The journal of international advanced otology最新文献

{"title":"The Impact of High Glycated Hemoglobin A1c on Prognosis in Patients with Bell's Palsy: A Propensity Score Matchingatched Analysis.","authors":"Erhui Yu, Binyan Yu, Fanyuan Jin, Huafeng Cai, Jinhua Hu, Yingtong Chen, Runcheng Wang, Xiuzhen Xie, Shuhan Yang, Lihua Xuan","doi":"10.5152/iao.2025.241759","DOIUrl":"https://doi.org/10.5152/iao.2025.241759","url":null,"abstract":"<p><strong>Background: </strong>Glycated hemoglobin A1c (HbA1c) is an indicator of blood glucose levels, but the impact of hyperglycemia on Bell's palsy (BP) remains unclear. This study aims to assess the influence of high and low HbA1c levels on the prognosis of patients with BP.</p><p><strong>Methods: </strong>This monocentric, retrospective study included 712 patients with BP, divided into 103 patients with HbA1c ≥ 6.5% and 609 patients with HbA1c < 6.5%. Receiver operating characteristic curve analysis was used to evaluate the main factors affecting HbA1c levels. Propensity score matching (PSM) was further utilized to avoid selection bias and disproportionate distributions of confounding factors between the 2 groups. The House-Brackmann (H-B) facial nerve grading system was employed to assess the severity of facial motor dysfunction.</p><p><strong>Results: </strong>Analysis showed that high HbA1c patients were older, had higher body mass index, less frequently suffered from dysgeusia, and more often had hypertension (P < .05). According to the area under the curve, age had the greatest impact on HbA1c levels (95% CI=0.748-0.803, P <.001). After PSM 1 : 1 matching, there was no statistical difference in initial H-B grade between the 2 groups, but there was a statistical difference in final H-B grade (P = .023), indicating a worse prognosis for patients with BP in the high HbA1c group.</p><p><strong>Conclusion: </strong>The study, after controlling for confounding factors, showed that patients with BP and high HbA1c have a worse prognosis, suggesting that controlling blood glucose levels has a positive significance for the recovery of patients with BP.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochlear Implantation in Patient with Arnold-Chiari Malformation.","authors":"Paulina Podlawska-Nowak, Anna Bartochowska, Andrzej Balcerowiak, Wojciech Gawecki","doi":"10.5152/iao.2024.231273","DOIUrl":"https://doi.org/10.5152/iao.2024.231273","url":null,"abstract":"<p><p>We report a case of a 74-year-old patient with Arnold-Chiari syndrome (type 1) who, due to the bilateral profound hearing loss, was qualified for cochlear implantation. The difficult anatomy of the temporal bone necessitated special preparation for the procedure. The use of neuronavigation, in combination with facial nerve monitoring, enabled a safe surgical approach to the cochlea and ensured accurate placement of the implant.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144040369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondrosarcoma of the Jugular Foramen: A Case Report.","authors":"Josip Prnjak, Andro Košec, Alan Pegan, Tomislav Greguric, Jakov Ajduk","doi":"10.5152/iao.2025.231362","DOIUrl":"https://doi.org/10.5152/iao.2025.231362","url":null,"abstract":"<p><p>The vast majority of chondrosarcomas of the skull (CS) are located at the skull base and represent locally aggressive malignant tumors that account for 0.15% of all intracranial neoplasms. Complete surgical resection with wide surgical margins is currently the main treatment strategy, but can be hard to achieve due to the complex anatomy of the head and neck. The jugular foramen, situated in the floor of the posterior fossa and posterolaterally to the petro-occipital suture, is a remarkably rare location for CS. A case of primary CS of the jugular foramen in a 65-year-old patient is reported, presenting with otalgia, pulsatile tinnitus, and mild hearing loss in the left ear, accompanied by peripheral facial nerve paresis. Radiographic imaging showed a mass in the left mastoid, middle ear and jugular fossa with bone destruction of the jugular fossa and mastoid, while magnetic resonance imaging showed additional involvement of the petroclival fissure, hypoglossal canal, jugular bulb, and sigmoid sinus. The tumor was resected with wide margins through a Fisch infratemporal fossa approach type A, followed by radiotherapy. Results of the immunophenotyping along with histological features primarily matched moderately differentiated chondrosarcoma. The patient is recurrence free at 6 months after treatment. Middle ear discharge with facial palsy as a first manifestation of the CS has not been described to date. The unique localization, treatment details and histopathologic data are relevant in expanding the current level of knowledge on the subject.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144046107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Patterns of Cav1.3 in the Developing Stria Vascularis of Sprague-Dawley Rats.","authors":"Zhihui Du, Han Liu, Hanqi Chu, Jin Chen","doi":"10.5152/iao.2025.241581","DOIUrl":"https://doi.org/10.5152/iao.2025.241581","url":null,"abstract":"<p><strong>Background: </strong>Although multiple functions of Cav1.3 in adult rat cochlea have been explored, its role in developing stria vascularis (SV) of Sprague-Dawley (SD) rats has rarely been reported.</p><p><strong>Methods: </strong>Sprague-Dawley rats from postnatal 0 to 21 days (p0-p21) were utilized for the experimental model and classified into 4 groups by age randomly: p0, p7, p14, and p21. p3 SD rats were employed to culture primary marginal cells (MCs). The quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunofluorescence technique were employed to identify Cav1.3 in vivo. Immunocytochemistry was applied to explore the expression of Cav1.3 in vitro.</p><p><strong>Results: </strong>Quantitative reverse transcription polymerase chain reaction showed that the Cav1.3 calcium channel gene (CACNA1D) was measured in the cochlear lateral wall (STV), which included SV and spiral ligament. Immunofluorescence photographs revealed that Cav1.3 was intensively expressed in the SV, weakly expressed in the spiral ligament and spiral prominence. In the SV, immunofluorescence labeling of Cav1.3 was present in MCs, intermediate cells, and basal cells. Immunocytochemistry confirmed that Cav1.3 was expressed in the cytomembrane of the MCs. Moreover, the expression of Cav1.3 was increased in the developmental STV at both the protein and mRNA levels.</p><p><strong>Conclusion: </strong>Cav1.3 was mainly present in the cytomembrane of MCs in the SV of postnatal SD rats. Additionally, Cav1.3 protein and mRNA increased with development in the cochlear lateral wall of SD rats, including in the SV. The alteration of Cav1.3 expression may influence the homeostasis of ions and benefit the normal function and development of the cochlea.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific Publishing is Still Awaiting for AI to be Geared Up.","authors":"Osman Nuri Özgirgin","doi":"10.5152/iao.2025.241581","DOIUrl":"https://doi.org/10.5152/iao.2025.241581","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Hearing Loss in Primary Ciliary Dyskinesia: A Study of Conductive and Sensorineural Mechanisms from Pediatric and Adult Cases.","authors":"Caroline Avgeri, Giorgos Sideris, Dafni Moriki, Konstantinos Douros, Alexander Delides, Thomas Nikolopoulos","doi":"10.5152/iao.2025.241872","DOIUrl":"https://doi.org/10.5152/iao.2025.241872","url":null,"abstract":"<p><strong>Background: </strong>Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects the respiratory and auditory systems. This study aims to assess the prevalence, type, and severity of bilateral hearing loss (HL) in PCD and Kartagener syndrome (KS) patients, examining age-related differences and chronic impacts of otologic pathologies.</p><p><strong>Methods: </strong>A total of 19 patients (38 ears), including 6 children and 13 adults, were evaluated from June to September 2021. Comprehensive clinical examinations included otoscopy, tympanometry, and pure tone audiometry (PTA) for air and bone conduction. Tympanometry findings were compared with otoscopic results. Statistical analyses were conducted using SPSS v16.0 (SPSS Inc.; Chicago, IL, USA), with a significance threshold of P ≤ .05.</p><p><strong>Results: </strong>Hearing loss was identified in 42.1% of patients, with conductive HL predominant in children (3 out of 4), while mixed HL was more common in adults (3 out of 4). Tympanometry results showed 57.9% type A and 42.1% type B findings, correlating with otoscopic observations. Chronic otitis media with effusion (OME) and tympanosclerosis (TS) were the primary pathologies contributing to middle ear damage. Age was significantly correlated with HL severity (P= .005). Mild HL was most common (62.5%), followed by moderate HL (25%) and moderately severe HL (12.5%).</p><p><strong>Conclusion: </strong>This study identifies distinct age-related patterns in the type and severity of HL among PCD patients, with sensorineural components observed in adults due to progressive middle ear damage. Audiological evaluations are essential for identifying these complications. Further research is needed to optimize treatment approaches and understand the progression of HL in PCD/KS patients.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sinus Vein Thrombosis in Pediatric Patients After Acute Mastoiditis.","authors":"Aviad Sapir, Yotam Eshel, Yotam Heilig, Hagit Miskin, Oren Ziv, Sabri El-Saied, Daniel M Kaplan","doi":"10.5152/iao.2025.241721","DOIUrl":"https://doi.org/10.5152/iao.2025.241721","url":null,"abstract":"<p><strong>Background: </strong>Acute mastoiditis (AM), a complication of acute otitis media, remains a concern despite medical advancements and often leads to severe complications such as cerebral sinus vein thrombosis (CSVT). This study aimed to characterize the clinical, microbiological, and hematological aspects of CSVT secondary to AM in children while assessing the necessity of thrombophilia evaluation in these patients.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on pediatric patients with CSVT secondary to AM between January 2015 and December 2022. This study examined clinical data, laboratory and microbiological results, imaging studies, treatment approaches, and patient outcomes.</p><p><strong>Results: </strong>Seventeen pediatric patients with a mean age of 3 years were included in this study. Most patients were female (76.5%) and of Jewish ethnicity (82.4%). Group A Streptococcus is the primary pathogen responsible for this condition. The treatment plan involved the administration of intravenous antibiotics and surgical intervention, including cortical mastoidectomy and ventilation tube insertion. Additionally, anticoagulation therapy with Clexane® was initiated and continued for at least 3 months post event. Follow-up imaging revealed recanalization in most cases within an average of 3 months. Hematologic follow-up revealed no recurrent thrombotic events and low thrombophilia incidence.</p><p><strong>Conclusion: </strong>Cerebral sinus vein thrombosis following AM is a provoked thrombotic event effectively managed with Clexane®. Thrombophilia evaluation may be reserved for patients with a high suspicion of underlying hematological conditions. Follow-up imaging within 3 months post event may be premature.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144039522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the Round Table Discussion on the Fifth International Symposium on Otosclerosis and Stapes Surgery.","authors":"Said Sönmez, Kadir Serkan Orhan, Wolf-Dieter Baumgartner, Andrzej Zarowski, Nuri Osman Özgirgin, Maurizio Barbara, Christof Röösli, Isabelle Mösnier, Marco Caversaccio, Yann Nguyen, Vedat Topsakal","doi":"10.5152/iao.2025.241839","DOIUrl":"https://doi.org/10.5152/iao.2025.241839","url":null,"abstract":"<p><strong>Background: </strong>Debates and research about otosclerosis and stapes surgery have continued since the time it was described, and there is still no consensus on many issues. The aim of this article is to report the controversies in the etiology, pathophysiology, diagnosis, imaging, treatment, and management of otosclerosis and address the points of consensus of experts.</p><p><strong>Methods: </strong>In the last session of the Fifth International Otosclerosis and Stapes Surgery Symposium held in Brussels, a round table meeting was held where controversial issues in otosclerosis and stapes surgery were discussed, and a survey was administered to all participants. Nine experienced panelists were interviewed by the moderator on stage, and 166 participants provided their answers interactively through the online voting system.</p><p><strong>Results: </strong>All of the panelists were experts in their field who had performed more than 1000 cases, and if we take into account the more experienced participants, the results are based on at least 16 968 stapes surgery experiences. While full consensus was reached by the expert panelists on 14 questions, agreement was reached by participants on only 2. The most striking difference between the panelists and attendees was regarding reparative granuloma.</p><p><strong>Conclusion: </strong>Even if a consensus was reached on some issues, controversies, especially the surgical technique, medical equipment and prostheses used are subjects to both discussion and development. Even the experts who come to present and share knowledge do not always agree. It is strongly recommended that clinicians follow all developments, compare their results with those of others, and use the techniques and materials with which they feel most comfortable for their patients.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Postoperative Management of Tympanoplasty with ChatGPT-4.0\".","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.5152/iao.2025.241915","DOIUrl":"https://doi.org/10.5152/iao.2025.241915","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive Ototoxicity of Baby Shampoo As An Antifog Agent: An Experimental Study.","authors":"Ahmet Mutlu, Burcu Bakici, Ayşe Yasemin Gunduz, Murat Erinc, Erdogan Bulut, Onur Ersoy, Hakan Bayraktar, Mahmut Tayyar Kalcioglu","doi":"10.5152/iao.2025.241526","DOIUrl":"https://doi.org/10.5152/iao.2025.241526","url":null,"abstract":"<p><strong>Background: </strong>Endoscopes play an important role in otologic surgery. Baby shampoos, known for their hypoallergenic, anti-irritant, and antifogging properties, are increasingly being used. The purpose of this study was to evaluate the safety and ototoxic effects of baby shampoo in an animal model using both electrophysiological and histological methods.</p><p><strong>Methods: </strong>Twenty-eight male Sprague-Dawley rats were divided into 4 groups: 7 control (group 1), 7 saline (group 2), 7 isopropyl alcohol (70%) + chlorhexidine (2%) antiseptic (group 3), and 7 baby shampoo (group 4). Baseline hearing was assessed by auditory brainstem response (ABR). All groups except the control received 3 doses of their respective substances by intratympanic injection. Auditory brainstem response measurements were performed on day 7 and day 21, after which the temporal bones were dissected. Histological evaluation of the cochlea and vascular endothelial growth factor (VEGF) immunoreactivity studies were performed.</p><p><strong>Results: </strong>Baseline hearing thresholds were similar and within normal limits. On days 7 and 21, hearing thresholds were significantly impaired at all frequencies in the experimental groups. In particular, groups 3 and 4 had higher thresholds than the other groups. Baby shampoo caused significant damage to outer hair cells and sustentacular cells and decreased VEGF immunoreactivity in the stria vascularis, spiral ligament, and organ of Corti.</p><p><strong>Conclusion: </strong>Baby shampoo was found to progressively impair hearing over time, indicating its potential to cause long-term ototoxicity.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"21 2","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}