The journal of international advanced otology最新文献

{"title":"Letter to the Editor Regarding \"Health-Related Quality of Life Evaluation in Children with Cochlear Implants\".","authors":"Nadeera Aboobacker, Valli Rajasekaran","doi":"10.65717/iao.2026.262330","DOIUrl":"https://doi.org/10.65717/iao.2026.262330","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 4","pages":"1"},"PeriodicalIF":1.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Eye Movements Using 3-Dimensional Video-oculography in Response to Galvanic Vestibular Stimulation.","authors":"Yosuke Okinaka, Makoto Hashimoto, Junko Tsuda, Yosuke Takemoto, Youhei Yamamoto, Shogo Nishimura, Tatsuya Masaki, Mei Sakamoto, Kazuma Sugahara","doi":"10.65717/iao.2026.252266","DOIUrl":"https://doi.org/10.65717/iao.2026.252266","url":null,"abstract":"<p><strong>Background: </strong>Quantitative assessment of vestibular nerve activity has been difficult with conventional electrophysiological techniques. This study aimed to develop a novel method combining galvanic vestibular stimulation (GVS) with 3-dimensional video-oculography (3D-VOG) to evaluate vestibular function noninvasively.</p><p><strong>Methods: </strong>Eye movements were recorded from healthy individuals using a high-resolution infrared VOG system (yVOG, Yamaguchi University). Bipolar GVS was applied bilaterally over the mastoid processes with various current intensities (0.5-2.0 mA) and polarities. Horizontal, vertical, and torsional eye-movement components were extracted and analyzed in relation to stimulus parameters.</p><p><strong>Results: </strong>Torsional nystagmus amplitude and slow-phase velocity increased proportionally with stimulus intensity and reversed with polarity. Healthy participants exhibited symmetric responses. The induced eye-movement responses showed reproducible polarity- and intensity-dependent characteristics.</p><p><strong>Conclusion: </strong>This study demonstrates that GVS-VOG provides a direct, reproducible, and noninvasive means of evaluating vestibular nerve function through eye movement analysis. The method may complement existing vestibular function tests in future clinical applications. Galvanic vestibular stimulation-video-oculography also offers utility in both research and clinical settings by linking physiological mechanisms with observable oculomotor responses. This approach holds promise as a diagnostic tool for vestibular disorders, especially when conventional tests yield inconclusive results.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 4","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Amniotic Membrane and Dexamethasone Improve Regeneration Following Facial Nerve Transection in a Rat Model.","authors":"Onur Çorakçı, Fatih Yılmaz, Canberk Kertmen, Cansu Söylemez, Rafet Güneş Öztürk, Osman Yılmaz, Abdullah Dalgic","doi":"10.65717/iao.2026.262447","DOIUrl":"https://doi.org/10.65717/iao.2026.262447","url":null,"abstract":"<p><strong>Background: </strong>Facial nerve transection leads to significant functional and aesthetic deficits. Although microsurgical repair is the standard of care, complete functional recovery remains rare. Biological scaffolds and corticosteroids have been explored as adjuncts to enhance nerve regeneration. To evaluate the effects of human amniotic membrane (AM) wrapping and intraperitoneal dexamethasone, used alone or in combination, on facial nerve regeneration in a murine model.</p><p><strong>Methods: </strong>Twenty-eight male albino mice underwent right facial nerve transection followed by epineural repair and were randomized into 4 groups (n= 7 each): (1) control (repair only), (2) dexamethasone (1 mg/kg IP for 7 days), (3) AM wrapping, and (4) combination therapy (AM + dexamethasone). Functional recovery was assessed using compound muscle action potential (CMAP) recordings on postoperative day 21. Histological analysis included axon count, myelin density, axon diameter, and CD44/Ki-67 immunohistochemistry.</p><p><strong>Results: </strong>Group 4 (combination therapy) demonstrated the highest CMAP amplitude (5.5 ± 2.7 mV), axon count (median: 92.0), and myelin density (median: 50.5). Significant intergroup differences were observed in axon count (P < .001), myelin density (P < .001), and nuclear vacuole reduction (P=.04). Group 4 (combination therapy) demonstrated the highest CMAP amplitude (5.5 ± 2.7 mV); however, this increase did not reach statistical significance when compared with other groups (P=.299). Significant intergroup differences were observed in axon count (P < .001), myelin density (P < .001), and nuclear vacuole reduction (P=.04). Thus, while histopathological outcomes clearly favored Group 4, functional superiority should be interpreted with caution.</p><p><strong>Conclusion: </strong>Combined use of AM and dexamethasone synergistically enhanced facial nerve regeneration in this model. This dual approach may serve as an effective adjunct to microsurgical repair in peripheral nerve injuries. Further studies are needed to confirm its translational potential.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 4","pages":"1-8"},"PeriodicalIF":1.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular Schwannoma in the Precision Medicine Era: An Updated Narrative Review of Molecular Insights, Imaging Biomarkers, and Evolving Management Strategies.","authors":"Flavio Donnini, Giovanni Rubino, Giuseppe Battaglia, Pierpaolo Pastina, Marta Vannini, Tommaso Carfagno, Salvatore Chibbaro, Paolo Tini","doi":"10.65717/iao.2026.262358","DOIUrl":"https://doi.org/10.65717/iao.2026.262358","url":null,"abstract":"<p><strong>Unlabelled: </strong>Vestibular schwannoma (VS) care is increasingly shaped by molecular and imaging advances that complement conventional size- and symptom-based decision-making. Recent multi-omic studies, including single-cell and spatial transcriptomics and methylation profiling, reveal biologically distinct Schwann cell states and microenvironmental programs that may help explain heterogeneous growth, hearing decline, and treatment response. In parallel, quantitative magnetic resonance imaging, radiomics, and early radiogenomic efforts are moving toward standardized, Image Biomarker Standardisation Initiative-compliant pipelines and automated segmentation, enabling more reproducible risk models. Clinically, prospective comparative evidence (e.g., Vestibular schwannoma: Radiosurgery or Expectation and Vestibular Schwannoma International Study of Active Surveillance has refined the observation vs. upfront radiosurgery debate for small-to-medium tumors, while contemporary planning emphasizes cochlear sparing to maximize hearing preservation. Targeted systemic therapy remains mainly relevant for NF2-related disease, with bevacizumab as proof of concept and multiple pathway-directed agents under evaluation. This narrative review synthesizes these developments and outlines a practical framework to integrate biology and imaging biomarkers into individualized surveillance and treatment selection, while highlighting limitations and priorities for multicenter validation.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 4","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blind Sac Closure of the External Auditory Canal in Temporal Bone Surgery: Long-Term Results.","authors":"Enrico Liaci, Maurizio Falcioni, Giuseppe De Donato, Giulia Bertoli, Giovanni Pepe, Enrico Pasanisi, Filippo Di Lella","doi":"10.65717/iao.2026.252228","DOIUrl":"10.65717/iao.2026.252228","url":null,"abstract":"<p><strong>Background: </strong>To report long-term results in patients who underwent blind sac closure (BSC) of the external auditory canal (EAC) for middle ear or skull base diseases, as part of subtotal petrosectomy (SP), performed either as a stand-alone procedure or in combination with cochlear implantation or lateral skull base approaches.</p><p><strong>Methods: </strong>A retrospective single-center cohort observational study was conducted on patients who underwent SP with BSC of the EAC between January 2015 and December 2022. Risk factors for BSC-related complications were considered, including preoperative EAC conditions (i.e., mal-formations, previous meatoplasty or previous BSC), surgical cavity status (i.e., active infection, cerebrospinal fluid (CSF) leak and dural opening), and presence of cochlear implant (CI).</p><p><strong>Results: </strong>Overall, 158 cases of SP with BSC of the EAC were analyzed, with a mean follow-up time of 49.6 months (range 6-102). Of these, 67 underwent SP alone, 55 SP with simultaneous CI surgery, and 36 SP in the context of lateral skull base approaches. Risk factors related to BSC were identified, including 23 previous meatoplasties, 12 previous BSC, 2 malformations of the EAC, 29 active infections, 37 cases of CSF or dural opening, and 56 CIs. A single case of BSC dehiscence requiring revision surgery was observed.</p><p><strong>Conclusions: </strong>Analysis of surgical outcomes specifically related to BSC of the EAC in the context of SP, either as a stand-alone procedure or combined with cochlear implantation or lateral skull base approaches, showed an extremely low rate of complications in the short and long term.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 4","pages":"1-7"},"PeriodicalIF":1.2,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Comment on \"Revisiting GAD Plasticity and Audiogenic Seizures in Central Auditory Pathways\".","authors":"Junjie Liu, Jiaye Tang, Datao Zou, Libin Zeng, Da Chen, Yonghua Liao, Shengqiang Chen","doi":"10.65717/iao.2026.26259101","DOIUrl":"https://doi.org/10.65717/iao.2026.26259101","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 3","pages":"1-2"},"PeriodicalIF":1.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Glutamic Acid Decarboxylase Plasticity and Audiogenic Seizures in Central Auditory Pathways.","authors":"Bülent Satar","doi":"10.65717/iao.2026.262591","DOIUrl":"https://doi.org/10.65717/iao.2026.262591","url":null,"abstract":"","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 3","pages":"1-2"},"PeriodicalIF":1.2,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Hearing Outcomes of NiTiBOND versus SMart Nitinol Prostheses in Stapes Surgery-A Retrospective Cohort Study.","authors":"Péter Révész, Kálmán Rígler, Imre Gerlinger, Tamás Tóth, Tímea Dergez, István Szanyi","doi":"10.65717/iao.2026.252163","DOIUrl":"https://doi.org/10.65717/iao.2026.252163","url":null,"abstract":"<p><strong>Background: </strong>Perform a statistical analysis of the long-term hearing results for 2 groups after stapedotomy using different heat-memory stapes prostheses.</p><p><strong>Methods: </strong>A retrospective study of 42 patients who underwent stapedotomy using either NiTiBOND (n=25) or SMart Nitinol (n=17) thermal shape memory prostheses. Statistical differences were assessed with univariate and multivariate analysis. Success was defined as a postoperative air-bone gap (ABG) ≤ 10 dB. A Pvalue < .05 was considered statistically significant.</p><p><strong>Results: </strong>The audiological outcomes were measured at an average of 7.3 and 13.4 years postoperatively for NiTiBOND and Nitinol, respectively. The postoperative ABG was a mean of 5.18 ± 5.59 dB and 4.71 ± 5.02 dB; no statistically significant difference was observed between the groups. Three patients achieving >10 dB postoperative ABG underwent high-resolution computed tomography, but none showed noticeable pathological changes.</p><p><strong>Conclusion: </strong>The study demonstrated excellent audiological outcomes with both prostheses and appears to be stable in the long term.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 3","pages":"1-5"},"PeriodicalIF":1.2,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amniotic Membrane for Tympanic Membrane Repair: An Experimental Study.","authors":"Ali Murati, Serdal Celik, Tulay Zenginkinet, Ahmet Mutlu, Tayyar M Kalcioglu","doi":"10.65717/iao.2026.262437","DOIUrl":"https://doi.org/10.65717/iao.2026.262437","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to evaluate the histopathological effects of using amniotic membranes to heal traumatic perforations of the tympanic membrane (TM).</p><p><strong>Methods: </strong>Thirty Wistar albino rats were randomly divided into 3 groups. Under general anesthesia, acute TM perforation was performed in the posterior quadrant of each ear. Group A received amniotic membrane (AM) treatment, while Group B received vector paper treatment. Group C was left to heal spontaneously. All the rats were killed on day 21 for a histopathological evaluation.</p><p><strong>Results: </strong>In total, 3 rats were excluded from the study for various reasons. Tympanic membrane thickness, the presence of residual perforation, fibroblastic activity, and neovascularization were evaluated histologically. There was persistent perforation in one of the 18 ears in Group A, 9 of the 20 ears in Group B, and 7 of the 16 ears in Group C. Significant differences in perforation closure rates were observed between Groups A and B and Groups A and C (P=.0089 and .0121, respectively). Tympanic membrane thickness also differed significantly between Groups A and B and Groups A and C (P=.0291 and .0106, respectively). However, no significant differences were found among the groups regarding neovascularization (P=.1094) or fibroblastic activity (P=.7275).</p><p><strong>Conclusion: </strong>This study demonstrates that applying an AM significantly improves the healing of the TM in terms of closure rate, and membrane thickness. These results suggest that AM could play a therapeutic role in enhancing the healing of traumatic TM perforations.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 3","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Atrial Fibrillation and Hearing Loss: A Cross-Sectional Study.","authors":"Ye Ji Shim","doi":"10.65717/iao.2026.262430","DOIUrl":"https://doi.org/10.65717/iao.2026.262430","url":null,"abstract":"<p><strong>Background: </strong>Atrial fibrillation (AF) is associated with various end-organ complications through mechanisms including thromboembolism and microvascular dysfunction. The cochlea, with its high metabolic demands and limited collateral circulation, is particularly vulnerable to circulatory disturbances. However, the association between AF and hearing loss remains poorly understood, with limited and conflicting evidence from prior studies. Therefore, this study aimed to investigate the association between AF and hearing thresholds.</p><p><strong>Methods: </strong>A single-center, cross-sectional study was conducted on 129 adults who underwent pure-tone audiometry, 12-lead electrocardiography, and 24-hour Holter monitoring. Subjects were categorized into an AF group (n=42) and a control group (n=87). The primary outcome was the better-ear average hearing threshold across 0.5, 1, 2, and 4 kHz. Generalized additive models were used to assess the association between AF and hearing thresholds, adjusting for age, sex, body mass index, and other cardiometabolic risk factors. Frequency-specific analyses were also conducted.</p><p><strong>Results: </strong>After adjusting for covariates, AF was independently associated with a 4.28 dB HL elevation in hearing thresholds (95% CI: 3.47-5.10, P=.017). Frequency-specific analyses revealed that the association was most pronounced at 4 kHz, with a 7.40 dB HL elevation at this frequency (95% CI: 2.27-10.05, P=.004).</p><p><strong>Conclusion: </strong>This study provides preliminary evidence of an association between AF and hearing loss, suggesting that AF could be considered in investigations aimed at identifying modifiable risk factors for hearing loss.</p>","PeriodicalId":94238,"journal":{"name":"The journal of international advanced otology","volume":"22 3","pages":"1-6"},"PeriodicalIF":1.2,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}