The Journal of investigative dermatology最新文献_第6页

Lower Prevalence of Overweight and Obesity in Adults with Neurofibromatosis. 神经纤维瘤病成人超重和肥胖患病率较低。

The Journal of investigative dermatology Pub Date : 2025-05-13 DOI: 10.1016/j.jid.2025.04.026

Laura Mengeot, Eric Pasmant, Annick Fontbonne, Patrick Tounian, Houda Ayache, Salah Ferkal, Bastien Peiffer, Khaled Ezzedine, Dominique Vidaud, Pierre Wolkenstein, Laura Fertitta

引用次数: 0

Urocanase-Positive Skin-Resident Bacteria Metabolize cis-Urocanic Acid and in Turn Reduce the Immunosuppressive Properties of UVR. 尿嘧啶酶阳性的皮肤常驻细菌代谢顺式尿嘧啶，从而降低紫外线辐射的免疫抑制特性。

The Journal of investigative dermatology Pub Date : 2025-05-13 DOI: 10.1016/j.jid.2025.03.035

VijayKumar Patra, Slave Trajanoski, Aaroh Joshi, Vanina Lenief, Chloe Goyet, Altan Cornu, Nicole Golob-Schwarzl, Meghana Somlapura, Amandine Mosnier, Maximilian Zarfl, Thomas Eichmann, Harald Köefeler, Mary Norval, Jean-Francois Nicolas, Peter Wolf, Marc Vocanson

{"title":"Urocanase-Positive Skin-Resident Bacteria Metabolize cis-Urocanic Acid and in Turn Reduce the Immunosuppressive Properties of UVR.","authors":"VijayKumar Patra, Slave Trajanoski, Aaroh Joshi, Vanina Lenief, Chloe Goyet, Altan Cornu, Nicole Golob-Schwarzl, Meghana Somlapura, Amandine Mosnier, Maximilian Zarfl, Thomas Eichmann, Harald Köefeler, Mary Norval, Jean-Francois Nicolas, Peter Wolf, Marc Vocanson","doi":"10.1016/j.jid.2025.03.035","DOIUrl":"10.1016/j.jid.2025.03.035","url":null,"abstract":"The skin microbiome plays an important role in health and disease. We have recently shown that microbes living on the skin regulate the immunomodulatory properties of UVR, but the underlying mechanisms remain to be uncovered. Using a preclinical model of immunosuppression against the chemical allergen 2,4-dinitrofluorobenzene, 16S microbiome sequencing, in vitro cultures, high-performance liquid chromatography-mass spectrometry and the generation of gnotobiotic-like mice, we report that acute UVB radiation induces a transient and significant restructuring of bacterial communities on the skin through one of its major photoproducts, cis-urocanic acid. Certain bacteria, such as Staphylococcus epidermidis, use urocanase (HutU) to metabolize cis-urocanic acid to proliferate. This in turn affects the concentration of cis-urocanic acid on the skin, limiting its ability to suppress adaptive immune responses and induce tolerance to 2,4-dinitrofluorobenzene. Interestingly, addition of a topical urocanase inhibitor restricts the metabolism of cis-urocanic acid by HutU+ bacteria and restores immunosuppression. Overall, these results illustrate how, by harnessing a unique nutrient produced in response to UVR, urocanase-positive skin-resident bacteria can fine tune immune responses to environmental antigens. They should open new avenues to enhance the beneficial effects of phototherapy protocols and sun protection.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ANTXR2 Deficiency Promotes Cellular Senescence and Chondroid Differentiation in Hyaline Fibromatosis Syndrome Fibroblasts. ANTXR2缺乏促进透明纤维瘤综合征成纤维细胞衰老和软骨样分化。

The Journal of investigative dermatology Pub Date : 2025-05-12 DOI: 10.1016/j.jid.2025.04.022

Alvise Schiavinato, Arthur-Lauri Pasanen-Zentz, Matthias Mörgelin, Anika Wehrle, Shreya Karmacharya, Matthias Rübsam, Paola Zigrino, Raimund Wagener, Mats Paulsson, Ekkehart Lausch

引用次数: 0

External Validation of an Artificial Intelligence Ensemble for Skin Cancer Detection: Enhancing Diagnostic Performance on Dermoscopic Images. 用于皮肤癌检测的人工智能集成的外部验证：增强皮肤镜图像的诊断性能。

The Journal of investigative dermatology Pub Date : 2025-05-09 DOI: 10.1016/j.jid.2025.04.021

María Agustina Ricci Lara, Eliana Ludmila Frutos, María Victoria Rodríguez Kowalczuk, Maria Guillermina Ferraresso, Sonia Elizabeth Benítez, Luis Daniel Mazzuoccolo

引用次数: 0

Inflammatory Cutaneous Reactions with Systemic CD8⁺ T-Cell Responses upon Photochemical Internalization of Antigens in Mice. 小鼠光化学内化抗原时全身CD8+ t细胞反应的炎性皮肤反应。

The Journal of investigative dermatology Pub Date : 2025-05-08 DOI: 10.1016/j.jid.2025.04.020

Zuzanna K Kotkowska, Veronika Haunerdinger, Ying Waeckerle-Men, Isabel Kolm-Djamei, Agathe Duda, Lucy Hausammann, Philipp Schineis, Hendrik Fischer, Federica Sella, Nick Li, Pål Kristian Selbo, Anders Høgset, Thomas M Kündig, Cornelia Halin, Pål Johansen

{"title":"Inflammatory Cutaneous Reactions with Systemic CD8+ T-Cell Responses upon Photochemical Internalization of Antigens in Mice.","authors":"Zuzanna K Kotkowska, Veronika Haunerdinger, Ying Waeckerle-Men, Isabel Kolm-Djamei, Agathe Duda, Lucy Hausammann, Philipp Schineis, Hendrik Fischer, Federica Sella, Nick Li, Pål Kristian Selbo, Anders Høgset, Thomas M Kündig, Cornelia Halin, Pål Johansen","doi":"10.1016/j.jid.2025.04.020","DOIUrl":"10.1016/j.jid.2025.04.020","url":null,"abstract":"Vaccination can prevent infections and modulate immune-related diseases. Although conventional vaccines primarily stimulate CD4+ T cells and antibody production, effective antitumor immunity requires activation of CD8+ T cells. Photochemical internalization (PCI) is a promising technology that can facilitate cytosolic antigen delivery, promoting CD8+ T-cell responses. In this study, we studied early immune and cutaneous reactions after PCI-based vaccination with the photosensitizer disulphonated tetraphenyl chlorine. Mice were vaccinated intradermally with ovalbumin antigen and disulphonated tetraphenyl chlorine, followed by light treatment. We assessed cutaneous inflammatory reactions through histology, immunohistochemistry, fluorescence microscopy, and real-time PCR. Systemic inflammatory and immune reactions were analyzed in blood, lymph nodes, and spleen by flow cytometry, clinical chemistry, and ELISA. Disulphonated tetraphenyl chlorine was retained in cutaneous structures and accumulated in draining lymph nodes, and light activation triggered dose- and time-dependent cutaneous inflammatory reactions, including infiltration of innate myeloid CD11b+ and GR1+ macrophages, cross-presenting dendritic cells, and neutrophils, alongside enhanced local and systemic production of proinflammatory cytokines. High disulphonated tetraphenyl chlorine doses triggered severe cutaneous and systemic reactions, but PCI-treated skin showed a high degree of plasticity and healing. These mechanistic insights into local and systemic effects of PCI-based vaccination may contribute to translating PCI into clinical practice and wider application.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Risk Factors for Premature Hair Graying in Young Adult Women: A Cross-Sectional Study in Shanghai, China. 探讨年轻成年女性头发过早变白的危险因素：一项来自中国上海的横断面研究。

The Journal of investigative dermatology Pub Date : 2025-05-07 DOI: 10.1016/j.jid.2025.03.027

Wen-Cai Jiang, Hui Zhang, Ya-Fei Xu, Hai-Mei Kong, Yi-Mei Tan, Da-Ru Lu

引用次数: 0

Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification. PRMT5的表皮缺失导致非典型基底角化细胞样细胞群的出现和皮肤分层缺陷。

The Journal of investigative dermatology Pub Date : 2025-05-06 DOI: 10.1016/j.jid.2025.04.008

Nicole Recka, Andrean Simons, Robert A Cornell, Eric Van Otterloo

{"title":"Epidermal loss of PRMT5 leads to the emergence of an atypical basal keratinocyte-like cell population and defective skin stratification.","authors":"Nicole Recka, Andrean Simons, Robert A Cornell, Eric Van Otterloo","doi":"10.1016/j.jid.2025.04.008","DOIUrl":"https://doi.org/10.1016/j.jid.2025.04.008","url":null,"abstract":"During skin development, ectoderm-derived cells undergo precisely coordinated proliferation, differentiation, and adhesion to yield stratified epidermis. Disruptions in these processes can result in congenital anomalies including ectodermal dysplasia and harlequin ichthyosis. Protein Arginine Methyl Transferase 5 (PRMT5)-an enzyme responsible for methylating arginine residues in histones and other proteins-maintains progenitor status in germ and limb bud cells. Similarly, in vitro evidence suggests that PRMT5 prevents differentiation of basal keratinocytes, leading us to hypothesize that PRMT5 preserves the stem-cell phenotype of keratinocytes in vivo. To test this possibility, we generated conditional knockout (cKO) mice lacking Prmt5 in early ectoderm (E7.5), impacting the entire epidermis. Prmt5 cKOs exhibited gross skin defects, compromised skin barrier function, and reduced postnatal viability. Histological analyses revealed significant defects in epidermal stratification, without alterations in apoptosis or proliferation. Single-cell RNA and ATAC-seq analysis identified an atypical population of basal keratinocyte-like cells in Prmt5 cKOs, that exhibited a senescence-like program, characterized by increased Cdkn1a (p21), elevated senescence-associated secretory phenotype (SASP) molecules (Igfbp2), and decreased developmental transcription factor (Trp63) expression. Our findings suggest that PRMT5 prevents basal keratinocyte senescence by repressing Cdkn1a, shedding light on the epigenetic regulation of basal keratinocyte maintenance and senescence in congenital skin disorders.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pyoderma Gangrenosum: A Retrospective Study Comparing TNF-α Inhibitors with Ustekinumab. 坏疽性脓皮病：比较肿瘤坏死因子α抑制剂和乌斯特金单抗的回顾性研究。

The Journal of investigative dermatology Pub Date : 2025-05-06 DOI: 10.1016/j.jid.2025.04.017

Howard Jie Yang, William Spratt, Francis Yi Xing Lai, Senhong Lee

引用次数: 0

Atuzabrutinib Topical Gel Does Not Improve Disease Activity in Patients with Mild-to-Moderate Atopic Dermatitis: Findings from a Phase 2a Trial. Atuzabrutinib局部凝胶不能改善轻度至中度特应性皮炎患者的疾病活动性：来自2a期试验的发现

The Journal of investigative dermatology Pub Date : 2025-05-05 DOI: 10.1016/j.jid.2025.03.046

Mark Lee, Vincent Mikol, Vinh Truong, Elham Attieh, Siying Huang, Marie Vigan, Maria Wiekowski, Christine Xu, Ben Lin, Dany Nassar

引用次数: 0

Classification of Skin Transcriptome Reveals 2 Molecular Subtypes in Hidradenitis Suppurativa. 皮肤转录组分类揭示化脓性汗腺炎的两种分子亚型。

The Journal of investigative dermatology Pub Date : 2025-05-05 DOI: 10.1016/j.jid.2025.04.016

Jing Wang, Siqi Sun, Heath Guay, Dan Chang

引用次数: 0