DOI: 10.1016/j.jid.2025.02.129

Keitaro Fukuda, Yoshihiro Ito, Masayuki Amagai

引用次数: 0

A Disproportionality Analysis on Benzoyl Peroxide and Its Risk of Malignancy Using the FDA Adverse Event Reporting System.

The Journal of investigative dermatology Pub Date : 2025-03-07 DOI: 10.1016/j.jid.2025.02.139

Kerry Yang, Sonia Czyz, Rayyan Zuberi, Jason Kreutz, Christopher G Bunick, Fatemeh Jafarian

引用次数: 0

Blood Transcriptome Signature as Indicator and Predictor for Efficacy of Abrocitinib in Treatment of Atopic Dermatitis.

The Journal of investigative dermatology Pub Date : 2025-03-07 DOI: 10.1016/j.jid.2025.02.145

Yu Wang, Huibin Yin, Zheng Li, Hao Wu, Qianhao Wang, Xingyu Chen, Liya Mao, Yuemeng Wu, Shangshang Wang, Haihong Qin, Chaoying Gu, Xu Yao, Wei Li

{"title":"Blood Transcriptome Signature as Indicator and Predictor for Efficacy of Abrocitinib in Treatment of Atopic Dermatitis.","authors":"Yu Wang, Huibin Yin, Zheng Li, Hao Wu, Qianhao Wang, Xingyu Chen, Liya Mao, Yuemeng Wu, Shangshang Wang, Haihong Qin, Chaoying Gu, Xu Yao, Wei Li","doi":"10.1016/j.jid.2025.02.145","DOIUrl":"10.1016/j.jid.2025.02.145","url":null,"abstract":"Patients with atopic dermatitis (AD) exhibit significant blood transcriptome alterations, reflecting systemic inflammation. The effects of abrocitinib, a Jak1 inhibitor, on the blood transcriptome of AD remain unclear. This study aimed to investigate abrocitinib's effects on the blood transcriptome in patients with AD and identify transcriptomic predictors of treatment efficacy. Blood cell mRNA sequencing was conducted on 31 patients with AD at baseline and 4 and 12 weeks of 100 mg abrocitinib daily treatment. Differential gene expression, immune infiltration, and weighted gene coexpression network analyses were performed, along with correlation analysis of transcriptomic data and clinical traits. We observed that abrocitinib treatment significantly improved clinical signs of AD. Correspondingly, blood transcriptome normalization, including downregulation of T helper 2, T helper 1, and eosinophil and an increase in type 1 regulatory T-cell abundance, rapidly occurred by week 4, with slight rebound by week 12. Higher baseline eosinophil counts predicted greater transcript normalization. Weighted gene coexpression network analyses identified an efficacy-related gene module, leading to a 5-gene (PLIN2, CAT, CLC, RAB44, and SMPD3) efficacy-predictive model, which was validated in another independent cohort of 30 patients with AD treated with abrocitinib. In conclusion, abrocitinib treatment resulted in rapid and extensive normalization of the dysregulated blood transcripts in AD, which was associated with its clinical efficacy.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular Granzyme B Mediates the Degradation of Collagen XVII in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.

The Journal of investigative dermatology Pub Date : 2025-03-06 DOI: 10.1016/j.jid.2025.02.140

Michael Lane, Alexandre Aubert, Anna Prudova, Faith Liu, Valerio Russo, Karen Jung, Touraj Khosravi-Hafshejani, Hongyan Zhao, Richard I Crawford, Elizabeth Phillips, David J Granville

引用次数: 0

Endothelial Piezo1 Mediates Barrier Dysfunction and NLRP3 Inflammasomes Activation in Psoriasis.

The Journal of investigative dermatology Pub Date : 2025-03-05 DOI: 10.1016/j.jid.2025.01.037

Lixin Yue, Bingyu Pang, Guohao Li, Chen Zhang, Qingyang Li, Kang Li, Hui Fang, Zhenlai Zhu, Shuai Shao, Erle Dang, Gang Wang, Pei Qiao

{"title":"Endothelial Piezo1 Mediates Barrier Dysfunction and NLRP3 Inflammasomes Activation in Psoriasis.","authors":"Lixin Yue, Bingyu Pang, Guohao Li, Chen Zhang, Qingyang Li, Kang Li, Hui Fang, Zhenlai Zhu, Shuai Shao, Erle Dang, Gang Wang, Pei Qiao","doi":"10.1016/j.jid.2025.01.037","DOIUrl":"10.1016/j.jid.2025.01.037","url":null,"abstract":"Psoriasis is a chronic inflammatory skin disease characterized by abnormal dilation of microvessels in the dermal papillary layer. Multiple studies have demonstrated that vascular endothelial cells regulate vascular function rather than merely acting as passive barriers. Piezo1 serves as a critical mechanical switch, sensing mechanical changes induced by vasodilation. However, the precise pathological role of Piezo1 in psoriasis remains unclear. In this study, we observed significant upregulation of Piezo1 in endothelial cells from the psoriatic dermis. Piezo1 activation impaired endothelial barrier function and promoted the expression of inflammatory factors. These alterations activated the NLRP3 inflammasome, which secretes IL-1β and IL-18, contributing to the local immune dysregulation characteristic of psoriasis. In addition, Piezo1 promoted mitochondrial ROS production and the release of mitochondrial DNA into the cytoplasm, thereby activating the NLRP3 inflammasome in endothelial cells. Furthermore, in mice with imiquimod-induced psoriasis-like dermatitis, Piezo1 suppression significantly alleviated the psoriasis-like phenotype, microvascular dilation, inflammatory infiltration, and NLRP3 inflammasome activation. Our findings suggest that the tortuous and dilated microvasculature in psoriatic skin disrupts vascular barriers and promotes NLRP3 inflammasome activation through Piezo1, contributing to the onset and progression of psoriasis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143589155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamatergic Projections from the Basolateral Amygdala to Medial Prefrontal Cortex Contribute to Acute Itch Sensation Processing.

The Journal of investigative dermatology Pub Date : 2025-03-03 DOI: 10.1016/j.jid.2025.02.138

Qiuying Zhao, Ze Fan, Yiwen Zhang, Jiaqi Li, Yuanyuan Zhu, Yiting Lin, Qingrong Ni, Xiaotong Shi, Ling Liu, Shengxi Wu, Jing Huang

{"title":"Glutamatergic Projections from the Basolateral Amygdala to Medial Prefrontal Cortex Contribute to Acute Itch Sensation Processing.","authors":"Qiuying Zhao, Ze Fan, Yiwen Zhang, Jiaqi Li, Yuanyuan Zhu, Yiting Lin, Qingrong Ni, Xiaotong Shi, Ling Liu, Shengxi Wu, Jing Huang","doi":"10.1016/j.jid.2025.02.138","DOIUrl":"10.1016/j.jid.2025.02.138","url":null,"abstract":"Itch refers to an aversive sensation that generates a desire to scratch. The basolateral amygdala (BLA) activity is crucial in driving motivation, sensation, and emotional responses. Excitatory projections from the BLA play a vital role in regulating neuronal activity throughout the brain, including the medial prefrontal cortex (mPFC). Nevertheless, whether the BLA neurons and BLA-mPFC circuit contribute to itch sensation remains elusive. In this study, fluoro-gold retrograde tracing, morphological staining, and neuronal manipulation approaches were employed to investigate the role of BLA-mPFC projections in itch processing. Results showed that glutamatergic neurons in the BLA were activated in response to histamine- and chloroquine-induced acute itch stimuli. Chemogenetic activation of these neurons significantly mitigated the scratching behavior, whereas their inhibition increased the number of scratching bouts. The percentages of fluoro-gold-labeled CaMKII+ neurons expressing FOS in the BLA, which project to the mPFC, were 40.10 ± 2.26% and 73.84 ± 6.48% in acute itch models induced by histamine and chloroquine, respectively. Optogenetic activation of the BLA-mPFC pathway reduced histamine- or chloroquine-induced scratching bouts, whereas its inhibition increased the scratching bouts. These results provide evidence that BLA-mPFC projections are implicated in the acute itch processing, expanding our understanding to the circuit mechanism underlying the modulation of itch.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Repurposing of Nitazoxanide for Psoriasis Treatment Exerts Therapeutic Effects through Skin Metabolic Reprogramming.

The Journal of investigative dermatology Pub Date : 2025-03-03 DOI: 10.1016/j.jid.2025.02.137

Jong Yeong Lee, Ha Eun Kim, Seung Taek Lee, Jin Park, Kyung-Hwa Nam, Jun-Young Park, Jin Kyeong Choi

{"title":"The Repurposing of Nitazoxanide for Psoriasis Treatment Exerts Therapeutic Effects through Skin Metabolic Reprogramming.","authors":"Jong Yeong Lee, Ha Eun Kim, Seung Taek Lee, Jin Park, Kyung-Hwa Nam, Jun-Young Park, Jin Kyeong Choi","doi":"10.1016/j.jid.2025.02.137","DOIUrl":"10.1016/j.jid.2025.02.137","url":null,"abstract":"Nitazoxanide (NTZ), a Food and Drug Administration-approved drug, was originally developed for the treatment of parasitic infections. Recent studies have revealed that NTZ may also be effective in treating other diseases, including inflammatory diseases, cancer, and bacterial and viral infections. Therefore, we investigated whether NTZ could inhibit specific inflammatory pathways and reprogram metabolic processes in psoriasis to regulate inflammation. To investigate the symptom-alleviating effects of NTZ on psoriasis and its underlying mechanisms, we used an imiquimod-induced psoriatic-like skin inflammation mouse model and IL-17-stimulated human keratinocytes. NTZ inhibited the transition of metabolic programs induced by IL-17-mediated inflammation in human keratinocytes. In particular, NTZ suppressed glucose uptake and the associated actions stimulated by IL-17 and reduced enhanced oxidative phosphorylation. NTZ inhibited the mTOR signaling pathway by inducing AMP-activated protein kinase and prevented the development of dysfunctional mitochondria characterized by high mitochondrial mass and high levels of ROS. Moreover, the administration of NTZ in a mouse model of psoriasis, an IL-17-mediated skin disease, inhibited the accumulation of damaged mitochondria and suppressed T helper 17-mediated inflammatory responses. These findings provide preclinical evidence that NTZ may be effective in treating psoriasis and suggest that targeting the energy metabolic pathways in the skin could be beneficial for the treatment and prevention of psoriasis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and Co-Occurrence of Eczema Types in Adults in the United States: Insights from the All of Us Research Program.

The Journal of investigative dermatology Pub Date : 2025-03-03 DOI: 10.1016/j.jid.2025.02.136

Allison R Loiselle, Jessica K Johnson, Wendy Smith Begolka

引用次数: 0

Skin-Associated Cartilage Is a Distinct Type of Lipid-Filled Tissue.

The Journal of investigative dermatology Pub Date : 2025-02-28 DOI: 10.1016/j.jid.2025.01.019

Raul Ramos, Maksim V Plikus

引用次数: 0

What Are Patients' Perceptions and Attitudes Regarding the Use of Artificial Intelligence in Skin Cancer Screening and Diagnosis? Narrative Review.

The Journal of investigative dermatology Pub Date : 2025-02-27 DOI: 10.1016/j.jid.2025.01.013

Preksha Machaiya Kuppanda, Monika Janda, H Peter Soyer, Liam J Caffery

引用次数: 0