The journal of international advanced otology最新文献

{"title":"Ten-Year Experience with Combined Hyperbaric Oxygen and Steroid Therapy for Idiopathic Sudden Sensorineural Hearing Loss: A Retrospective Cohort of 332 Patients.","authors":"Alfonso Scarpa, Giovanni Granata, Francesco Pio Tedesco, Luigi Falchetta, Arianna Montanino, Federico Maria Gioacchini, Massimo Re, Antonio Siglioccolo, Francesco Antonio Salzano","doi":"10.65717/iao.2026.252388","DOIUrl":"https://doi.org/10.65717/iao.2026.252388","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the clinical efficacy and safety of hyperbaric oxygen therapy (HBOT) combined with systemic corticosteroids in patients with idiopathic sudden sensorineural hearing loss (ISSNHL), with particular focus on treatment timing, predictors of hearing recovery, and the impact of comorbidities.</p><p><strong>Methods: </strong>This retrospective observational cohort study was conducted at a tertiary referral center (AOU \"San Giovanni di Dio e Ruggi d'Aragona,\" Salerno, Italy). A total of 332 adult patients with ISSNHL treated between 2014 and 2024 were included. All patients received combined therapy with systemic corticosteroids (oral prednisone 1 mg/kg/day, tapered over 10-15 days) and HBOT (2.4 atmospheres absolute, 90 minutes per session; median of 10 sessions). Audiometric outcomes were assessed using pure-tone average (PTA). Treatment response was defined as a ≥30% improvement in PTA compared with baseline. Multivariate logistic regression was performed to identify independent predictors of hearing improvement. Safety outcomes were also recorded.</p><p><strong>Results: </strong>Mean baseline PTA was 61.3 ± 21.5 dB HL, improving to 44.6 ± 22.7 dB HL after treatment, with a mean hearing gain of 16.7 ± 14.2 dB HL (P < .001). Overall, 151 patients (43.5%) met the response criteria. Responders presented with significantly higher baseline PTA compared with nonresponders (67.6 vs. 56.8 dB HL, P < .001) and more frequently reported tinnitus (64.2% vs. 51.5%, P = .014). Median time to treatment initiation was 15 days (interquartile range: 7-30). Multivariate analysis identified shorter time to treatment (odds ratio [OR]: 0.95, 95% CI: 0.92-0.98), presence of tinnitus (OR: 1.79, 95% CI: 1.15-2.80), and higher baseline PTA (OR: 1.03, 95% CI: 1.01-1.05) as independent predictors of hearing improvement. Common comorbidities, including hypertension, diabetes, and cardiovascular disease, were not significantly associated with treatment response. No serious adverse events related to HBOT were observed.</p><p><strong>Conclusion: </strong>Hyperbaric oxygen therapy combined with systemic corticosteroids was associated with improved audiometric outcomes in patients with ISSNHL, particularly when initiated early. Shorter time to treatment, greater baseline hearing loss, and the presence of tinnitus emerged as independent predictors of hearing recovery. Overall, these findings suggest an association between early HBOT use and improved audiometric outcomes and support its consideration as an adjunctive component of multimodal treatment strategies for ISSNHL.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Application of Laser Technology in Cholesteatoma Surgery: Systematic Review and Meta-analysis.","authors":"Amenah Al Manasef, Amer Alsulaymi, Aryam Althobaiti, Faisal Al-Dhafeeri, Lamar Fatani, Mohammad Bawazir, Munira Albeshr, Nawaf Alrabie, Rawan Almutairi, Sufian Alsweed, Thikra Alsenani, Ziad Abdullah, Faisal Zawawi","doi":"10.65717/iao.2026.262322","DOIUrl":"10.65717/iao.2026.262322","url":null,"abstract":"<p><strong>Unlabelled: </strong>To evaluate the effectiveness of laser-assisted cholesteatoma surgery compared with conventional techniques, with a focus on residual disease, postoperative complications, and hearing preservation. A systematic review and meta-analysis were conducted following PRISMA guidelines. Databases were searched for studies comparing laser and non-laser cholesteatoma surgery. Eligible studies were screened, and risk ratios (RR) with 95% CI were calculated using a random-effects model. Three studies including 271 participants reported residual disease outcomes. The pooled risk ratio was RR = 0.53; 95% CI, 0.12-2.39; P = .406, indicating no statistically significant difference between laser and non-laser groups. Moderate heterogeneity was observed (I2 = 63.5%). Only 1 study reported postoperative complications, with RR = 1.04; 95% CI, 0.18-5.97. A subgroup analysis from 1 study compared laser myringotomy with endaural laser-assisted single-stage inside-out cholesteatoma, showing RR = 0.57; 95% CI, 0.15-2.19. Laser-assisted cholesteatoma surgery demonstrates comparable rates of residual disease and complications to conventional surgery. While lasers may offer technical advantages, current evidence is limited and underpowered. Larger, high-quality trials are needed to clarify their role in cholesteatoma management.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Exanatide on Recovery of the Facial Nerve Crush Injury in the Rat.","authors":"Begüm Yılmaz, Ayşe Aslı Şahin Yılmaz, Kadri İla, Reyhan Sürmeli, Murat Hakan Karabulut, Mehmet Sürmeli","doi":"10.65717/iao.2026.252134","DOIUrl":"https://doi.org/10.65717/iao.2026.252134","url":null,"abstract":"<p><strong>Background: </strong>Exenatide, a glucagon-like peptide-1 receptor agonist, has been shown to promote functional recovery and nerve regeneration after nerve crush injury. The aim of this study was to investigate the effect of exenatide on facial nerve regeneration in traumatic facial paralysis.</p><p><strong>Methods: </strong>This prospective, randomized animal study included 28 healthy female Sprague-Dawley rats divided into 4 groups of 7 rats each: control group, sham group, 2.5 μg/rat/day exenatide-treated group, and 10 μg/rat/day exenatide-treated group. Exenatide was injected subcutaneously for 14 days. Crush injury was applied to the left facial nerve in all groups except the sham group. Functional assessment, electrophysiological, histopathological, and immunohistochemical examinations were performed after crush injury.</p><p><strong>Results: </strong>The blink reflex score was higher in 10 μg exenatide-treated rats than in other rats at week 1. At weeks 3 and 4, the vibrissae movement score was higher in exenatide-treated rats than in untreated rats. Electromyographic assessments performed at weeks 2 and 4 showed higher amplitude values and shorter latency periods in the exenatide treatment groups. Exenatide was found to have a dose-dependent effect on reducing the severity of vasoconstriction, and this effect was statistically significant. When comparing the exenatide treatment groups with the control group, a significant reduction in the incidence of severe macrovacuolation and an increase in myelin thickness were observed (P < .05).</p><p><strong>Conclusion: </strong>Functional, electrophysiological, and histopathological evaluations have shown that exenatide treatment has a positive and accelerating effect on facial nerve recovery in traumatic facial paralysis.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-9"},"PeriodicalIF":1.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Prognostic Capacity of the Imaging Features in Cochlear Implant Patients with Cochlear Nerve Deficiency.","authors":"Zhencheng Gao, Simeng Lu, Xingmei Wei, Ying Kong, Shujin Xue, Jingxian Wang, Chunling Ma, Yongxin Li","doi":"10.65717/iao.2026.252234","DOIUrl":"https://doi.org/10.65717/iao.2026.252234","url":null,"abstract":"<p><strong>Background: </strong>Cochlear nerve deficiency (CND) is a prevalent inner ear malformation, and several studies have identified a correlation between imaging features and postoperative outcomes in cochlear implant patients with CND. Nevertheless, the extent to which various imaging features influence postoperative cochlear implantation (CI) outcomes remains unclear. This study sought to identify the imaging parameter with the most significant impact on postoperative outcomes in CND patients.</p><p><strong>Methods: </strong>A total of 107 CND children were included in this study. Imaging features, including internal auditory canal (IAC) diameter, IAC nerve grade, vestibulocochlear nerve (VCN) area, and the area ratio of the vestibulocochlear nerve to the facial nerve (VCN/FN), were evaluated. The optimal cut-off values for each continuous imaging parameter were calculated via maximally selected rank statistics. The effects of imaging features and clinical data on the postoperative auditory and speech outcomes of CND children were analyzed.</p><p><strong>Results: </strong>Univariate Cox regression identified higher IAC nerve grade (Grade IV), IAC diameter, VCN area, and VCN/FN ratio as predictors of better auditory performance after CI. Female sex, higher IAC nerve grade, IAC diameter, VCN area, and VCN/FN ratio were associated with better speech performance. Multivariate analysis showed that higher IAC nerve grade and VCN/FN ratio independently predicted auditory performance, whereas only the VCN/FN ratio independently predicted speech performance.</p><p><strong>Conclusion: </strong>A higher VCN/FN ratio is the most robust imaging predictor of postoperative outcomes in CND children, independently predicting both auditory and speech performance after CI.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Efficacy of Appiani and Zuma Maneuvers in Patients with Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo.","authors":"Asuman Feda Bayrak, Deniz Fırat Öztürk, Baturalp Çetin","doi":"10.65717/iao.2026.262489","DOIUrl":"https://doi.org/10.65717/iao.2026.262489","url":null,"abstract":"<p><strong>Background: </strong>Apogeotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV) is a challenging variant of BPPV with lower treatment success rates compared to the geotropic form. The Appiani maneuver (ApM) and the Zuma maneuver (ZmM) represent 2 repositioning strategies targeting this condition, but head-to-head comparative data remain limited.</p><p><strong>Methods: </strong>A prospective randomized comparative study was conducted between December 2024 and November 2025. Patients with unilateral apogeotropic HC-BPPV confirmed by videonystagmography (VNG)-assisted supine roll testing were assigned to either the ApM (n = 38) or the ZmM (n = 39). The primary outcome was resolution of positional nystagmus; the secondary outcome was the number of maneuver sessions required (maximum 4). Patients who developed canal conversion to another semicircular canal during follow-up were excluded from efficacy analysis.</p><p><strong>Results: </strong>Among 77 patients (63.6% female; 59.7% aged ≥ 60 years), the overall single-session resolution rate was 63.6%. Resolution after 1 session was achieved in 68.4% (ApM) and 59.0% (ZmM) of patients, with no significant between-group difference (P = .389). Older age (≥60 years) was the only factor significantly associated with requiring ≥2 sessions (82.1% vs. 46.9%; P = .002).</p><p><strong>Conclusion: </strong>Both the ApM and ZmM are effective and comparable treatments for apogeotropic HC-BPPV. Advanced age (≥60 years) was identified as an exploratory factor associated with requiring multiple treatment sessions.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Residual Low-to-Mid Frequency Hearing in the Poorer-Hearing Ear Is Associated with Better Sound Localization in Single-Sided Deafness.","authors":"Seung-Ik Jeon, Hyo-Jeong Lee","doi":"10.65717/iao.2026.252277","DOIUrl":"https://doi.org/10.65717/iao.2026.252277","url":null,"abstract":"<p><strong>Background: </strong>Single-sided deafness (SSD) impairs spatial hearing because of the loss of binaural cues. However, some individuals with SSD show unexpectedly accurate localization, suggesting compensatory mechanisms. This study investigated whether residual hearing in the poorer-hearing ear is related to localization ability and whether this relationship varies across frequency bands.</p><p><strong>Methods: </strong>Fourteen SSD patients participated in a sound localization task using broadband (BB), low-pass (LP), and high-pass (HP) filtered noise stimuli. Residual hearing thresholds (125-20 000 Hz) were measured across 7 frequency bands, and their associations with localization performance were analyzed. Clinical variables (duration and onset age of SSD) were also assessed.</p><p><strong>Results: </strong>Significant correlations between localization performance and residual hearing were observed only under BB conditions and only in the poorer-hearing ear. The strongest associations emerged in low-to-mid frequency bands (up to approximately 4000 Hz) and remained significant after controlling for clinical variables and for high-frequency hearing in the same ear. No significant associations were found with HP- or LP-filtered stimuli. Neither onset age nor duration of SSD was significantly associated with localization performance after correction for multiple comparisons. Localization was also more accurate for stimuli presented on the better-hearing side, an asymmetry that reached significance only for stimuli containing high-frequency energy.</p><p><strong>Conclusion: </strong>Preserved low-to-mid frequency hearing in the poorer-hearing ear was associated with better localization in patients with SSD when the stimulus contained rich spatial cues, such as broadband noise. These findings highlight the relevance of frequency-specific residual hearing, particularly at low-to-mid frequencies, to spatial hearing in this population.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-10"},"PeriodicalIF":1.2,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium Pyrophosphate Deposition Disease of the Temporomandibular Joint Extending into the External Auditory Canal and the Middle Ear, Coexisting with Otosclerosis: A Case Report.","authors":"Nao Nojiri, Tetsuya Tono, Ryo Takagi, Yu Tanaka, Takashi Koike, Soichiro Matsumoto, Yusuke Matsuda","doi":"10.65717/iao.2026.262372","DOIUrl":"https://doi.org/10.65717/iao.2026.262372","url":null,"abstract":"<p><strong>Unlabelled: </strong>Calcium pyrophosphate deposition disease (CPPD) is caused by CPP crystals and rarely forms tumors in joints. The authors describe a case of tumoral CPPD in the temporomandibular joint (TMJ), extending into the external auditory canal (EAC) and the middle ear. A 71-year-old man was referred to the department with a tentative diagnosis of CPPD in the right TMJ. Computed tomography showed the mass extending into the EAC, tympanic cavity, and bony Eustachian tube, with opacification of the mastoid cells. The audiogram revealed bilateral mixed hearing loss, suggesting the coexistence of bilateral otosclerosis. Partial resection of the mass and simultaneous implantation of a Baha® on the same side were performed. Histopathological findings revealed indistinct crystals in the surgical specimens. Calcium pyrophosphate crystals were identified using thin-film X-ray diffraction (XRD) analysis. The comorbidity of CPPD and otosclerosis in the same ear is a rare condition. Considering the unpredictable nature of CPPD, the authors opted for partial resection of the lesion involving the EAC and the middle ear to avoid any complications. Due to coexisting otosclerosis, Baha® played an important role in the auditory management of bilateral mixed hearing loss in this patient.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masseteric Vestibular-Evoked Myogenic Potentials in Cochlear-Implanted Children: An Analysis of Dual Stimulation Modes.","authors":"Anuj Kumar Neupane, Sejal Somani","doi":"10.65717/iao.2026.262475","DOIUrl":"https://doi.org/10.65717/iao.2026.262475","url":null,"abstract":"<p><strong>Background: </strong>Cochlear implants (CIs) are widely used for auditory rehabilitation but have often been linked to adverse vestibular insults. While cervical vestibular-evoked myogenic potential (cVEMP) and ocular vestibular-evoked myogenic potential (oVEMP) have been studied, the vestibulo-trigeminal pathway via masseteric vestibular-evoked myogenic potential (mVEMP) in children with CIs remains unexplored. The present study explored the mVEMP responses among children with CIs using dual stimulation modes (air and bone conduction modes of stimulation).</p><p><strong>Methods: </strong>The study included 15 children (aged 6-10 years) using unilateral CI, having implant age >6 months and no radiological impairments. A reference group constituted 15 normal hearing children of the same age range with no comorbidities. mVEMP was recorded at 95 dBnHL for air conduction mode and 55 dBnHL for bone conduction mode using 500 Hz narrowband chirp stimulus.</p><p><strong>Results: </strong>In the study, air conduction resulted in a lack of response in implanted ear and reduced responses in non-implanted ears. Bone conduction revealed no significant variation between implanted and non-implanted ears, with response rate of 86.6% and 93.3%, respectively. A significant difference was found in mVEMP amplitude between children using CI and the reference group. No significant relationship was observed between chronological age and mVEMP responses, or between implant age and mVEMP responses in implanted ear. However, a moderate positive relationship was noted between implant age and mVEMP amplitude in non-implanted ear.</p><p><strong>Conclusion: </strong>This study identified diminished mVEMP responses to air conduction stimulation in children with CIs, while bone conduction elicited more robust responses, supporting its superior efficacy in evaluating otolith function in implanted ears.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Biomarker for Bell's Palsy: The Pan-Immune-Inflammation Value.","authors":"Serkan Altıparmak, Ayhan Kars","doi":"10.65717/iao.2026.251877","DOIUrl":"https://doi.org/10.65717/iao.2026.251877","url":null,"abstract":"<p><strong>Background: </strong>The pan-immune-inflammation value (PIV) is a recently described novel biomarker obtained from complete blood count parameters. Systemic biomarkers have been investigated in a number of studies aimed at confirming the role of the inflammatory process in the etiology of Bell's palsy (BP) and elucidating the association with prognosis. This study investigated the relationship between PIV and BP.</p><p><strong>Methods: </strong>Sixty patients aged 18-75 years presenting with BP and 51 healthy controls with similar age and sex profiles were included in this retrospective study. Pan-immune-inflammation value and systemic immune-inflammation index (SII) values were calculated and compared between the 2 groups. The severity of paralysis in the BP group was recorded according to the House-Brackmann (HB) grading system and compared between the 2 groups.</p><p><strong>Results: </strong>Both PIV and SII values were significantly higher in the BP group (P < .001). Intra-group comparisons based on paralysis grading revealed a significant difference in SII values in grades IV and V (P = .04).</p><p><strong>Conclusion: </strong>The findings suggest that PIV may represent a useful and readily available biomarker reflecting systemic inflammation in patients with BP. However, larger prospective studies are now required to confirm its diagnostic and prognostic values.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab as a Therapeutic Option in Chronic Eustachian Tube Dysfunction and Chronic Rhinosinusitis with Nasal Polyposis: A Case-Based Observation.","authors":"Holger Sudhoff","doi":"10.65717/iao.2026.252071","DOIUrl":"https://doi.org/10.65717/iao.2026.252071","url":null,"abstract":"<p><strong>Background: </strong>To report the first documented case of complete resolution of refractory dilatory Eustachian tube dysfunction (ETD) following dupilumab treatment in patients with severe chronic rhinosinusitis with nasal polyposis (CRSwNP).</p><p><strong>Methods: </strong>Four consecutive patients with longstanding refractory dilatory ETD, severe CRSwNP, and asthma, unresponsive to multiple sinus and mastoid surgeries, were treated with dupilumab.</p><p><strong>Results: </strong>Dupilumab resulted in complete remission of both CRSwNP and dilatory ETD symptoms within 6 weeks. Audiometry and tubomanometry confirmed restoration of middle ear function.</p><p><strong>Conclusion: </strong>Dupilumab may offer a novel therapeutic option for patients with dilatory ETD associated with type 2 inflammation. Further prospective studies are needed to assess its long-term efficacy.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 5","pages":"1-4"},"PeriodicalIF":1.2,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149187245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}