The journal of international advanced otology最新文献

{"title":"Speech-Evoked Auditory Brainstem Responses (Speech ABR) in Children with Speech Delay, Autism Spectrum Disorder (ASD), and Normal Development.","authors":"Paulo Almeida Rocha, Roberto Miquelino De Oliveira Beck, Clayson Alan Dos Santos, João Pedro Afonso Nascimento, Guilherme Rodrigues Marinho, Signe Schuster Grasel","doi":"10.65717/iao.2026.251986","DOIUrl":"10.65717/iao.2026.251986","url":null,"abstract":"<p><strong>Introduction: </strong>Speech auditory brainstem response (ABR) provides useful information about how the brainstem encodes complex sounds and is a powerful tool to evaluate auditory processing deficiencies not assessed by click stimuli.</p><p><strong>Objective: </strong>Compare speech ABR responses among preschool children with normal hearing thresholds, divided into 3 groups: speech delay, autism spectrum disorder (ASD), and control group of typically developing children.</p><p><strong>Methods: </strong>Retrospective analysis of 366 children, aged between 10 and 84 months, evaluated between 2015 and 2022. Click and speech ABR, and auditory steady-state responses (ASSR) were obtained in the same test session. We included subjects with normal hearing thresholds and well-defined click ABR waves in both ears. The patients were divided into groups (A) speech delay (n=268), (B) ASD (n=68), and (C) control (n=30). We used the speech ABR stimulus /da/ and evaluated 7 components: Onset (V-A), transition (C), sustained portion (D, E, and F), and Offset (O). Statistical analysis compared age, sex, and wave latencies between the groups.</p><p><strong>Results: </strong>Three hundred three (82.8%) were boys, with a predominance in all groups. There was no sex difference between the groups (P=.12). Autism spectrum disorder (ASD) children were older than children in the other groups (P < .001). We did not find the differences between the groups for V, A, C, D, E, F, and O latencies or pure-tone audiometry (PTA) /ASSR thresholds. Compared to boys, girls had shorter latencies. Comparing boys, no latency differences were observed between groups.</p><p><strong>Conclusion: </strong>There was no difference in speech ABR wave latencies between the groups of children with speech delay, ASD, and controls.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Study of Gadolinium-Enhanced Inner Ear Magnetic Resonance Imaging for the Prognosis of Idiopathic Sudden Sensorineural Hearing Loss.","authors":"Heng Xiao, Qinrong Huang, Zheming Fang, Guohao Chen","doi":"10.65717/iao.2026.252129","DOIUrl":"10.65717/iao.2026.252129","url":null,"abstract":"<p><strong>Background: </strong>To investigate the clinical features of patients with and without endolymphatic hydrops (EH) under idiopathic sudden sensorineural hearing loss (ISSNHL) and to evaluate the predictive value of gadolinium (Gd)-enhanced inner ear magnetic resonance imaging (MRI) in the prognosis of ISSNHL.</p><p><strong>Methods: </strong>Seventy ISSNHL patients were enrolled, of whom 15 (21.4%) were identified with EH via Gd-enhanced MRI. Using 1 : 1 nearestneighbor propensity score matching (PSM) based on age, sex, and body mass index (BMI), 13 matched pairs (n=26) were generated for adjusted analysis. Factors influencing hearing recovery were analyzed by univariate and multivariate analysis.</p><p><strong>Results: </strong>After adjusting for age, sex, and BMI using PSM, the EH group demonstrated significantly higher bilirubin levels (P=.044) and a markedly lower hearing recovery rate (P=.030) compared to the non-EH group. Univariate analysis identified that older age (P=.013), certain audiogram curve types (P=.024), a higher (poorer) initial hearing threshold (P=.002), and a positive finding on Gd-enhanced inner ear MRI (presence of EH) (P =.015) were negatively associated with hearing recovery. Multivariate logistic regression indicated that the presence of EH on MRI (odds ratio [OR]=9.80, P=.048) and increasing age (OR=0.95 per year, P=.041) were independently associated with a lower likelihood of hearing recovery.</p><p><strong>Conclusion: </strong>The significantly poorer hearing recovery in EH patients, even after adjusting for demographics, strengthens the evidence for EH as a negative prognostic factor. Consequently, Gd-enhanced inner ear MRI, which reliably detects EH, could serve as a novel prognostic biomarker. This tool aids in early risk stratification, identifying patients who may benefit from more aggressive or alternative treatment strategies, thereby potentially guiding a more personalized management approach for ISSNHL.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Dynamic Postural Control in People with Diabetes: An Exploratory Cross-Sectional Study Using Computerized Dynamic Posturography (Bertec).","authors":"Asger Krohn Jespersen, Aksayan Arunanthy Mahalingasivam, Niels Ejskjær, Dan Dupont Hougaard, Peter Vestergaard, Johan Røikjer, Nicklas Højgaard-Hessellund Rasmussen","doi":"10.65717/iao.2026.252191","DOIUrl":"10.65717/iao.2026.252191","url":null,"abstract":"<p><strong>Background: </strong>This study assessed static and dynamic postural control in individuals with type 1 (T1D) and type 2 diabetes (T2D) using Computerized Dynamic Posturography (Bertec), hypothesizing that diabetes, especially with diabetic peripheral neuropathy (DPN), leads to significant impairments in postural stability.</p><p><strong>Methods: </strong>A total of 94 participants with diabetes (T1D: n=49, T2D: n=45) and 94 age- and sex-matched controls underwent postural assessments using the Sensory Organization Test (SOT) and Motor Control Test (MCT). The SOT evaluated sensory system contributions (somatosensory,visual, vestibular), while the MCT assessed postural recovery responses.</p><p><strong>Results: </strong>Both T1D and T2D groups exhibited impaired SOT performance compared to controls (P < .05). Type 1 diabetes showed impaired visual function (P < .05), while both groups demonstrated poorer postural stability in conditions requiring vestibular input (P < .05) and slower MCT response times (10 of 14 abnormal, P < .05). T2D participants relied excessively on visual input (preference function: P < .05). No significant associations were detected between DPN, body mass index, Hemoglobin A1c (HbA1c), or diabetes duration with postural control impairments.</p><p><strong>Conclusion: </strong>Diabetes impairs postural control, particularly in conditions that rely heavily on vestibular and visual inputs, regardless of DPN. Advanced tools like Bertec reveal real-world deficits, highlighting the potential value of these findings in informing future fall-prevention strategies for individuals with diabetes.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear Implantation in a Child with Cornelia de Lange Syndrome: Challenges and Prospect.","authors":"I-Hsiu Chen, Pei-Hsuan Ho, Mei-Chi Chiu, Chia-Huei Chu, Pey-Yu Chen, Hung-Ching Lin","doi":"10.65717/iao.2026.252138","DOIUrl":"https://doi.org/10.65717/iao.2026.252138","url":null,"abstract":"<p><strong>Unlabelled: </strong>Cornelia de Lange syndrome (CdLS) is a rare congenital multisystem syndrome characterized by a distinctive craniofacial appearance, developmental delay, intellectual disability, limb abnormalities, and hypertrichosis. Hearing loss is one of the common manifestations in CdLS. This study presents a 6-year-old child with CdLS, who exhibited developmental delay, intellectual disability, and displayed autistic features, and experienced challenges during right cochlear implant (CI) surgery at the age of 5 due to inner ear abnormality. After the CI, the sound field hearing test showed minimal response levels of 60-70 dB HL at post-CI 12 months. He obtained scores of 2%, 14%, 16%, and 27% on the PEACH rating scale at pre-CI, post-CI 3 months, post-CI 6 months, and post-CI 12 months, respectively. Nevertheless, for CdLS patients with severe-to-profound hearing loss, CI can offer potential improvements in auditory skills and social connections, even though the benefits may be limited. It remains a viable solution.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2026-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Quality of Life Between Patients with Chronic Unilateral Vestibular Hypofunction and Bilateral Vestibulopathy.","authors":"Mustafa Karabulut, Wolfgang Viechtbauer, Lisa Van Stiphout, Merel Kimman, Vincent Van Rompaey, Alfarghal Mohamad, Nils Guinand, Angélica Perez Fornos, Raymond Van de Berg","doi":"10.65717/iao.2026.252104","DOIUrl":"10.65717/iao.2026.252104","url":null,"abstract":"<p><strong>Background: </strong>To compare symptom burden, functional impact, emotional well-being, and health-related quality of life (HRQoL) between patients with chronic unilateral vestibular hypofunction (UVH) and bilateral vestibulopathy (BVP).</p><p><strong>Methods: </strong>This cross-sectional study included 100 patients with chronic UVH and 148 patients with BVP from a tertiary referral center. Symptom burden and functional impact were assessed using the Bilateral Vestibulopathy Questionnaire, Dizziness Handicap Inventory, and Oscillopsia Severity Questionnaire (OSQ). Emotional well-being was evaluated with the Hospital Anxiety and Depression Scale, and HRQoL with the EuroQol 5-Dimension 5-Level and Health Utility Index Mark 3. Total scores were compared across groups. Standardized mean differences (SMDs) were calculated to quantify the differences across all patient-reported outcome measures.</p><p><strong>Results: </strong>Bilateral vestibulopathy patients reported significantly greater symptom burden and functional limitations than chronic UVH patients (P < .05). No significant group differences were found in emotional well-being or generic HRQoL. Both patient groups showed significantly worse outcomes than healthy controls across most domains (P < .05). Standardized mean difference analysis showed that when effect sizes between groups were large or moderate, the differences were statistically significant. Conversely, when effect sizes were very low or small, there were no statistically significant differences (except for the OSQ, which remained significant despite a small effect size).</p><p><strong>Conclusion: </strong>Chronic UVH and BVP are associated with significantly reduced QoL. Bilateral vestibulopathy patients report a greater symptom burden and functional limitations compared to patients with chronic UVH. These findings demonstrate the need for tailored assessments and targeted rehabilitation strategies for vestibular patients.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Response to: \"Comparison of cervical and trapezius vestibular evoked myogenic potentials (VEMPs) in the assessment of vestibular pathway disorders\".","authors":"Regin William","doi":"10.65717/iao.2026.252335","DOIUrl":"10.65717/iao.2026.252335","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1"},"PeriodicalIF":1.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter Regarding \"The Vestibular Evoked Myogenic Potentials (VEMPs) Test over the Trapezius Muscle: Neurophysiological Grounds in Muscle Extensor and Flexor Conditions\".","authors":"Bülent Satar, Ercan Karababa, Ceren Karaçaylı","doi":"10.65717/iao.2026.25233501","DOIUrl":"https://doi.org/10.65717/iao.2026.25233501","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1"},"PeriodicalIF":1.2,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Link Between Chronic Tinnitus and miR-30e, miR-206 , and miR-124 Polymorphisms Modulating the Brain-Derived Neurotrophic Factor Gene.","authors":"Gul Dogan, Olcay Boyacioglu, Murat Dogan, Mustafa Sahin, Seda Orenay Boyacioglu","doi":"10.65717/iao.2026.252009","DOIUrl":"10.65717/iao.2026.252009","url":null,"abstract":"<p><strong>Background: </strong>Brain-derived neurotrophic factor (BDNF) plays a crucial role in the initial formation of the central auditory system and the sensory epithelium within the inner ear. Mounting evidence indicates that BDNF administration promotes microRNA (miRNA) production in neurons, despite the typical suppressive effect of miRNAs on BDNF expression. Therefore, miRNAs regulating BDNF expression may impact the auditory system and serve as potential gene polymorphisms affecting human hearing ability. This study aimed to investigate the contribution of miRNA polymorphisms affecting BDNF to tinnitus pathophysiology.</p><p><strong>Methods: </strong>A total of 70 tinnitus patients aged 18-55 years and 70 age-matched healthy controls without tinnitus or systemic illnesses were recruited from an Ear, Nose & Throat clinic. Tinnitus assessment included tympanometric, audiological, and psychoacoustic evaluations. Seven miRNA single-nucleotide polymorphisms (miR-30e rs112439044, rs10489167, miR-206 rs16882131, miR-30a rs1491500379, miR-26b rs565919718, rs188612260, and miR-124 rs5315564) regulating the BDNF gene were analyzed using the Fluidigm platform.</p><p><strong>Results: </strong>Significant differences in genotype distributions were observed for miR-30e rs112439044, miR-124 rs5315564, and miR-206 rs16882131 between the tinnitus patients and controls (P < .05). Genetic inheritance-model analysis revealed that miR-30e rs112439044 was associated with 0.20- and 0.83-fold risks under dominant and additive models, respectively. The miR-124 rs5315564 showed a 1.65-fold risk in the dominant model, while miR-206 rs16882131 exhibited an 11.1-fold protective effect under the dominant model and an 8.57-fold risk under the additive model.</p><p><strong>Conclusion: </strong>The findings suggest that polymorphisms in miR-206, miR-30e, and miR-124 may influence the auditory pathway by modulating BDNF gene expression, potentially contributing to the pathophysiology of chronic tinnitus.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravestibular Lipoma with Intracochlear Extension: A Case Report on Surgical Management and Cochlear Implantation.","authors":"Jasmine Van de Kerkhof, Ellen Vermaete, Robert Hermans, Elke Loos, Nicolas Verhaert","doi":"10.65717/iao.2026.252197","DOIUrl":"10.65717/iao.2026.252197","url":null,"abstract":"<p><strong>Background: </strong>Intracochlear and intravestibular lipomas are rare benign lesions that may clinically and radiologically mimic retrocochlear pathologies such as vestibular schwannomas. They typically present with progressive sensorineural hearing loss, tinnitus, or dizziness. Due to their rarity, optimal management strategies, particularly in pediatric patients, remain challenging and require individualized decision-making.</p><p><strong>Methods: </strong>We report the case of an 8-year-old girl who presented with progressive right-sided sensorineural hearing loss. Magnetic resonance imaging (MRI) revealed an intravestibular lipoma extending into the cochlea. Considering the patient's young age and the potential for tumor growth, surgical excision was performed via a translabyrinthine approach. Simultaneous cochlear implantation was undertaken to facilitate auditory rehabilitation. Histopathological analysis was conducted to confirm the diagnosis.</p><p><strong>Results: </strong>Histopathological examination confirmed the lesion as a lipoma. The postoperative course was uneventful. The cochlear implant was successfully activated and provided effective hearing restoration.</p><p><strong>Conclusion: </strong>Intravestibular lipomas are rare entities that require careful radiological evaluation to ensure accurate diagnosis and differentiation from other retrocochlear lesions. Management should be individualized, particularly in pediatric patients, balancing surgical risks against the benefits of tumor removal and hearing rehabilitation. Simultaneous cochlear implantation may represent a viable strategy for auditory restoration in selected cases.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of the Additional Effect of Stellate Ganglion Block in Combination of Intratympanic Steroid and Hyperbaric Oxygen Therapy for Refractory Sudden Sensorineural Hearing Loss.","authors":"Huimei Li, Chenyang Zhao, Weihong Zhang, Yin Fu","doi":"10.65717/iao.2026.252151","DOIUrl":"10.65717/iao.2026.252151","url":null,"abstract":"<p><strong>Background: </strong>Refractory sudden sensorineural hearing loss (RSSNHL) underscores the need for more effective salvage therapies. This study aimed to investigate the efficacy of stellate ganglion block (SGB) combined with intratympanic steroid (ITS) and hyperbaric oxygen therapy (HBO) as triple salvage therapy in patients with RSSNHL.</p><p><strong>Methods: </strong>This retrospective study analyzed 73 patients with unilateral RSSNHL admitted between January 2022 and December 2023. All patients underwent salvage therapy with HBO and ITS, with (n=31) or without SGB (n=42). The primary efficacy endpoint was the change in pure tone average thresholds, with secondary endpoints comprising demographic characteristics, tinnitus evaluation, and psychological distress scores.</p><p><strong>Results: </strong>Both groups showed post-treatment hearing improvement (P < .05), but the SGB group achieved greater hearing gain, higher efficacy rates, and superior low-frequency recovery (P < .05). Tinnitus relief and psychological outcomes were also significantly better in the SGB group (P < .05). Patients with both shorter intervals from symptom onset to salvage therapy and relatively lower baseline hearing thresholds demonstrated significantly greater hearing improvement. Neither group experienced severe adverse events.</p><p><strong>Conclusion: </strong>Lower baseline hearing thresholds and earlier therapy initiation predicted better outcomes. The triple salvage therapy significantly improved hearing recovery in RSSNHL patients, particularly in low-frequency ranges, while also reducing tinnitus severity and enhancing psychological well-being.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 1","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148321539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}