The Journal of investigative dermatology最新文献_第8页

Use and Overuse of Diagnostic Imaging in Pyoderma Gangrenosum. 坏疽性脓皮病诊断影像的使用和过度使用。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-28 DOI: 10.1016/j.jid.2025.08.021

Moira Shea, Alec Furst, Rama Abu Zanet, Iksha Kumar, Khoa Nguyen, Emile Latour, Alex G Ortega-Loayza

引用次数: 0

Metformin Treatment Protects Mice from Glucose-Promoted Psoriasiform Dermatitis through Enrichment of Akkermansia muciniphila with Modulation of Bacterial Tryptophan Metabolites. 二甲双胍治疗通过调节细菌色氨酸代谢物富集嗜粘液阿克曼氏菌，保护小鼠免受葡萄糖促进的牛皮癣样皮炎。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-27 DOI: 10.1016/j.jid.2025.08.017

Yuhsien Lai, Zhuoyu Jiang, Xiaonan Qiu, Dan Hong, Xiuting Liu, Shenyin Liu, Xuesong Wu, Shumeng Guo, Joshua D Bloomstein, Sam T Hwang, Guozhen Tan, Liangchun Wang, Zhan Zhang, Zhenrui Shi

{"title":"Metformin Treatment Protects Mice from Glucose-Promoted Psoriasiform Dermatitis through Enrichment of Akkermansia muciniphila with Modulation of Bacterial Tryptophan Metabolites.","authors":"Yuhsien Lai, Zhuoyu Jiang, Xiaonan Qiu, Dan Hong, Xiuting Liu, Shenyin Liu, Xuesong Wu, Shumeng Guo, Joshua D Bloomstein, Sam T Hwang, Guozhen Tan, Liangchun Wang, Zhan Zhang, Zhenrui Shi","doi":"10.1016/j.jid.2025.08.017","DOIUrl":"10.1016/j.jid.2025.08.017","url":null,"abstract":"Although diet has been regarded as a potential environmental risk factor for psoriasis, the precise contribution of specific dietary components, such as sugar, to its pathogenesis remains uncertain. Metformin, a primary medication for type II diabetes mellitus, has been documented to yield improvements in psoriasis. Earlier research indicates that the antihyperglycemic impact of metformin is associated with changes in gut microbiota. Nonetheless, the role of gut microbiota in the antipsoriatic effects of metformin remains unclear. In this study, we showed that 4 weeks of glucose intake exacerbated psoriasiform dermatitis (PsD) in mice, which resolved with oral metformin treatment. The exacerbation and resolution of PsD were mediated through effects on the gut microbiota. Supplementation with Akkermansia muciniphila, enriched by metformin, or Amuc_1100 improved PsD in glucose-fed mice but not in the control mice. Glucose intake resulted in reduced serum levels of indole-3-acetic acid, a microbial tryptophan metabolite, which were reversed by A muciniphila and Amuc_1100 treatment. Oral administration and intradermal injection of indole-3-acetic acid protected mice from glucose-promoted PsD with suppressed expression of antimicrobial peptides, specifically S100A8, in the epidermis. Collectively, increases of A muciniphila through metformin treatment led to reversal of glucose-promoted PsD in mice, possibly through production of the microbial tryptophan metabolite indole-3-acetic acid.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathogenic T Follicular Helper Cells in Bullous Pemphigoid: Lessons from a Murine Model. 大疱性类天疱疮的致病性T滤泡辅助细胞：来自小鼠模型的教训。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-26 DOI: 10.1016/j.jid.2025.07.012

Paul Engeroff

引用次数: 0

Multiomics Mendelian Randomization Reveals Causal Oxidative Stress Genes in Androgenetic Alopecia. 多组学孟德尔随机化揭示雄激素性脱发的氧化应激基因。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-25 DOI: 10.1016/j.jid.2025.08.014

Yuan Zhu, Changjiang Zhao, He Yan, Mingyang Lu, Ruiyu Luo, Zhenxing Wang, Lingling Jia, Zihan Li, Hua Jiang, Yufei Li

{"title":"Multiomics Mendelian Randomization Reveals Causal Oxidative Stress Genes in Androgenetic Alopecia.","authors":"Yuan Zhu, Changjiang Zhao, He Yan, Mingyang Lu, Ruiyu Luo, Zhenxing Wang, Lingling Jia, Zihan Li, Hua Jiang, Yufei Li","doi":"10.1016/j.jid.2025.08.014","DOIUrl":"10.1016/j.jid.2025.08.014","url":null,"abstract":"Androgenetic alopecia (AGA) has now become a common disorder, yet treatment options remain relatively limited. Smoking, alcohol consumption, and coffee drinking have become habitual, and it is widely believed that these lifestyle factors contribute to AGA. Similarly, as researchers have reported, oxidative stress-related multiomics genes are reviewed as risk factors for AGA, which have been proven to be related to the lifestyles mentioned earlier. However, current research suggests that the link between these factors and AGA is still unclear. To address this, we performed a series of Mendelian randomization analyses on the lifestyle factors mentioned earlier and oxidative stress-related multiomics genes, identifying 12 expression quantitative trait loci genes and 21 protein quantitative trait loci genes with causal associations. The analysis revealed that the ORs for these 33 loci were greater than 1, indicating a positive association with AGA. On the basis of these findings, we inferred potential therapeutic drugs for AGA. This study explores the pathogenic mechanisms of AGA, confirms the complexity of its risk factors as a polygenic disease, and provides causally associated evidence to guide future research into the mechanisms underlying AGA development. This study provides potential therapeutic targets for the development of new drugs for AGA.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nephronectin Mediates the Interaction between Hair Follicle Epithelial Progenitors and Dermal Stem Cells and Is Involved in Hair Cycle Progression. Nephronectin介导毛囊上皮祖细胞和真皮干细胞之间的相互作用，并参与毛发周期的进展。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-25 DOI: 10.1016/j.jid.2025.07.031

Weiwen Liu, Noriko Sanzen, Takaya Abe, Hiroshi Kiyonari, Nick Barker, Zhiqi Hu, Hironobu Fujiwara

引用次数: 0

Photographic Quantification of Actinic Keratoses Using Human- and Artificial Intelligence-Based Assessment: A Pilot Study. 基于人类和人工智能评估的光化性角化病的摄影量化：一项试点研究。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-25 DOI: 10.1016/j.jid.2025.08.015

Yingjoy Li, Viviane Liao, Ian R Nykaza, Michael M Ong, Kivanc Kose, Nicholas R Kurtansky, Allan C Halpern, Mackenzie R Wehner, Veronica Rotemberg

引用次数: 0

A Phase 2, Randomized, Placebo-Controlled Study of Bermekimab in Moderate-to-Severe Hidradenitis Suppurativa. Bermekimab治疗中重度化脓性汗腺炎的2期随机安慰剂对照研究

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-25 DOI: 10.1016/j.jid.2025.07.032

Seth Forman, Lea Kephart, Takayuki Ota, Jeff Pawlikowski, Jingzhi Jiang, Alexa B Kimball

引用次数: 0

High-Resolution Spatial Transcriptomics Unveils Spatially Resolved Gene Modules and Fatty Acid Metabolism Dysregulation in Human Skin Aging. 高分辨率空间转录组学揭示了人类皮肤衰老中空间分解的基因模块和脂肪酸代谢失调。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-23 DOI: 10.1016/j.jid.2025.08.011

Yin Li, Wenwan Zhang, Yao Teng, Xia Zhang, Sweelin Chew, Yang Liu, Peng Hua, Tingting Yu, Yuao Yan, Yu Bu, Yidan Sun, Luwen Xu, Qiaoyu Fu, Lifang Lei, Yining Chen, Zhengcheng Liu, Caibing Wang, Peiying Zhu, Yao Yu, Nan Huang, Qingfeng Li, Caiyue Liu, Liang Zhang

{"title":"High-Resolution Spatial Transcriptomics Unveils Spatially Resolved Gene Modules and Fatty Acid Metabolism Dysregulation in Human Skin Aging.","authors":"Yin Li, Wenwan Zhang, Yao Teng, Xia Zhang, Sweelin Chew, Yang Liu, Peng Hua, Tingting Yu, Yuao Yan, Yu Bu, Yidan Sun, Luwen Xu, Qiaoyu Fu, Lifang Lei, Yining Chen, Zhengcheng Liu, Caibing Wang, Peiying Zhu, Yao Yu, Nan Huang, Qingfeng Li, Caiyue Liu, Liang Zhang","doi":"10.1016/j.jid.2025.08.011","DOIUrl":"10.1016/j.jid.2025.08.011","url":null,"abstract":"Human skin aging involves intricate micrometer-scale changes in cellular organization. High-resolution spatial transcriptomic analysis is crucial for deciphering the complex interplay of cell types and molecular processes underlying skin aging. In this study, the spatially enhanced-resolution omics-sequencing technique was employed to generate a high-resolution spatial transcriptomic atlas of human eyelid skin, capturing age-related alterations in gene expression. Integrating this atlas with multiplexed FISH, we spatially mapped known cell populations, identified 8 spatial tissue clusters, and uncovered 18 spatially correlated gene modules in human skin. Our analysis revealed that human eyelid skin aging is characterized not only by dermal atrophy and chronic inflammation but also by reduced dermal-epidermal communication, decreased epidermal fatty acid synthesis, potential loss of epidermal cell identity, and diminished c-FOS expression in the epidermis. Functional studies using primary human keratinocytes and a reconstructed full-thickness skin model (T-SkinTM) demonstrated that reduced activity of fatty acid synthesis enzymes farnesyl diphosphate synthase and fatty acid synthase promoted epidermal senescence and barrier dysfunction. This spatially resolved transcriptomic analysis provides, to our knowledge, previously unreported insights into the molecular mechanism driving skin aging, offering a potential target for aging intervention strategies.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":5.7,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strength and Tenderness: Fibronectin Joins Hair Follicle Stem Cell Niche. 强度和柔软：纤维连接蛋白加入毛囊干细胞生态位。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-22 DOI: 10.1016/j.jid.2025.07.015

Richa Nayak, Yejing Ge

引用次数: 0

A New Role of Non-Sex Hormone in the Pathogenesis of Female Pattern Hair Loss. 非性激素在女性型脱发发病机制中的新作用。

IF 5.7

The Journal of investigative dermatology Pub Date : 2025-08-22 DOI: 10.1016/j.jid.2025.06.1595

Tyng-Shiuan Hsieh, Wei-Hung Wang, Sung-Jan Lin

引用次数: 0