The Journal of investigative dermatology最新文献_第6页

Current Insights on Lipidomics in Dermatology: A Systematic Review. 关于皮肤病学中脂质组学的最新见解：系统回顾

The Journal of investigative dermatology Pub Date : 2024-09-18 DOI: 10.1016/j.jid.2024.09.003

Raquel Sanabria-de la Torre, Trinidad Montero-Vílchez, Juan García-Gavín, Salvador Arias-Santiago

{"title":"Current Insights on Lipidomics in Dermatology: A Systematic Review.","authors":"Raquel Sanabria-de la Torre, Trinidad Montero-Vílchez, Juan García-Gavín, Salvador Arias-Santiago","doi":"10.1016/j.jid.2024.09.003","DOIUrl":"10.1016/j.jid.2024.09.003","url":null,"abstract":"Inflammatory dermatoses and lipid disturbances are interrelated, especially owing to chronic inflammatory conditions. This study aimed to investigate recent findings about lipidomic and dermatologic diseases as well as on the sampling techniques developed to study lipidomics in vivo and analytical and statistical approaches employed. A systematic review was designed using the search algorithm (lipidomics) AND (skin OR dermatology OR stratum corneum OR sebum OR epidermis), following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The literature search identified 1013 references, and finally, only 48 were selected, including a total of 2651 participants with a mean age of 34.13 ± 16.28 years. The dermatologic diseases evaluated were atopic dermatitis, acne, psoriasis, hidradenitis suppurativa, and other skin diseases. Sebutape was the primary sampling technique for lipidomics research. Most of the studies performed untargeted profiling through liquid chromatography with tandem mass spectrometry statistically analyzed with principal component analysis, orthogonal partial least-squares discriminate analysis, heatmap, and volcano plot models. The most consulted databases were LIPIDMAPS Structure Database, MetaboAnalyst, and Human Metabolome Database. A large heterogeneity of lipidomic and lipid metabolism profiles was observed in patients with skin diseases. Skin lipidomic analysis is valuable in exploring skin disease and has ample translational potential.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142305319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Boosting Skin Wound Healing by Agrin-Mediated YAP/TAZ Activation. 通过 Agrin 介导的 YAP/TAZ 激活促进皮肤伤口愈合

The Journal of investigative dermatology Pub Date : 2024-09-14 DOI: 10.1016/j.jid.2024.06.1291

Ute Jungwirth, Gernot Walko

引用次数: 0

Mystery of Melanotransferrin in Melanoma. 黑色素瘤中黑色素转铁蛋白的奥秘。

The Journal of investigative dermatology Pub Date : 2024-09-14 DOI: 10.1016/j.jid.2024.07.024

Gagan Chhabra, Nihal Ahmad

引用次数: 0

Flipping the Script: Are Cellular Assays and Wound Fluids the Next Frontier in Personalized Wound Care? 翻转剧本：细胞检测和伤口输液是个性化伤口护理的下一个前沿领域吗？

The Journal of investigative dermatology Pub Date : 2024-09-14 DOI: 10.1016/j.jid.2024.08.007

Ivan Jozic, Marjana Tomic-Canic

引用次数: 0

Classification of Cutaneous Melanoma and Melanocytic Nevi with MicroRNA Ratios Is Preserved in the Acral Melanoma Subtype. 用 microRNA 比率对皮肤黑色素瘤和黑色素细胞痣进行分类在口腔黑色素瘤亚型中得以保留。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.030

Dekker C Deacon, Chris Stubben, Eleonora Marcacci, Caroline J Stone, Michael Birdsall, Scott R Florell, Ken Boucher, Douglas Grossman, Robert L Judson-Torres

引用次数: 0

FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2α/GLI2 Signaling Axis. FGF21通过抑制CK2α/GLI2信号轴改善成纤维细胞活化和系统性硬化症

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.026

Yeyi Zheng, Wenjie Gong, Zhaohang Wu, Siyi Zhang, Nan Wang, Zhenyu Hu, Yanni Shou, Tianpeng Xu, Yingjie Shen, Xiaokun Li, Litai Jin, Weitao Cong, Zhongxin Zhu

{"title":"FGF21 Ameliorates Fibroblasts Activation and Systemic Sclerosis by Inhibiting CK2α/GLI2 Signaling Axis.","authors":"Yeyi Zheng, Wenjie Gong, Zhaohang Wu, Siyi Zhang, Nan Wang, Zhenyu Hu, Yanni Shou, Tianpeng Xu, Yingjie Shen, Xiaokun Li, Litai Jin, Weitao Cong, Zhongxin Zhu","doi":"10.1016/j.jid.2024.07.026","DOIUrl":"10.1016/j.jid.2024.07.026","url":null,"abstract":"Systemic sclerosis is a typical fibrotic disease of unknown etiology that is characterized by abnormal fibroblast activation and excessive deposition of extracellular matrix. Unfortunately, effective therapeutic approaches are lacking. FGF21 plays a key role in mediating a variety of biological activities. However, its specific function in systemic sclerosis is unclear. In this study, we found that the expression of FGF21 was significantly downregulated in fibrotic skin tissue and in TGF-β-stimulated fibroblasts. Furthermore, our studies demonstrated that treatment with recombinant FGF21 in the skin significantly alleviated bleomycin-induced and TBRI-activated fibrosis and inhibited the activation of fibroblasts, whereas skin fibrosis was exacerbated by deletion of FGF21. Mechanistically, FGF21 inhibits the activity of CK2α and promotes the degradation of GLI2. In conclusion, these results indicate that FGF21 attenuates skin fibrosis through the CK2α/GLI2 signaling pathway and therefore may be a potential therapeutic target for systemic sclerosis.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining Automated Lesion Risk and Change Assessment Improves Melanoma Detection: A Retrospective Accuracy Study. 结合自动病变风险和变化评估可提高黑色素瘤检测率：回顾性准确性研究

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.027

Chantal Rutjes, Adam Mothershaw, Brian M D'Alessandro, Clare A Primiero, Aideen McInerney-Leo, H Peter Soyer, Monika Janda, Brigid Betz-Stablein

引用次数: 0

Resolving 3-Dimensional Genomic Landscape of CD4+ T Cells in the Peripheral Blood of Patients with Psoriasis. 解析银屑病患者外周血中 CD4+ T 细胞的三维基因组图谱。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.08.006

Yueqi Qiu, Wenjuan Jiang, Delong Feng, Yaqin Yu, Huihui Hou, Min Deng, Xiaoyun Chen, Lin Liu, Ruifang Wu, Qianjin Lu, Ming Zhao

{"title":"Resolving 3-Dimensional Genomic Landscape of CD4+ T Cells in the Peripheral Blood of Patients with Psoriasis.","authors":"Yueqi Qiu, Wenjuan Jiang, Delong Feng, Yaqin Yu, Huihui Hou, Min Deng, Xiaoyun Chen, Lin Liu, Ruifang Wu, Qianjin Lu, Ming Zhao","doi":"10.1016/j.jid.2024.08.006","DOIUrl":"10.1016/j.jid.2024.08.006","url":null,"abstract":"A precise regulation of gene expression depends on the accuracy of the 3-dimensional (3D) structure of chromatin; however, the effects of the 3D genome on gene expression in psoriasis remain unknown. In this study, we conducted Hi-C and RNA sequencing on CD4+ T cells collected from 5 patients with psoriasis and 3 healthy controls and constructed a comprehensive 3D chromatin interaction map to delineate the genomic hierarchies, including A/B compartments, topologically associated domains, and chromatin loops. Then, the specific superenhancers related to psoriasis were identified by Hi-C and H3K27ac chromatin immunoprecipitation sequencing data. Subsequently, comprehensive analyses were carried out on the differentially expressed genes that are associated with altered topologically associated domains, loops, and superenhancers in psoriasis. Finally, we screened the candidate target genes and examined the potential functional SNP in psoriasis affected by disruptions of the spatial organization. This study provides a comprehensive reference for examining the 3D genome interactions in psoriasis and elucidating the interplay between spatial organization disruption and gene regulation. We hope that our findings can help clarify the mechanisms underlying the pathogenesis of psoriasis and shed light on the role of 3D genomic structure, therefore informing potential therapeutic approaches.","PeriodicalId":94239,"journal":{"name":"The Journal of investigative dermatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142057750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vasoactive Intestinal Peptide Operates as a Negative Regulator of Human Hair Follicle Pigmentation Ex Vivo. 血管活性肠肽（VIP）是人体内毛囊色素沉着的负向调节因子。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.06.1290

Tatiana Gomez Gomez, Jérémy Chéret, Barbara Bedogni, Ramtin Kassir, Marta Bertolini, Ralf Paus

引用次数: 0

Invasion of Human Epidermis by Malassezia furfur Is Strain Dependent. 糠秕马拉色菌侵入人体表皮与菌株有关。

The Journal of investigative dermatology Pub Date : 2024-09-07 DOI: 10.1016/j.jid.2024.07.028

Bastien Tirtiaux, Giuseppe Ianiri, Valérie De Glas, Eléa Denil, Emilie Faway, Yves Poumay

引用次数: 0