The Journal of investigative dermatology最新文献_第4页

The Clinical and Molecular Response of Pyoderma Gangrenosum to Interleukin 23 Blockade: Result from a proof-of-concept open-label clinical trial. 脓皮病对白细胞介素 23 阻断剂的临床和分子反应：概念验证开放标签临床试验的结果。

The Journal of investigative dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jid.2024.10.602

Akshay Flora, James Pham, Jane A Woods, Michael Radzeika, Hugh Dickson, Mathew Malone, John W Frew

{"title":"The Clinical and Molecular Response of Pyoderma Gangrenosum to Interleukin 23 Blockade: Result from a proof-of-concept open-label clinical trial.","authors":"Akshay Flora, James Pham, Jane A Woods, Michael Radzeika, Hugh Dickson, Mathew Malone, John W Frew","doi":"10.1016/j.jid.2024.10.602","DOIUrl":"https://doi.org/10.1016/j.jid.2024.10.602","url":null,"abstract":"Pyoderma Gangrenosum is a severe ulcerative disease with a great need for novel therapies. A major barrier to the development of novel therapies is a lack of understanding of disease pathogenesis. We present the results of a proof-of-concept open label clinical trial of IL-23p19 antagonism with Tildrakizumab ion Pyoderma Gangrenosum. Gene expression analysis identified pro-inflammatory genes associated with interferon responses and dendritic cell activity including IFI27, XBP1, SAA1 LGALS3 and STAT3 significantly downregulated in lesional tissue after 12 weeks of therapy. Immunohistochemistry confirmed reduction in IL-17A and IL-17 F positive cells as well as reduction in TNF-a, C5a and IL-1B positive cells in week 12 samples compared to baseline. Significant reduction in serum inflammation was observed via serum proteomics, with IL-8, IL-6, and CASP-8 levels reduced comparable to healthy controls at Week 12. Clinical outcomes demonstrated significant reduction in ulcer size, pain, itch and quality of life outcomes in line with the molecular findings. Differential expression of key inflammatory cytokines such as IL-8, CXCL5, PD-L1, SPP1 and MMP1 were observed in tissue and serum when stratified by clinical responders and non-responders. This data provides insights into the clinical relevance of alterations in molecular markers in pyoderma gangrenosum and the potential for the identification of clinically relevant biomarkers of disease activity.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Apocrine gland damage and the release of specific keratins in early stage indicate the crucial involvement of apocrine glands in hidradenitis suppurativa. 分泌腺损伤和早期特异性角蛋白的释放表明，分泌腺在化脓性扁桃体炎中起着至关重要的作用。

The Journal of investigative dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jid.2024.09.021

Jiaqi Li, Sitong Li, Qiujing Zhang, Mengchen Liang, Xiang Chen, Yibo Feng, Zhanyan Pan, Tingting Hu, Qiong Wu, Guangjie Chen, Christos C Zouboulis, Xiaohui Mo, Qiang Ju

{"title":"Apocrine gland damage and the release of specific keratins in early stage indicate the crucial involvement of apocrine glands in hidradenitis suppurativa.","authors":"Jiaqi Li, Sitong Li, Qiujing Zhang, Mengchen Liang, Xiang Chen, Yibo Feng, Zhanyan Pan, Tingting Hu, Qiong Wu, Guangjie Chen, Christos C Zouboulis, Xiaohui Mo, Qiang Ju","doi":"10.1016/j.jid.2024.09.021","DOIUrl":"https://doi.org/10.1016/j.jid.2024.09.021","url":null,"abstract":"The apocrine glands (AGs) are not considered to be primarily involved in hidradenitis suppurativa (HS). This study investigated the potential role of AGs in HS pathogenesis using immunohistochemistry and single-cell sequencing of nonlesional skin (NLS) and early lesional skin (LS) from patients with HS (n = 12) and healthy controls (HC, n = 8). AG cell destruction was more frequent and AG size was significantly reduced in the NLS and LS. Barrier-related genes (e.g., claudin 1 and E-cadherin) were downregulated in the AGs of the NLS and LS. Damaged AGs in the LS primarily recruit and activate neutrophils via the CXCL-CXCR and SAA1-FPR2 pathways. Elevated levels of specific keratins (KRT18 and KRT19) released from damaged AGs were observed on the skin surface of patients and were associated with disease severity. KRT19 was also detected in the dermis of the NLS and LS and was surrounded by neutrophils and macrophages. Moreover, serum KRT19 levels in patients (n = 20) were significantly negatively correlated with the age at HS onset. Collectively, our findings provide previously unreported evidence that the AGs are damaged and release specific keratins in early HS lesions, indicating a crucial role of the AGs in HS pathogenesis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FoxO3a Plays a Role in Wound Healing by Regulating Fibroblast Mitochondrial Dynamics. FoxO3a 通过调节成纤维细胞线粒体动力学在伤口愈合中发挥作用

The Journal of investigative dermatology Pub Date : 2024-11-13 DOI: 10.1016/j.jid.2024.10.600

Mariko Moriyama, Ryoichi Mori, Takao Hayakawa, Hiroyuki Moriyama

{"title":"FoxO3a Plays a Role in Wound Healing by Regulating Fibroblast Mitochondrial Dynamics.","authors":"Mariko Moriyama, Ryoichi Mori, Takao Hayakawa, Hiroyuki Moriyama","doi":"10.1016/j.jid.2024.10.600","DOIUrl":"https://doi.org/10.1016/j.jid.2024.10.600","url":null,"abstract":"The skin plays a protective role against harmful environmental stress such as ultraviolet rays. Therefore, the skin is constantly exposed to potential injuries, and wound healing is a vital process for the survival of all higher organisms. Wound healing is dependent on aging and metabolic status at a whole-body level. Because the forkhead box O (FOXO) family plays a role in aging and metabolism, we investigated the molecular functions of FOXO3a in skin wound healing using FoxO3a-/- mice. We observed that FoxO3a-/- mice showed accelerated skin wound healing. During wound healing, more fibroblasts accumulated at the wound edges and migrated into the wound bed in FoxO3a-/- mice. Moreover, cell migration of dermal fibroblasts isolated from FoxO3a-/- mice was significantly induced. During the in vitro cell migration, we observed accelerated mitochondrial fragmentation and decreased oxygen consumption in the mitochondria of FoxO3a-/- fibroblasts. These changes were caused by the upregulation of mitochondrial Rho GTPase 1 (Miro1), which is an essential mediator of microtubule-based mitochondrial motility. Miro1 inhibition significantly attenuated cell migration, mitochondrial fragmentation, and mitochondrial recruitment to the leading edge of the cells. These data indicate that FoxO3a plays a crucial role in wound healing by regulating mitochondrial dynamics.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased mortality in diffuse systemic sclerosis patients with high circulating IFNα levels. 循环 IFNα 水平较高的弥漫性系统性硬化症患者死亡率增加。

The Journal of investigative dermatology Pub Date : 2024-11-12 DOI: 10.1016/j.jid.2024.09.020

François Maillet, Carine Schmidt, Vincent Bondet, Alexandre Bense, Darragh Duffy, Luc Mouthon, Mathieu Rodero, Benjamin Chaigne

引用次数: 0

Cell Therapy and the Skin: Great Potential but in Need of Optimization. 细胞疗法与皮肤：潜力巨大但亟待优化。

The Journal of investigative dermatology Pub Date : 2024-11-12 DOI: 10.1016/j.jid.2024.09.011

Sam S Lee, Eddie Gibson Martinez Peña, Aiden A Willis, Chen Chia Wang, Nina Rossa Haddad, Luis A Garza

引用次数: 0

Recent Advances in Juvenile Dermatomyositis: Moving toward Integration of Myositis-Specific Antibody Clinical Phenotypes, IFN-Driven Pathogenesis, and Targeted Therapies. 幼年皮肌炎的最新进展：迈向肌炎特异性抗体临床表型、IFN驱动发病机制和靶向治疗的整合。

The Journal of investigative dermatology Pub Date : 2024-11-11 DOI: 10.1016/j.jid.2024.09.017

Kristen L Chen, Yvonne E Chiu, Ruth Ann Vleugels, Dominic O Co, Hanna Kim, Sara E Sabbagh, Lisa M Arkin

引用次数: 0

Chronic Obstructive Pulmonary Disease Outcomes in Psoriasis Patients. 银屑病患者的慢性阻塞性肺病预后

The Journal of investigative dermatology Pub Date : 2024-11-08 DOI: 10.1016/j.jid.2024.10.596

Lily Guo, Sara N Bilimoria, Robin Kikuchi, Audrey Hao, Kaviyon Sadrolashrafi, Rebecca K Yamamoto, Hannah Tolson, Danielle Yee, April W Armstrong

引用次数: 0

Topical Application of Nano-sized Graphene Oxide Cream Ameliorates Acute Skin Inflammation in Mice. 局部使用纳米级氧化石墨烯霜可改善小鼠急性皮肤炎症。

The Journal of investigative dermatology Pub Date : 2024-11-08 DOI: 10.1016/j.jid.2024.08.041

Hyun Jung Park, Sung Won Lee, Tae-Cheol Kim, Yun Hoo Park, Keun Soo Kim, Luc Van Kaer, Suklyun Hong, Seokmann Hong

{"title":"Topical Application of Nano-sized Graphene Oxide Cream Ameliorates Acute Skin Inflammation in Mice.","authors":"Hyun Jung Park, Sung Won Lee, Tae-Cheol Kim, Yun Hoo Park, Keun Soo Kim, Luc Van Kaer, Suklyun Hong, Seokmann Hong","doi":"10.1016/j.jid.2024.08.041","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.041","url":null,"abstract":"We have previously shown that nano-sized graphene oxide (NGO) displays anti-inflammatory activities against natural killer T (NKT) cell-mediated sepsis. To address whether NGO could be applied to treat acute skin inflammation we developed a conventional skin Cetaphil® cream containing NGO (NGO cream) for topical application to skin lesions and investigated its therapeutic efficacy by employing the tape-stripping-induced acute skin inflammation model. Topical application of NGO cream to the wounded area significantly reduced skin lesions compared with the control cream. Moreover, NGO cream treatment prevented the tape-stripping-elicited infiltration of and IL1β production by skin neutrophils and dendritic cells (DCs). Furthermore, such anti-inflammatory effects of NGO cream were attributed to decreased infiltration of IL12-producing DCs and IFNγ-producing cells (e.g., CD4+ T, CD8+ T, γδ T, NK, and NKT cells) into the skin. In addition, topical NGO cream administration enhanced the expression of suppressive molecules such as FR4 on skin regulatory T cells. Through RNA sequencing analysis, we found that the preventive effect of NGO cream on acute skin inflammation may be correlated with the activation of keratinocytes located in the epidermis. Our results support NGO cream as a therapeutic option to control acute skin inflammation.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deconvoluted methylation profiles discriminate between closely related melanocytic nevi. 去卷积甲基化图谱可区分密切相关的黑素细胞痣。

The Journal of investigative dermatology Pub Date : 2024-11-08 DOI: 10.1016/j.jid.2024.10.595

Daniel Aldea, Nicolas Macagno, Elise Marechal, Mathias Moreno, Pauline Romanet, Morgane Pertuit, Jérémy Garcia, Nathalie Degardin, Stéphanie Mallet, Isabelle James, Guillaume Captier, Anne Barlier, Heather C Etchevers

引用次数: 0

Disentangling Race from Skin Color in Modern Biology and Medicine. 在现代生物学和医学中将种族与肤色区分开来。

The Journal of investigative dermatology Pub Date : 2024-11-06 DOI: 10.1016/j.jid.2024.08.029

Valerie Horsley, Ophelia E Dadzie, Russell Hall, Nina G Jablonski

{"title":"Disentangling Race from Skin Color in Modern Biology and Medicine.","authors":"Valerie Horsley, Ophelia E Dadzie, Russell Hall, Nina G Jablonski","doi":"10.1016/j.jid.2024.08.029","DOIUrl":"https://doi.org/10.1016/j.jid.2024.08.029","url":null,"abstract":"In this review, we examine the taxonomies used to classify people, which influenced the development of the modern disciplines of biology and medicine, including dermatology, throughout the world. Early European scientists and physicians were intertwined with the social environment that created classifications and hierarchies of skin-color-based races, which were reinforced by prevailing political systems that supported colonial economic structures and, in many cases, chattel slavery. Even after genomic analysis of diverse human DNA sequences have revealed that systems of skin color-based racial and ethnic classification lacked biological meaning and were socially constructed, these classifications persist and are reinforced by census classifications and frameworks for comparisons in biomedicine in many parts of the world. The bodies of knowledge and practices that were built on these classifications did not reflect the observable biological diversity of people but the dominant cultural institutions and economic systems of their times. We provide actions for our modern institutions to reduce the underpinnings and ramifications of racial and ethnic classifications ultimately to improve biomedical research and medical care for all patients.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142585269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0