The journal of international advanced otology最新文献

Intratympanic Injection of Edaravone for Idiopathic Sudden Sensorineural Hearing Loss with Profound Hearing Loss. 鼓室内注射依达拉奉治疗特发性突发性感音神经性听力损失伴深度听力损失。

The journal of international advanced otology Pub Date : 2025-05-22 DOI: 10.5152/iao.2025.251875

Yoshihiro Nitta, Hajime Sano, Takaomi Kurioka, Taku Yamashita

{"title":"Intratympanic Injection of Edaravone for Idiopathic Sudden Sensorineural Hearing Loss with Profound Hearing Loss.","authors":"Yoshihiro Nitta, Hajime Sano, Takaomi Kurioka, Taku Yamashita","doi":"10.5152/iao.2025.251875","DOIUrl":"https://doi.org/10.5152/iao.2025.251875","url":null,"abstract":"BACKGROUND: In Japan, edaravone, a free radical scavenger, is used clinically to reduce neuronal damage after acute cerebral infarction. In this study, a clinical trial has been designed utilizing intratympanic edaravone injection (ITE), which was hypothesized to exhibit high transitivity into the inner ear, with the aim of identifying an improved treatment modality for patients with idiopathic sudden sensorineural hearing loss (ISSHL) presenting with profound hearing loss. METHODS: Between April 2012 and December 2015, 17 patients with ISSHL, with mean hearing levels equal to or greater than 90 dB HL at the time of the initial visit, were treated with ITE. Fourteen patients with ISSHL under the same conditions were extracted, who received intratym- panic steroid injection (ITS) in the department between January 2015 and December 2019 as a historical control. The hearing thresholds were compared between the ITE and ITS groups. RESULTS: The improvement between the initial and final hearing levels was significantly greater in the ITE group than in the ITS group at 250- 1000 Hz. The average hearing improvement was 49.1 (± 21.0) dB in ITE group and 35.2 (± 11.8) dB in ITS group, and the degree of improvement was significantly greater in ITE group. No detectable adverse events associated with ITE were observed in patients' subjective symptoms. CONCLUSION: The final hearing thresholds of patients treated with ITE were significantly better than those of patients treated with ITS. It has been concluded that ITE treatment may be useful in future clinical studies.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 3","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Middle Ear Transfer Function in Acromegaly Patients. 肢端肥大症患者的中耳转移功能。

The journal of international advanced otology Pub Date : 2025-05-22 DOI: 10.5152/iao.2025.241691

Eray Bayindir, Emel Aslantas, Bulent Can, Berina Slipcevic, Serdal Celik, Basak Mutlu, Mahmut Tayyar Kalcioglu

{"title":"Middle Ear Transfer Function in Acromegaly Patients.","authors":"Eray Bayindir, Emel Aslantas, Bulent Can, Berina Slipcevic, Serdal Celik, Basak Mutlu, Mahmut Tayyar Kalcioglu","doi":"10.5152/iao.2025.241691","DOIUrl":"https://doi.org/10.5152/iao.2025.241691","url":null,"abstract":"BACKGROUND: Acromegaly is a rare disorder in which growth hormone is secreted uncontrollably by the pituitary gland. Considering the risk of pathological effects of acromegaly on middle ear (ME) transfer function and hearing, we aimed to investigate the ME transfer functions of acromegaly patients who underwent transsphenoidal surgery using wide-band tympanometry (WBT) in this study. METHODS: Pure tone audiometry (PTA), 226 Hz probe-tone acoustic immitancemetry, and WBT were performed on all participants. Twenty-eight patients with acromegaly and 29 healthy subjects were included in the current study. RESULTS: The mean age of the acromegaly group (11 males, 17 females) was 49.25 ± 9.57 years, and that of the healthy controls (13 males, 16 females) was 45 ± 10.02 years. The PTA means of the acromegaly and healthy groups were between normal limits, but the mean of the acromeg- aly group (20.73 ± 10.95) was significantly worse than that of the healthy group (12.02 ± 6.67, P = .000). The WBT non-pressurized and pressurized absorbance values of the acromegaly and healthy groups did not show statistically significant differences. The equivalent ear canal volumes at 1000 Hz (P =.041) and the equivalent ear canal volume measured by averaging the WBT (P=.023) of the acromegaly group were larger than those of the healthy controls. CONCLUSION: The investigation revealed that the equivalent ear canal volumes were statistically significantly higher in patients with acromeg- aly. However, this did not impact the ME transfer function.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 3","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144145286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Tooth Loss and Hearing Impairment: Partial Compensation with Dental Implants. 牙齿脱落与听力障碍的关系：种植牙的部分补偿。

The journal of international advanced otology Pub Date : 2025-05-21 DOI: 10.5152/iao.2025.241786

Sang-Yoon Han, Hee Won Seo, Seung Hwan Lee, Jae Ho Chung

{"title":"The Association Between Tooth Loss and Hearing Impairment: Partial Compensation with Dental Implants.","authors":"Sang-Yoon Han, Hee Won Seo, Seung Hwan Lee, Jae Ho Chung","doi":"10.5152/iao.2025.241786","DOIUrl":"10.5152/iao.2025.241786","url":null,"abstract":"BACKGROUND: Some studies have described a relationship between hearing loss and the number of teeth. However, a connection between treatment for tooth loss and hearing improvement remains uncertain. This study aimed to evaluate the association between hearing loss and the number of natural teeth, as well as the association between hearing improvement and dental implants METHODS: Relevant subjects were retrieved from participants in the 8th Korea National Health and Nutrition Examination Survey conducted between 2020 and 2021. Individuals with available information on demographic factors, underlying diseases, audiological results, and the num- ber of natural teeth and dental implants were included in the analysis. Subjects were categorized into normal hearing, mild hearing loss, and moderate hearing loss groups based on the hearing level of the worse ear. RESULTS: The normal hearing group had the highest number of natural teeth and dental implants, followed by the mild hearing loss group, and then the moderate hearing loss group (P < .001 after adjusting for other factors). Additionally, a linear decrease in hearing level was observed in correlation with the number of natural teeth (P < .001) and dental implants (P < .001). CONCLUSION: Hearing loss was significantly associated with tooth loss, and the number of dental implants showed a relationship with lower hearing threshold. Since most sensorineural hearing loss is not curable, and rehabilitation is important, identifying aggravated hearing status in cases of significant tooth loss may be helpful for managing hearing loss.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Sequencing to Detect Mutations for the Molecular Diagnosis of Auditory Neuropathy Spectrum Disorder in a Chinese Series. 新一代测序检测听神经病变谱系障碍分子诊断中的突变。

The journal of international advanced otology Pub Date : 2025-05-21 DOI: 10.5152/iao.2025.241690

Fan Yuan, Zhe Chen, Yanmei Zhang, Yueqi Wang, Jing Xie, Yuhe Liu

{"title":"Next-Generation Sequencing to Detect Mutations for the Molecular Diagnosis of Auditory Neuropathy Spectrum Disorder in a Chinese Series.","authors":"Fan Yuan, Zhe Chen, Yanmei Zhang, Yueqi Wang, Jing Xie, Yuhe Liu","doi":"10.5152/iao.2025.241690","DOIUrl":"10.5152/iao.2025.241690","url":null,"abstract":"BACKGROUND: Auditory neuropathy spectrum disorder (ANSD) encompasses a range of hearing impairments caused by disrupted sound trans- mission from the cochlea to the brain. The atypical symptoms or signs of ANSD often complicate both diagnosis and treatment. To improve the identification of lesion sites and gain insights into the disease mechanisms, we employed next-generation sequencing (NGS) to detect mutations in ANSD-related genes. METHODS: We studied 23 patients with ANSD from non-consanguineous Chinese families. Clinical data were collected and analyzed from medi- cal records. Genomic DNA was extracted from blood samples, followed by whole-exome capture, NGS, and confirmation through bidirectional Sanger sequencing. RESULTS: Based on ANSD classification, 10 patients had non-syndromic (NS) ANSD, 7 had syndromic peripheral neuropathy, and 6 had syndromic central neuropathy. Thirteen novel variants (8 missense variants and 1 deletion variant) and 21 previously reported variants were identified in 23 patients. Several cases exhibited mild-to-profound hearing loss. CONCLUSION: Multiple genes have been identified to cause ANSD. Next-generation sequencing plays a role in differentiating ANSD from other clinical conditions and identifying it as a symptom of syndromic ANSD. Molecular diagnosis offers valuable insights into prognosis and helps guide treatment strategies.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transmeatal Section of the Array in Cochlear Implant Explantation and Reimplantation: How I Do It. 在人工耳蜗移植和再植中的经颅切片：我是怎么做的？

The journal of international advanced otology Pub Date : 2025-05-20 DOI: 10.5152/iao.2025.241771

Stefano Concheri, Elisabetta Zanoletti, Sebastiano Franchella

引用次数: 0

Cochlear Implantation: A Treatment Approach of Hearing Loss in Superficial Siderosis. 人工耳蜗植入术：一种治疗浅表性黄铁矿性听力损失的方法。

The journal of international advanced otology Pub Date : 2025-05-20 DOI: 10.5152/iao.2025.241682

Enrico Liaci, Francesco Maccarrone, Maurizio Negri, Martina Silvestri, Benincasa Paola, Maurizio Guida, Rosa Maria Minniti, Sauro Tassi, Filippo Di Lella

{"title":"Cochlear Implantation: A Treatment Approach of Hearing Loss in Superficial Siderosis.","authors":"Enrico Liaci, Francesco Maccarrone, Maurizio Negri, Martina Silvestri, Benincasa Paola, Maurizio Guida, Rosa Maria Minniti, Sauro Tassi, Filippo Di Lella","doi":"10.5152/iao.2025.241682","DOIUrl":"10.5152/iao.2025.241682","url":null,"abstract":"BACKGROUND: Superficial siderosis (SS) is a chronic condition characterized by progressive hemosiderin accumulation in the central nervous system (CNS) due to chronic subarachnoid hemorrhage. Common clinical features include progressive bilateral sensorineural hearing loss (SNHL), cerebellar ataxia and myelopathy. The aim of the study was to analyze the clinical presentation, management, and outcomes of patients affected by SS with bilateral severe-to-profound hearing loss and treated with cochlear implantation (CI), with a particular focus on the course of hearing benefit. METHODS: A retrospective monocentric review was performed, including patients affected by CNS SS and profound SNHL that underwent CI between January 2012 and December 2021. Outcomes were assessed by comparing pre- and post-operative tonal and vocal hearing thresholds together with verbal perception tests. RESULTS: A total of 4 patients were identified, with a mean follow-up time of 48.25 months. All patients showed significant improvement of hear- ing threshold and verbal perception in the first 6 months after surgery (preoperative mean aided PTA of 58.3 dB with a mean open-set speech perception score of 20.3% versus postoperative mean PTA in bimodal stimulation of 41.1 dB and open-set speech perception score of 60.1%). At the last follow-up evaluation, despite progressive deterioration of auditory performances, all patients were users and maintained subjective benefit from CIs. CONCLUSION: Patients affected by SS who underwent CI showed a significant improvement in auditory and auditory-verbal performances in the first post-operative period. Despite a progressive decline of hearing benefit due to retrocochlear disease progression, CI represents valid support for lip-reading and spatial orientation even in the advanced stages of the disease.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Non-Invasive Imaging in Differentiating LCH and Cholesteatoma in Clinical Practice. 无创影像学在LCH与胆脂瘤鉴别中的临床应用。

The journal of international advanced otology Pub Date : 2025-03-25 DOI: 10.5152/iao.2025.241742

Ammara Jamil

引用次数: 0

Temporal Bone Magnetic Resonance Imaging in Sudden Sensorineural Hearing Loss: Low Frequency Versus Other Types. 突发性感音神经性听力损失的颞骨磁共振成像：低频与其他类型。

The journal of international advanced otology Pub Date : 2025-03-25 DOI: 10.5152/iao.2025.241490

Yun Ji Lee, Doyeon Kim, Joong Ho Ahn, Hong Ju Park, Jong Woo Chung, Woo Seok Kang

{"title":"Temporal Bone Magnetic Resonance Imaging in Sudden Sensorineural Hearing Loss: Low Frequency Versus Other Types.","authors":"Yun Ji Lee, Doyeon Kim, Joong Ho Ahn, Hong Ju Park, Jong Woo Chung, Woo Seok Kang","doi":"10.5152/iao.2025.241490","DOIUrl":"https://doi.org/10.5152/iao.2025.241490","url":null,"abstract":"Background: Gadolinium-enhanced magnetic resonance imaging (MRI) is the gold standard for diagnosing vestibular schwannoma (VS). This study aimed to compare the incidence of VS among patients with low-frequency, high-frequency, and flat-type sudden sensorineural hearing loss (SSNHL) and to assess the effectiveness of MRI for each SSNHL type.Methods: We analyzed 755 patients diagnosed with SSNHL at a single tertiary center between January 2014 and March 2020. All underwent temporal bone MRI. Logistic regression was used to determine the associations of SSNHL types with VS. Additionally, we conducted a correlation analysis to examine the relationship between word recognition scores (WRS) and the size of tumors measured on MRI at the time of diagnosis.Results: Magnetic resonance imaging identified VS in 23 of 755 cases (3.0%). Of the patients, 123 (16.3%) had low-frequency SSNHL; none of these patients had VS. The incidence of VS differed significantly between the low-frequency SSNHL group and other SSNHL types (P < .001). A significant negative correlation was found between initial tumor size and WRS (r2 = 0.2905, P=.008).Conclusion: The prevalence of VS was rare in patients with low-frequency SSNHL. The pattern of hearing loss may provide insights into the likelihood of tumor presence, thereby aiding in more effective audiometric screening and decision-making regarding MRI for detecting VS.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Audio-Vestibular Findings in Young Regular and Non-Regular Personal Music System Users. 经常和不经常使用个人音乐系统的青少年的听觉前庭功能调查。

The journal of international advanced otology Pub Date : 2025-03-25 DOI: 10.5152/iao.2025.241676

Darshan Devananda, Vipin Ghosh, Nayana Benny, Mereena James

{"title":"Audio-Vestibular Findings in Young Regular and Non-Regular Personal Music System Users.","authors":"Darshan Devananda, Vipin Ghosh, Nayana Benny, Mereena James","doi":"10.5152/iao.2025.241676","DOIUrl":"https://doi.org/10.5152/iao.2025.241676","url":null,"abstract":"Background: Younger adults frequently utilize personal music systems (PMSs) for extended periods for leisure. It has been reported in the literature that hearing abilities are affected in such individuals. However, its effect on auditory processing abilities and the vestibular system remains unclear. Hence, the present study was carried out to investigate the audiological and vestibular functioning in young adults who use PMSs regularly.Methods: Forty participants between 18 and 25 years of age were divided into 2 groups. Group 1 included 20 regular PMSs users from 2 to 3 years, and group 2 comprised 20 participants who were non-regular PMSs users. Detailed audiological evaluations were carried out on 15 participants in each group, and vestibular evaluations were carried out on all the participants.Results: It was observed that the extended high-frequency hearing thresholds and otoacoustic emissions were affected in the regular PMSs users. The gap in noise test and vestibular evoked myogenic potential testing revealed that temporal resolution abilities and vestibular system functioning are also compromised among regular PMS users.Conclusion: Thus, this study highlights the subtle vestibular and auditory impairments that PMS may produce in young adults, as well as the significance of a battery of tests to detect them.","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144056279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing AI Horizons: Scientific Conversations on Tympanoplasty Postoperative Management. 推进人工智能视野：鼓室成形术术后管理的科学对话。

The journal of international advanced otology Pub Date : 2025-03-25 DOI: 10.5152/iao.2025.2419152

Aynur Aliyeva

引用次数: 0